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TargetNeuronal acetylcholine receptor subunit alpha-7(Human)
Temple University

Curated by ChEMBL
LigandPNGBDBM50465065(CHEMBL4284137)
Affinity DataEC50:  83nMAssay Description:Positive allosteric modulation of human alpha 7 nAChR expressed in HEK cells co-expressing human RIC3 assessed as increase in acetylcholine-induced c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Human)
Temple University

Curated by ChEMBL
LigandPNGBDBM50465066(CHEMBL4289508)
Affinity DataEC50:  88nMAssay Description:Positive allosteric modulation of human alpha 7 nAChR expressed in HEK cells co-expressing human RIC3 assessed as increase in acetylcholine-induced c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Human)
Temple University

Curated by ChEMBL
LigandPNGBDBM50465067(CHEMBL4293983)
Affinity DataEC50:  93nMAssay Description:Positive allosteric modulation of human alpha 7 nAChR expressed in HEK cells co-expressing human RIC3 assessed as increase in acetylcholine-induced c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Human)
Temple University

Curated by ChEMBL
LigandPNGBDBM50465068(CHEMBL4287163)
Affinity DataEC50:  83nMAssay Description:Positive allosteric modulation of human alpha 7 nAChR expressed in HEK cells co-expressing human RIC3 assessed as increase in acetylcholine-induced c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Human)
Temple University

Curated by ChEMBL
LigandPNGBDBM50465069(CHEMBL4279241)
Affinity DataEC50:  93nMAssay Description:Positive allosteric modulation of human alpha 7 nAChR expressed in HEK cells co-expressing human RIC3 assessed as increase in acetylcholine-induced c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Human)
Temple University

Curated by ChEMBL
LigandPNGBDBM50465070(CHEMBL4283808)
Affinity DataEC50:  98nMAssay Description:Positive allosteric modulation of human alpha 7 nAChR expressed in HEK cells co-expressing human RIC3 assessed as increase in acetylcholine-induced c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Human)
Temple University

Curated by ChEMBL
LigandPNGBDBM50465071(CHEMBL4290583)
Affinity DataEC50:  69nMAssay Description:Positive allosteric modulation of human alpha 7 nAChR expressed in HEK cells co-expressing human RIC3 assessed as increase in acetylcholine-induced c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Human)
Temple University

Curated by ChEMBL
LigandPNGBDBM50465072(CHEMBL4286080)
Affinity DataEC50:  110nMAssay Description:Positive allosteric modulation of human alpha 7 nAChR expressed in HEK cells co-expressing human RIC3 assessed as increase in acetylcholine-induced c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Human)
Temple University

Curated by ChEMBL
LigandPNGBDBM50465073(CHEMBL4282703)
Affinity DataEC50:  98nMAssay Description:Positive allosteric modulation of human alpha 7 nAChR expressed in HEK cells co-expressing human RIC3 assessed as increase in acetylcholine-induced c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Human)
Temple University

Curated by ChEMBL
LigandPNGBDBM50465074(CHEMBL4294379)
Affinity DataEC50:  71nMAssay Description:Positive allosteric modulation of human alpha 7 nAChR expressed in HEK cells co-expressing human RIC3 assessed as increase in acetylcholine-induced c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetPresenilin-1(Human)
Temple University

Curated by ChEMBL
LigandPNGBDBM50465075(CHEMBL4289425)
Affinity DataEC50:  111nMAssay Description:Inhibition of gamma-secretase (unknown origin) assessed as reduction in amyloid beta (1 to 42) production after 60 mins by cell based AlphaLisa assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetPresenilin-1(Human)
Temple University

Curated by ChEMBL
LigandPNGBDBM50465076(CHEMBL4290617)
Affinity DataEC50:  19nMAssay Description:Inhibition of gamma-secretase (unknown origin) assessed as reduction in amyloid beta (1 to 42) production after 60 mins by cell based AlphaLisa assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetPresenilin-1(Human)
Temple University

Curated by ChEMBL
LigandPNGBDBM50465077(CHEMBL4282341)
Affinity DataEC50:  14nMAssay Description:Inhibition of gamma-secretase (unknown origin) assessed as reduction in amyloid beta (1 to 42) production after 60 mins by cell based AlphaLisa assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetPresenilin-1(Human)
Temple University

