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TargetD(1A) dopamine receptor(Human)
Amri

Curated by ChEMBL
LigandPNGBDBM50509149(CHEMBL3421836)
Affinity DataEC50:  76nMAssay Description:Positive allosteric modulator activity at human D1 receptor stably expressed in HEK293 cells assessed as potentiation of EC20 dopamine-induced cAMP a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetD(1B) dopamine receptor(Human)
Amri

Curated by ChEMBL
LigandPNGBDBM50509150(LY-3154207 | Ly3154207 | Mevidalen)
Affinity DataEC50: >1.00E+4nMAssay Description:Positive allosteric modulator activity at human D5 receptor transiently expressed in HEK293 cells assessed as potentiation of EC20 dopamine-induced c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetD(1A) dopamine receptor(Human)
Amri

Curated by ChEMBL
LigandPNGBDBM50509150(LY-3154207 | Ly3154207 | Mevidalen)
Affinity DataEC50:  3nMAssay Description:Positive allosteric modulator activity at human D1 receptor stably expressed in HEK293 cells assessed as potentiation of EC20 dopamine-induced cAMP a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetD(1A) dopamine receptor(Human)
Amri

Curated by ChEMBL
LigandPNGBDBM50509151(CHEMBL3421730)
Affinity DataEC50:  14nMAssay Description:Positive allosteric modulator activity at human D1 receptor stably expressed in HEK293 cells assessed as potentiation of EC20 dopamine-induced cAMP a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetD(1A) dopamine receptor(Human)
Amri

Curated by ChEMBL
LigandPNGBDBM50509150(LY-3154207 | Ly3154207 | Mevidalen)
Affinity DataEC50:  13nMAssay Description:Agonist activity at human D1 receptor stably expressed in HEK293 cells assessed as induction of cAMP accumulation incubated for 60 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetD(1A) dopamine receptor(Human)
Amri

Curated by ChEMBL
LigandPNGBDBM50509150(LY-3154207 | Ly3154207 | Mevidalen)
Affinity DataEC50:  2.30nMAssay Description:Positive allosteric modulator activity at human D1 receptor transiently expressed in HEK293 cells assessed as potentiation of EC20 dopamine-induced c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetD(1A) dopamine receptor(Mouse)
Amri

Curated by ChEMBL
LigandPNGBDBM50509150(LY-3154207 | Ly3154207 | Mevidalen)
Affinity DataEC50:  62nMAssay Description:Positive allosteric modulator activity at mouse D1 receptor transiently expressed in HEK293 cells assessed as potentiation of EC20 dopamine-induced c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetMitogen-activated protein kinase 14(Human)
University of Minnesota Twin Cities

Curated by ChEMBL
LigandPNGBDBM50503387(CHEMBL4475135)
Affinity DataKd:  2.20nMAssay Description:Binding affinity to wild-type human full length p38-alpha (M1 to S360 residues) expressed in bacterial expression system by Kinomescan methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetCREB-binding protein(Human)
University of Minnesota Twin Cities

Curated by ChEMBL
LigandPNGBDBM50517156(CHEMBL4559894)
Affinity DataKd: >1.00E+5nMAssay Description:Binding affinity to human partial length CREBBP (R1081 to G1197 residues) expressed in bacterial expression system by BROMOscan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
University of Minnesota Twin Cities

Curated by ChEMBL
LigandPNGBDBM50517157(CHEMBL4437764)
Affinity DataKd:  6.50E+3nMAssay Description:Binding affinity to wild-type human full length p38-alpha (M1 to S360 residues) expressed in bacterial expression system by Kinomescan methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
University of Minnesota Twin Cities

Curated by ChEMBL
LigandPNGBDBM50517158(CHEMBL4589422)
Affinity DataKd:  5.00E+3nMAssay Description:Binding affinity to wild-type human full length p38-alpha (M1 to S360 residues) expressed in bacterial expression system by Kinomescan methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
University of Minnesota Twin Cities

Curated by ChEMBL
LigandPNGBDBM50517156(CHEMBL4559894)
Affinity DataKd: >2.00E+5nMAssay Description:Binding affinity to wild-type human full length p38-alpha (M1 to S360 residues) expressed in bacterial expression system by Kinomescan methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetBromodomain-containing protein 4(Human)
University of Minnesota Twin Cities

