Compile Data Set for Download or QSAR
Report error Found 137 of Enz. Inhib. data with enzyme = 'cAMP-dependent protein kinase catalytic subunit alpha' and Substrate = 'Lysine-rich histone'
LigandChemical structure of BindingDB Monomer ID 2685BDBM2685(3-(1H-indol-3-yl)-4-{1-[2-(piperidin-2-yl)ethyl]-1...)
Affinity DataIC50: 5nMAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2004
Entry Details
PubMed
LigandChemical structure of BindingDB Monomer ID 2683BDBM2683(2-[1-(3-dimethylaminopropyl)-indol-3-yl]-3-(indol-...)
Affinity DataIC50: 10nMAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2004
Entry Details
PubMed
LigandChemical structure of BindingDB Monomer ID 2694BDBM2694(3-(1H-indol-3-yl)-4-{1-[2-(1-methylpyrrolidin-2-yl...)
Affinity DataIC50: 13nMAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2004
Entry Details
PubMed
LigandChemical structure of BindingDB Monomer ID 2691BDBM2691(Bisindolyl deriv. 19 | 3-[1-(3-aminopropyl)-1H-ind...)
Affinity DataIC50: 26nMAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2004
Entry Details
PubMed
LigandChemical structure of BindingDB Monomer ID 2681BDBM2681(3-{1-[3-(dimethylamino)propyl]-1H-indol-3-yl}-4-(1...)
Affinity DataIC50: 40nMpH: 7.4 T: 2°CAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2004
Entry Details
PubMed
LigandChemical structure of BindingDB Monomer ID 6717BDBM6717(1,4,14,24-tetraazaheptacyclo[16.10.1.0^{2,17}.0^{3...)
Affinity DataIC50: 40nMT: 2°CAssay Description:In vitro CDK assay using purified enzyme, was incubated at room temperature with substrate, and test compounds in the presence of ATP/[gamma-33P]ATP....More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2005
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 2692BDBM2692(3-(1H-indol-3-yl)-4-{1-[(1-methylpiperidin-3-yl)me...)
Affinity DataIC50: 45nMAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2004
Entry Details
PubMed
LigandChemical structure of BindingDB Monomer ID 2686BDBM2686(3-(1H-indol-3-yl)-4-{1-[3-(piperazin-1-yl)propyl]-...)
Affinity DataIC50: 52nMAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2004
Entry Details
PubMed
LigandChemical structure of BindingDB Monomer ID 2693BDBM2693(3-(1H-indol-3-yl)-4-{1-[3-(morpholin-4-yl)propyl]-...)
Affinity DataIC50: 70nMAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2004
Entry Details
PubMed
LigandChemical structure of BindingDB Monomer ID 2690BDBM2690(3-(1-{2-[(dimethylamino)methyl]propyl}-1H-indol-3-...)
Affinity DataIC50: 80nMAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2004
Entry Details
PubMed
LigandChemical structure of BindingDB Monomer ID 2682BDBM2682(3-{1-[3-(dimethylamino)propyl]-1H-indol-3-yl}-4-[1...)
Affinity DataIC50: 100nMpH: 7.4 T: 2°CAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2004
Entry Details
PubMed
LigandChemical structure of BindingDB Monomer ID 2583BDBM2583(bis-indolylmaleimide deriv. 8a | 3,4-bis(1H-indol-...)
Affinity DataIC50: 100nMpH: 7.4 T: 2°CAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2004
Entry Details
PubMed
LigandChemical structure of BindingDB Monomer ID 6858BDBM6858(8-bromo-3,13,23-triazahexacyclo[14.7.0.0^{2,10}.0^...)
Affinity DataIC50: 103nMT: 2°CAssay Description:In vitro kinase assay using purified enzyme, was incubated at room temperature with substrate, and test compounds in the presence of ATP/[gamma-33P]A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2005
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 6772BDBM6772(3-[3-(methylamino)propyl]-3,13,23-triazahexacyclo[...)
Affinity DataIC50: 120nMT: 2°CAssay Description:In vitro CDK assay using purified enzyme, was incubated at room temperature with substrate, and test compounds in the presence of ATP/[gamma-33P]ATP....More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2005
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 6706BDBM6706(1,4,14,24-tetraazaheptacyclo[16.8.1.0^{2,17}.0^{3,...)
