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Found 1065 from Institute
TargetTransient receptor potential cation channel subfamily V member 1(Rattus norvegicus (rat))
Institute

Curated by ChEMBL
LigandPNGBDBM50366620(RESINIFERATOXIN)
Affinity DataKi:  0.0200nMAssay Description:Displacement of [3H]RTX from Vanilloid receptor in Rat spinal cord membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Cavia porcellus (domestic guinea pig))
Institute

Curated by ChEMBL
LigandPNGBDBM50001023((2R,6R,11R)-3-Cyclopropylmethyl-6,11-dimethyl-1,2,...)
Affinity DataKi:  0.0520nMAssay Description:Binding affinity was determined against Opioid receptor kappa 1 obtained from guinea pig brain membranes using [3H]U-69593 as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Rattus norvegicus (rat))
Institute

Curated by ChEMBL
LigandPNGBDBM50052440(CHEMBL104647 | Phenyl-acetic acid (1aR,1bS,4aR,7aS...)
Affinity DataKi:  0.0540nMAssay Description:Inhibitory constant for RTX binding to rat spinal cordMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
Institute

Curated by ChEMBL
LigandPNGBDBM50097579((6S,11R)-3-Cyclopropylmethyl-6,11-dimethyl-1,2,3,4...)
Affinity DataKi:  0.0600nMAssay Description:Displacement of [3H]U-69593 from kappa opioid receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
Institute

Curated by ChEMBL
LigandPNGBDBM50224870((6S,11R)-3-cyclopropylmethyl-6,11-dimethyl-1,2,3,4...)
Affinity DataKi:  0.0630nMAssay Description:Displacement of [3H]U-69593 from kappa opioid receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
Institute

Curated by ChEMBL
LigandPNGBDBM50224873((6S,11R)-3-cyclopropylmethyl-6,11-dimethyl-1,2,3,4...)
Affinity DataKi:  0.0840nMAssay Description:Displacement of [3H]DAMGO from mu opioid receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(GUINEA PIG)
Institute

Curated by ChEMBL
LigandPNGBDBM50001023((2R,6R,11R)-3-Cyclopropylmethyl-6,11-dimethyl-1,2,...)
Affinity DataKi:  0.100nMAssay Description:Binding affinity was determined against Opioid receptor mu 1 obtained from guinea pig brain membranes using [3H]DAMGO as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Institute

Curated by ChEMBL
LigandPNGBDBM50052440(CHEMBL104647 | Phenyl-acetic acid (1aR,1bS,4aR,7aS...)
Affinity DataKi:  0.120nMAssay Description:Inhibitory constant for RTX binding to porcine spinal cordMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2b(Homo sapiens (Human))
Institute

Curated by ChEMBL
LigandPNGBDBM50268151(1-Ethyl-8-(4-(4-(4-trifluoromethylbenzyl)piperazin...)
Affinity DataKi:  0.157nMAssay Description:Displacement of [3H]PSB-603 from human recombinant adenosine A2B receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Cavia porcellus (domestic guinea pig))
Institute

Curated by ChEMBL
LigandPNGBDBM50083926((6S,11R)-3-Cyclopropylmethyl-6,11-dimethyl-1,2,3,4...)
Affinity DataKi:  0.180nMAssay Description:Binding affinity was determined against Opioid receptor kappa 1 obtained from guinea pig brain membranes using [3H]U-69593 as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
Institute

Curated by ChEMBL
LigandPNGBDBM50224879((6S,11R)-3-cyclopropylmethyl-6,11-dimethyl-1,2,3,4...)
Affinity DataKi:  0.180nMAssay Description:Displacement of [3H]DAMGO from mu opioid receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
Institute

Curated by ChEMBL
LigandPNGBDBM50224871((6S,11R)-3-cyclopropylmethyl-6,11-dimethyl-1,2,3,4...)
Affinity DataKi:  0.180nMAssay Description:Displacement of [3H]U-69593 from kappa opioid receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Homo sapiens (Human))
Institute