Curated by ChEMBL
LigandPNGBDBM50517156(CHEMBL4559894)
Affinity DataKd:  1.10E+3nMAssay Description:Binding affinity to human partial length BRD4 bromodomain 1 long isoform (N44 to E168 residues) expressed in bacterial expression system by BROMOscan...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetBromodomain-containing protein 4(Human)
University of Minnesota Twin Cities

Curated by ChEMBL
LigandPNGBDBM50517166(CHEMBL4527581)
Affinity DataKd:  1.20E+3nMAssay Description:Binding affinity to human partial length BRD4 bromodomain 1 long isoform (N44 to E168 residues) expressed in bacterial expression system by BROMOscan...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetBromodomain-containing protein 4(Human)
University of Minnesota Twin Cities

Curated by ChEMBL
LigandPNGBDBM50517166(CHEMBL4527581)
Affinity DataKd:  2.10E+3nMAssay Description:Binding affinity to human partial length BRD4 bromodomain 2 long isoform (K333 to E460 residues) expressed in bacterial expression system by BROMOsca...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetProbable global transcription activator SNF2L2(Human)
University of Minnesota Twin Cities

Curated by ChEMBL
LigandPNGBDBM50517156(CHEMBL4559894)
Affinity DataKd: >1.00E+5nMAssay Description:Binding affinity to human partial length SMARCA2 (S1377 to Q1486 residues) expressed in bacterial expression system by BROMOscan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetCREB-binding protein(Human)
University of Minnesota Twin Cities

Curated by ChEMBL
LigandPNGBDBM50517166(CHEMBL4527581)
Affinity DataKd:  7.80E+4nMAssay Description:Binding affinity to human partial length CREBBP (R1081 to G1197 residues) expressed in bacterial expression system by BROMOscan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
University of Minnesota Twin Cities

Curated by ChEMBL
LigandPNGBDBM50517159(CHEMBL4461170)
Affinity DataKd:  120nMAssay Description:Binding affinity to wild-type human full length p38-alpha (M1 to S360 residues) expressed in bacterial expression system by Kinomescan methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
University of Minnesota Twin Cities

Curated by ChEMBL
LigandPNGBDBM50517166(CHEMBL4527581)
Affinity DataKd: >2.50E+4nMAssay Description:Binding affinity to wild-type human full length p38-alpha (M1 to S360 residues) expressed in bacterial expression system by Kinomescan methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetProbable global transcription activator SNF2L2(Human)
University of Minnesota Twin Cities

Curated by ChEMBL
LigandPNGBDBM50517166(CHEMBL4527581)
Affinity DataKd: >1.00E+5nMAssay Description:Binding affinity to human partial length SMARCA2 (S1377 to Q1486 residues) expressed in bacterial expression system by BROMOscan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetBromodomain-containing protein 4(Human)
University of Minnesota Twin Cities

Curated by ChEMBL
LigandPNGBDBM50517156(CHEMBL4559894)
Affinity DataKd:  940nMAssay Description:Binding affinity to human partial length BRD4 bromodomain 2 long isoform (K333 to E460 residues) expressed in bacterial expression system by BROMOsca...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetSterol 14-alpha demethylase(Trypanosoma cruzi (strain CL Brener))
"Sapienza" Universit£

Curated by ChEMBL
LigandPNGBDBM50529951(CHEMBL4468270)
Affinity DataKd:  5.50E+3nMAssay Description:Binding affinity to Trypanosoma cruzi CYP51 by UV-vis spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetSterol 14-alpha demethylase(Trypanosoma cruzi (strain CL Brener))
"Sapienza" Universit£

