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LigandPNGBDBM342149(US9771359, EX-56 | 1-((2-(tert-butyl)-4-(3-chlorop...)
Affinity DataKi:  0.100nMAssay Description:The FLIPR protocol consists of 2 substance additions during a kinetic measurement. First the compounds to be tested (5 μM) are pipetted onto the...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2019
Entry Details
US Patent

LigandPNGBDBM50025367(4a,6a-Dimethyl-2-oxo-hexadecahydro-indeno[5,4-f]qu...)
Affinity DataIC50: 0.130nMAssay Description:In vitro inhibitory activity against rat prostatic steroid 5-alpha-reductaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/14/2012
Entry Details Article
PubMed
LigandPNGBDBM50225985(CHEMBL3349105)
Affinity DataIC50: 0.210nMAssay Description:In vitro inhibitory activity against rat prostatic steroid 5-alpha-reductaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/14/2012
Entry Details Article
PubMed
LigandPNGBDBM342128(US9771359, EX-20 | N-((4-(3-chlorophenyl)-2-(trifl...)
Affinity DataKi:  0.300nMAssay Description:The FLIPR protocol consists of 2 substance additions during a kinetic measurement. First the compounds to be tested (5 μM) are pipetted onto the...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2019
Entry Details
US Patent

LigandPNGBDBM342122(US9771359, EX-14 | US9771359, EX-15 | US9771359, E...)
Affinity DataKi:  0.400nMAssay Description:The FLIPR protocol consists of 2 substance additions during a kinetic measurement. First the compounds to be tested (5 μM) are pipetted onto the...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2019
Entry Details
US Patent

LigandPNGBDBM50025454(1,4,4a,6a-Tetramethyl-2-oxo-hexadecahydro-indeno[5...)
Affinity DataIC50: 0.560nMAssay Description:In vitro inhibitory activity against rat prostatic steroid 5-alpha-reductaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/14/2012
Entry Details Article
PubMed
LigandPNGBDBM342117(US9771359, EX-03 | N-((2-(tert-butyl)-4-(3-chlorop...)
Affinity DataKi:  0.600nMAssay Description:The FLIPR protocol consists of 2 substance additions during a kinetic measurement. First the compounds to be tested (5 μM) are pipetted onto the...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2019
Entry Details
US Patent

LigandPNGBDBM342122(US9771359, EX-14 | US9771359, EX-15 | US9771359, E...)
Affinity DataKi:  0.700nMAssay Description:The FLIPR protocol consists of 2 substance additions during a kinetic measurement. First the compounds to be tested (5 μM) are pipetted onto the...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2019
Entry Details
US Patent

LigandPNGBDBM342121(US9771359, EX-13 | US9771359, EX-18 | N-((4-(3-chl...)
Affinity DataKi:  0.700nMAssay Description:The FLIPR protocol consists of 2 substance additions during a kinetic measurement. First the compounds to be tested (5 μM) are pipetted onto the...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2019
Entry Details
US Patent

LigandPNGBDBM342119(US9771359, EX-06 | N-((4-(3-chlorophenyl)-2-(trifl...)
Affinity DataKi:  0.700nMAssay Description:The FLIPR protocol consists of 2 substance additions during a kinetic measurement. First the compounds to be tested (5 μM) are pipetted onto the...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2019
Entry Details
US Patent

LigandPNGBDBM342120(US9771359, EX-12 | N-((4-(3-chlorophenyl)-2-(trifl...)
Affinity DataKi:  1.10nMAssay Description:The FLIPR protocol consists of 2 substance additions during a kinetic measurement. First the compounds to be tested (5 μM) are pipetted onto the...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2019
Entry Details
US Patent

