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TargetAlpha-galactosidase(Arabian coffee)
University of Toyama

Curated by ChEMBL
LigandPNGBDBM50163440((2R,3S,4R,5S)-2-(hydroxymethyl)piperidine-3,4,5-tr...)
Affinity DataIC50: 3nMpH: 6.5Assay Description:Inhibition of coffee bean alpha-galactosidase assessed as p-nitrophenol release at pH 6.5 by spectrometric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetTissue alpha-L-fucosidase(Human)
University of Toyama

Curated by ChEMBL
LigandPNGBDBM50442341(CHEMBL2442786)
Affinity DataIC50: 7.90nMAssay Description:Inhibition of human lysosome alpha-L-fucosidase using 4-methylumbelliferyl-alpha-L-fucopyranoside by spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetTissue alpha-L-fucosidase(Bovine)
University of Toyama

Curated by ChEMBL
LigandPNGBDBM50442341(CHEMBL2442786)
Affinity DataIC50: 12nMAssay Description:Inhibition of bovine kidney alpha-L-fucosidase assessed as inhibition of release of p-nitrophenol by spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetTissue alpha-L-fucosidase(Human)
University of Toyama

Curated by ChEMBL
LigandPNGBDBM50442339(CHEMBL2442788)
Affinity DataIC50: 14nMAssay Description:Inhibition of human lysosome alpha-L-fucosidase using 4-methylumbelliferyl-alpha-L-fucopyranoside by spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetTissue alpha-L-fucosidase(Human)
University of Toyama

Curated by ChEMBL
LigandPNGBDBM50442344(CHEMBL2442783)
Affinity DataIC50: 15nMAssay Description:Inhibition of human lysosome alpha-L-fucosidase using 4-methylumbelliferyl-alpha-L-fucopyranoside by spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetTissue alpha-L-fucosidase(Human)
University of Toyama

Curated by ChEMBL
LigandPNGBDBM50442343(CHEMBL2442784)
Affinity DataIC50: 19nMAssay Description:Inhibition of human lysosome alpha-L-fucosidase using 4-methylumbelliferyl-alpha-L-fucopyranoside by spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetTissue alpha-L-fucosidase(Bovine)
University of Toyama

Curated by ChEMBL
LigandPNGBDBM50442343(CHEMBL2442784)
Affinity DataIC50: 21nMAssay Description:Inhibition of bovine kidney alpha-L-fucosidase assessed as inhibition of release of p-nitrophenol by spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetTissue alpha-L-fucosidase(Human)
University of Toyama

Curated by ChEMBL
LigandPNGBDBM50442348(CHEMBL2442779)
Affinity DataIC50: 26nMAssay Description:Inhibition of human lysosome alpha-L-fucosidase using 4-methylumbelliferyl-alpha-L-fucopyranoside by spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetTissue alpha-L-fucosidase(Bovine)
University of Toyama

Curated by ChEMBL
LigandPNGBDBM50442344(CHEMBL2442783)
Affinity DataIC50: 26nMAssay Description:Inhibition of bovine kidney alpha-L-fucosidase assessed as inhibition of release of p-nitrophenol by spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetSucrase-isomaltase, intestinal(Rat)
Tohoku Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50048090(CHEMBL3311519)
Affinity DataIC50: 26nMAssay Description:Inhibition of Wistar rat intestinal sucrase assessed as inhibition of D-glucose release after 30 mins by spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2016
Entry Details Article
PubMed
TargetTissue alpha-L-fucosidase(Bovine)
University of Toyama

Curated by ChEMBL
LigandPNGBDBM50442340(CHEMBL2442787)
Affinity DataIC50: 28nMAssay Description:Inhibition of bovine kidney alpha-L-fucosidase assessed as inhibition of release of p-nitrophenol by spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetPutative alpha-glucosidase(Rice)
Toyama Medical and Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM18351((2R,3R,4R,5S)-2-(hydroxymethyl)piperidine-3,4,5-tr...)
Affinity DataIC50: 30nMAssay Description:Inhibitory concentration against rice alpha-glucosidaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2012
Entry Details Article
PubMed
TargetTissue alpha-L-fucosidase(Human)
University of Toyama

Curated by ChEMBL
LigandPNGBDBM50442345(CHEMBL2442782)
Affinity DataIC50: 30nMAssay Description:Inhibition of human lysosome alpha-L-fucosidase using 4-methylumbelliferyl-alpha-L-fucopyranoside by spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetTissue alpha-L-fucosidase(Human)
University of Toyama

Curated by ChEMBL
LigandPNGBDBM50442350(CHEMBL2442777)
Affinity DataIC50: 30nMAssay Description:Inhibition of human lysosome alpha-L-fucosidase using 4-methylumbelliferyl-alpha-L-fucopyranoside by spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetTissue alpha-L-fucosidase(Bovine)
University of Toyama

Curated by ChEMBL
LigandPNGBDBM50442339(CHEMBL2442788)
Affinity DataIC50: 30nMAssay Description:Inhibition of bovine kidney alpha-L-fucosidase assessed as inhibition of release of p-nitrophenol by spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetTissue alpha-L-fucosidase(Human)
University of Toyama

Curated by ChEMBL
LigandPNGBDBM50442340(CHEMBL2442787)
Affinity DataIC50: 31nMAssay Description:Inhibition of human lysosome alpha-L-fucosidase using 4-methylumbelliferyl-alpha-L-fucopyranoside by spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetSucrase-isomaltase, intestinal(Rat)
Tohoku Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50333455((2S,3S,4S,5S)-2-butyl-5-(hydroxymethyl)pyrrolidine...)
Affinity DataIC50: 32nMAssay Description:Inhibition of Wistar rat small intestine sucrase after 30 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2011
Entry Details Article
PubMed
TargetSucrase-isomaltase, intestinal(Rat)
Tohoku Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50333455((2S,3S,4S,5S)-2-butyl-5-(hydroxymethyl)pyrrolidine...)
Affinity DataIC50: 32nMAssay Description:Inhibition of rat intestinal sucrase using sucrose as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetSucrase-isomaltase, intestinal(Rat)
Tohoku Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50333455((2S,3S,4S,5S)-2-butyl-5-(hydroxymethyl)pyrrolidine...)
Affinity DataIC50: 32nMAssay Description:Inhibition of Wistar rat intestinal sucrase assessed as inhibition of D-glucose release after 30 mins by spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2016
Entry Details Article
PubMed
TargetAldo-keto reductase family 1 member B10(Human)
Kyushu University

Curated by ChEMBL
LigandPNGBDBM50049730(Epalrestat | 2-(5-(2-methyl-3-phenylallylidene)-4-...)
Affinity DataIC50: 35nMAssay Description:Inhibition of AKR1B10 (unknown origin) pretreated with 0.25M DMSO followed by compound treatment by DMSO-perturbation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2021
Entry Details Article
PubMed
TargetTissue alpha-L-fucosidase(Human)
University of Toyama

Curated by ChEMBL
LigandPNGBDBM50442338(CHEMBL2442773)
Affinity DataIC50: 35nMAssay Description:Inhibition of human lysosome alpha-L-fucosidase using 4-methylumbelliferyl-alpha-L-fucopyranoside by spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetAldo-keto reductase family 1 member B1(Human)
Kyushu University

Curated by ChEMBL
LigandPNGBDBM16452((4-oxo-3-{[5-(trifluoromethyl)-1,3-benzothiazol-2-...)
Affinity DataIC50: 38nMAssay Description:Inhibition of human recombinant AKR1B1 assessed as D,L-glyceraldehyde reduction pretreated with 0.3M DMSO followed by compound addition by DMSO-pertu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetAldo-keto reductase family 1 member B10(Human)
Kyushu University

Curated by ChEMBL
LigandPNGBDBM50049730(Epalrestat | 2-(5-(2-methyl-3-phenylallylidene)-4-...)
Affinity DataIC50: 39nMAssay Description:Inhibition of AKR1B10 (unknown origin) pretreated with 0.42M DMSO followed by compound treatment by DMSO-perturbation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2021
Entry Details Article
PubMed
TargetMaltase-glucoamylase(Human)
Toyama Medical and Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM18351((2R,3R,4R,5S)-2-(hydroxymethyl)piperidine-3,4,5-tr...)
Affinity DataIC50: 40nMAssay Description:Inhibitory concentration against human alpha-glucosidaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2012
Entry Details Article
PubMed
TargetSucrase-isomaltase, intestinal(Rat)
Tohoku Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50375510(CHEMBL405957)
Affinity DataIC50: 40nMAssay Description:Inhibition of rat isomaltaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetTissue alpha-L-fucosidase(Bovine)
University of Toyama

