Compile Data Set for Download or QSAR
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LigandPNGBDBM24945(20-hydroxy-3,13-diazahexacyclo[14.8.0.0^{2,10}.0^{...)
Affinity DatapH: 7.2 T: 2°CAssay Description:The MLK kinase assays were performed by using the Millipore multiscreen trichloroacetic acid (TCA) in-plate format. The inhibition curves were genera...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
LigandPNGBDBM24946(3-(2-hydroxyethyl)-3,13-diazahexacyclo[14.8.0.0^{2...)
Affinity DatapH: 7.2 T: 2°CAssay Description:The MLK kinase assays were performed by using the Millipore multiscreen trichloroacetic acid (TCA) in-plate format. The inhibition curves were genera...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
LigandPNGBDBM24950(20-hydroxy-3-(2-hydroxyethyl)-3,13-diazahexacyclo[...)
Affinity DatapH: 7.2 T: 2°CAssay Description:The MLK kinase assays were performed by using the Millipore multiscreen trichloroacetic acid (TCA) in-plate format. The inhibition curves were genera...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
LigandPNGBDBM24951(20-(cyclopropylmethoxy)-3-(2-hydroxyethyl)-3,13-di...)
Affinity DatapH: 7.2 T: 2°CAssay Description:The MLK kinase assays were performed by using the Millipore multiscreen trichloroacetic acid (TCA) in-plate format. The inhibition curves were genera...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
LigandPNGBDBM24953(20-(cyclohexyloxy)-3-(2-hydroxyethyl)-3,13-diazahe...)
Affinity DatapH: 7.2 T: 2°CAssay Description:The MLK kinase assays were performed by using the Millipore multiscreen trichloroacetic acid (TCA) in-plate format. The inhibition curves were genera...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
LigandPNGBDBM24954(3-(2-hydroxyethyl)-20-(pyridin-2-ylmethoxy)-3,13-d...)
Affinity DatapH: 7.2 T: 2°CAssay Description:The MLK kinase assays were performed by using the Millipore multiscreen trichloroacetic acid (TCA) in-plate format. The inhibition curves were genera...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
LigandPNGBDBM24955(3-(2-hydroxyethyl)-20-(2-methoxyethoxy)-3,13-diaza...)
Affinity DatapH: 7.2 T: 2°CAssay Description:The MLK kinase assays were performed by using the Millipore multiscreen trichloroacetic acid (TCA) in-plate format. The inhibition curves were genera...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
LigandPNGBDBM24956(20-[2-(benzyloxy)ethoxy]-3-(2-hydroxyethyl)-3,13-d...)
Affinity DatapH: 7.2 T: 2°CAssay Description:The MLK kinase assays were performed by using the Millipore multiscreen trichloroacetic acid (TCA) in-plate format. The inhibition curves were genera...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
LigandPNGBDBM24957(20-(2-hydroxyethoxy)-3-(2-hydroxyethyl)-3,13-diaza...)
Affinity DatapH: 7.2 T: 2°CAssay Description:The MLK kinase assays were performed by using the Millipore multiscreen trichloroacetic acid (TCA) in-plate format. The inhibition curves were genera...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
LigandPNGBDBM24958(2-{[3-(2-hydroxyethyl)-14-oxo-3,13-diazahexacyclo[...)
Affinity DatapH: 7.2 T: 2°CAssay Description:The MLK kinase assays were performed by using the Millipore multiscreen trichloroacetic acid (TCA) in-plate format. The inhibition curves were genera...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
LigandPNGBDBM24959(4-{[3-(2-hydroxyethyl)-14-oxo-3,13-diazahexacyclo[...)
Affinity DatapH: 7.2 T: 2°CAssay Description:The MLK kinase assays were performed by using the Millipore multiscreen trichloroacetic acid (TCA) in-plate format. The inhibition curves were genera...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
LigandPNGBDBM24945(20-hydroxy-3,13-diazahexacyclo[14.8.0.0^{2,10}.0^{...)
Affinity DatapH: 7.2 T: 2°CAssay Description:The MLK kinase assays were performed by using the Millipore multiscreen trichloroacetic acid (TCA) in-plate format. The inhibition curves were genera...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
LigandPNGBDBM24950(20-hydroxy-3-(2-hydroxyethyl)-3,13-diazahexacyclo[...)
Affinity DatapH: 7.2 T: 2°CAssay Description:The MLK kinase assays were performed by using the Millipore multiscreen trichloroacetic acid (TCA) in-plate format. The inhibition curves were genera...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
LigandPNGBDBM24951(20-(cyclopropylmethoxy)-3-(2-hydroxyethyl)-3,13-di...)
Affinity DataAssay Description:The MLK kinase assays were performed by using the Millipore multiscreen trichloroacetic acid (TCA) in-plate format. The inhibition curves were genera...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
LigandPNGBDBM24952(20-(cyclopentyloxy)-3-(2-hydroxyethyl)-3,13-diazah...)
Affinity DataAssay Description:The MLK kinase assays were performed by using the Millipore multiscreen trichloroacetic acid (TCA) in-plate format. The inhibition curves were genera...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
LigandPNGBDBM24953(20-(cyclohexyloxy)-3-(2-hydroxyethyl)-3,13-diazahe...)
Affinity DataAssay Description:The MLK kinase assays were performed by using the Millipore multiscreen trichloroacetic acid (TCA) in-plate format. The inhibition curves were genera...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
LigandPNGBDBM24954(3-(2-hydroxyethyl)-20-(pyridin-2-ylmethoxy)-3,13-d...)
Affinity DataAssay Description:The MLK kinase assays were performed by using the Millipore multiscreen trichloroacetic acid (TCA) in-plate format. The inhibition curves were genera...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
LigandPNGBDBM24955(3-(2-hydroxyethyl)-20-(2-methoxyethoxy)-3,13-diaza...)
Affinity DataAssay Description:The MLK kinase assays were performed by using the Millipore multiscreen trichloroacetic acid (TCA) in-plate format. The inhibition curves were genera...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
LigandPNGBDBM24956(20-[2-(benzyloxy)ethoxy]-3-(2-hydroxyethyl)-3,13-d...)
Affinity DataAssay Description:The MLK kinase assays were performed by using the Millipore multiscreen trichloroacetic acid (TCA) in-plate format. The inhibition curves were genera...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
LigandPNGBDBM24957(20-(2-hydroxyethoxy)-3-(2-hydroxyethyl)-3,13-diaza...)
Affinity DataAssay Description:The MLK kinase assays were performed by using the Millipore multiscreen trichloroacetic acid (TCA) in-plate format. The inhibition curves were genera...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
LigandPNGBDBM24958(2-{[3-(2-hydroxyethyl)-14-oxo-3,13-diazahexacyclo[...)
Affinity DataAssay Description:The MLK kinase assays were performed by using the Millipore multiscreen trichloroacetic acid (TCA) in-plate format. The inhibition curves were genera...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
LigandPNGBDBM24959(4-{[3-(2-hydroxyethyl)-14-oxo-3,13-diazahexacyclo[...)
Affinity DataAssay Description:The MLK kinase assays were performed by using the Millipore multiscreen trichloroacetic acid (TCA) in-plate format. The inhibition curves were genera...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetGlycogen synthase kinase-3 beta(Human)
Institute of Harvard and Mit

