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TargetLegumain(Mouse)
Stanford University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50364367(CHEMBL1950283)
Affinity DataIC50: 4.40nMAssay Description:Inhibition of mouse recombinant legumain using Cbz-Ala-Ala-Asn-AMC as substrate measured every 30 secs for 2.5 hrs by fluorimetryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/23/2012
Entry Details Article
PubMed
TargetLegumain(Mouse)
Stanford University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50364353(CHEMBL1950109)
Affinity DataIC50: 6.5nMAssay Description:Inhibition of mouse recombinant legumain using Cbz-Ala-Ala-Asn-AMC as substrate measured every 30 secs for 2.5 hrs by fluorimetryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/23/2012
Entry Details Article
PubMed
TargetCathepsin B(Rat)
Stanford University

LigandPNGBDBM36331(Ac-YFR-AMOK 10b)
Affinity DataIC50: 7.30nMpH: 5.5 T: 2°CAssay Description:Protease enzyme inhibition assay targeting diverse member of the cysteine protease families:cathepsin B, Z, and HMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/4/2011
Entry Details Article
PubMed
TargetLegumain(Mouse)
Stanford University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50364366(CHEMBL1950282)
Affinity DataIC50: 8.10nMAssay Description:Inhibition of mouse recombinant legumain using Cbz-Ala-Ala-Asn-AMC as substrate measured every 30 secs for 2.5 hrs by fluorimetryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/23/2012
Entry Details Article
PubMed
TargetLegumain(Mouse)
Stanford University School of Medicine

Curated by ChEMBL
LigandPNGBDBM228618(BDBM50364365 | US9345789, LI-2)
Affinity DataIC50: 8.30nMAssay Description:Inhibition of mouse recombinant legumain using Cbz-Ala-Ala-Asn-AMC as substrate measured every 30 secs for 2.5 hrs by fluorimetryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/23/2012
Entry Details Article
PubMed
TargetLegumain(Mouse)
Stanford University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50364368(CHEMBL1950284)
Affinity DataIC50: 8.60nMAssay Description:Inhibition of mouse recombinant legumain using Cbz-Ala-Ala-Asn-AMC as substrate measured every 30 secs for 2.5 hrs by fluorimetryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/23/2012
Entry Details Article
PubMed
TargetLegumain(Mouse)
Stanford University School of Medicine

Curated by ChEMBL
LigandPNGBDBM36332(LI-1 | Legumain Inhibitor -1)
Affinity DataIC50: 9.30nMAssay Description:Inhibition of mouse recombinant legumain using Cbz-Ala-Ala-Asn-AMC as substrate measured every 30 secs for 2.5 hrs by fluorimetryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/23/2012
Entry Details Article
PubMed
TargetLegumain(Mouse)
Stanford University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50364356(CHEMBL1950112)
Affinity DataIC50: 9.30nMAssay Description:Inhibition of mouse recombinant legumain using Cbz-Ala-Ala-Asn-AMC as substrate measured every 30 secs for 2.5 hrs by fluorimetryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/23/2012
Entry Details Article
PubMed
TargetLegumain(Human)
The Leland Stanford Junior University

US Patent
LigandPNGBDBM228617(US9345789, LI-0)
Affinity DataIC50: 11.5nMpH: 5.8Assay Description:Assay buffers consist of 20 mM citric acid, 60 mM disodium hydrogen orthophosphate, 1 mM EDTA, 0.1% CHAPS, 4 mM DTT, pH 5.8 for legumain, 50 mM dihyd...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2017
Entry Details
US Patent

TargetLegumain(Mouse)
Stanford University School of Medicine

Curated by ChEMBL
LigandPNGBDBM36332(LI-1 | Legumain Inhibitor -1)
Affinity DataIC50: 11.5nMpH: 5.8 T: 2°CAssay Description:IC50 measurements and enzyme kinetics assays were performed on a Spectramax M5 fluorescent plate reader (Molecular Devices).More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/5/2011
Entry Details Article
PubMed
TargetCathepsin B(Rat)
Stanford University