Curated by ChEMBL
LigandPNGBDBM50529951(CHEMBL4468270)
Affinity DataKd:  5.50E+3nMAssay Description:Binding affinity to Trypanosoma cruzi CYP51 by UV-vis spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetFatty acid-binding protein, adipocyte(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM50536996(CHEMBL4581404)
Affinity DataKd:  10nMAssay Description:Binding affinity to recombinant FABP4 (unknown origin) expressed in Escherichia coli by sypro orange dye-based TdF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMed
TargetFatty acid-binding protein, adipocyte(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM50536998(CHEMBL4568855)
Affinity DataKd:  860nMAssay Description:Binding affinity to recombinant FABP4 (unknown origin) expressed in Escherichia coli by sypro orange dye-based TdF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMed
TargetFatty acid-binding protein, adipocyte(Human)
University of California

Curated by ChEMBL
LigandPNGBDBM50536999(CHEMBL4547281)
Affinity DataKd:  20nMAssay Description:Binding affinity to recombinant FABP4 (unknown origin) expressed in Escherichia coli by sypro orange dye-based TdF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2B(Human)
Athersys

Curated by ChEMBL
LigandPNGBDBM50184584((3aS,6aS)-1-(4-(trifluoromethyl)pyrimidin-2-yl)-oc...)
Affinity DataEC50:  62nMAssay Description:Induction of 5HT2B receptor mediated increase in intracellular calcium concentration in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2B(Human)
Athersys

Curated by ChEMBL
LigandPNGBDBM50184585((3aS,6aS)-1-(3-chlorophenyl)-octahydropyrrolo[3,4-...)
Affinity DataEC50:  59nMAssay Description:Induction of 5HT2B receptor mediated increase in intracellular calcium concentration in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2B(Human)
Athersys

Curated by ChEMBL
LigandPNGBDBM50184586(rac-1-(4-(trifluoromethyl)pyrimidin-2-yl)-octahydr...)
Affinity DataEC50:  320nMAssay Description:Induction of 5HT2B receptor mediated increase in intracellular calcium concentration in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
Athersys

Curated by ChEMBL
LigandPNGBDBM50184587((2R,3aS,6aS)-2-methyl-1-(4-(trifluoromethyl)pyrimi...)
Affinity DataEC50:  25nMAssay Description:Induction of 5HT2A receptor mediated increase in intracellular calcium concentration in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
Athersys

Curated by ChEMBL
LigandPNGBDBM50184588((3aS,4S,6aR)-4-(3-(trifluoromethyl)phenyl)-octahyd...)
Affinity DataEC50:  420nMAssay Description:Induction of 5HT2C receptor mediated increase in intracellular calcium concentration in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
Athersys

Curated by ChEMBL
LigandPNGBDBM50184589((3aS,6aS)-1-(4-(2,5-dichlorophenyl)pyrimidin-2-yl)...)
Affinity DataEC50: >1.00E+3nMAssay Description:Induction of 5HT2C receptor mediated increase in intracellular calcium concentration in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
Athersys

Curated by ChEMBL
LigandPNGBDBM50184590((3aS,6aS)-1-(3-fluorophenyl)-octahydropyrrolo[3,4-...)
Affinity DataEC50:  319nMAssay Description:Induction of 5HT2C receptor mediated increase in intracellular calcium concentration in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
Athersys

Curated by ChEMBL
LigandPNGBDBM50184591((3aS,6aS)-1-(4-(2,5-difluorophenyl)pyrimidin-2-yl)...)
Affinity DataEC50: >1.00E+3nMAssay Description:Induction of 5HT2C receptor mediated increase in intracellular calcium concentration in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
Athersys

Curated by ChEMBL
LigandPNGBDBM50184586(rac-1-(4-(trifluoromethyl)pyrimidin-2-yl)-octahydr...)
Affinity DataEC50:  220nMAssay Description:Induction of 5HT2A receptor mediated increase in intracellular calcium concentration in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
Athersys

Curated by ChEMBL
LigandPNGBDBM50184588((3aS,4S,6aR)-4-(3-(trifluoromethyl)phenyl)-octahyd...)
Affinity DataEC50:  1.08E+3nMAssay Description:Induction of 5HT2A receptor mediated increase in intracellular calcium concentration in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2B(Human)
Athersys

Curated by ChEMBL
LigandPNGBDBM50184588((3aS,4S,6aR)-4-(3-(trifluoromethyl)phenyl)-octahyd...)
Affinity DataEC50:  187nMAssay Description:Induction of 5HT2B receptor mediated increase in intracellular calcium concentration in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2B(Human)
Athersys