Curated by ChEMBL
LigandPNGBDBM50192839(CHEMBL3984982)
Affinity DataKd:  6.00E+5nMAssay Description:Binding affinity to GSK-3 beta (unknown origin) after 30 mins by isothermal titration calorimetryMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
TargetGlycogen synthase kinase-3 beta(Human)
Institute of Harvard and Mit

Curated by ChEMBL
LigandPNGBDBM50192879(CHEMBL3969394)
Affinity DataKd:  9.00E+3nMAssay Description:Binding affinity to GSK-3 beta (unknown origin) after 30 mins by isothermal titration calorimetryMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50318946(rac-9-(2-hydroxyethyl)-5-methyl-12-(tetrahydro-2H-...)
Affinity DataIC50: 3nMAssay Description:Inhibition of human recombinant VEGFR2 by time resolved fluorescence measurementsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAngiopoietin-1 receptor(Human)
Cephalon

Curated by ChEMBL
LigandPNGBDBM50318963(rac-5-methyl-9-propyl-12-(tetrahydro-2H-pyran-2-yl...)
Affinity DataIC50: 3nMAssay Description:Inhibition of human recombinant TIE-2 by time resolved fluorescence measurementsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAngiopoietin-1 receptor(Human)
Cephalon

Curated by ChEMBL
LigandPNGBDBM50318959(rac-9-isobutyl-5-methyl-12-(tetrahydro-2H-pyran-2-...)
Affinity DataIC50: 3nMAssay Description:Inhibition of human recombinant TIE-2 by time resolved fluorescence measurementsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50318958(rac-9-butyl-5-methyl-12-(tetrahydro-2H-pyran-2-yl)...)
Affinity DataIC50: 5nMAssay Description:Inhibition of VEGFR3 at 3 uMMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50318960(rac-5-methyl-12-(tetrahydro-2H-pyran-2-yl)-5,7,8,9...)
Affinity DataIC50: 5nMAssay Description:Inhibition of human recombinant VEGFR2 by time resolved fluorescence measurementsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50318962(rac-9-ethyl-5-methyl-12-(tetrahydro-2H-pyran-2-yl)...)
Affinity DataIC50: 6nMAssay Description:Inhibition of human recombinant VEGFR2 by time resolved fluorescence measurementsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50318957(9-(2-hydroxyethyl)-6-methyl-12-(tetrahydro-2H-pyra...)
Affinity DataIC50: 7nMAssay Description:Inhibition of human recombinant VEGFR2 by time resolved fluorescence measurementsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50318949(6-methyl-12-(tetrahydro-2H-pyran-2-yl)-6,7,8,9-tet...)
Affinity DataIC50: 8nMAssay Description:Inhibition of human recombinant VEGFR2 by time resolved fluorescence measurementsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50318963(rac-5-methyl-9-propyl-12-(tetrahydro-2H-pyran-2-yl...)
Affinity DataIC50: 8nMAssay Description:Inhibition of human recombinant VEGFR2 by time resolved fluorescence measurementsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50318959(rac-9-isobutyl-5-methyl-12-(tetrahydro-2H-pyran-2-...)
Affinity DataIC50: 9nMAssay Description:Inhibition of VEGFR3 at 3 uMMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50318951(9-ethyl-6-methyl-12-(tetrahydro-2H-pyran-2-yl)-6,7...)
Affinity DataIC50: 9nMAssay Description:Inhibition of human recombinant VEGFR2 by time resolved fluorescence measurementsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAngiopoietin-1 receptor(Human)
Cephalon