LigandPNGBDBM36328(Z-FR-AMOK 9b)
Affinity DataIC50: 15nMpH: 5.5 T: 2°CAssay Description:Protease enzyme inhibition assay targeting diverse member of the cysteine protease families:cathepsin B, Z, and HMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/4/2011
Entry Details Article
PubMed
TargetLegumain(Mouse)
Stanford University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50364358(CHEMBL1950273)
Affinity DataIC50: 17nMAssay Description:Inhibition of mouse recombinant legumain using Cbz-Ala-Ala-Asn-AMC as substrate measured every 30 secs for 2.5 hrs by fluorimetryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/23/2012
Entry Details Article
PubMed
TargetDipeptidyl peptidase 1(Mouse)
Stanford School of Medicine

LigandPNGBDBM81407(ML4118S | ML4118R | ML4118)
Affinity DataIC50: 19nMAssay Description:DPAP1 inhibtion was measured using DPAP1-specific fluorogenic assay. IC50 DPAP1 were determined after 30 min incubation of parasite lysates with 5 n...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/6/2011
Entry Details Article
PubMed
TargetCathepsin B(Human)
University of California San Francisco

LigandPNGBDBM36812(CA-074)
Affinity DataIC50: 40nMpH: 5.5 T: 2°CAssay Description:Inhibition assay using pre-treatment of recombinant cathepsin-L-like cysteine protease cruzain lacking the carboxy-terminal domain or cathepsin B fr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2011
Entry Details Article
PubMed
TargetCathepsin B(Human)
University of California San Francisco

LigandPNGBDBM36813(CA-074b)
Affinity DataIC50: 60nMpH: 5.5 T: 2°CAssay Description:Inhibition assay using pre-treatment of recombinant cathepsin-L-like cysteine protease cruzain lacking the carboxy-terminal domain or cathepsin B fr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2011
Entry Details Article
PubMed
TargetCathepsin B(Rat)
Stanford University

LigandPNGBDBM36327(Z-FG-AOMK 9a)
Affinity DataIC50: 120nMpH: 5.5 T: 2°CAssay Description:Protease enzyme inhibition assay targeting diverse member of the cysteine protease families:cathepsin B, Z, and HMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/4/2011
Entry Details Article
PubMed
TargetCaspase-3(Human)
The Leland Stanford Junior University

US Patent
LigandPNGBDBM228619(US9345789, Z-DEVD-FMK)
Affinity DataIC50: 130nMpH: 5.8Assay Description:Assay buffers consist of 20 mM citric acid, 60 mM disodium hydrogen orthophosphate, 1 mM EDTA, 0.1% CHAPS, 4 mM DTT, pH 5.8 for legumain, 50 mM dihyd...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2017
Entry Details
US Patent

TargetCaspase-3(Mouse)
Stanford University

LigandPNGBDBM228619(US9345789, Z-DEVD-FMK)
Affinity DataIC50: 130nMpH: 7.4 T: 2°CAssay Description:IC50 measurements and enzyme kinetics assays were performed on a Spectramax M5 fluorescent plate reader (Molecular Devices).More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/5/2011
Entry Details Article
PubMed
TargetLegumain(Mouse)
Stanford University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50364354(CHEMBL1950110)
Affinity DataIC50: 141nMAssay Description:Inhibition of mouse recombinant legumain using Cbz-Ala-Ala-Asn-AMC as substrate measured every 30 secs for 2.5 hrs by fluorimetryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/23/2012
Entry Details Article
PubMed
TargetLegumain(Human)
The Leland Stanford Junior University

US Patent
LigandPNGBDBM228617(US9345789, LI-0)
Affinity DataIC50: 145nMpH: 5.8Assay Description:Assay buffers consist of 20 mM citric acid, 60 mM disodium hydrogen orthophosphate, 1 mM EDTA, 0.1% CHAPS, 4 mM DTT, pH 5.8 for legumain, 50 mM dihyd...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2017
Entry Details
US Patent

TargetLegumain(Mouse)
Stanford University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50364355(CHEMBL1950111)
Affinity DataIC50: 148nMAssay Description:Inhibition of mouse recombinant legumain using Cbz-Ala-Ala-Asn-AMC as substrate measured every 30 secs for 2.5 hrs by fluorimetryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/23/2012
Entry Details Article
PubMed
TargetLegumain(Mouse)
Stanford University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50364360(CHEMBL1950275)
Affinity DataIC50: 167nMAssay Description:Inhibition of mouse recombinant legumain using Cbz-Ala-Ala-Asn-AMC as substrate measured every 30 secs for 2.5 hrs by fluorimetryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/23/2012
Entry Details Article
PubMed
TargetDipeptidyl peptidase 1(Mouse)
Stanford School of Medicine

LigandPNGBDBM81407(ML4118S | ML4118R | ML4118)
Affinity DataIC50: 186nMAssay Description:DPAP1 inhibtion was measured using DPAP1-specific fluorogenic assay. IC50 DPAP1 were determined after 30 min incubation of parasite lysates with 5 n...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/6/2011
Entry Details Article
PubMed
TargetLegumain(Mouse)
Stanford University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50364357(CHEMBL1950272)
Affinity DataIC50: 198nMAssay Description:Inhibition of mouse recombinant legumain using Cbz-Ala-Ala-Asn-AMC as substrate measured every 30 secs for 2.5 hrs by fluorimetryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/23/2012
Entry Details Article
PubMed
TargetCathepsin B(Rat)
Stanford University

LigandPNGBDBM36330(AC-YFG-AMOK 10a)
Affinity DataIC50: 220nMpH: 5.5 T: 2°CAssay Description:Protease enzyme inhibition assay targeting diverse member of the cysteine protease families:cathepsin B, Z, and HMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/4/2011
Entry Details Article
PubMed
TargetSentrin-specific protease 2(Human)
Stanford University

LigandPNGBDBM81515(VEA-499)
Affinity DataIC50: 250nMpH: 8.0 T: 2°CAssay Description:The fluorogenic substrate library screen was performed with hSENP1 in low salt tris buffer at final concentration of 2uM. Fluorophore release (AFC) ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/27/2011
Entry Details Article
PubMed
TargetLegumain(Mouse)
Stanford University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50364363(CHEMBL1950278)
Affinity DataIC50: 267nMAssay Description:Inhibition of mouse recombinant legumain using Cbz-Ala-Ala-Asn-AMC as substrate measured every 30 secs for 2.5 hrs by fluorimetryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/23/2012
Entry Details Article
PubMed
TargetCathepsin B(Human)
University of California San Francisco

LigandPNGBDBM36814(MB-074)
Affinity DataIC50: 400nMpH: 5.5 T: 2°CAssay Description:Inhibition assay using pre-treatment of recombinant cathepsin-L-like cysteine protease cruzain lacking the carboxy-terminal domain or cathepsin B fr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2011
Entry Details Article
PubMed
TargetDipeptidyl peptidase 1(Mouse)
Stanford School of Medicine

LigandPNGBDBM81404(ML4161)
Affinity DataIC50: 410nMAssay Description:DPAP1 inhibtion was measured using DPAP1-specific fluorogenic assay. IC50 DPAP1 were determined after 30 min incubation of parasite lysates with 5 n...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/6/2011
Entry Details Article
PubMed
TargetDipeptidyl peptidase 1(Mouse)
Stanford School of Medicine

LigandPNGBDBM81405(ML4123)
Affinity DataIC50: 410nMAssay Description:DPAP1 inhibtion was measured using DPAP1-specific fluorogenic assay. IC50 DPAP1 were determined after 30 min incubation of parasite lysates with 5 n...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/6/2011
Entry Details Article
PubMed
TargetDipeptidyl peptidase 1(Mouse)
Stanford School of Medicine

LigandPNGBDBM81414(ML6076)
Affinity DataIC50: 420nMAssay Description:DPAP1 inhibtion was measured using DPAP1-specific fluorogenic assay. IC50 DPAP1 were determined after 30 min incubation of parasite lysates with 5 n...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/6/2011
Entry Details Article
PubMed
TargetDipeptidyl peptidase 1(Mouse)
Stanford School of Medicine

LigandPNGBDBM81403(HN3019)
Affinity DataIC50: 560nMAssay Description:DPAP1 inhibtion was measured using DPAP1-specific fluorogenic assay. IC50 DPAP1 were determined after 30 min incubation of parasite lysates with 5 n...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/6/2011
Entry Details Article
PubMed
TargetLegumain(Mouse)
Stanford University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50364359(CHEMBL1950274)
Affinity DataIC50: 638nMAssay Description:Inhibition of mouse recombinant legumain using Cbz-Ala-Ala-Asn-AMC as substrate measured every 30 secs for 2.5 hrs by fluorimetryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/23/2012
Entry Details Article
PubMed
TargetDipeptidyl peptidase 1(Mouse)
Stanford School of Medicine

LigandPNGBDBM81399(ML4046A)
Affinity DataIC50: 700nMAssay Description:DPAP1 inhibtion was measured using DPAP1-specific fluorogenic assay. IC50 DPAP1 were determined after 30 min incubation of parasite lysates with 5 n...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/6/2011
Entry Details Article
PubMed
TargetDipeptidyl peptidase 1(Mouse)
Stanford School of Medicine

LigandPNGBDBM81397(ML4057)
Affinity DataIC50: 700nMAssay Description:DPAP1 inhibtion was measured using DPAP1-specific fluorogenic assay. IC50 DPAP1 were determined after 30 min incubation of parasite lysates with 5 n...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/6/2011
Entry Details Article
PubMed
TargetDipeptidyl peptidase 1(Mouse)
Stanford School of Medicine

LigandPNGBDBM81406(ML4124)
Affinity DataIC50: 700nMAssay Description:DPAP1 inhibtion was measured using DPAP1-specific fluorogenic assay. IC50 DPAP1 were determined after 30 min incubation of parasite lysates with 5 n...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/6/2011
Entry Details Article
PubMed
TargetLegumain(Human)
The Leland Stanford Junior University

US Patent
LigandPNGBDBM228617(US9345789, LI-0)
Affinity DataIC50: 704nMpH: 5.8Assay Description:Assay buffers consist of 20 mM citric acid, 60 mM disodium hydrogen orthophosphate, 1 mM EDTA, 0.1% CHAPS, 4 mM DTT, pH 5.8 for legumain, 50 mM dihyd...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2017
Entry Details
US Patent

TargetLegumain(Mouse)
Stanford University School of Medicine

Curated by ChEMBL
LigandPNGBDBM36333(LI-0 | Legumain Inhibitor -0)
Affinity DataIC50: 704nMpH: 5.8 T: 2°CAssay Description:IC50 measurements and enzyme kinetics assays were performed on a Spectramax M5 fluorescent plate reader (Molecular Devices).More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/5/2011
Entry Details Article
PubMed
TargetCathepsin B(Human)
University of California San Francisco

LigandPNGBDBM36334(JPM 565 | CID644294 | JPM-OEt | US9345789, JPM-Oet)
Affinity DataIC50: 780nMpH: 5.8Assay Description:Assay buffers consist of 20 mM citric acid, 60 mM disodium hydrogen orthophosphate, 1 mM EDTA, 0.1% CHAPS, 4 mM DTT, pH 5.8 for legumain, 50 mM dihyd...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2017
Entry Details
US Patent

TargetCathepsin B(Mouse)
Stanford University

LigandPNGBDBM36334(JPM 565 | CID644294 | JPM-OEt | US9345789, JPM-Oet)
Affinity DataIC50: 780nMpH: 6.25 T: 2°CAssay Description:IC50 measurements and enzyme kinetics assays were performed on a Spectramax M5 fluorescent plate reader (Molecular Devices).More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/5/2011
Entry Details Article
PubMed
TargetSentrin-specific protease 2(Human)
Stanford University

LigandPNGBDBM81516(VEA-500)
Affinity DataIC50: 860nMpH: 8.0 T: 2°CAssay Description:The fluorogenic substrate library screen was performed with hSENP1 in low salt tris buffer at final concentration of 2uM. Fluorophore release (AFC) ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/27/2011
Entry Details Article
PubMed
TargetCathepsin B(Rat)
Stanford University

LigandPNGBDBM36329(Z-LG-AOMK 9c)
Affinity DataIC50: 920nMpH: 5.5 T: 2°CAssay Description:Protease enzyme inhibition assay targeting diverse member of the cysteine protease families:cathepsin B, Z, and HMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/4/2011
Entry Details Article
PubMed
TargetLegumain(Mouse)
Stanford University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50364364(CHEMBL1950279)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of mouse recombinant legumain using Cbz-Ala-Ala-Asn-AMC as substrate measured every 30 secs for 2.5 hrs by fluorimetryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/23/2012
Entry Details Article
PubMed
TargetLegumain(Mouse)
Stanford University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50364361(CHEMBL1950276)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of mouse recombinant legumain using Cbz-Ala-Ala-Asn-AMC as substrate measured every 30 secs for 2.5 hrs by fluorimetryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/23/2012
Entry Details Article
PubMed
TargetLegumain(Mouse)
Stanford University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50364362(CHEMBL1950277)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of mouse recombinant legumain using Cbz-Ala-Ala-Asn-AMC as substrate measured every 30 secs for 2.5 hrs by fluorimetryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/23/2012
Entry Details Article
PubMed
TargetProthrombin(Human)
Celera Genomics

Curated by ChEMBL
LigandPNGBDBM50410910(CHEMBL377651)
Affinity DataKi:  1.07E+3nMAssay Description:Inhibition of thrombinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2013
Entry Details Article
PubMed
TargetDipeptidyl peptidase 1(Mouse)
Stanford School of Medicine

LigandPNGBDBM81398(ML4066)
Affinity DataIC50: 1.10E+3nMAssay Description:DPAP1 inhibtion was measured using DPAP1-specific fluorogenic assay. IC50 DPAP1 were determined after 30 min incubation of parasite lysates with 5 n...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/6/2011
Entry Details Article
PubMed
TargetCathepsin B(Rat)
Stanford University

LigandPNGBDBM36325(Cathepsin Inhibitor III)
Affinity DataIC50: 1.20E+3nMpH: 5.5 T: 2°CAssay Description:Protease enzyme inhibition assay targeting diverse member of the cysteine protease families:cathepsin B, Z, and HMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/4/2011
Entry Details Article
PubMed
TargetCathepsin Z(Rat)
Stanford University

LigandPNGBDBM36325(Cathepsin Inhibitor III)
Affinity DataIC50: 1.50E+3nMpH: 5.5 T: 2°CAssay Description:Protease enzyme inhibition assay targeting diverse member of the cysteine protease families:cathepsin B, Z, and HMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/4/2011
Entry Details Article
PubMed
TargetTryptase beta-2(Human)
Celera Genomics

Curated by ChEMBL
LigandPNGBDBM50410912(CHEMBL379174)
Affinity DataKi:  2.50E+3nMAssay Description:Inhibition of beta tryptaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2013
Entry Details Article
PubMed
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