Curated by ChEMBL
LigandPNGBDBM50465078(CHEMBL4293906)
Affinity DataEC50:  35nMAssay Description:Inhibition of gamma-secretase (unknown origin) assessed as reduction in amyloid beta (1 to 42) production after 60 mins by cell based AlphaLisa assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetPresenilin-1(Human)
Temple University

Curated by ChEMBL
LigandPNGBDBM50465079(CHEMBL4290214)
Affinity DataEC50:  34nMAssay Description:Inhibition of gamma-secretase (unknown origin) assessed as reduction in amyloid beta (1 to 42) production after 60 mins by cell based AlphaLisa assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetPresenilin-1(Human)
Temple University

Curated by ChEMBL
LigandPNGBDBM50465080(CHEMBL4278756)
Affinity DataEC50:  36nMAssay Description:Inhibition of gamma-secretase (unknown origin) assessed as reduction in amyloid beta (1 to 42) production after 60 mins by cell based AlphaLisa assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetPresenilin-1(Human)
Temple University

Curated by ChEMBL
LigandPNGBDBM50465354(CHEMBL4293045 | US10669276, Example 4)
Affinity DataEC50:  7nMAssay Description:Inhibition of gamma-secretase in human H4 cells harboring APP695 K595N/M596L swedish mutant after 24 hrs by AlphaLisa assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetPresenilin-1(Human)
Temple University

Curated by ChEMBL
LigandPNGBDBM50465355(CHEMBL4285214 | US10669276, Example 1)
Affinity DataEC50:  5nMAssay Description:Inhibition of gamma-secretase in human H4 cells harboring APP695 K595N/M596L swedish mutant after 24 hrs by AlphaLisa assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetPresenilin-1(Human)
Temple University

Curated by ChEMBL
LigandPNGBDBM50465356(CHEMBL4289270 | US10669276, Example 16)
Affinity DataEC50:  30nMAssay Description:Inhibition of gamma-secretase in human H4 cells harboring APP695 K595N/M596L swedish mutant after 24 hrs by AlphaLisa assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetPresenilin-1(Human)
Temple University

Curated by ChEMBL
LigandPNGBDBM50465357(CHEMBL4283902 | US10669276, Example 25)
Affinity DataEC50:  8nMAssay Description:Inhibition of gamma-secretase in human H4 cells harboring APP695 K595N/M596L swedish mutant after 24 hrs by AlphaLisa assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetPresenilin-1(Human)
Temple University

Curated by ChEMBL
LigandPNGBDBM50465358(CHEMBL4284649 | US10669276, Example 31)
Affinity DataEC50:  15nMAssay Description:Inhibition of gamma-secretase in human H4 cells harboring APP695 K595N/M596L swedish mutant after 24 hrs by AlphaLisa assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetPresenilin-1(Human)
Temple University

Curated by ChEMBL
LigandPNGBDBM50465359(CHEMBL4279052 | US10669276, Example 11)
Affinity DataEC50:  33nMAssay Description:Inhibition of gamma-secretase in human H4 cells harboring APP695 K595N/M596L swedish mutant after 24 hrs by AlphaLisa assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetPresenilin-1(Human)
Temple University

Curated by ChEMBL
LigandPNGBDBM50465360(CHEMBL4294948 | US10669276, Example 28)
Affinity DataEC50:  8nMAssay Description:Inhibition of gamma-secretase in human H4 cells harboring APP695 K595N/M596L swedish mutant after 24 hrs by AlphaLisa assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetPresenilin-1(Human)
Temple University

Curated by ChEMBL
LigandPNGBDBM50465361(CHEMBL4293005)
Affinity DataEC50:  14nMAssay Description:Inhibition of gamma-secretase in human H4 cells harboring APP695 K595N/M596L swedish mutant after 24 hrs by AlphaLisa assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetPresenilin-1(Human)
Temple University

Curated by ChEMBL
LigandPNGBDBM50465362(CHEMBL4286544)
Affinity DataEC50:  8nMAssay Description:Inhibition of gamma-secretase in human H4 cells harboring APP695 K595N/M596L swedish mutant after 24 hrs by AlphaLisa assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetPresenilin-1(Human)
Temple University

Curated by ChEMBL
LigandPNGBDBM50465363(CHEMBL4278310 | US10669276, Example 35)
Affinity DataEC50:  13nMAssay Description:Inhibition of gamma-secretase in human H4 cells harboring APP695 K595N/M596L swedish mutant after 24 hrs by AlphaLisa assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetKelch-like ECH-associated protein 1(Human)
Temple University

