Compile Data Set for Download or QSAR
Report error Found 1414 with Last Name = 'audia' and Initial = 'je'
Target5-hydroxytryptamine receptor 1D(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50073682(N-methyl-2-[3-(1-methylpiperidin-4-yl)-1H-indol-5-...)
Affinity DataEC50:  1.60nMAssay Description:Ability to inhibit forskolin-stimulated adenylate cyclase in a cell line expressing human 5-hydroxytryptamine 1D receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetLysine-specific histone demethylase 1A(Human)
Constellation Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50545732(CHEMBL4638408)
Affinity DataEC50:  362nMAssay Description:Inhibition of LSD1 in human MV4-11 cells assessed as induction of LY96 mRNA expression incubated for 16 hrs by chemiluminescent methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetProbable global transcription activator SNF2L2(Human)
Constellation, A Morphosys

Curated by ChEMBL
LigandPNGBDBM394530(US10308614, Example 131 | (R)-1-(4-(3-amino-6-(2-)
Affinity DataKd:  16nMAssay Description:Binding affinity to human SMARCA2 (S1337 to Q1486 residues) expressed in bacterial expression system by bromoscan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetBromodomain-containing protein 7(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50269687(CHEMBL4073178)
Affinity DataKd:  1.10E+6nMAssay Description:Binding affinity to human DNA-tagged BRD7 (125 to 254 residues) expressed in mammalian expression system by BROMOscan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/17/2020
Entry Details Article
PubMed
TargetBromodomain-containing protein 4(Human)
Constellation Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50613459(CHEMBL5287013)
Affinity DataEC50:  250nMAssay Description:Inhibition of BRD4 BD1 in human MV4-11 cells assessed as reduction of MYC RNA expression after 4 hrs by PCR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetBromodomain-containing protein 4(Human)
Constellation Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50613469(CHEMBL5279452)
Affinity DataEC50:  1.10E+3nMAssay Description:Inhibition of BRD4 BD1 in human MV4-11 cells assessed as reduction of MYC RNA expression after 4 hrs by PCR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetChromatin remodeling regulator CECR2(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50269687(CHEMBL4073178)
Affinity DataEC50:  370nMAssay Description:Binding affinity to ZsGreen fused-CECR2 bromodomain (M404 to H515 residues) (unknown origin) expressed in human U2OS-C433 cells co expressing (MDPKKK...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/17/2020
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1D(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50073688([2-(5-tert-Butyl-1H-indol-3-yl)-ethyl]-methyl-amin...)
Affinity DataEC50:  0.220nMAssay Description:Ability to inhibit forskolin-stimulated adenylate cyclase in a cell line expressing human 5-hydroxytryptamine 1D receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetHistone-lysine N-methyltransferase EZH2(Human)
Constellation Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50541914(CHEMBL4635102)
Affinity DataEC50:  3.5nMAssay Description:Inhibition of EZH2 in human HeLa cells assessed as inhibition of trimethylation of H3K27 after 72 hrs by AlphaLISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetTranscription activator BRG1(Human)
Constellation, A Morphosys

Curated by ChEMBL
LigandPNGBDBM50598934(CHEMBL5183240)
Affinity DataKd:  510nMAssay Description:Binding affinity to human SMARCA4 (A1448 to S1575 residues) expressed in bacterial expression system by bromoscan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetProbable global transcription activator SNF2L2(Human)
Constellation, A Morphosys

Curated by ChEMBL
LigandPNGBDBM394583(US10308614, Example 186 | 2-(6-amino-5-phenylpyrid...)
Affinity DataKd:  1.10E+3nMAssay Description:Binding affinity to human MHHHHHHGSLVPRGS-tagged SMARAC2 isoform B L1412P/P1413V/S1414N mutant (S1377 to Q1486 residues) by isothermal titration calo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetProtein polybromo-1(Human)
Constellation, A Morphosys

