Compile Data Set for Download or QSAR
Report error Found 114 of Enz. Inhib. data with enzyme = 'Cathepsin K' and Substrate = 'BDBM19485'
TargetCathepsin K(Human)
Novartis Pharmaceuticals

LigandChemical structure of BindingDB Monomer ID 19736BDBM19736(2-cyano-4-[(2,2-dimethylpropyl)amino]-N-[2-(4-meth...)
Affinity DataIC50: 0.00300nMpH: 7.0 T: 2°CAssay Description:The substrate hydrolysis with or without inhibitor was monitored at an excitation wavelength of 360nm and an emission wavelength of 460 nm on a fluor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/5/2008
Entry Details Article
PubMed
TargetCathepsin K(Human)
Novartis Pharmaceuticals

LigandChemical structure of BindingDB Monomer ID 19737BDBM19737(2-cyano-4-[(2,2-dimethylpropyl)amino]-N-[2-(3-meth...)
Affinity DataIC50: 0.00300nMpH: 7.0 T: 2°CAssay Description:The substrate hydrolysis with or without inhibitor was monitored at an excitation wavelength of 360nm and an emission wavelength of 460 nm on a fluor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/5/2008
Entry Details Article
PubMed
TargetCathepsin K(Human)
Novartis Pharmaceuticals

LigandChemical structure of BindingDB Monomer ID 19743BDBM19743(2-cyano-4-[(2,2-dimethylpropyl)amino]-N-(2-{4-[2-(...)
Affinity DataIC50: 0.00300nMpH: 7.0 T: 2°CAssay Description:The substrate hydrolysis with or without inhibitor was monitored at an excitation wavelength of 360nm and an emission wavelength of 460 nm on a fluor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/5/2008
Entry Details Article
PubMed
TargetCathepsin K(Human)
Novartis Pharmaceuticals

LigandChemical structure of BindingDB Monomer ID 19744BDBM19744(2-cyano-4-[(2,2-dimethylpropyl)amino]-N-(2-{3-[2-(...)
Affinity DataIC50: 0.00300nMpH: 7.0 T: 2°CAssay Description:The substrate hydrolysis with or without inhibitor was monitored at an excitation wavelength of 360nm and an emission wavelength of 460 nm on a fluor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/5/2008
Entry Details Article
PubMed
TargetCathepsin K(Human)
Novartis Pharmaceuticals

LigandChemical structure of BindingDB Monomer ID 19733BDBM19733(2-cyano-4-(cyclohexylamino)-N-[2-(3-methoxyphenyl)...)
Affinity DataIC50: 0.00900nMpH: 7.0 T: 2°CAssay Description:The substrate hydrolysis with or without inhibitor was monitored at an excitation wavelength of 360nm and an emission wavelength of 460 nm on a fluor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/5/2008
Entry Details Article
PubMed
TargetCathepsin K(Human)
Novartis Pharmaceuticals

LigandChemical structure of BindingDB Monomer ID 19770BDBM19770((2S)-2-(1-benzofuran-2-ylformamido)-4-methyl-N-[(4...)
Affinity DataKi:  0.00990nM ΔG°:  -14.9kcal/molepH: 5.5 T: 2°CAssay Description:Potential inhibitors were evaluated using the progress curve method. Assays were carried out in the presence of variable concentrations of test compo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/5/2008
Entry Details Article
PubMed
TargetCathepsin K(Human)
Novartis Pharmaceuticals

LigandChemical structure of BindingDB Monomer ID 19731BDBM19731(2-cyano-4-(cyclohexylamino)-N-(2-phenylethyl)pyrim...)
Affinity DataIC50: 0.0100nMpH: 7.0 T: 2°CAssay Description:The substrate hydrolysis with or without inhibitor was monitored at an excitation wavelength of 360nm and an emission wavelength of 460 nm on a fluor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/5/2008
Entry Details Article
PubMed
TargetCathepsin K(Human)
Novartis Pharmaceuticals

LigandChemical structure of BindingDB Monomer ID 19740BDBM19740(2-cyano-4-[(2,2-dimethylpropyl)amino]-N-{2-[3-(4-m...)
Affinity DataIC50: 0.0110nMpH: 7.0 T: 2°CAssay Description:The substrate hydrolysis with or without inhibitor was monitored at an excitation wavelength of 360nm and an emission wavelength of 460 nm on a fluor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/5/2008
Entry Details Article
PubMed
TargetCathepsin K(Human)
Novartis Pharmaceuticals

LigandChemical structure of BindingDB Monomer ID 19741BDBM19741(2-cyano-4-[(2,2-dimethylpropyl)amino]-N-(2-{4-[(4-...)
Affinity DataIC50: 0.0110nMpH: 7.0 T: 2°CAssay Description:The substrate hydrolysis with or without inhibitor was monitored at an excitation wavelength of 360nm and an emission wavelength of 460 nm on a fluor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/5/2008
Entry Details Article
PubMed
TargetCathepsin K(Human)
Novartis Pharmaceuticals

LigandChemical structure of BindingDB Monomer ID 19742BDBM19742(2-cyano-4-[(2,2-dimethylpropyl)amino]-N-(2-{4-[(1-...)
Affinity DataIC50: 0.0130nMpH: 7.0 T: 2°CAssay Description:The substrate hydrolysis with or without inhibitor was monitored at an excitation wavelength of 360nm and an emission wavelength of 460 nm on a fluor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/5/2008
Entry Details Article
PubMed
TargetCathepsin K(Human)
Novartis Pharmaceuticals

LigandChemical structure of BindingDB Monomer ID 19732BDBM19732(2-cyano-4-(cyclohexylamino)-N-[2-(4-methoxyphenyl)...)
Affinity DataIC50: 0.0220nMpH: 7.0 T: 2°CAssay Description:The substrate hydrolysis with or without inhibitor was monitored at an excitation wavelength of 360nm and an emission wavelength of 460 nm on a fluor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/5/2008
Entry Details Article
PubMed
TargetCathepsin K(Human)
Novartis Pharmaceuticals

LigandChemical structure of BindingDB Monomer ID 19739BDBM19739(2-cyano-4-[(2,2-dimethylpropyl)amino]-N-{2-[4-(4-m...)
Affinity DataIC50: 0.0250nMpH: 7.0 T: 2°CAssay Description:The substrate hydrolysis with or without inhibitor was monitored at an excitation wavelength of 360nm and an emission wavelength of 460 nm on a fluor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/5/2008
Entry Details Article
PubMed
TargetCathepsin K(Human)
Novartis Pharmaceuticals

LigandChemical structure of BindingDB Monomer ID 19745BDBM19745(2-cyano-4-[(2,2-dimethylpropyl)amino]-N-(2-{3-[2-(...)
Affinity DataIC50: 0.0310nMpH: 7.0 T: 2°CAssay Description:The substrate hydrolysis with or without inhibitor was monitored at an excitation wavelength of 360nm and an emission wavelength of 460 nm on a fluor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/5/2008
Entry Details Article
PubMed
TargetCathepsin K(Human)
Novartis Pharmaceuticals

LigandChemical structure of BindingDB Monomer ID 19778BDBM19778((2S)-2-(1-benzofuran-2-ylformamido)-4-methyl-N-[(4...)
Affinity DataKi:  0.0410nM ΔG°:  -14.0kcal/molepH: 5.5 T: 2°CAssay Description:Potential inhibitors were evaluated using the progress curve method. Assays were carried out in the presence of variable concentrations of test compo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/5/2008
Entry Details Article
PubMed
TargetCathepsin K(Human)
Novartis Pharmaceuticals

LigandChemical structure of BindingDB Monomer ID 19735BDBM19735(2-cyano-4-(cyclohexylamino)-N-{2-[4-(4-methylpiper...)
Affinity DataIC50: 0.0470nMpH: 7.0 T: 2°CAssay Description:The substrate hydrolysis with or without inhibitor was monitored at an excitation wavelength of 360nm and an emission wavelength of 460 nm on a fluor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/5/2008
Entry Details Article
PubMed
TargetCathepsin K(Human)
Novartis Pharmaceuticals

LigandChemical structure of BindingDB Monomer ID 19783BDBM19783((2S)-3,3-dimethyl-1-{3-[4-(trifluoromethyl)phenyl]...)
Affinity DataIC50: 0.0720nMpH: 5.5 T: 2°CAssay Description:Assays were carried out in the presence of variable concentrations of test compound. Reactions were initiated by addition of enzyme to buffered solut...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/5/2008
Entry Details Article
PubMed
TargetCathepsin K(Human)
Novartis Pharmaceuticals