Curated by ChEMBL
LigandPNGBDBM50502723(CHEMBL4462699 | US11479539, Compound 196)
Affinity DataEC50:  18nMAssay Description:Inhibition of KEAP1 interaction with Nrf2 in human HEK293 cells transfected with ARE-LUC assessed as activation of Nrf2 signaling pathway measured af...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetKelch-like ECH-associated protein 1(Human)
Temple University

Curated by ChEMBL
LigandPNGBDBM50502724(CHEMBL4463989 | US11479539, Compound 122)
Affinity DataEC50:  24nMAssay Description:Inhibition of KEAP1 interaction with Nrf2 in human HEK293 cells transfected with ARE-LUC assessed as activation of Nrf2 signaling pathway measured af...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetKelch-like ECH-associated protein 1(Human)
Temple University

Curated by ChEMBL
LigandPNGBDBM50502725(CHEMBL4565642 | US11479539, Compound 168)
Affinity DataEC50:  7nMAssay Description:Inhibition of KEAP1 interaction with Nrf2 in human HEK293 cells transfected with ARE-LUC assessed as activation of Nrf2 signaling pathway measured af...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetKelch-like ECH-associated protein 1(Human)
Temple University

Curated by ChEMBL
LigandPNGBDBM50502726(CHEMBL4583328 | US11479539, Compound 55)
Affinity DataEC50:  14nMAssay Description:Inhibition of KEAP1 interaction with Nrf2 in human HEK293 cells transfected with ARE-LUC assessed as activation of Nrf2 signaling pathway measured af...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetKelch-like ECH-associated protein 1(Human)
Temple University

Curated by ChEMBL
LigandPNGBDBM50502727(CHEMBL4584154 | US11479539, Compound 48)
Affinity DataEC50:  6nMAssay Description:Inhibition of KEAP1 interaction with Nrf2 in human HEK293 cells transfected with ARE-LUC assessed as activation of Nrf2 signaling pathway measured af...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetKelch-like ECH-associated protein 1(Human)
Temple University

Curated by ChEMBL
LigandPNGBDBM50502728(CHEMBL4542755 | US11479539, Compound 174)
Affinity DataEC50:  8nMAssay Description:Inhibition of KEAP1 interaction with Nrf2 in human HEK293 cells transfected with ARE-LUC assessed as activation of Nrf2 signaling pathway measured af...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetKelch-like ECH-associated protein 1(Human)
Temple University

Curated by ChEMBL
LigandPNGBDBM50502729(CHEMBL4593124 | US11479539, Compound 23)
Affinity DataEC50:  56nMAssay Description:Inhibition of KEAP1 interaction with Nrf2 in human HEK293 cells transfected with ARE-LUC assessed as activation of Nrf2 signaling pathway measured af...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetKelch-like ECH-associated protein 1(Human)
Temple University

Curated by ChEMBL
LigandPNGBDBM50502730(CHEMBL4535670)
Affinity DataEC50:  45nMAssay Description:Inhibition of KEAP1 interaction with Nrf2 in human HEK293 cells transfected with ARE-LUC assessed as activation of Nrf2 signaling pathway measured af...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetKelch-like ECH-associated protein 1(Human)
Temple University

Curated by ChEMBL
LigandPNGBDBM50502731(CHEMBL4530659)
Affinity DataEC50:  70nMAssay Description:Inhibition of KEAP1 interaction with Nrf2 in human HEK293 cells transfected with ARE-LUC assessed as activation of Nrf2 signaling pathway measured af...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetKelch-like ECH-associated protein 1(Human)
Temple University

Curated by ChEMBL
LigandPNGBDBM50502732(CHEMBL4557371 | US11479539, Compound 69)
Affinity DataEC50:  2nMAssay Description:Inhibition of KEAP1 interaction with Nrf2 in human HEK293 cells transfected with ARE-LUC assessed as activation of Nrf2 signaling pathway measured af...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetKelch-like ECH-associated protein 1(Human)
Temple University

Curated by ChEMBL
LigandPNGBDBM50502733(CHEMBL4446699 | US11479539, Compound 80)
Affinity DataEC50:  2nMAssay Description:Inhibition of KEAP1 interaction with Nrf2 in human HEK293 cells transfected with ARE-LUC assessed as activation of Nrf2 signaling pathway measured af...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetKelch-like ECH-associated protein 1(Human)
Temple University