Curated by ChEMBL
LigandPNGBDBM50224873((6S,11R)-3-cyclopropylmethyl-6,11-dimethyl-1,2,3,4...)
Affinity DataKi:  0.180nMAssay Description:Displacement of [3H]naltrindole from delta opioid receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
Institute

Curated by ChEMBL
LigandPNGBDBM50224879((6S,11R)-3-cyclopropylmethyl-6,11-dimethyl-1,2,3,4...)
Affinity DataKi:  0.200nMAssay Description:Displacement of [3H]U-69593 from kappa opioid receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
Institute

Curated by ChEMBL
LigandPNGBDBM50224869((6S,11R)-3-cyclopropylmethyl-6,11-dimethyl-1,2,3,4...)
Affinity DataKi:  0.200nMAssay Description:Displacement of [3H]DAMGO from mu opioid receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2b(Homo sapiens (Human))
Institute

Curated by ChEMBL
LigandPNGBDBM50268109(8-(4-(4-(4-chlorobenzyl)piperazin-1-ylsulfonyl)phe...)
Affinity DataKi:  0.215nMAssay Description:Displacement of [3H]PSB-603 from human recombinant adenosine A2B receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2b(Homo sapiens (Human))
Institute

Curated by ChEMBL
LigandPNGBDBM50268164(1-Ethyl-8-(4-(4-(3-trifluoromethylbenzyl)piperazin...)
Affinity DataKi:  0.281nMAssay Description:Displacement of [3H]PSB-603 from human recombinant adenosine A2B receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
Institute

Curated by ChEMBL
LigandPNGBDBM50224881((6S,11R)-3-cyclopropylmethyl-6,11-dimethyl-1,2,3,4...)
Affinity DataKi:  0.290nMAssay Description:Displacement of [3H]DAMGO from mu opioid receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
Institute

Curated by ChEMBL
LigandPNGBDBM50194264((+/-)-3-(cyclopropylmethyl)-1,2,3,4,5,6-hexahydro-...)
Affinity DataKi:  0.300nMAssay Description:Displacement of [3H]DAMGO from mu opioid receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2b(Homo sapiens (Human))
Institute

Curated by ChEMBL
LigandPNGBDBM50268163(1-Propyl-8-(4-(4-(4-trifluoromethylbenzyl)piperazi...)
Affinity DataKi:  0.303nMAssay Description:Displacement of [3H]PSB-603 from human recombinant adenosine A2B receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
Institute

Curated by ChEMBL
LigandPNGBDBM50097579((6S,11R)-3-Cyclopropylmethyl-6,11-dimethyl-1,2,3,4...)
Affinity DataKi:  0.310nMAssay Description:Displacement of [3H]DAMGO from mu opioid receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(GUINEA PIG)
Institute

Curated by ChEMBL
LigandPNGBDBM50083926((6S,11R)-3-Cyclopropylmethyl-6,11-dimethyl-1,2,3,4...)
Affinity DataKi:  0.320nMAssay Description:Binding affinity was determined against Opioid receptor mu 1 obtained from guinea pig brain membranes using [3H]DAMGO as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
Institute

Curated by ChEMBL
LigandPNGBDBM50224870((6S,11R)-3-cyclopropylmethyl-6,11-dimethyl-1,2,3,4...)
Affinity DataKi:  0.350nMAssay Description:Displacement of [3H]DAMGO from mu opioid receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
Institute

Curated by ChEMBL
LigandPNGBDBM50224877((6S,11R)-3-cyclopropylmethyl-6,11-dimethyl-1,2,3,4...)
Affinity DataKi:  0.380nMAssay Description:Displacement of [3H]U-69593 from kappa opioid receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2b(Homo sapiens (Human))
Institute

Curated by ChEMBL
LigandPNGBDBM50268129(8-(4-(4-(4-chlorobenzyl)piperazin-1-ylsulfonyl)phe...)
Affinity DataKi:  0.393nMAssay Description:Displacement of [3H]PSB-603 from human recombinant adenosine A2B receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2b(Homo sapiens (Human))
Institute