LigandChemical structure of BindingDB Monomer ID 19775BDBM19775((2S)-2-(1-benzofuran-2-ylformamido)-4-methyl-N-[(4...)
Affinity DataKi:  0.140nM ΔG°:  -13.3kcal/molepH: 5.5 T: 2°CAssay Description:Potential inhibitors were evaluated using the progress curve method. Assays were carried out in the presence of variable concentrations of test compo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/5/2008
Entry Details Article
PubMed
TargetCathepsin K(Human)
Novartis Pharmaceuticals

LigandChemical structure of BindingDB Monomer ID 19769BDBM19769(CHEMBL286364 | (2S)-2-(1-benzofuran-2-ylformamido)...)
Affinity DataKi:  0.160nM ΔG°:  -13.2kcal/molepH: 5.5 T: 2°CAssay Description:Potential inhibitors were evaluated using the progress curve method. Assays were carried out in the presence of variable concentrations of test compo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/5/2008
Entry Details Article
PubMed
TargetCathepsin K(Human)
Novartis Pharmaceuticals

LigandChemical structure of BindingDB Monomer ID 19738BDBM19738(2-cyano-4-[(2,2-dimethylpropyl)amino]-N-{2-[4-(pyr...)
Affinity DataIC50: 0.300nMpH: 7.0 T: 2°CAssay Description:The substrate hydrolysis with or without inhibitor was monitored at an excitation wavelength of 360nm and an emission wavelength of 460 nm on a fluor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/5/2008
Entry Details Article
PubMed
TargetCathepsin K(Human)
Novartis Pharmaceuticals

LigandChemical structure of BindingDB Monomer ID 19808BDBM19808(benzyl N-[(1S)-1-({1-[(2S)-2-{[(benzyloxy)carbonyl...)
Affinity DataKi:  0.600nM ΔG°:  -12.4kcal/molepH: 5.5 T: 2°CAssay Description:Assays were carried out in the presence of variable concentrations of test compound. Reactions were initiated by addition of enzyme to buffered solut...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/5/2008
Entry Details Article
PubMed
TargetCathepsin K(Human)
Novartis Pharmaceuticals

LigandChemical structure of BindingDB Monomer ID 19734BDBM19734(2-cyano-4-(cyclohexylamino)-N-{2-[4-(pyrrolidin-1-...)
Affinity DataIC50: 0.75nMpH: 7.0 T: 2°CAssay Description:The substrate hydrolysis with or without inhibitor was monitored at an excitation wavelength of 360nm and an emission wavelength of 460 nm on a fluor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/5/2008
Entry Details Article
PubMed
TargetCathepsin K(Human)
Novartis Pharmaceuticals

LigandChemical structure of BindingDB Monomer ID 19764BDBM19764((2S)-N-[(1R)-2-(benzyloxy)-1-cyanoethyl]-2-(1H-ind...)
Affinity DataIC50: 1nMpH: 7.0 T: 2°CAssay Description:The substrate hydrolysis with or without inhibitor was monitored at an excitation wavelength of 360nm and an emission wavelength of 460 nm on a fluor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2008
Entry Details Article
PubMed
TargetCathepsin K(Human)
Novartis Pharmaceuticals

LigandChemical structure of BindingDB Monomer ID 19765BDBM19765((2S)-N-[(1R)-2-(benzyloxy)-1-cyanoethyl]-4-methyl-...)
Affinity DataIC50: 1nMpH: 7.0 T: 2°CAssay Description:The substrate hydrolysis with or without inhibitor was monitored at an excitation wavelength of 360nm and an emission wavelength of 460 nm on a fluor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2008
Entry Details Article
PubMed
TargetCathepsin K(Human)
Novartis Pharmaceuticals

LigandChemical structure of BindingDB Monomer ID 19762BDBM19762((2S)-N-[(1R)-2-(benzyloxy)-1-cyanoethyl]-2-[2-(4-c...)
Affinity DataIC50: 1nMpH: 7.0 T: 2°CAssay Description:The substrate hydrolysis with or without inhibitor was monitored at an excitation wavelength of 360nm and an emission wavelength of 460 nm on a fluor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2008
Entry Details Article
PubMed
TargetCathepsin K(Human)
Novartis Pharmaceuticals