Curated by ChEMBL
LigandPNGBDBM50502734(CHEMBL4442320 | US11479539, Compound 42)
Affinity DataEC50:  33nMAssay Description:Inhibition of KEAP1 interaction with Nrf2 in human HEK293 cells transfected with ARE-LUC assessed as activation of Nrf2 signaling pathway measured af...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetPresenilin-1(Human)
Temple University

Curated by ChEMBL
LigandPNGBDBM50521238(CHEMBL4589937)
Affinity DataEC50:  0.00640nMAssay Description:Inhibition of gamma-secretase (unknown origin) assessed as decrease in amyloid beta-42 secretion by cell based AlphaLisa assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetPresenilin-1(Human)
Temple University

Curated by ChEMBL
LigandPNGBDBM50521239(CHEMBL4443026)
Affinity DataEC50:  0.0114nMAssay Description:Inhibition of gamma-secretase (unknown origin) assessed as decrease in amyloid beta-42 secretion by cell based AlphaLisa assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetPresenilin-1(Human)
Temple University

Curated by ChEMBL
LigandPNGBDBM50521240(CHEMBL4535601)
Affinity DataEC50:  0.0139nMAssay Description:Inhibition of gamma-secretase (unknown origin) assessed as decrease in amyloid beta-42 secretion by cell based AlphaLisa assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetPresenilin-1(Human)
Temple University

Curated by ChEMBL
LigandPNGBDBM50521241(CHEMBL4456936)
Affinity DataEC50:  0.00920nMAssay Description:Inhibition of gamma-secretase (unknown origin) assessed as decrease in amyloid beta-42 secretion by cell based AlphaLisa assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetPresenilin-1(Human)
Temple University

Curated by ChEMBL
LigandPNGBDBM50521242(CHEMBL4456488)
Affinity DataEC50:  0.0103nMAssay Description:Inhibition of gamma-secretase (unknown origin) assessed as decrease in amyloid beta-42 secretion by cell based AlphaLisa assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetPresenilin-1(Human)
Temple University

Curated by ChEMBL
LigandPNGBDBM50521243(CHEMBL4532868)
Affinity DataEC50:  0.00590nMAssay Description:Inhibition of gamma-secretase (unknown origin) assessed as decrease in amyloid beta-42 secretion by cell based AlphaLisa assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetPresenilin-1(Human)
Temple University

Curated by ChEMBL
LigandPNGBDBM50521244(CHEMBL4525398)
Affinity DataEC50:  0.0117nMAssay Description:Inhibition of gamma-secretase (unknown origin) assessed as decrease in amyloid beta-42 secretion by cell based AlphaLisa assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetPresenilin-1(Human)
Temple University

Curated by ChEMBL
LigandPNGBDBM50521245(CHEMBL4547187)
Affinity DataEC50:  0.0130nMAssay Description:Inhibition of gamma-secretase (unknown origin) assessed as decrease in amyloid beta-42 secretion by cell based AlphaLisa assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetMuscarinic acetylcholine receptor M1(Human)
Temple University

Curated by ChEMBL
LigandPNGBDBM50557697(CHEMBL4756433)
Affinity DataEC50:  80nMAssay Description:Positive allosteric modulation of recombinant human muscarinic M1 receptor co-expressing pCRE-Luc reporter gene in CHO cells assessed as stimulation ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetMuscarinic acetylcholine receptor M1(Human)
Temple University

Curated by ChEMBL
LigandPNGBDBM50557698(CHEMBL4756974)
Affinity DataEC50:  181nMAssay Description:Positive allosteric modulation of recombinant human muscarinic M1 receptor co-expressing pCRE-Luc reporter gene in CHO cells assessed as stimulation ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetMuscarinic acetylcholine receptor M1(Human)
Temple University

Curated by ChEMBL
LigandPNGBDBM50557699(CHEMBL4783540)
Affinity DataEC50:  182nMAssay Description:Positive allosteric modulation of recombinant human muscarinic M1 receptor co-expressing pCRE-Luc reporter gene in CHO cells assessed as stimulation ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetMuscarinic acetylcholine receptor M1(Human)
Temple University

Curated by ChEMBL
LigandPNGBDBM50557700(CHEMBL4790436)
Affinity DataEC50:  75nMAssay Description:Positive allosteric modulation of recombinant human muscarinic M1 receptor co-expressing pCRE-Luc reporter gene in CHO cells assessed as stimulation ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
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