Curated by ChEMBL
LigandPNGBDBM50598934(CHEMBL5183240)
Affinity DataKd:  580nMAssay Description:Binding affinity to human PBRM1 bromodomain 5 (S645 to D766 residues) expressed in bacterial expression system by bromoscan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetBromodomain-containing protein 4(Human)
Constellation Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50613461(CHEMBL5274793)
Affinity DataEC50:  170nMAssay Description:Inhibition of BRD4 BD1 in human MV4-11 cells assessed as reduction of MYC RNA expression after 4 hrs by PCR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetLysine-specific histone demethylase 1A(Human)
Constellation Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50545729(CHEMBL4646795)
Affinity DataEC50:  52nMAssay Description:Inhibition of LSD1 in human MV4-11 cells assessed as induction of LY96 mRNA expression incubated for 16 hrs by chemiluminescent methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetProtein polybromo-1(Human)
Constellation, A Morphosys

Curated by ChEMBL
LigandPNGBDBM394530(US10308614, Example 131 | (R)-1-(4-(3-amino-6-(2-)
Affinity DataKd:  18nMAssay Description:Binding affinity to human PBRM1 bromodomain 5 (S645 to D766 residues) expressed in bacterial expression system by bromoscan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetProtein polybromo-1(Human)
Constellation, A Morphosys