LigandChemical structure of BindingDB Monomer ID 19780BDBM19780((2S)-2-(1-benzofuran-2-ylformamido)-4-methyl-N-[(4...)
Affinity DataKi:  1.40nM ΔG°:  -11.9kcal/molepH: 5.5 T: 2°CAssay Description:Potential inhibitors were evaluated using the progress curve method. Assays were carried out in the presence of variable concentrations of test compo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/5/2008
Entry Details Article
PubMed
TargetCathepsin K(Human)
Novartis Pharmaceuticals

LigandChemical structure of BindingDB Monomer ID 19793BDBM19793((2S)-1-(5,6-dichloro-1H-1,3-benzodiazol-1-yl)-3,3-...)
Affinity DataIC50: 1.40nMpH: 5.5 T: 2°CAssay Description:Assays were carried out in the presence of variable concentrations of test compound. Reactions were initiated by addition of enzyme to buffered solut...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/5/2008
Entry Details Article
PubMed
TargetCathepsin K(Human)
Novartis Pharmaceuticals

LigandChemical structure of BindingDB Monomer ID 19771BDBM19771((2S)-2-(1-benzofuran-2-ylformamido)-4-methyl-N-[(4...)
Affinity DataKi:  1.5nM ΔG°:  -11.9kcal/molepH: 5.5 T: 2°CAssay Description:Potential inhibitors were evaluated using the progress curve method. Assays were carried out in the presence of variable concentrations of test compo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/5/2008
Entry Details Article
PubMed
TargetCathepsin K(Human)
Novartis Pharmaceuticals

LigandChemical structure of BindingDB Monomer ID 19813BDBM19813(benzyl N-[(2S)-4-methyl-1-{3-[(2S)-4-methyl-2-(qui...)
Affinity DataKi:  1.60nM ΔG°:  -11.9kcal/molepH: 5.5 T: 2°CAssay Description:Assays were carried out in the presence of variable concentrations of test compound. Reactions were initiated by addition of enzyme to buffered solut...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/5/2008
Entry Details Article
PubMed
TargetCathepsin K(Human)
Novartis Pharmaceuticals

LigandChemical structure of BindingDB Monomer ID 19811BDBM19811(benzyl N-[(1S)-1-({1-[(2S)-2-{[(benzyloxy)carbonyl...)
Affinity DataKi:  1.90nM ΔG°:  -11.8kcal/molepH: 5.5 T: 2°CAssay Description:Assays were carried out in the presence of variable concentrations of test compound. Reactions were initiated by addition of enzyme to buffered solut...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/5/2008
Entry Details Article
PubMed
TargetCathepsin K(Human)
Novartis Pharmaceuticals

LigandChemical structure of BindingDB Monomer ID 19796BDBM19796((2S)-3,3-dimethyl-1-{3-[4-(trifluoromethyl)phenyl]...)
Affinity DataIC50: 2.10nMpH: 5.5 T: 2°CAssay Description:Assays were carried out in the presence of variable concentrations of test compound. Reactions were initiated by addition of enzyme to buffered solut...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/5/2008
Entry Details Article
PubMed
TargetCathepsin K(Human)
Novartis Pharmaceuticals

LigandChemical structure of BindingDB Monomer ID 19807BDBM19807(benzyl N-[(1S)-1-({1-[(2S)-2-{[(benzyloxy)carbonyl...)
Affinity DataKi:  2.30nM ΔG°:  -11.7kcal/molepH: 5.5 T: 2°CAssay Description:Assays were carried out in the presence of variable concentrations of test compound. Reactions were initiated by addition of enzyme to buffered solut...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/5/2008
Entry Details Article
PubMed
TargetCathepsin K(Human)
Novartis Pharmaceuticals

LigandChemical structure of BindingDB Monomer ID 19779BDBM19779((2S)-2-(1-benzofuran-2-ylformamido)-4-methyl-N-[(4...)
Affinity DataKi:  2.5nM ΔG°:  -11.6kcal/molepH: 5.5 T: 2°CAssay Description:Potential inhibitors were evaluated using the progress curve method. Assays were carried out in the presence of variable concentrations of test compo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/5/2008
Entry Details Article
PubMed
TargetCathepsin K(Human)
Novartis Pharmaceuticals

LigandChemical structure of BindingDB Monomer ID 19810BDBM19810(benzyl N-[(1S)-1-({1-[(2S)-2-{[(benzyloxy)carbonyl...)
Affinity DataKi:  2.60nM ΔG°:  -11.6kcal/molepH: 5.5 T: 2°CAssay Description:Assays were carried out in the presence of variable concentrations of test compound. Reactions were initiated by addition of enzyme to buffered solut...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/5/2008
Entry Details Article
PubMed
TargetCathepsin K(Human)
Novartis Pharmaceuticals

