Compile Data Set for Download or QSAR
Report error Found 43 of Enz. Inhib. data with enzyme = 'Cathepsin S' and Substrate = 'BDBM19963'
TargetCathepsin S(Human)
Novartis Pharmaceuticals

LigandPNGBDBM19731(2-cyano-4-(cyclohexylamino)-N-(2-phenylethyl)pyrim...)
Affinity DataIC50: 0.130nMAssay Description:The substrate hydrolysis with or without inhibitor was monitored at an excitation wavelength of 360nm and an emission wavelength of 460 nm on a fluor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/5/2008
Entry Details Article
PubMed
TargetCathepsin S(Human)
Novartis Pharmaceuticals

LigandPNGBDBM19733(2-cyano-4-(cyclohexylamino)-N-[2-(3-methoxyphenyl)...)
Affinity DataIC50: 0.230nMAssay Description:The substrate hydrolysis with or without inhibitor was monitored at an excitation wavelength of 360nm and an emission wavelength of 460 nm on a fluor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/5/2008
Entry Details Article
PubMed
TargetCathepsin S(Human)
Novartis Pharmaceuticals

LigandPNGBDBM19735(2-cyano-4-(cyclohexylamino)-N-{2-[4-(4-methylpiper...)
Affinity DataIC50: 0.480nMAssay Description:The substrate hydrolysis with or without inhibitor was monitored at an excitation wavelength of 360nm and an emission wavelength of 460 nm on a fluor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/5/2008
Entry Details Article
PubMed
TargetCathepsin S(Human)
Novartis Pharmaceuticals

LigandPNGBDBM19744(2-cyano-4-[(2,2-dimethylpropyl)amino]-N-(2-{3-[2-(...)
Affinity DataIC50: 0.510nMAssay Description:The substrate hydrolysis with or without inhibitor was monitored at an excitation wavelength of 360nm and an emission wavelength of 460 nm on a fluor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/5/2008
Entry Details Article
PubMed
TargetCathepsin S(Human)
Novartis Pharmaceuticals

LigandPNGBDBM19732(2-cyano-4-(cyclohexylamino)-N-[2-(4-methoxyphenyl)...)
Affinity DataIC50: 0.700nMAssay Description:The substrate hydrolysis with or without inhibitor was monitored at an excitation wavelength of 360nm and an emission wavelength of 460 nm on a fluor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/5/2008
Entry Details Article
PubMed
TargetCathepsin S(Human)
Novartis Pharmaceuticals

LigandPNGBDBM19737(2-cyano-4-[(2,2-dimethylpropyl)amino]-N-[2-(3-meth...)
Affinity DataIC50: 0.900nMAssay Description:The substrate hydrolysis with or without inhibitor was monitored at an excitation wavelength of 360nm and an emission wavelength of 460 nm on a fluor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/5/2008
Entry Details Article
PubMed
TargetCathepsin S(Human)
Novartis Pharmaceuticals

LigandPNGBDBM19743(2-cyano-4-[(2,2-dimethylpropyl)amino]-N-(2-{4-[2-(...)
Affinity DataIC50: 0.900nMAssay Description:The substrate hydrolysis with or without inhibitor was monitored at an excitation wavelength of 360nm and an emission wavelength of 460 nm on a fluor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/5/2008
Entry Details Article
PubMed
TargetCathepsin S(Human)
Novartis Pharmaceuticals

LigandPNGBDBM19736(2-cyano-4-[(2,2-dimethylpropyl)amino]-N-[2-(4-meth...)
Affinity DataIC50: 1.60nMAssay Description:The substrate hydrolysis with or without inhibitor was monitored at an excitation wavelength of 360nm and an emission wavelength of 460 nm on a fluor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/5/2008
Entry Details Article
PubMed
TargetCathepsin S(Human)
Novartis Pharmaceuticals

LigandPNGBDBM19740(2-cyano-4-[(2,2-dimethylpropyl)amino]-N-{2-[3-(4-m...)
Affinity DataIC50: 1.80nMAssay Description:The substrate hydrolysis with or without inhibitor was monitored at an excitation wavelength of 360nm and an emission wavelength of 460 nm on a fluor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/5/2008
Entry Details Article
PubMed
TargetCathepsin S(Human)
Novartis Pharmaceuticals

LigandPNGBDBM19734(2-cyano-4-(cyclohexylamino)-N-{2-[4-(pyrrolidin-1-...)
Affinity DataIC50: 2.30nMAssay Description:The substrate hydrolysis with or without inhibitor was monitored at an excitation wavelength of 360nm and an emission wavelength of 460 nm on a fluor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/5/2008
Entry Details Article
PubMed
TargetCathepsin S(Human)
Novartis Pharmaceuticals

LigandPNGBDBM19741(2-cyano-4-[(2,2-dimethylpropyl)amino]-N-(2-{4-[(4-...)
Affinity DataIC50: 2.5nMAssay Description:The substrate hydrolysis with or without inhibitor was monitored at an excitation wavelength of 360nm and an emission wavelength of 460 nm on a fluor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/5/2008
Entry Details Article
PubMed
TargetCathepsin S(Human)
Novartis Pharmaceuticals

LigandPNGBDBM19745(2-cyano-4-[(2,2-dimethylpropyl)amino]-N-(2-{3-[2-(...)
Affinity DataIC50: 2.60nMAssay Description:The substrate hydrolysis with or without inhibitor was monitored at an excitation wavelength of 360nm and an emission wavelength of 460 nm on a fluor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/5/2008
Entry Details Article
PubMed
TargetCathepsin S(Human)
Novartis Pharmaceuticals

LigandPNGBDBM19739(2-cyano-4-[(2,2-dimethylpropyl)amino]-N-{2-[4-(4-m...)
Affinity DataIC50: 3.10nMAssay Description:The substrate hydrolysis with or without inhibitor was monitored at an excitation wavelength of 360nm and an emission wavelength of 460 nm on a fluor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/5/2008
Entry Details Article
PubMed
TargetCathepsin S(Human)
Novartis Pharmaceuticals

LigandPNGBDBM25138(7-(2-cyclopentylethyl)-6-[4-(4-acetylpiperazin-1-y...)
Affinity DataIC50: 5nMpH: 7.0 T: 2°CAssay Description:The substrate hydrolysis with or without inhibitor was monitored at an excitation wavelength of 360nm and an emission wavelength of 460 nm on a fluor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/28/2008
Entry Details Article
PubMed
TargetCathepsin S(Human)
Novartis Pharmaceuticals

LigandPNGBDBM25136(7-(2-cyclohexylethyl)-6-[4-(4-acetylpiperazin-1-yl...)
Affinity DataIC50: 9nMpH: 7.0 T: 2°CAssay Description:The substrate hydrolysis with or without inhibitor was monitored at an excitation wavelength of 360nm and an emission wavelength of 460 nm on a fluor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/28/2008
Entry Details Article
PubMed
TargetCathepsin S(Human)
Novartis Pharmaceuticals

LigandPNGBDBM25134(CHEMBL481170 | 7-(2-cyclohexylethyl)-6-[4-(4-acety...)
Affinity DataIC50: 9nMpH: 7.0 T: 2°CAssay Description:The substrate hydrolysis with or without inhibitor was monitored at an excitation wavelength of 360nm and an emission wavelength of 460 nm on a fluor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/28/2008
Entry Details Article
PubMed
TargetCathepsin S(Human)
Novartis Pharmaceuticals

LigandPNGBDBM19738(2-cyano-4-[(2,2-dimethylpropyl)amino]-N-{2-[4-(pyr...)
Affinity DataIC50: 10nMAssay Description:The substrate hydrolysis with or without inhibitor was monitored at an excitation wavelength of 360nm and an emission wavelength of 460 nm on a fluor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/5/2008
Entry Details Article
PubMed
TargetCathepsin S(Human)
Novartis Pharmaceuticals

LigandPNGBDBM25141(7-[2-(4,4-difluorocyclohexyl)ethyl]-6-[4-(4-acetyl...)
Affinity DataIC50: 10nMpH: 7.0 T: 2°CAssay Description:The substrate hydrolysis with or without inhibitor was monitored at an excitation wavelength of 360nm and an emission wavelength of 460 nm on a fluor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/28/2008
Entry Details Article
PubMed
TargetCathepsin S(Mouse)
Novartis

LigandPNGBDBM25134(CHEMBL481170 | 7-(2-cyclohexylethyl)-6-[4-(4-acety...)
Affinity DataIC50: 10nMpH: 7.0 T: 2°CAssay Description:The substrate hydrolysis with or without inhibitor was monitored at an excitation wavelength of 360nm and an emission wavelength of 460 nm on a fluor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/28/2008
Entry Details Article
PubMed
TargetCathepsin S(Human)
Novartis Pharmaceuticals

LigandPNGBDBM19742(2-cyano-4-[(2,2-dimethylpropyl)amino]-N-(2-{4-[(1-...)
Affinity DataIC50: 10nMAssay Description:The substrate hydrolysis with or without inhibitor was monitored at an excitation wavelength of 360nm and an emission wavelength of 460 nm on a fluor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/5/2008
Entry Details Article
PubMed
TargetCathepsin S(Human)
Novartis Pharmaceuticals

LigandPNGBDBM25137(7-(2-cyclohexylethyl)-6-[4-(4-acetyl-1,4-diazepan-...)
Affinity DataIC50: 11nMpH: 7.0 T: 2°CAssay Description:The substrate hydrolysis with or without inhibitor was monitored at an excitation wavelength of 360nm and an emission wavelength of 460 nm on a fluor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/28/2008
Entry Details Article
PubMed
TargetCathepsin S(Mouse)
Novartis

LigandPNGBDBM25135(7-(2-cyclohexylethyl)-6-[4-(4-acetylpiperazin-1-yl...)
Affinity DataIC50: 14nMpH: 7.0 T: 2°CAssay Description:The substrate hydrolysis with or without inhibitor was monitored at an excitation wavelength of 360nm and an emission wavelength of 460 nm on a fluor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/28/2008
Entry Details Article
PubMed
TargetCathepsin S(Human)
Novartis Pharmaceuticals

LigandPNGBDBM25139(7-[2-(4-chlorophenyl)ethyl]-6-[4-(4-acetylpiperazi...)
Affinity DataIC50: 17nMpH: 7.0 T: 2°CAssay Description:The substrate hydrolysis with or without inhibitor was monitored at an excitation wavelength of 360nm and an emission wavelength of 460 nm on a fluor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/28/2008
Entry Details Article
PubMed
TargetCathepsin S(Human)
Novartis Pharmaceuticals

LigandPNGBDBM25135(7-(2-cyclohexylethyl)-6-[4-(4-acetylpiperazin-1-yl...)
Affinity DataIC50: 18nMpH: 7.0 T: 2°CAssay Description:The substrate hydrolysis with or without inhibitor was monitored at an excitation wavelength of 360nm and an emission wavelength of 460 nm on a fluor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/28/2008
Entry Details Article
PubMed
TargetCathepsin S(Mouse)
Novartis

LigandPNGBDBM25141(7-[2-(4,4-difluorocyclohexyl)ethyl]-6-[4-(4-acetyl...)
Affinity DataIC50: 20nMpH: 7.0 T: 2°CAssay Description:The substrate hydrolysis with or without inhibitor was monitored at an excitation wavelength of 360nm and an emission wavelength of 460 nm on a fluor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/28/2008
Entry Details Article
PubMed
TargetCathepsin S(Human)
Novartis Pharmaceuticals