Curated by ChEMBL
LigandPNGBDBM50268231(8-(4-(4-(4-Chlorophenyl)piperazine-1-sulfonyl)phen...)
Affinity DataKi:  0.406nMAssay Description:Displacement of [3H]PSB-603 from human recombinant adenosine A2B receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2b(Homo sapiens (Human))
Institute

Curated by ChEMBL
LigandPNGBDBM50268107(CHEMBL485862 | CHEMBL500634 | N-(2-(2-phenyl-6-(4-...)
Affinity DataKi:  0.410nMAssay Description:Binding affinity to human adenosine A2B receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2b(Homo sapiens (Human))
Institute

Curated by ChEMBL
LigandPNGBDBM50268150(8-(4-(4-(3-Fluorobenzyl)piperazine-1-sulfonyl)phen...)
Affinity DataKi:  0.446nMAssay Description:Displacement of [3H]PSB-603 from human recombinant adenosine A2B receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Institute

Curated by ChEMBL
LigandPNGBDBM50052440(CHEMBL104647 | Phenyl-acetic acid (1aR,1bS,4aR,7aS...)
Affinity DataKi:  0.450nMAssay Description:Inhibitory constant for RTX binding to human spinal cordMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2b(Homo sapiens (Human))
Institute

Curated by ChEMBL
LigandPNGBDBM50268233(8-(4-(4-(4-Chlorophenyl)piperazine-1-sulfonyl)phen...)
Affinity DataKi:  0.473nMAssay Description:Displacement of [3H]PSB-603 from human recombinant adenosine A2B receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Cavia porcellus (domestic guinea pig))
Institute

Curated by ChEMBL
LigandPNGBDBM50369586(CHEMBL326516)
Affinity DataKi:  0.540nMAssay Description:Binding affinity was determined against Opioid receptor kappa 1 obtained from guinea pig brain membranes using [3H]U-69593 as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Cavia porcellus (domestic guinea pig))
Institute

Curated by ChEMBL
LigandPNGBDBM50369586(CHEMBL326516)
Affinity DataKi:  0.540nMAssay Description:Binding affinity was determined against Opioid receptor kappa 1 obtained from guinea pig brain membranes using [3H]U-69593 as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2b(Homo sapiens (Human))
Institute

Curated by ChEMBL
LigandPNGBDBM50268232(8-(4-(4-(4-Chlorophenyl)piperazine-1-sulfonyl)phen...)
Affinity DataKi:  0.553nMAssay Description:Displacement of [3H]PSB-603 from human recombinant adenosine A2B receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Homo sapiens (Human))
Institute

Curated by ChEMBL
LigandPNGBDBM50001023((2R,6R,11R)-3-Cyclopropylmethyl-6,11-dimethyl-1,2,...)
Affinity DataKi:  0.580nMAssay Description:Binding affinity was determined against Opioid receptor delta 1 obtained from guinea pig brain membranes using [3H]naltrindole as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2b(Homo sapiens (Human))
Institute

Curated by ChEMBL
LigandPNGBDBM50268132(8-(4-(4-(4-Fluorobenzyl)piperazine-1-sulfonyl)phen...)
Affinity DataKi:  0.595nMAssay Description:Displacement of [3H]PSB-603 from human recombinant adenosine A2B receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2b(Homo sapiens (Human))
Institute

Curated by ChEMBL
LigandPNGBDBM50268130(8-(4-(4-(3-Chlorobenzyl)piperazine-1-sulfonyl)phen...)
Affinity DataKi:  0.610nMAssay Description:Displacement of [3H]PSB-603 from human recombinant adenosine A2B receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2b(Homo sapiens (Human))
Institute

Curated by ChEMBL
LigandPNGBDBM50268149(1-Ethyl-8-(4-(4-(3-fluorobenzyl)piperazine-1-sulfo...)
Affinity DataKi:  0.695nMAssay Description:Displacement of [3H]PSB-603 from human recombinant adenosine A2B receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Homo sapiens (Human))
Institute

Curated by ChEMBL
LigandPNGBDBM50224869((6S,11R)-3-cyclopropylmethyl-6,11-dimethyl-1,2,3,4...)
Affinity DataKi:  0.710nMAssay Description:Displacement of [3H]naltrindole from delta opioid receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Homo sapiens (Human))
Institute