LigandChemical structure of BindingDB Monomer ID 19794BDBM19794((2S)-1-(5,6-dichloro-1H-1,3-benzodiazol-1-yl)-3,3-...)
Affinity DataIC50: 3.20nMpH: 5.5 T: 2°CAssay Description:Assays were carried out in the presence of variable concentrations of test compound. Reactions were initiated by addition of enzyme to buffered solut...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/5/2008
Entry Details Article
PubMed
TargetCathepsin K(Human)
Novartis Pharmaceuticals

LigandChemical structure of BindingDB Monomer ID 19791BDBM19791((2S)-3,3-dimethyl-1-[3-(pyridin-4-yl)-1H-pyrazol-1...)
Affinity DataIC50: 3.80nMpH: 5.5 T: 2°CAssay Description:Assays were carried out in the presence of variable concentrations of test compound. Reactions were initiated by addition of enzyme to buffered solut...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/5/2008
Entry Details Article
PubMed
TargetCathepsin K(Human)
Novartis Pharmaceuticals

LigandChemical structure of BindingDB Monomer ID 19781BDBM19781((2S)-2-(1-benzofuran-2-ylformamido)-4-methyl-N-[(4...)
Affinity DataKi:  4nM ΔG°:  -11.3kcal/molepH: 5.5 T: 2°CAssay Description:Potential inhibitors were evaluated using the progress curve method. Assays were carried out in the presence of variable concentrations of test compo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/5/2008
Entry Details Article
PubMed
TargetCathepsin K(Human)
Novartis Pharmaceuticals

LigandChemical structure of BindingDB Monomer ID 19786BDBM19786((2S)-3,3-dimethyl-1-{3-[4-(trifluoromethyl)phenyl]...)
Affinity DataIC50: 4nMpH: 5.5 T: 2°CAssay Description:Assays were carried out in the presence of variable concentrations of test compound. Reactions were initiated by addition of enzyme to buffered solut...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/5/2008
Entry Details Article
PubMed
TargetCathepsin K(Human)
Novartis Pharmaceuticals

LigandChemical structure of BindingDB Monomer ID 19777BDBM19777((2S)-2-(1-benzofuran-2-ylformamido)-4-methyl-N-[(4...)
Affinity DataKi:  4.5nM ΔG°:  -11.3kcal/molepH: 5.5 T: 2°CAssay Description:Potential inhibitors were evaluated using the progress curve method. Assays were carried out in the presence of variable concentrations of test compo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/5/2008
Entry Details Article
PubMed
TargetCathepsin K(Human)
Novartis Pharmaceuticals

LigandChemical structure of BindingDB Monomer ID 19792BDBM19792((2S)-3,3-dimethyl-1-[3-(pyridin-3-yl)-1H-pyrazol-1...)
Affinity DataIC50: 5.5nMpH: 5.5 T: 2°CAssay Description:Assays were carried out in the presence of variable concentrations of test compound. Reactions were initiated by addition of enzyme to buffered solut...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/5/2008
Entry Details Article
PubMed
TargetCathepsin K(Human)
Novartis Pharmaceuticals

LigandChemical structure of BindingDB Monomer ID 19746BDBM19746(CHEMBL363847 | Purine lead structure, 1 | 6-(cyclo...)
Affinity DataIC50: 6nMAssay Description:The substrate hydrolysis with or without inhibitor was monitored at an excitation wavelength of 360nm and an emission wavelength of 460 nm on a fluor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/5/2008
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCathepsin K(Human)
Novartis Pharmaceuticals

LigandChemical structure of BindingDB Monomer ID 19789BDBM19789((2S)-3,3-dimethyl-1-{4-[4-(trifluoromethyl)phenyl]...)
Affinity DataIC50: 6.40nMpH: 5.5 T: 2°CAssay Description:Assays were carried out in the presence of variable concentrations of test compound. Reactions were initiated by addition of enzyme to buffered solut...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/5/2008
Entry Details Article
PubMed
TargetCathepsin K(Human)
Novartis Pharmaceuticals