Curated by ChEMBL
LigandPNGBDBM50442345(CHEMBL2442782)
Affinity DataIC50: 40nMAssay Description:Inhibition of bovine kidney alpha-L-fucosidase assessed as inhibition of release of p-nitrophenol by spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetTissue alpha-L-fucosidase(Bovine)
University of Toyama

Curated by ChEMBL
LigandPNGBDBM50442338(CHEMBL2442773)
Affinity DataIC50: 42nMAssay Description:Inhibition of bovine kidney alpha-L-fucosidase assessed as inhibition of release of p-nitrophenol by spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetAldo-keto reductase family 1 member B1(Human)
Kyushu University

Curated by ChEMBL
LigandPNGBDBM16452((4-oxo-3-{[5-(trifluoromethyl)-1,3-benzothiazol-2-...)
Affinity DataIC50: 43nMAssay Description:Inhibition of human recombinant AKR1B1 assessed as D,L-glyceraldehyde reduction pretreated with 0.7M DMSO followed by compound addition by DMSO-pertu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetTissue alpha-L-fucosidase(Bovine)
University of Toyama

Curated by ChEMBL
LigandPNGBDBM50442348(CHEMBL2442779)
Affinity DataIC50: 43nMAssay Description:Inhibition of bovine kidney alpha-L-fucosidase assessed as inhibition of release of p-nitrophenol by spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetTissue alpha-L-fucosidase(Rat)
University of Toyama

Curated by ChEMBL
LigandPNGBDBM50442341(CHEMBL2442786)
Affinity DataIC50: 44nMAssay Description:Inhibition of rat epididymis alpha-L-fucosidase assessed as inhibition of release of p-nitrophenol by spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetSucrase-isomaltase, intestinal(Rat)
Tohoku Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50048086(CHEMBL3311515)
Affinity DataIC50: 45nMAssay Description:Inhibition of Wistar rat intestinal sucrase assessed as inhibition of D-glucose release after 30 mins by spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2016
Entry Details Article
PubMed
TargetTissue alpha-L-fucosidase(Bovine)
University of Toyama

Curated by ChEMBL
LigandPNGBDBM50442346(CHEMBL2442781)
Affinity DataIC50: 47nMAssay Description:Inhibition of bovine kidney alpha-L-fucosidase assessed as inhibition of release of p-nitrophenol by spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetTissue alpha-L-fucosidase(Bovine)
University of Toyama

Curated by ChEMBL
LigandPNGBDBM50442350(CHEMBL2442777)
Affinity DataIC50: 47nMAssay Description:Inhibition of bovine kidney alpha-L-fucosidase assessed as inhibition of release of p-nitrophenol by spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetAldo-keto reductase family 1 member B1(Human)
Kyushu University

Curated by ChEMBL
LigandPNGBDBM16452((4-oxo-3-{[5-(trifluoromethyl)-1,3-benzothiazol-2-...)
Affinity DataIC50: 53nMAssay Description:Inhibition of human recombinant AKR1B1 assessed as D,L-glyceraldehyde reduction pretreated with 1M DMSO followed by compound addition by DMSO-perturb...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetTissue alpha-L-fucosidase(Human)
University of Toyama

Curated by ChEMBL
LigandPNGBDBM50442346(CHEMBL2442781)
Affinity DataIC50: 58nMAssay Description:Inhibition of human lysosome alpha-L-fucosidase using 4-methylumbelliferyl-alpha-L-fucopyranoside by spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetLysosomal acid glucosylceramidase(Human)
Hokuriku University

Curated by ChEMBL
LigandPNGBDBM50182801(CHEMBL206468 | AFEGOSTAT TARTRATE | D-Isofagomine ...)
Affinity DataIC50: 60nMAssay Description:Inhibition of human lysosomal beta-glucosidaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2012
Entry Details Article
PubMed
TargetLysosomal alpha-glucosidase(Human)
Hokuriku University

Curated by ChEMBL
LigandPNGBDBM18351((2R,3R,4R,5S)-2-(hydroxymethyl)piperidine-3,4,5-tr...)
Affinity DataIC50: 60nMAssay Description:Inhibition of maltase in human Caco-2 cell model system after 2 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2012
Entry Details Article
PubMed
TargetLysosomal acid glucosylceramidase(Human)
Hokuriku University