Curated by ChEMBL
LigandPNGBDBM50318970(rac-9-allyl-5-methyl-12-(tetrahydro-2H-pyran-2-yl)...)
Affinity DataIC50: 9nMAssay Description:Inhibition of human recombinant TIE-2 by time resolved fluorescence measurementsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50318959(rac-9-isobutyl-5-methyl-12-(tetrahydro-2H-pyran-2-...)
Affinity DataIC50: 10nMAssay Description:Inhibition of VEGF-stimulated VEGFR2 autophosphorylation in HUVECMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50318963(rac-5-methyl-9-propyl-12-(tetrahydro-2H-pyran-2-yl...)
Affinity DataIC50: 10nMAssay Description:Inhibition of VEGF-stimulated VEGFR2 autophosphorylation in HUVECMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50318962(rac-9-ethyl-5-methyl-12-(tetrahydro-2H-pyran-2-yl)...)
Affinity DataIC50: 10nMAssay Description:Inhibition of VEGF-stimulated VEGFR2 autophosphorylation in HUVECMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50318958(rac-9-butyl-5-methyl-12-(tetrahydro-2H-pyran-2-yl)...)
Affinity DataIC50: 10nMAssay Description:Inhibition of VEGF-stimulated VEGFR2 autophosphorylation in HUVECMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAngiopoietin-1 receptor(Human)
Cephalon

Curated by ChEMBL
LigandPNGBDBM50318964(rac-9-isopropyl-5-methyl-12-(tetrahydro-2H-pyran-2...)
Affinity DataIC50: 10nMAssay Description:Inhibition of human recombinant TIE-2 by time resolved fluorescence measurementsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAngiopoietin-1 receptor(Human)
Cephalon

Curated by ChEMBL
LigandPNGBDBM50318958(rac-9-butyl-5-methyl-12-(tetrahydro-2H-pyran-2-yl)...)
Affinity DataIC50: 10nMAssay Description:Inhibition of human recombinant TIE-2 by time resolved fluorescence measurementsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50318960(rac-5-methyl-12-(tetrahydro-2H-pyran-2-yl)-5,7,8,9...)
Affinity DataIC50: 10nMAssay Description:Inhibition of human recombinant VEGFR2 by time resolved fluorescence measurementsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50318961(rac-5,9-dimethyl-12-(tetrahydro-2H-pyran-2-yl)-5,7...)
Affinity DataIC50: 10nMAssay Description:Inhibition of human recombinant VEGFR2 by time resolved fluorescence measurementsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50318964(rac-9-isopropyl-5-methyl-12-(tetrahydro-2H-pyran-2...)
Affinity DataIC50: 10nMAssay Description:Inhibition of human recombinant VEGFR2 by time resolved fluorescence measurementsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50318959(rac-9-isobutyl-5-methyl-12-(tetrahydro-2H-pyran-2-...)
Affinity DataIC50: 11nMAssay Description:Inhibition of human recombinant VEGFR2 by time resolved fluorescence measurementsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAngiopoietin-1 receptor(Human)
Cephalon

Curated by ChEMBL
LigandPNGBDBM50318962(rac-9-ethyl-5-methyl-12-(tetrahydro-2H-pyran-2-yl)...)
Affinity DataIC50: 14nMAssay Description:Inhibition of human recombinant TIE-2 by time resolved fluorescence measurementsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50318961(rac-5,9-dimethyl-12-(tetrahydro-2H-pyran-2-yl)-5,7...)
Affinity DataIC50: 15nMAssay Description:Inhibition of human recombinant VEGFR2 by time resolved fluorescence measurementsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 3A4(Human)
Global Blood Therapeutics

Curated by ChEMBL
LigandPNGBDBM151585(US8987315, Ketoconazole | US9180183, Ketoconazole ...)
Affinity DataIC50: 15nMAssay Description:Inhibition of CYP3A4 using in human liver microsomes using testosterone as substrate after 5 to 15 minsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50318947(rac-9-(3-hydroxypropyl)-5-methyl-12-(tetrahydro-2H...)
Affinity DataIC50: 16nMAssay Description:Inhibition of human recombinant VEGFR2 by time resolved fluorescence measurementsMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
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