LigandPNGBDBM50025341(4a,6a-Dimethyl-7-(3-methyl-butyryl)-hexadecahydro-...)
Affinity DataIC50: 1.20nMAssay Description:In vitro inhibitory activity against rat prostatic steroid 5-alpha-reductaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/14/2012
Entry Details Article
PubMed
LigandPNGBDBM342115(US9771359, EX-01 | N-((4-(3-chlorophenyl)-2-(trifl...)
Affinity DataKi:  1.40nMAssay Description:The FLIPR protocol consists of 2 substance additions during a kinetic measurement. First the compounds to be tested (5 μM) are pipetted onto the...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2019
Entry Details
US Patent

TargetAndrogen receptor(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM50025425(17-Hydroxy-10,13-dimethyl-4,5,6,7,8,9,10,11,12,13,...)
Affinity DataIC50: 1.5nMAssay Description:In vitro antagonist activity against rat prostatic androgen receptor (AR)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/14/2012
Entry Details Article
PubMed
LigandPNGBDBM50025450(Sodium; 1,4a,6a-trimethyl-2-oxo-hexadecahydro-inde...)
Affinity DataKi:  1.70nMAssay Description:Apparent inhibitory constant value for rat prostatic steroid 5-alpha reductase was determinedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/14/2012
Entry Details Article
PubMed
LigandPNGBDBM50025450(Sodium; 1,4a,6a-trimethyl-2-oxo-hexadecahydro-inde...)
Affinity DataIC50: 1.70nMAssay Description:In vitro inhibitory activity against rat prostatic steroid 5-alpha-reductaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/14/2012
Entry Details Article
PubMed
LigandPNGBDBM50025332(1,4a,6a-Trimethyl-7-(2-methyl-butyryl)-hexadecahyd...)
Affinity DataIC50: 1.90nMAssay Description:In vitro inhibitory activity against rat prostatic steroid 5-alpha-reductaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/14/2012
Entry Details Article
PubMed
TargetAndrogen receptor(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM18161(DHT | Dihydrotestosterone | [3H]DHT | (5alpha,17be...)
Affinity DataIC50: 2.20nMAssay Description:In vitro antagonist activity against rat prostatic androgen receptor (AR)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/14/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM342151(US9771359, EX-58 | N-(4-(3-((2-(tert-butyl)-4-(m-t...)
Affinity DataKi:  2.30nMAssay Description:The FLIPR protocol consists of 2 substance additions during a kinetic measurement. First the compounds to be tested (5 μM) are pipetted onto the...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2019
Entry Details
US Patent

LigandPNGBDBM342130(US9771359, EX-24 | N-((4-(3-chlorophenyl)-2-(trifl...)
Affinity DataKi:  2.35nMAssay Description:The FLIPR protocol consists of 2 substance additions during a kinetic measurement. First the compounds to be tested (5 μM) are pipetted onto the...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2019
Entry Details
US Patent