Curated by ChEMBL
LigandPNGBDBM50598935(CHEMBL5194650)
Affinity DataKd:  5.70E+3nMAssay Description:Binding affinity to human PBRM1 bromodomain 2 (S178 to E291 residues) expressed in bacterial expression system by bromoscan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase EZH2(Human)
Constellation Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50563825(CHEMBL4794859)
Affinity DataEC50:  20nMAssay Description:Inhibition of EZH2 in human HeLa cells assessed as inhibition of trimethylation of H3K27 after 72 hrs by AlphaLISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetLysine-specific histone demethylase 1A(Human)
Constellation Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50545734(CHEMBL4647263)
Affinity DataEC50:  312nMAssay Description:Inhibition of LSD1 in human MV4-11 cells assessed as induction of LY96 mRNA expression incubated for 16 hrs by chemiluminescent methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetCREB-binding protein(Human)
Constellation Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50178170(CHEMBL3814881)
Affinity DataEC50: >1.00E+4nMAssay Description:Inhibition of Halo-tagged histone H3.3 binding to CBP (unknown origin) expressed in HEK293 cells after overnight incubation by luciferase reporter ge...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/17/2017
Entry Details Article
PubMed
TargetHistone-lysine N-methyltransferase EZH2(Human)
Constellation Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50563827(CHEMBL4797333)
Affinity DataEC50:  39nMAssay Description:Inhibition of EZH2 in human HeLa cells assessed as inhibition of trimethylation of H3K27 after 72 hrs by AlphaLISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetHistone-lysine N-methyltransferase EZH2(Human)
Constellation Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50541917(CHEMBL4644363)
Affinity DataEC50: >1.00E+3nMAssay Description:Inhibition of EZH2 in human HeLa cells assessed as inhibition of trimethylation of H3K27 after 72 hrs by AlphaLISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetBromodomain-containing protein 4(Human)
Constellation Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50613458(CHEMBL5266575)
Affinity DataEC50:  100nMAssay Description:Inhibition of BRD4 BD1 in human MV4-11 cells assessed as reduction of MYC RNA expression after 4 hrs by PCR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetLysine-specific histone demethylase 1A(Human)
Constellation Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50158869(CHEMBL3786182 | US10836743, Compound GSK-2879552 |...)
Affinity DataEC50:  54nMAssay Description:Inhibition of LSD1 in human MV4-11 cells assessed as induction of LY96 mRNA expression incubated for 16 hrs by chemiluminescent methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetHistone-lysine N-methyltransferase EZH2(Human)
Constellation Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50541920(Lirametostat | Cpi-1205)
Affinity DataEC50:  28nMAssay Description:Inhibition of EZH2 in human HeLa cells assessed as inhibition of trimethylation of H3K27 after 72 hrs by AlphaLISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetBromodomain-containing protein 4(Human)
Constellation Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50613452(CHEMBL5269306)
Affinity DataEC50:  720nMAssay Description:Inhibition of BRD4 BD1 in human Raji cells assessed as reduction of MYC RNA expression after 4 hrs by PCR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetBromodomain-containing protein 4(Human)
Constellation Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50613467(CHEMBL5276602)
Affinity DataEC50: >4.00E+3nMAssay Description:Inhibition of BRD4 BD1 in human MV4-11 cells assessed as reduction of MYC RNA expression after 4 hrs by PCR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetLysine-specific histone demethylase 1A(Human)
Constellation Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50545727(CHEMBL4637906)
Affinity DataEC50:  6nMAssay Description:Inhibition of LSD1 in human MV4-11 cells assessed as induction of LY96 mRNA expression incubated for 16 hrs by chemiluminescent methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetHistone-lysine N-methyltransferase EZH2(Human)
Constellation Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50563826(CHEMBL4782143)
Affinity DataEC50:  38nMAssay Description:Inhibition of EZH2 in human HeLa cells assessed as inhibition of trimethylation of H3K27 after 72 hrs by AlphaLISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetBromodomain-containing protein 4(Human)
Constellation Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50613471(CHEMBL5276365)
Affinity DataEC50:  440nMAssay Description:Inhibition of BRD4 BD1 in human MV4-11 cells assessed as reduction of MYC RNA expression after 4 hrs by PCR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase EZH2(Human)
Constellation Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50541902(CHEMBL4635809 | US11459315, Example 11)
Affinity DataEC50:  26nMAssay Description:Inhibition of EZH2 in human HeLa cells assessed as inhibition of trimethylation of H3K27 after 72 hrs by AlphaLISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetLysine-specific histone demethylase 1A(Human)
Constellation Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50545722(CHEMBL4649041)
Affinity DataEC50:  7nMAssay Description:Inhibition of LSD1 in human MV4-11 cells assessed as induction of LY96 mRNA expression incubated for 16 hrs by chemiluminescent methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetBromodomain-containing protein 4(Human)
Constellation Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50613463(CHEMBL5277826)
Affinity DataEC50:  140nMAssay Description:Inhibition of BRD4 BD1 in human MV4-11 cells assessed as reduction of MYC RNA expression after 4 hrs by PCR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
Target5-hydroxytryptamine receptor 1D(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50033437(N,N-dimethyl-2-[5-(1H-1,2,4-triazol-1-ylmethyl)-1H...)
Affinity DataEC50:  3nMAssay Description:Ability to inhibit forskolin-stimulated adenylate cyclase in a cell line expressing human 5-hydroxytryptamine 1D receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50269687(CHEMBL4073178)
Affinity DataKd:  2.40E+6nMAssay Description:Binding affinity to human DNA-tagged TAF1L bromodomain 2 (1523 to 1654 residues) expressed in bacterial expression system by BROMOscan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/17/2020
Entry Details Article
PubMed
TargetLysine-specific histone demethylase 1A(Human)
Constellation Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM424912(2-(6-(((1R,2S)-2-((E)-1-phenylbut-1-en-2-yl)cyclop...)
Affinity DataEC50:  2nMAssay Description:Inhibition of LSD1 in human MV4-11 cells assessed as induction of LY96 mRNA expression incubated for 16 hrs by chemiluminescent methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetHistone-lysine N-methyltransferase EZH2(Human)
Constellation Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50541911(CHEMBL4639983)
Affinity DataEC50:  1.80nMAssay Description:Inhibition of EZH2 in human HeLa cells assessed as inhibition of trimethylation of H3K27 after 72 hrs by AlphaLISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetHistone-lysine N-methyltransferase EZH2(Human)
Constellation Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50541910(CHEMBL4635863)
Affinity DataEC50:  3.5nMAssay Description:Inhibition of EZH2 in human HeLa cells assessed as inhibition of trimethylation of H3K27 after 72 hrs by AlphaLISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetHistone-lysine N-methyltransferase EZH2(Human)
Constellation Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50563821(CHEMBL4780697)
Affinity DataEC50:  930nMAssay Description:Inhibition of EZH2 in human HeLa cells assessed as inhibition of trimethylation of H3K27 after 72 hrs by AlphaLISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetTranscription activator BRG1(Human)
Constellation, A Morphosys