Curated by ChEMBL
LigandPNGBDBM50184592((3aS,6aS)-1-(3-(trifluoromethyl)phenyl)-octahydrop...)
Affinity DataEC50:  65nMAssay Description:Induction of 5HT2B receptor mediated increase in intracellular calcium concentration in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
Athersys

Curated by ChEMBL
LigandPNGBDBM50184586(rac-1-(4-(trifluoromethyl)pyrimidin-2-yl)-octahydr...)
Affinity DataEC50:  180nMAssay Description:Induction of 5HT2C receptor mediated increase in intracellular calcium concentration in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2B(Human)
Athersys

Curated by ChEMBL
LigandPNGBDBM50184587((2R,3aS,6aS)-2-methyl-1-(4-(trifluoromethyl)pyrimi...)
Affinity DataEC50:  48nMAssay Description:Induction of 5HT2B receptor mediated increase in intracellular calcium concentration in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
Athersys

Curated by ChEMBL
LigandPNGBDBM50184590((3aS,6aS)-1-(3-fluorophenyl)-octahydropyrrolo[3,4-...)
Affinity DataEC50:  1.12E+3nMAssay Description:Induction of 5HT2A receptor mediated increase in intracellular calcium concentration in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
Athersys

Curated by ChEMBL
LigandPNGBDBM50184592((3aS,6aS)-1-(3-(trifluoromethyl)phenyl)-octahydrop...)
Affinity DataEC50:  103nMAssay Description:Induction of 5HT2C receptor mediated increase in intracellular calcium concentration in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
Athersys

Curated by ChEMBL
LigandPNGBDBM50184584((3aS,6aS)-1-(4-(trifluoromethyl)pyrimidin-2-yl)-oc...)
Affinity DataEC50:  116nMAssay Description:Induction of 5HT2A receptor mediated increase in intracellular calcium concentration in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
Athersys

Curated by ChEMBL
LigandPNGBDBM50184593((3aS,6aS)-5-(4-(2,5-difluorophenyl)pyrimidin-2-yl)...)
Affinity DataEC50: >2.00E+4nMAssay Description:Induction of 5HT2C receptor mediated increase in intracellular calcium concentration in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2B(Human)
Athersys

Curated by ChEMBL
LigandPNGBDBM50184590((3aS,6aS)-1-(3-fluorophenyl)-octahydropyrrolo[3,4-...)
Affinity DataEC50:  108nMAssay Description:Induction of 5HT2B receptor mediated increase in intracellular calcium concentration in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
Athersys

Curated by ChEMBL
LigandPNGBDBM50184585((3aS,6aS)-1-(3-chlorophenyl)-octahydropyrrolo[3,4-...)
Affinity DataEC50:  416nMAssay Description:Induction of 5HT2A receptor mediated increase in intracellular calcium concentration in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
Athersys

Curated by ChEMBL
LigandPNGBDBM50184595((3aR,6aR)-1-(4-(trifluoromethyl)pyrimidin-2-yl)-oc...)
Affinity DataEC50:  519nMAssay Description:Induction of 5HT2C receptor mediated increase in intracellular calcium concentration in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
Athersys

Curated by ChEMBL
LigandPNGBDBM50184594((3aS,6aS)-5-(4-(trifluoromethyl)pyrimidin-2-yl)-oc...)
Affinity DataEC50: >2.00E+4nMAssay Description:Induction of 5HT2C receptor mediated increase in intracellular calcium concentration in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2B(Human)
Athersys

Curated by ChEMBL
LigandPNGBDBM50184596((2S,3aS,6aS)-2-methyl-1-(4-(trifluoromethyl)pyrimi...)
Affinity DataEC50:  151nMAssay Description:Induction of 5HT2B receptor mediated increase in intracellular calcium concentration in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
Athersys

Curated by ChEMBL
LigandPNGBDBM50184584((3aS,6aS)-1-(4-(trifluoromethyl)pyrimidin-2-yl)-oc...)
Affinity DataEC50:  23nMAssay Description:Induction of 5HT2C receptor mediated increase in intracellular calcium concentration in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
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