TargetAndrogen receptor(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM50025417(7-Hydroxy-1,4a,6a-trimethyl-1,4a,4b,5,6,6a,7,8,9,9...)
Affinity DataIC50: 2.40nMAssay Description:In vitro antagonist activity against rat prostatic androgen receptor (AR)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/14/2012
Entry Details Article
PubMed
LigandPNGBDBM50025415(N,N-Diethyl-2-(1,4a,6a-trimethyl-2-oxo-hexadecahyd...)
Affinity DataIC50: 2.5nMAssay Description:In vitro inhibitory activity against rat prostatic steroid 5-alpha-reductaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/14/2012
Entry Details Article
PubMed
LigandPNGBDBM50025353(7-(1-Hydroxy-ethyl)-1,4a,6a-trimethyl-hexadecahydr...)
Affinity DataIC50: 2.80nMAssay Description:In vitro inhibitory activity against rat prostatic steroid 5-alpha-reductaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/14/2012
Entry Details Article
PubMed
TargetAndrogen receptor(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM8885(Testosterone, 1 | (1S,2R,10R,11S,14S,15S)-14-hydro...)
Affinity DataIC50: 3.20nMAssay Description:In vitro antagonist activity against rat prostatic androgen receptor (AR)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/14/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50025413(4-(1,4a,6a-Trimethyl-2-oxo-hexadecahydro-indeno[5,...)
Affinity DataIC50: 3.40nMAssay Description:In vitro inhibitory activity against rat prostatic steroid 5-alpha-reductaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/14/2012
Entry Details Article
PubMed
LigandPNGBDBM50025375(7-Acetyl-1,4a,6a,8-tetramethyl-hexadecahydro-inden...)
Affinity DataIC50: 3.40nMAssay Description:In vitro inhibitory activity against rat prostatic steroid 5-alpha-reductaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/14/2012
Entry Details Article
PubMed
LigandPNGBDBM50405303(CHEMBL2021336)
Affinity DataIC50: 3.5nMAssay Description:In vitro inhibitory activity against rat prostatic steroid 5-alpha-reductaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/14/2012
Entry Details Article
PubMed
LigandPNGBDBM50025399(Sodium; 4-(1,4a,6a-trimethyl-2-oxo-hexadecahydro-i...)
Affinity DataIC50: 3.60nMAssay Description:In vitro inhibitory activity against rat prostatic steroid 5-alpha-reductaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/14/2012
Entry Details Article
PubMed
LigandPNGBDBM50025337(7-(2-Hydroxy-1-methyl-ethyl)-1,4a,6a-trimethyl-hex...)
Affinity DataIC50: 3.80nMAssay Description:In vitro inhibitory activity against rat prostatic steroid 5-alpha-reductaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/14/2012
Entry Details Article
PubMed
LigandPNGBDBM50025379(1,4a,6a-Trimethyl-2-oxo-hexadecahydro-indeno[5,4-f...)
Affinity DataIC50: 4.60nMAssay Description:In vitro inhibitory activity against rat prostatic steroid 5-alpha-reductaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/14/2012
Entry Details Article
PubMed
LigandPNGBDBM50025330(1',4a',6a'-trimethylspiro[tetrahydrofuran-2,7'-per...)
Affinity DataIC50: 4.60nMAssay Description:In vitro inhibitory activity against rat prostatic steroid 5-alpha-reductaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/14/2012
Entry Details Article
PubMed
LigandPNGBDBM342129(US9771359, EX-23 | N-((4-(3-chlorophenyl)-2-(trifl...)
Affinity DataKi:  4.70nMAssay Description:The FLIPR protocol consists of 2 substance additions during a kinetic measurement. First the compounds to be tested (5 μM) are pipetted onto the...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2019
Entry Details
US Patent

LigandPNGBDBM50213061(CHEMBL2298601)
Affinity DataKi:  5nMAssay Description:Apparent inhibitory constant value for rat prostatic steroid 5alpha reductase was determinedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/14/2012
Entry Details Article
PubMed
LigandPNGBDBM342121(US9771359, EX-13 | US9771359, EX-18 | N-((4-(3-chl...)
Affinity DataKi:  5.20nMAssay Description:The FLIPR protocol consists of 2 substance additions during a kinetic measurement. First the compounds to be tested (5 μM) are pipetted onto the...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2019
Entry Details
US Patent

LigandPNGBDBM342147(US9771359, EX-54 | 1-((2-(tert-butyl)-4-(3-chlorop...)
Affinity DataKi:  5.90nMAssay Description:The FLIPR protocol consists of 2 substance additions during a kinetic measurement. First the compounds to be tested (5 μM) are pipetted onto the...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2019
Entry Details
US Patent

LigandPNGBDBM50367296(CHEMBL1790284)
Affinity DataKi:  6nMAssay Description:Apparent inhibitory constant value for rat prostatic steroid 5-alpha reductase was determinedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/14/2012
Entry Details Article
PubMed
LigandPNGBDBM50025455(4a,6a-Dimethyl-2-oxo-hexadecahydro-indeno[5,4-f]qu...)
Affinity DataIC50: 6.30nMAssay Description:In vitro inhibitory activity against rat prostatic steroid 5-alpha-reductaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/14/2012
Entry Details Article
PubMed
LigandPNGBDBM342150(US9771359, EX-57 | N-(4-(3-((2-(tert-butyl)-4-(3-c...)
Affinity DataKi:  6.60nMAssay Description:The FLIPR protocol consists of 2 substance additions during a kinetic measurement. First the compounds to be tested (5 μM) are pipetted onto the...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2019
Entry Details
US Patent