Curated by ChEMBL
LigandPNGBDBM50598935(CHEMBL5194650)
Affinity DataKd:  1.00E+4nMAssay Description:Binding affinity to human SMARCA4 (A1448 to S1575 residues) expressed in bacterial expression system by bromoscan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetCREB-binding protein(Human)
Constellation Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50178164(CHEMBL3815023 | US10206931, Example 173)
Affinity DataEC50:  3.40E+3nMAssay Description:Inhibition of Halo-tagged histone H3.3 binding to CBP (unknown origin) expressed in HEK293 cells after overnight incubation by luciferase reporter ge...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/17/2017
Entry Details Article
PubMed
TargetBromodomain-containing protein 4(Human)
Constellation Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50613455(CHEMBL5288449)
Affinity DataEC50:  270nMAssay Description:Inhibition of BRD4 BD1 in human MV4-11 cells assessed as reduction of MYC RNA expression after 4 hrs by PCR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetChromatin remodeling regulator CECR2(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50503406(CHEMBL4463538)
Affinity DataKd:  1.20E+3nMAssay Description:Binding affinity to recombinant human DNA-tagged CECR2 (423 to 543 residues) expressed in bacterial expression system by bromoscan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetProbable global transcription activator SNF2L2(Human)
Constellation, A Morphosys

Curated by ChEMBL
LigandPNGBDBM394530(US10308614, Example 131 | (R)-1-(4-(3-amino-6-(2-)
Affinity DataEC50:  100nMAssay Description:Inhibition of SMARAC2 isoform B (unknown origin) expressed in U2OS cells co-expressed in NLS-ZsGreen incubated for 1 hrs by cellular target engagemen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase EZH2(Human)
Constellation Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50541897(CHEMBL4634390 | US11459315, Example 109)
Affinity DataEC50:  49nMAssay Description:Inhibition of EZH2 in human HeLa cells assessed as inhibition of trimethylation of H3K27 after 72 hrs by AlphaLISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetLysine-specific histone demethylase 1A(Human)
Constellation Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50545726(CHEMBL4639957)
Affinity DataEC50:  430nMAssay Description:Inhibition of LSD1 in human MV4-11 cells assessed as induction of LY96 mRNA expression incubated for 16 hrs by chemiluminescent methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetBromodomain-containing protein 4(Human)
Constellation Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50613462(CHEMBL5280537)
Affinity DataEC50:  170nMAssay Description:Inhibition of BRD4 BD1 in human MV4-11 cells assessed as reduction of MYC RNA expression after 4 hrs by PCR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetLysine-specific demethylase 5A(Human)
Constellation Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM195608(CPI-455 | US20240139197, Compound 3)
Affinity DataEC50:  5.20E+3nMAssay Description:Inhibition of KDM5A in human PC9 cells assessed as increase in H3K4me3 levels preincubated for 4 days measured up to 24 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetBromodomain-containing protein 4(Human)
Constellation Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50613465(CHEMBL5271336)
Affinity DataEC50:  33nMAssay Description:Inhibition of BRD4 BD1 in human MV4-11 cells assessed as reduction of MYC RNA expression after 4 hrs by PCR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetBromodomain-containing protein 4(Human)
Constellation Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50503406(CHEMBL4463538)
Affinity DataKd:  8.90E+3nMAssay Description:Binding affinity to recombinant human full length DNA-tagged BRD4 short isoform expressed in bacterial expression system by bromoscan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetHistone-lysine N-methyltransferase EZH2(Human)
Constellation Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50563820(CHEMBL4779123)
Affinity DataEC50:  110nMAssay Description:Inhibition of EZH2 in human HeLa cells assessed as inhibition of trimethylation of H3K27 after 72 hrs by AlphaLISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
Displayed 1 to 50 (of 1414 total ) | Next | Last >>
Jump to: