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TargetIntegrin alpha-IIb/beta-3(Human)
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50075566(CHEMBL117989 | CHEMBL275611 | (S)-3-{2-[(R)-3-(4-C...)
Affinity DataKd:  0.600nMAssay Description:Dissociation constant for activated Fibrinogen ReceptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetIntegrin alpha-IIb/beta-3(Human)
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50075580((R)-3-{2-[(S)-3-(4-Carbamimidoyl-phenyl)-4,5-dihyd...)
Affinity DataKd:  253nMAssay Description:Dissociation constant for unactivated Fibrinogen ReceptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetIntegrin alpha-IIb/beta-3(Human)
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50075563((R)-3-{2-[(R)-3-(4-Carbamimidoyl-phenyl)-4,5-dihyd...)
Affinity DataKd:  5.90nMAssay Description:Dissociation constant for activated Fibrinogen ReceptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetIntegrin alpha-IIb/beta-3(Human)
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50075579(2-Butoxycarbonylamino-3-{2-[3-(4-carbamimidoyl-phe...)
Affinity DataKd:  2.80nMAssay Description:Dissociation constant for activated Fibrinogen ReceptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetIntegrin alpha-IIb/beta-3(Human)
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50075579(2-Butoxycarbonylamino-3-{2-[3-(4-carbamimidoyl-phe...)
Affinity DataKd:  2.40nMAssay Description:Dissociation constant for unactivated Fibrinogen ReceptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetIntegrin alpha-IIb/beta-3(Human)
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50075572((S)-3-{2-[(S)-3-(4-Carbamimidoyl-phenyl)-4,5-dihyd...)
Affinity DataKd:  3.70nMAssay Description:Dissociation constant for unactivated Fibrinogen ReceptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetIntegrin alpha-IIb/beta-3(Human)
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50075566(CHEMBL117989 | CHEMBL275611 | (S)-3-{2-[(R)-3-(4-C...)
Affinity DataKd:  0.900nMAssay Description:Dissociation constant for unactivated Fibrinogen ReceptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetIntegrin alpha-IIb/beta-3(Human)
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50075580((R)-3-{2-[(S)-3-(4-Carbamimidoyl-phenyl)-4,5-dihyd...)
Affinity DataKd:  186nMAssay Description:Dissociation constant for activated Fibrinogen ReceptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetIntegrin alpha-IIb/beta-3(Human)
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50075572((S)-3-{2-[(S)-3-(4-Carbamimidoyl-phenyl)-4,5-dihyd...)
Affinity DataKd:  2.70nMAssay Description:Dissociation constant for activated Fibrinogen ReceptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetIntegrin alpha-IIb/beta-3(Human)
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50075563((R)-3-{2-[(R)-3-(4-Carbamimidoyl-phenyl)-4,5-dihyd...)
Affinity DataKd:  24nMAssay Description:Dissociation constant for unactivated Fibrinogen ReceptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
TBA

Curated by ChEMBL
LigandPNGBDBM50283729((S)-1-[(2S,4R)-2-Hydroxy-4-((1S,2R)-2-hydroxy-inda...)
Affinity DataIC50: 0.0150nMAssay Description:Inhibition of Human Immunodeficiency virus-1 proteaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2010
Entry Details Article

TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
TBA

Curated by ChEMBL
LigandPNGBDBM50283726((S)-4-(4-Bromo-thiophen-2-ylmethyl)-1-[(2S,4R)-2-h...)
Affinity DataIC50: 0.0300nMAssay Description:Inhibition of Human Immunodeficiency virus-1 proteaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2010
Entry Details Article

TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
TBA

Curated by ChEMBL
LigandPNGBDBM50283732((S)-1-[(2S,4R)-2-Hydroxy-4-((1S,2R)-2-hydroxy-inda...)
Affinity DataIC50: 0.0300nMAssay Description:Inhibition of Human Immunodeficiency virus-1 proteaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2010
Entry Details Article

TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
TBA

Curated by ChEMBL
LigandPNGBDBM50285450([(1S,2R)-1-Benzyl-3-((S)-4-[2,2']bithiophenyl-5-yl...)
Affinity DataIC50: 0.0400nMAssay Description:Inhibition of HIV-1 ProteaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2010
Entry Details Article

TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
TBA

Curated by ChEMBL
LigandPNGBDBM50283723((S)-1-[(2S,4R)-2-Hydroxy-4-((1S,2R)-2-hydroxy-inda...)
Affinity DataIC50: 0.0500nMAssay Description:Inhibition of Human Immunodeficiency virus-1 proteaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2010
Entry Details Article

TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
TBA

Curated by ChEMBL
LigandPNGBDBM383((3S)-oxolan-3-yl N-[(2S,3S,5R)-5-benzyl-3-hydroxy-...)
Affinity DataIC50: 0.0600nMAssay Description:Compound was tested for inhibitory activity against Human immunodeficiency virus (HIV-1) proteaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2010
Entry Details Article

TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
TBA

Curated by ChEMBL
LigandPNGBDBM50283722((S)-1-[(2S,4R)-2-Hydroxy-4-((1S,2R)-2-hydroxy-inda...)
Affinity DataIC50: 0.0600nMAssay Description:Inhibition of Human Immunodeficiency virus-1 proteaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2010
Entry Details Article

TargetCholecystokinin receptor type A(Rat)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50005463(1H-Indole-2-carboxylic acid (1-methyl-2-oxo-5-phen...)
Affinity DataIC50: 0.0800nMAssay Description:Half-maximal inhibition of [125I]CCK-33 binding to cholecystokinin A receptor from rat pancreatic tissueMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCholecystokinin receptor type A(Rat)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50005463(1H-Indole-2-carboxylic acid (1-methyl-2-oxo-5-phen...)
Affinity DataIC50: 0.0800nMAssay Description:Displacement of [125 I] CCK-8 from Cholecystokinin type A receptor of rat pancreasMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
TBA

Curated by ChEMBL
LigandPNGBDBM50283733((S)-1-[(2S,4R)-2-Hydroxy-4-((1S,2R)-2-hydroxy-inda...)
Affinity DataIC50: 0.0900nMAssay Description:Inhibition of Human Immunodeficiency virus-1 proteaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2010
Entry Details Article

TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
TBA

Curated by ChEMBL
LigandPNGBDBM50285455([(1S,2R)-3-((S)-4-Benzo[b]thiophen-2-ylmethyl-2-te...)
Affinity DataIC50: 0.100nMAssay Description:Inhibition of HIV-1 ProteaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2010
Entry Details Article

TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Merck Sharp and Dohme Research Laboratories

LigandPNGBDBM842(CHEMBL419923 | tert-butyl N-[(2S,3S,5R)-5-benzyl-5...)
Affinity DataIC50: 0.100nMpH: 5.5 T: 2°CAssay Description:Sensitivity of HIV-1 protease activity to protease inhibitors was determined by a peptide substrate cleavage assay. Protease products were analyzed o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2004
Entry Details Article
PubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
TBA

Curated by ChEMBL
LigandPNGBDBM50283731((S)-4-(4-Bromo-thiophen-2-ylmethyl)-1-[(2S,4R)-2-h...)
Affinity DataIC50: 0.110nMAssay Description:Inhibition of Human Immunodeficiency virus-1 proteaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2010
Entry Details Article

TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
TBA

Curated by ChEMBL
LigandPNGBDBM50285454([(1S,2R)-1-Benzyl-3-((S)-2-tert-butylcarbamoyl-4-t...)
Affinity DataIC50: 0.110nMAssay Description:Inhibition of HIV-1 ProteaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2010
Entry Details Article

TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
TBA

Curated by ChEMBL
LigandPNGBDBM50283727((S)-1-[(2S,4R)-2-Hydroxy-4-((1S,2R)-2-hydroxy-inda...)
Affinity DataIC50: 0.120nMAssay Description:Inhibition of Human Immunodeficiency virus-1 proteaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2010
Entry Details Article

TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
TBA

Curated by ChEMBL
LigandPNGBDBM50283730((S)-4-(2,6-Difluoro-benzyl)-1-[(2S,4R)-2-hydroxy-4...)
Affinity DataIC50: 0.140nMAssay Description:Inhibition of Human Immunodeficiency virus-1 proteaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2010
Entry Details Article

TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
TBA

Curated by ChEMBL
LigandPNGBDBM50285453({(1S,2R)-1-Benzyl-3-[(S)-4-(4-bromo-thiophen-2-ylm...)
Affinity DataIC50: 0.180nMAssay Description:Inhibition of HIV-1 ProteaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2010
Entry Details Article

TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
TBA

Curated by ChEMBL
LigandPNGBDBM50039563((R)-N*1*-[(1S,2R)-1-Benzyl-3-((3S,4aS,8aS)-3-tert-...)
Affinity DataIC50: 0.230nMAssay Description:Tested for inhibitory activity against HIV protease enzymeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
TBA

Curated by ChEMBL
LigandPNGBDBM50285456({(1S,2R)-1-Benzyl-3-[(S)-4-(5-bromo-thiophen-2-ylm...)
Affinity DataIC50: 0.25nMAssay Description:Inhibition of HIV-1 ProteaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2010
Entry Details Article

TargetGastrin/cholecystokinin type B receptor(Human)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50020270(CHEMBL445095 | 1-(4-Chloro-phenyl)-3-[2-oxo-1-(2-o...)
Affinity DataIC50: 0.280nMAssay Description:Displacement of [125 I] CCK-8 from Cholecystokinin type B receptor of guinea pig cerebral cortexMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2012
Entry Details Article
PubMed
TargetCholecystokinin receptor type A(Rat)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50367648(CHEMBL1907661)
Affinity DataIC50: 0.300nMAssay Description:Half-maximal inhibition of [125I]CCK-8 binding to cholecystokinin receptor from rat pancreatic tissueMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2012
Entry Details Article
PubMed
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Merck Sharp and Dohme Research Laboratories

LigandPNGBDBM1030(tert-butyl N-[(2S,3S,5R)-5-benzyl-3-hydroxy-5-{[(1...)
Affinity DataIC50: 0.300nMpH: 5.5 T: 2°CAssay Description:Sensitivity of HIV-1 protease activity to protease inhibitors was determined by a peptide substrate cleavage assay. Protease products were analyzed o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2004
Entry Details Article
PubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
TBA

Curated by ChEMBL
LigandPNGBDBM50285459([(1S,2R)-1-Benzyl-3-((S)-2-tert-butylcarbamoyl-4-t...)
Affinity DataIC50: 0.320nMAssay Description:Inhibition of HIV-1 ProteaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2010
Entry Details Article

TargetCholecystokinin receptor type A(Rat)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50367623(CHEMBL1907852)
Affinity DataIC50: 0.390nMAssay Description:Displacement of [125 I] CCK-8 from Cholecystokinin type A receptor of rat pancreasMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2012
Entry Details Article
PubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
TBA

Curated by ChEMBL
LigandPNGBDBM517(Crixivan | CHEMBL115 | L-735, 524 | MK639 | Indina...)
Affinity DataIC50: 0.410nMAssay Description:Inhibition of Human Immunodeficiency virus-1 proteaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2010
Entry Details Article

TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
TBA

Curated by ChEMBL
LigandPNGBDBM50285452({(1S,2R)-1-Benzyl-3-[(S)-2-tert-butylcarbamoyl-4-(...)
Affinity DataIC50: 0.470nMAssay Description:Inhibition of HIV-1 ProteaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2010
Entry Details Article

TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
TBA

Curated by ChEMBL
LigandPNGBDBM50283724((S)-4-(2,6-Difluoro-benzyl)-1-[(2S,4R)-2-hydroxy-4...)
Affinity DataIC50: 0.480nMAssay Description:Inhibition of Human Immunodeficiency virus-1 proteaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2010
Entry Details Article

TargetGastrin/cholecystokinin type B receptor(Human)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50020270(CHEMBL445095 | 1-(4-Chloro-phenyl)-3-[2-oxo-1-(2-o...)
Affinity DataIC50: 0.5nMAssay Description:Displacement of 125 I-gastrin from gastrin receptor of guinea pig gastric glandsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2012
Entry Details Article
PubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
TBA