LigandChemical structure of BindingDB Monomer ID 19782BDBM19782((2S)-2-(1-benzofuran-2-ylformamido)-4-methyl-N-[(2...)
Affinity DataIC50: 7.5nMpH: 5.5 T: 2°CAssay Description:Assays were carried out in the presence of variable concentrations of test compound. Reactions were initiated by addition of enzyme to buffered solut...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/5/2008
Entry Details Article
PubMed
TargetCathepsin K(Human)
Novartis Pharmaceuticals

LigandChemical structure of BindingDB Monomer ID 19790BDBM19790((2S)-3,3-dimethyl-1-{4-[4-(trifluoromethyl)phenyl]...)
Affinity DataIC50: 7.60nMpH: 5.5 T: 2°CAssay Description:Assays were carried out in the presence of variable concentrations of test compound. Reactions were initiated by addition of enzyme to buffered solut...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/5/2008
Entry Details Article
PubMed
TargetCathepsin K(Rat)
Gsk

LigandChemical structure of BindingDB Monomer ID 19778BDBM19778((2S)-2-(1-benzofuran-2-ylformamido)-4-methyl-N-[(4...)
Affinity DataKi:  8nMAssay Description:Potential inhibitors were evaluated using the progress curve method. Assays were carried out in the presence of variable concentrations of test compo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/5/2008
Entry Details Article
PubMed
TargetCathepsin K(Human)
Novartis Pharmaceuticals

LigandChemical structure of BindingDB Monomer ID 19759BDBM19759(benzyl N-[(1S)-1-{[(1R)-2-(benzyloxy)-1-cyanoethyl...)
Affinity DataIC50: 9nMpH: 7.0 T: 2°CAssay Description:The substrate hydrolysis with or without inhibitor was monitored at an excitation wavelength of 360nm and an emission wavelength of 460 nm on a fluor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2008
Entry Details Article
PubMed
TargetCathepsin K(Human)
Novartis Pharmaceuticals

LigandChemical structure of BindingDB Monomer ID 19761BDBM19761((2S)-N-[(1R)-2-(benzyloxy)-1-cyanoethyl]-4-methyl-...)
Affinity DataIC50: 9nMpH: 7.0 T: 2°CAssay Description:The substrate hydrolysis with or without inhibitor was monitored at an excitation wavelength of 360nm and an emission wavelength of 460 nm on a fluor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2008
Entry Details Article
PubMed
TargetCathepsin K(Human)
Novartis Pharmaceuticals

LigandChemical structure of BindingDB Monomer ID 19815BDBM19815((2S)-2-(1-benzothiophen-2-ylformamido)-4-methyl-N-...)
Affinity DataKi:  11nM ΔG°:  -10.7kcal/molepH: 5.5 T: 2°CAssay Description:Assays were carried out in the presence of variable concentrations of test compound. Reactions were initiated by addition of enzyme to buffered solut...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/5/2008
Entry Details Article
PubMed
TargetCathepsin K(Human)
Novartis Pharmaceuticals

LigandChemical structure of BindingDB Monomer ID 19785BDBM19785((2S)-3,3-dimethyl-1-{3-[4-(trifluoromethyl)phenyl]...)
Affinity DataIC50: 18nMpH: 5.5 T: 2°CAssay Description:Assays were carried out in the presence of variable concentrations of test compound. Reactions were initiated by addition of enzyme to buffered solut...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/5/2008
Entry Details Article
PubMed
TargetCathepsin K(Human)
Novartis Pharmaceuticals

LigandChemical structure of BindingDB Monomer ID 19772BDBM19772((2S)-2-(1-benzofuran-2-ylformamido)-4-methyl-N-[(4...)
Affinity DataKi:  19nM ΔG°:  -10.4kcal/molepH: 5.5 T: 2°CAssay Description:Potential inhibitors were evaluated using the progress curve method. Assays were carried out in the presence of variable concentrations of test compo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/5/2008
Entry Details Article
PubMed
TargetCathepsin K(Human)
Novartis Pharmaceuticals

LigandChemical structure of BindingDB Monomer ID 19766BDBM19766((2S)-N-[(1R)-2-(benzyloxy)-1-cyanoethyl]-4-methyl-...)
Affinity DataIC50: 24nMpH: 7.0 T: 2°CAssay Description:The substrate hydrolysis with or without inhibitor was monitored at an excitation wavelength of 360nm and an emission wavelength of 460 nm on a fluor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2008
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PubMed
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