Curated by ChEMBL
LigandPNGBDBM50224881((6S,11R)-3-cyclopropylmethyl-6,11-dimethyl-1,2,3,4...)
Affinity DataKi:  0.720nMAssay Description:Displacement of [3H]naltrindole from delta opioid receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Homo sapiens (Human))
Institute

Curated by ChEMBL
LigandPNGBDBM50194264((+/-)-3-(cyclopropylmethyl)-1,2,3,4,5,6-hexahydro-...)
Affinity DataKi:  0.740nMAssay Description:Displacement of [3H]naltrindole from delta opioid receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2b(Homo sapiens (Human))
Institute

Curated by ChEMBL
LigandPNGBDBM50268165(1-Propyl-8-(4-(4-(3-trifluoromethylbenzyl)piperazi...)
Affinity DataKi:  0.775nMAssay Description:Displacement of [3H]PSB-603 from human recombinant adenosine A2B receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2b(Homo sapiens (Human))
Institute

Curated by ChEMBL
LigandPNGBDBM50268110(8-(4-(4-(3-Chlorobenzyl)piperazine-1-sulfonyl)phen...)
Affinity DataKi:  0.782nMAssay Description:Displacement of [3H]PSB-603 from human recombinant adenosine A2B receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Cavia porcellus (domestic guinea pig))
Institute

Curated by ChEMBL
LigandPNGBDBM50369586(CHEMBL326516)
Affinity DataKi:  0.830nMAssay Description:Binding affinity was determined against Opioid receptor kappa 1 obtained from guinea pig brain membranes using [3H]U-69593 as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2b(Homo sapiens (Human))
Institute

Curated by ChEMBL
LigandPNGBDBM50268181(8-(4-(4-(4-Methylbenzyl)piperazine-1-sulfonyl)phen...)
Affinity DataKi:  0.858nMAssay Description:Displacement of [3H]PSB-603 from human recombinant adenosine A2B receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2b(Homo sapiens (Human))
Institute

Curated by ChEMBL
LigandPNGBDBM50268210(8-(4-(4-Benzo[1,3]dioxol-5-ylmethylpiperazine-1-su...)
Affinity DataKi:  0.875nMAssay Description:Displacement of [3H]PSB-603 from human recombinant adenosine A2B receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Homo sapiens (Human))
Institute

Curated by ChEMBL
LigandPNGBDBM50224879((6S,11R)-3-cyclopropylmethyl-6,11-dimethyl-1,2,3,4...)
Affinity DataKi:  0.900nMAssay Description:Displacement of [3H]naltrindole from delta opioid receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(CALF)
Institute

Curated by ChEMBL
LigandPNGBDBM50000092((-)-(etorphine) | (-)-morphine | (1S,5R,13R,14S)-1...)
Affinity DataKi:  0.900nMAssay Description:Activity of the compound was evaluated by inhibition of the binding of 0.8 nM [3H]- DAMGO at Opioid receptor mu 1 binding siteMore data for this Ligand-Target Pair
TargetAdenosine receptor A2b(Homo sapiens (Human))
Institute

Curated by ChEMBL
LigandPNGBDBM50268209(8-(4-(4-(4-Methoxybenzyl)piperazine-1-sulfonyl)phe...)
Affinity DataKi:  0.944nMAssay Description:Displacement of [3H]PSB-603 from human recombinant adenosine A2B receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
Institute

Curated by ChEMBL
LigandPNGBDBM50224872((6S,11R)-3-cyclopropylmethyl-6,11-dimethyl-1,2,3,4...)
Affinity DataKi:  0.950nMAssay Description:Displacement of [3H]DAMGO from mu opioid receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
Institute

Curated by ChEMBL
LigandPNGBDBM50224868((6S,11R)-3-cyclopropylmethyl-6,11-dimethyl-1,2,3,4...)
Affinity DataKi:  0.980nMAssay Description:Displacement of [3H]DAMGO from mu opioid receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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