LigandPNGBDBM50025395((1,4a,6a-Trimethyl-2-oxo-hexadecahydro-indeno[5,4-...)
Affinity DataIC50: 6.80nMAssay Description:In vitro inhibitory activity against rat prostatic steroid 5-alpha-reductaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/14/2012
Entry Details Article
PubMed
LigandPNGBDBM50334788((17beta-(N-tert-butylcarbamoyl)-4-aza-5alpha-andro...)
Affinity DataIC50: 6.80nMAssay Description:In vitro inhibitory activity against rat prostatic steroid 5-alpha-reductaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/14/2012
Entry Details Article
PubMed
TargetAndrogen receptor(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM50025443(7-Hydroxy-1,4a,6a-trimethyl-1,3,4,4a,4b,5,6,6a,7,8...)
Affinity DataIC50: 7.40nMAssay Description:In vitro antagonist activity against rat prostatic androgen receptor (AR)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/14/2012
Entry Details Article
PubMed
LigandPNGBDBM342118(US9771359, EX-05 | N-((4-(3-chlorophenyl)-2-(trifl...)
Affinity DataKi:  7.5nMAssay Description:The FLIPR protocol consists of 2 substance additions during a kinetic measurement. First the compounds to be tested (5 μM) are pipetted onto the...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2019
Entry Details
US Patent

LigandPNGBDBM50367296(CHEMBL1790284)
Affinity DataIC50: 7.60nMAssay Description:In vitro inhibitory activity against rat prostatic steroid 5-alpha-reductaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/14/2012
Entry Details Article
PubMed
LigandPNGBDBM50025364(2-(1,4a,6a-Trimethyl-2-oxo-hexadecahydro-indeno[5,...)
Affinity DataIC50: 7.60nMAssay Description:In vitro inhibitory activity against rat prostatic steroid 5-alpha-reductaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/14/2012
Entry Details Article
PubMed
LigandPNGBDBM50025359(1,4a,6a-Trimethyl-2-oxo-hexadecahydro-indeno[5,4-f...)
Affinity DataIC50: 7.60nMAssay Description:In vitro inhibitory activity against rat prostatic steroid 5-alpha-reductaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/14/2012
Entry Details Article
PubMed
LigandPNGBDBM50025447(N,N-Diethyl-2-(1,4a,6a-trimethyl-2-oxo-hexadecahyd...)
Affinity DataIC50: 7.90nMAssay Description:In vitro inhibitory activity against rat prostatic steroid 5-alpha-reductaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/14/2012
Entry Details Article
PubMed
LigandPNGBDBM342144(US9771359, EX-45 | N-((5-(3-chlorophenyl)-2-(tertb...)
Affinity DataKi:  9.10nMAssay Description:The FLIPR protocol consists of 2 substance additions during a kinetic measurement. First the compounds to be tested (5 μM) are pipetted onto the...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2019
Entry Details
US Patent

LigandPNGBDBM50213061(CHEMBL2298601)
Affinity DataIC50: 11nMAssay Description:In vitro inhibitory activity against rat prostatic steroid 5-alpha-reductaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/14/2012
Entry Details Article
PubMed
LigandPNGBDBM50226049(CHEMBL3349139)
Affinity DataIC50: 11nMAssay Description:In vitro inhibitory activity against rat prostatic steroid 5-alpha-reductaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/14/2012
Entry Details Article
PubMed
TargetAndrogen receptor(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM50025385(Acetic acid 17-acetyl-10,13-dimethyl-6-methylene-3...)
Affinity DataIC50: 12nMAssay Description:In vitro antagonist activity against rat prostatic androgen receptor (AR)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/14/2012
Entry Details Article
PubMed
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