Affinity DataIC50: 160nMT: 2°CAssay Description:In vitro CDK assay using purified enzyme, was incubated at room temperature with substrate, and test compounds in the presence of ATP/[gamma-33P]ATP....More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2005
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 2687BDBM2687(methyl 3-{3-[4-(1H-indol-3-yl)-2,5-dioxo-2,5-dihyd...)
Affinity DataIC50: 200nMAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2004
Entry Details
PubMed
LigandChemical structure of BindingDB Monomer ID 2688BDBM2688(3-(1H-indol-3-yl)-4-[1-(2-methoxyethyl)-1H-indol-3...)
Affinity DataIC50: 200nMAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2004
Entry Details
PubMed
LigandChemical structure of BindingDB Monomer ID 6707BDBM6707(8-fluoro-1,4,14,24-tetraazaheptacyclo[16.8.1.0^{2,...)
Affinity DataIC50: 200nMT: 2°CAssay Description:In vitro CDK assay using purified enzyme, was incubated at room temperature with substrate, and test compounds in the presence of ATP/[gamma-33P]ATP....More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2005
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 2680BDBM2680(3-(6-hydroxy-1H-indol-3-yl)-4-(1H-indol-3-yl)-2,5-...)
Affinity DataIC50: 200nMpH: 7.4 T: 2°CAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2004
Entry Details
PubMed
LigandChemical structure of BindingDB Monomer ID 2684BDBM2684(indolocarbazole deriv. 4f | 3-[3-(dimethylamino)pr...)
Affinity DataIC50: 260nMAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2004
Entry Details
PubMed
LigandChemical structure of BindingDB Monomer ID 6756BDBM6756(7-fluoro-24-[(methylamino)methyl]-1,4,14-triazahep...)
Affinity DataIC50: 383nMT: 2°CAssay Description:In vitro CDK assay using purified enzyme, was incubated at room temperature with substrate, and test compounds in the presence of ATP/[gamma-33P]ATP....More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2005
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 6708BDBM6708(7-fluoro-1,4,14,24-tetraazaheptacyclo[16.8.1.0^{2,...)
Affinity DataIC50: 430nMT: 2°CAssay Description:In vitro CDK assay using purified enzyme, was incubated at room temperature with substrate, and test compounds in the presence of ATP/[gamma-33P]ATP....More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2005
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 6781BDBM6781(3-(2,3-dihydroxypropyl)-23-methyl-3,13,23-triazahe...)
Affinity DataIC50: 810nMT: 2°CAssay Description:In vitro CDK assay using purified enzyme, was incubated at room temperature with substrate, and test compounds in the presence of ATP/[gamma-33P]ATP....More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2005
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 6742BDBM6742(25-(hydroxymethyl)-1,4,14-triazaheptacyclo[16.7.1....)
Affinity DataIC50: 858nMT: 2°CAssay Description:In vitro CDK assay using purified enzyme, was incubated at room temperature with substrate, and test compounds in the presence of ATP/[gamma-33P]ATP....More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2005
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 6800BDBM6800(6-hydroxy-3,13,18-triazahexacyclo[14.7.0.0^{2,10}....)
Affinity DataIC50: 949nMT: 2°CAssay Description:In vitro CDK assay using purified enzyme, was incubated at room temperature with substrate, and test compounds in the presence of ATP/[gamma-33P]ATP....More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/28/2005
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 6822BDBM6822(3-(3-hydroxypropyl)-6-methoxy-18-methyl-3,13,18-tr...)
Affinity DataIC50: 1.04E+3nMT: 2°CAssay Description:In vitro CDK assay using purified enzyme, was incubated at room temperature with substrate, and test compounds in the presence of ATP/[gamma-33P]ATP....More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/28/2005
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 6821BDBM6821(3-(2-hydroxyethyl)-6-methoxy-18-methyl-3,13,18-tri...)
Affinity DataIC50: 1.62E+3nMT: 2°CAssay Description:In vitro CDK assay using purified enzyme, was incubated at room temperature with substrate, and test compounds in the presence of ATP/[gamma-33P]ATP....More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/28/2005
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 2586BDBM2586(3,4-bis(1H-indol-3-yl)-2,5-dihydro-1H-pyrrol-2-one...)
Affinity DataIC50: 2.00E+3nMpH: 7.4 T: 2°CAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2004
Entry Details
PubMed
LigandChemical structure of BindingDB Monomer ID 6709BDBM6709(7,8-difluoro-1,4,14,24-tetraazaheptacyclo[16.8.1.0...)
Affinity DataIC50: 2.00E+3nMT: 2°CAssay Description:In vitro CDK assay using purified enzyme, was incubated at room temperature with substrate, and test compounds in the presence of ATP/[gamma-33P]ATP....More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2005
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 6710BDBM6710(7-(trifluoromethyl)-1,4,14,24-tetraazaheptacyclo[1...)
Affinity DataIC50: 2.00E+3nMT: 2°CAssay Description:In vitro CDK assay using purified enzyme, was incubated at room temperature with substrate, and test compounds in the presence of ATP/[gamma-33P]ATP....More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2005
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 6712BDBM6712(24-methanesulfonyl-1,4,14,24-tetraazaheptacyclo[16...)
Affinity DataIC50: 2.00E+3nMT: 2°CAssay Description:In vitro CDK assay using purified enzyme, was incubated at room temperature with substrate, and test compounds in the presence of ATP/[gamma-33P]ATP....More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2005
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 6743BDBM6743(24-(hydroxymethyl)-1,4,14-triazaheptacyclo[16.7.1....)
Affinity DataIC50: 2.00E+3nMT: 2°CAssay Description:In vitro CDK assay using purified enzyme, was incubated at room temperature with substrate, and test compounds in the presence of ATP/[gamma-33P]ATP....More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2005
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 6713BDBM6713(24-[(1-methyl-1H-imidazole-4-)sulfonyl]-1,4,14,24-...)
Affinity DataIC50: 2.00E+3nMT: 2°CAssay Description:In vitro CDK assay using purified enzyme, was incubated at room temperature with substrate, and test compounds in the presence of ATP/[gamma-33P]ATP....More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2005
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 6744BDBM6744(23-(hydroxymethyl)-1,4,14-triazaheptacyclo[16.7.1....)
Affinity DataIC50: 2.00E+3nMT: 2°CAssay Description:In vitro CDK assay using purified enzyme, was incubated at room temperature with substrate, and test compounds in the presence of ATP/[gamma-33P]ATP....More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2005
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 6714BDBM6714(24-(2-aminoacetyl)-1,4,14,24-tetraazaheptacyclo[16...)
Affinity DataIC50: 2.00E+3nMT: 2°CAssay Description:In vitro CDK assay using purified enzyme, was incubated at room temperature with substrate, and test compounds in the presence of ATP/[gamma-33P]ATP....More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2005
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 6745BDBM6745(7-fluoro-25-(hydroxymethyl)-1,4,14-triazaheptacycl...)
Affinity DataIC50: 2.00E+3nMT: 2°CAssay Description:In vitro CDK assay using purified enzyme, was incubated at room temperature with substrate, and test compounds in the presence of ATP/[gamma-33P]ATP....More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2005
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 6715BDBM6715(24-(propan-2-yl)-1,4,14,24-tetraazaheptacyclo[16.8...)
Affinity DataIC50: 2.00E+3nMT: 2°CAssay Description:In vitro CDK assay using purified enzyme, was incubated at room temperature with substrate, and test compounds in the presence of ATP/[gamma-33P]ATP....More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2005
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 6746BDBM6746(7-fluoro-24-(hydroxymethyl)-1,4,14-triazaheptacycl...)
Affinity DataIC50: 2.00E+3nMT: 2°CAssay Description:In vitro CDK assay using purified enzyme, was incubated at room temperature with substrate, and test compounds in the presence of ATP/[gamma-33P]ATP....More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2005
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 6747BDBM6747(7-bromo-24-(hydroxymethyl)-1,4,14-triazaheptacyclo...)
Affinity DataIC50: 2.00E+3nMT: 2°CAssay Description:In vitro CDK assay using purified enzyme, was incubated at room temperature with substrate, and test compounds in the presence of ATP/[gamma-33P]ATP....More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2005
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 6748BDBM6748(24-(hydroxymethyl)-7-(trifluoromethyl)-1,4,14-tria...)
Affinity DataIC50: 2.00E+3nMT: 2°CAssay Description:In vitro CDK assay using purified enzyme, was incubated at room temperature with substrate, and test compounds in the presence of ATP/[gamma-33P]ATP....More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2005
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 6749BDBM6749(24-(hydroxymethyl)-7-methoxy-1,4,14-triazaheptacyc...)
Affinity DataIC50: 2.00E+3nMT: 2°CAssay Description:In vitro CDK assay using purified enzyme, was incubated at room temperature with substrate, and test compounds in the presence of ATP/[gamma-33P]ATP....More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2005
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 6751BDBM6751(26-(hydroxymethyl)-1,15-diazaheptacyclo[17.7.1.0^{...)
Affinity DataIC50: 2.00E+3nMT: 2°CAssay Description:In vitro CDK assay using purified enzyme, was incubated at room temperature with substrate, and test compounds in the presence of ATP/[gamma-33P]ATP....More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2005
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 6752BDBM6752(25-(hydroxymethyl)-1,15-diazaheptacyclo[17.7.1.0^{...)
Affinity DataIC50: 2.00E+3nMT: 2°CAssay Description:In vitro CDK assay using purified enzyme, was incubated at room temperature with substrate, and test compounds in the presence of ATP/[gamma-33P]ATP....More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2005
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 6782BDBM6782(3,13,18-triazahexacyclo[14.7.0.0^{2,10}.0^{4,9}.0^...)
Affinity DataIC50: 2.00E+3nMT: 2°CAssay Description:In vitro CDK assay using purified enzyme, was incubated at room temperature with substrate, and test compounds in the presence of ATP/[gamma-33P]ATP....More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/28/2005
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 6784BDBM6784(18-ethyl-3,13,18-triazahexacyclo[14.7.0.0^{2,10}.0...)
Affinity DataIC50: 2.00E+3nMT: 2°CAssay Description:In vitro CDK assay using purified enzyme, was incubated at room temperature with substrate, and test compounds in the presence of ATP/[gamma-33P]ATP....More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/28/2005
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 2672BDBM2672(6,7,12,13-Tetrahydro-5,7-dioxo-5H-indolo[2,3-a]pyr...)
Affinity DataIC50: 2.00E+3nMT: 2°CAssay Description:In vitro kinase assay using purified enzyme, was incubated at room temperature with substrate, and test compounds in the presence of ATP/[gamma-33P]A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2005
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 6768BDBM6768(indolocarbazole deriv. 4(f) | 20-bromo-3-methyl-3,...)
Affinity DataIC50: 2.00E+3nMT: 2°CAssay Description:In vitro kinase assay using purified enzyme, was incubated at room temperature with substrate, and test compounds in the presence of ATP/[gamma-33P]A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2005
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 6862BDBM6862(6-fluoro-3,13,23-triazahexacyclo[14.7.0.0^{2,10}.0...)
Affinity DataIC50: 2.00E+3nMT: 2°CAssay Description:In vitro kinase assay using purified enzyme, was incubated at room temperature with substrate, and test compounds in the presence of ATP/[gamma-33P]A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2005
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 6766BDBM6766(indolocarbazole deriv. 4(h) | 20-fluoro-3-methyl-3...)
Affinity DataIC50: 2.00E+3nMT: 2°CAssay Description:In vitro kinase assay using purified enzyme, was incubated at room temperature with substrate, and test compounds in the presence of ATP/[gamma-33P]A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2005
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 6854BDBM6854(6-chloro-3,13,23-triazahexacyclo[14.7.0.0^{2,10}.0...)
Affinity DataIC50: 2.00E+3nMT: 2°CAssay Description:In vitro kinase assay using purified enzyme, was incubated at room temperature with substrate, and test compounds in the presence of ATP/[gamma-33P]A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/21/2005
Entry Details Article
PubMed
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