Curated by ChEMBL
LigandPNGBDBM50283282({(1S,2R)-1-Benzyl-3-[(S)-2-tert-butylcarbamoyl-4-(...)
Affinity DataIC50: 0.540nMAssay Description:Inhibition of HIV-1 ProteaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2010
Entry Details Article

TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
TBA

Curated by ChEMBL
LigandPNGBDBM50285451({(1S,2R)-1-Benzyl-3-[(S)-2-tert-butylcarbamoyl-4-(...)
Affinity DataIC50: 0.590nMAssay Description:Inhibition of HIV-1 ProteaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2010
Entry Details Article

TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
TBA

Curated by ChEMBL
LigandPNGBDBM50285458([(1S,2R)-1-Benzyl-3-((S)-2-tert-butylcarbamoyl-4-t...)
Affinity DataIC50: 0.600nMAssay Description:Inhibition of HIV-1 ProteaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2010
Entry Details Article

TargetCholecystokinin receptor type A(Rat)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50019231(CHEMBL73946 | N-[5-(2-Fluoro-phenyl)-1-methyl-2-ox...)
Affinity DataIC50: 0.75nMAssay Description:Half-maximal inhibition of [125I]CCK-33 binding to cholecystokinin A receptor from rat pancreatic tissueMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2012
Entry Details Article
PubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
TBA

Curated by ChEMBL
LigandPNGBDBM50285460(((1S,2R)-1-Benzyl-3-{(S)-2-tert-butylcarbamoyl-4-[...)
Affinity DataIC50: 0.760nMAssay Description:Inhibition of HIV-1 ProteaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2010
Entry Details Article

TargetCholecystokinin receptor type A(Rat)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50452486(Rac-Devazepide | CHEMBL39263)
Affinity DataIC50: 0.800nMAssay Description:Half-maximal inhibition of [125I]CCK-33 binding to cholecystokinin A receptor from rat pancreatic tissueMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2012
Entry Details Article
PubMed
TargetCholecystokinin receptor type A(Rat)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50367643(CHEMBL1907848)
Affinity DataIC50: 0.800nMAssay Description:Half-maximal inhibition of [125I]CCK-33 binding to cholecystokinin A receptor from rat pancreatic tissueMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2012
Entry Details Article
PubMed
TargetCholecystokinin receptor type A(Rat)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50367626(CHEMBL1907850)
Affinity DataIC50: 0.800nMAssay Description:Half-maximal inhibition of [125I]CCK-33 binding to cholecystokinin A receptor from rat pancreatic tissueMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2012
Entry Details Article
PubMed
LigandPNGBDBM50003240(2,2-Dimethyl-butyric acid 8-[2-(4-hydroxy-6-oxo-te...)
Affinity DataIC50: 0.900nMAssay Description:Inhibition of solubilized, purified rat liver HMG-CoA reductase.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
TBA

Curated by ChEMBL
LigandPNGBDBM50285277({(1S,2R)-1-Benzyl-3-[(S)-2-tert-butylcarbamoyl-4-(...)
Affinity DataIC50: 0.950nMAssay Description:In vitro inhibitory activity against HIV-1 protease enzyme.More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2010
Entry Details Article

TargetCholecystokinin receptor type A(Rat)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50019204(4-Bromo-N-(1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-...)
Affinity DataIC50: 1nMAssay Description:Half-maximal inhibition of [125I]CCK-8 binding to cholecystokinin receptor from rat pancreatic tissueMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/16/2012
Entry Details Article
PubMed
TargetGastrin/cholecystokinin type B receptor(Human)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50020269((RS)-{3-[3-(4-Chloro-phenyl)-ureido]-2-oxo-5-pheny...)
Affinity DataIC50: 1nMAssay Description:Displacement of [125 I] CCK-8 from Cholecystokinin type B receptor of guinea pig cerebral cortexMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2012
Entry Details Article
PubMed
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