LigandPNGBDBM19764((2S)-N-[(1R)-2-(benzyloxy)-1-cyanoethyl]-2-(1H-ind...)
Affinity DataIC50: 29nMAssay Description:The substrate hydrolysis with or without inhibitor was monitored at an excitation wavelength of 360nm and an emission wavelength of 460 nm on a fluor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2008
Entry Details Article
PubMed
TargetCathepsin S(Human)
Novartis Pharmaceuticals

LigandPNGBDBM19763((2S)-N-[(1R)-2-(benzyloxy)-1-cyanoethyl]-2-{2-[(4-...)
Affinity DataIC50: 41nMAssay Description:The substrate hydrolysis with or without inhibitor was monitored at an excitation wavelength of 360nm and an emission wavelength of 460 nm on a fluor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2008
Entry Details Article
PubMed
TargetCathepsin S(Human)
Novartis Pharmaceuticals

LigandPNGBDBM19765((2S)-N-[(1R)-2-(benzyloxy)-1-cyanoethyl]-4-methyl-...)
Affinity DataIC50: 47nMAssay Description:The substrate hydrolysis with or without inhibitor was monitored at an excitation wavelength of 360nm and an emission wavelength of 460 nm on a fluor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2008
Entry Details Article
PubMed
TargetCathepsin S(Human)
Novartis Pharmaceuticals

LigandPNGBDBM25140(7-(2-cycloheptylethyl)-6-[4-(4-acetylpiperazin-1-y...)
Affinity DataIC50: 50nMpH: 7.0 T: 2°CAssay Description:The substrate hydrolysis with or without inhibitor was monitored at an excitation wavelength of 360nm and an emission wavelength of 460 nm on a fluor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/28/2008
Entry Details Article
PubMed
TargetCathepsin S(Human)
Novartis Pharmaceuticals

LigandPNGBDBM19762((2S)-N-[(1R)-2-(benzyloxy)-1-cyanoethyl]-2-[2-(4-c...)
Affinity DataIC50: 52nMAssay Description:The substrate hydrolysis with or without inhibitor was monitored at an excitation wavelength of 360nm and an emission wavelength of 460 nm on a fluor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2008
Entry Details Article
PubMed
TargetCathepsin S(Human)
Novartis Pharmaceuticals

LigandPNGBDBM19766((2S)-N-[(1R)-2-(benzyloxy)-1-cyanoethyl]-4-methyl-...)
Affinity DataIC50: 130nMAssay Description:The substrate hydrolysis with or without inhibitor was monitored at an excitation wavelength of 360nm and an emission wavelength of 460 nm on a fluor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2008
Entry Details Article
PubMed
TargetCathepsin S(Human)
Novartis Pharmaceuticals

LigandPNGBDBM19760((2S)-N-[(1R)-2-(benzyloxy)-1-cyanoethyl]-4-methyl-...)
Affinity DataIC50: 140nMAssay Description:The substrate hydrolysis with or without inhibitor was monitored at an excitation wavelength of 360nm and an emission wavelength of 460 nm on a fluor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2008
Entry Details Article
PubMed
TargetCathepsin S(Human)
Novartis Pharmaceuticals

LigandPNGBDBM19746(CHEMBL363847 | Purine lead structure, 1 | 6-(cyclo...)
Affinity DataIC50: 150nMAssay Description:The substrate hydrolysis with or without inhibitor was monitored at an excitation wavelength of 360nm and an emission wavelength of 460 nm on a fluor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/5/2008
Entry Details Article
PubMed
TargetCathepsin S(Human)
Novartis Pharmaceuticals

LigandPNGBDBM19761((2S)-N-[(1R)-2-(benzyloxy)-1-cyanoethyl]-4-methyl-...)
Affinity DataIC50: 180nMAssay Description:The substrate hydrolysis with or without inhibitor was monitored at an excitation wavelength of 360nm and an emission wavelength of 460 nm on a fluor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2008
Entry Details Article
PubMed
TargetCathepsin S(Human)
Novartis Pharmaceuticals