Curated by ChEMBL
LigandPNGBDBM50182801(CHEMBL206468 | AFEGOSTAT TARTRATE | D-Isofagomine ...)
Affinity DataIC50: 63nMAssay Description:Inhibition of human lysosome beta-glucosidase assessed as production of 4-methylumbelliferone using 4-methylumbelliferyl beta-D-glucoside as substrat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetAlpha-galactosidase A(Human)
University of Toyama

Curated by ChEMBL
LigandPNGBDBM50163440((2R,3S,4R,5S)-2-(hydroxymethyl)piperidine-3,4,5-tr...)
Affinity DataIC50: 70nMAssay Description:Inhibition of human lysosome alpha-galactosidase assessed as p-nitrophenol release by spectrometric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetAlpha-galactosidase A(Human)
University of Toyama

Curated by ChEMBL
LigandPNGBDBM50163440((2R,3S,4R,5S)-2-(hydroxymethyl)piperidine-3,4,5-tr...)
Affinity DataIC50: 70nMAssay Description:Inhibitory concentration against human alpha-galactosidaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetSucrase-isomaltase, intestinal(Rat)
Tohoku Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50263044(Voglibose | CHEMBL476960)
Affinity DataIC50: 70nMAssay Description:Inhibition of rat intestinal brush border membrane sucraseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2012
Entry Details Article
PubMed
TargetLysosomal alpha-glucosidase(Human)
Hokuriku University

Curated by ChEMBL
LigandPNGBDBM50263044(Voglibose | CHEMBL476960)
Affinity DataIC50: 70nMAssay Description:Inhibition of maltase in human Caco-2 cell model system after 2 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2012
Entry Details Article
PubMed
TargetSucrase-isomaltase, intestinal(Rat)
Tohoku Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50375511(CHEMBL406973)
Affinity DataIC50: 80nMAssay Description:Inhibition of rat isomaltaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetLysosomal alpha-glucosidase(Rat)
Hokuriku University

Curated by ChEMBL
LigandPNGBDBM50259956(2,6-Bis-hydroxymethyl-piperidine-3,4,5-triol | alp...)
Affinity DataIC50: 80nMAssay Description:Inhibition of rat intestinal brush border membrane maltaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2012
Entry Details Article
PubMed
TargetTissue alpha-L-fucosidase(Rat)
University of Toyama

Curated by ChEMBL
LigandPNGBDBM50442344(CHEMBL2442783)
Affinity DataIC50: 81nMAssay Description:Inhibition of rat epididymis alpha-L-fucosidase assessed as inhibition of release of p-nitrophenol by spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetTissue alpha-L-fucosidase(Human)
University of Toyama

Curated by ChEMBL
LigandPNGBDBM50442351(CHEMBL2442776)
Affinity DataIC50: 86nMAssay Description:Inhibition of human lysosome alpha-L-fucosidase using 4-methylumbelliferyl-alpha-L-fucopyranoside by spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetAldo-keto reductase family 1 member B1(Human)
Kyushu University

Curated by ChEMBL
LigandPNGBDBM50049730(Epalrestat | 2-(5-(2-methyl-3-phenylallylidene)-4-...)
Affinity DataIC50: 100nMAssay Description:Inhibition of human recombinant AKR1B1 expressed in Escherichia coli BL21 cells using pyridine-3-aldehyde as substrate by spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed
TargetSucrase-isomaltase, intestinal(Rat)
Tohoku Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50375510(CHEMBL405957)
Affinity DataIC50: 100nMAssay Description:Inhibition of rat sucraseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetLysosomal alpha-glucosidase(Human)
Hokuriku University

Curated by ChEMBL
LigandPNGBDBM50259956(2,6-Bis-hydroxymethyl-piperidine-3,4,5-triol | alp...)
Affinity DataIC50: 100nMAssay Description:Inhibition of maltase in human Caco-2 cell model system after 2 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2012
Entry Details Article
PubMed
TargetTissue alpha-L-fucosidase(Rat)
University of Toyama

Curated by ChEMBL
LigandPNGBDBM50442339(CHEMBL2442788)
Affinity DataIC50: 100nMAssay Description:Inhibition of rat epididymis alpha-L-fucosidase assessed as inhibition of release of p-nitrophenol by spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
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