LigandPNGBDBM19767((2S)-N-[(1R)-2-(benzyloxy)-1-cyanoethyl]-4-methyl-...)
Affinity DataIC50: 240nMAssay Description:The substrate hydrolysis with or without inhibitor was monitored at an excitation wavelength of 360nm and an emission wavelength of 460 nm on a fluor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2008
Entry Details Article
PubMed
TargetCathepsin S(Human)
Novartis Pharmaceuticals

LigandPNGBDBM19754(benzyl N-[(1S)-1-{[(1S)-1-cyano-2-(4-methoxyphenyl...)
Affinity DataIC50: 700nMAssay Description:The substrate hydrolysis with or without inhibitor was monitored at an excitation wavelength of 360nm and an emission wavelength of 460 nm on a fluor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2008
Entry Details Article
PubMed
TargetCathepsin S(Human)
Novartis Pharmaceuticals

LigandPNGBDBM19758(benzyl N-[(1S)-1-{[(1R)-2-(tert-butoxy)-1-cyanoeth...)
Affinity DataIC50: 900nMAssay Description:The substrate hydrolysis with or without inhibitor was monitored at an excitation wavelength of 360nm and an emission wavelength of 460 nm on a fluor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2008
Entry Details Article
PubMed
TargetCathepsin S(Human)
Novartis Pharmaceuticals

LigandPNGBDBM19759(benzyl N-[(1S)-1-{[(1R)-2-(benzyloxy)-1-cyanoethyl...)
Affinity DataIC50: 969nMAssay Description:The substrate hydrolysis with or without inhibitor was monitored at an excitation wavelength of 360nm and an emission wavelength of 460 nm on a fluor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2008
Entry Details Article
PubMed
TargetCathepsin S(Human)
Novartis Pharmaceuticals

LigandPNGBDBM19753(benzyl N-[(1S)-1-{[(1S)-1-cyano-2-(3-methylphenyl)...)
Affinity DataIC50: 2.30E+3nMAssay Description:The substrate hydrolysis with or without inhibitor was monitored at an excitation wavelength of 360nm and an emission wavelength of 460 nm on a fluor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2008
Entry Details Article
PubMed
TargetCathepsin S(Human)
Novartis Pharmaceuticals

LigandPNGBDBM19752(benzyl N-[(1S)-1-{[(1S)-1-cyano-2-(4-methylphenyl)...)
Affinity DataIC50: 1.00E+4nMAssay Description:The substrate hydrolysis with or without inhibitor was monitored at an excitation wavelength of 360nm and an emission wavelength of 460 nm on a fluor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2008
Entry Details Article
PubMed
TargetCathepsin S(Human)
Novartis Pharmaceuticals

LigandPNGBDBM19755(benzyl N-[(1S)-1-{[(1S)-2-[4-(tert-butoxy)phenyl]-...)
Affinity DataIC50: 1.00E+4nMAssay Description:The substrate hydrolysis with or without inhibitor was monitored at an excitation wavelength of 360nm and an emission wavelength of 460 nm on a fluor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2008
Entry Details Article
PubMed
TargetCathepsin S(Human)
Novartis Pharmaceuticals

LigandPNGBDBM19756(benzyl N-[(1S)-1-{[(1S)-2-[4-(benzyloxy)phenyl]-1-...)
Affinity DataIC50: 1.00E+4nMAssay Description:The substrate hydrolysis with or without inhibitor was monitored at an excitation wavelength of 360nm and an emission wavelength of 460 nm on a fluor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2008
Entry Details Article
PubMed
TargetCathepsin S(Human)
Novartis Pharmaceuticals

LigandPNGBDBM19757(benzyl N-[(1S)-1-{[(1S)-1-cyano-2-[4-(trifluoromet...)
Affinity DataIC50: 1.00E+4nMAssay Description:The substrate hydrolysis with or without inhibitor was monitored at an excitation wavelength of 360nm and an emission wavelength of 460 nm on a fluor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2008
Entry Details Article
PubMed