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TargetE3 ubiquitin-protein ligase XIAP(Human)
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM156169(US9018214, 220)
Affinity DataEC50:  180nMAssay Description:Inhibition of full length FLAG-tagged XIAP (unknown origin) interaction with full length untagged caspase-9 expressed in HEK293 cells after 2 hrs by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/22/2019
Entry Details Article
PubMed
TargetE3 ubiquitin-protein ligase XIAP(Human)
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50239420(CHEMBL4062646)
Affinity DataEC50:  67nMAssay Description:Inhibition of full length FLAG-tagged XIAP (unknown origin) interaction with full length untagged caspase-9 expressed in HEK293 cells after 2 hrs by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/22/2019
Entry Details Article
PubMed
TargetE3 ubiquitin-protein ligase XIAP(Human)
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM156139(US9018214, 190)
Affinity DataEC50:  150nMAssay Description:Inhibition of full length FLAG-tagged XIAP (unknown origin) interaction with full length untagged caspase-9 expressed in HEK293 cells after 2 hrs by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/22/2019
Entry Details Article
PubMed
TargetE3 ubiquitin-protein ligase XIAP(Human)
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM156137(US9018214, 188)
Affinity DataEC50:  130nMAssay Description:Inhibition of full length FLAG-tagged XIAP (unknown origin) interaction with full length untagged caspase-9 expressed in HEK293 cells after 2 hrs by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/22/2019
Entry Details Article
PubMed
TargetE3 ubiquitin-protein ligase XIAP(Human)
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM156148(US9018214, 199)
Affinity DataEC50:  69nMAssay Description:Inhibition of full length FLAG-tagged XIAP (unknown origin) interaction with full length untagged caspase-9 expressed in HEK293 cells after 2 hrs by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/22/2019
Entry Details Article
PubMed
TargetE3 ubiquitin-protein ligase XIAP(Human)
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50239421(CHEMBL4092217)
Affinity DataEC50:  73nMAssay Description:Inhibition of full length FLAG-tagged XIAP (unknown origin) interaction with full length untagged caspase-9 expressed in HEK293 cells after 2 hrs by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/22/2019
Entry Details Article
PubMed
TargetE3 ubiquitin-protein ligase XIAP(Human)
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM156129(US9018214, 180)
Affinity DataEC50:  120nMAssay Description:Inhibition of full length FLAG-tagged XIAP (unknown origin) interaction with full length untagged caspase-9 expressed in HEK293 cells after 2 hrs by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/22/2019
Entry Details Article
PubMed
TargetE3 ubiquitin-protein ligase XIAP(Human)
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM156151(US9018214, 202)
Affinity DataEC50:  24nMAssay Description:Inhibition of full length FLAG-tagged XIAP (unknown origin) interaction with full length untagged caspase-9 expressed in HEK293 cells after 2 hrs by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/22/2019
Entry Details Article
PubMed
TargetE3 ubiquitin-protein ligase XIAP(Human)
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM156168(US9018214, 219)
Affinity DataEC50:  14nMAssay Description:Inhibition of full length FLAG-tagged XIAP (unknown origin) interaction with full length untagged caspase-9 expressed in HEK293 cells after 2 hrs by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/22/2019
Entry Details Article
PubMed
TargetE3 ubiquitin-protein ligase XIAP(Human)
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM156183(US9018214, 234)
Affinity DataEC50:  13nMAssay Description:Inhibition of full length FLAG-tagged XIAP (unknown origin) interaction with full length untagged caspase-9 expressed in HEK293 cells after 2 hrs by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/22/2019
Entry Details Article
PubMed
TargetE3 ubiquitin-protein ligase XIAP(Human)
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM156189(US9018214, 240)
Affinity DataEC50:  37nMAssay Description:Inhibition of full length FLAG-tagged XIAP (unknown origin) interaction with full length untagged caspase-9 expressed in HEK293 cells after 2 hrs by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/22/2019
Entry Details Article
PubMed
TargetBaculoviral IAP repeat-containing protein 2(Human)
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50441356(CHEMBL2431768)
Affinity DataEC50:  0.400nMAssay Description:Induction of cIAP1 degradation in human MDA-MB-231 cells after 2 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/22/2019
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetBaculoviral IAP repeat-containing protein 2(Human)
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM156129(US9018214, 180)
Affinity DataEC50:  7.5nMAssay Description:Induction of cIAP1 degradation in human MDA-MB-231 cells after 2 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/22/2019
Entry Details Article
PubMed
TargetBaculoviral IAP repeat-containing protein 2(Human)
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM156148(US9018214, 199)
Affinity DataEC50:  2.40nMAssay Description:Induction of cIAP1 degradation in human MDA-MB-231 cells after 2 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/22/2019
Entry Details Article
PubMed
TargetBaculoviral IAP repeat-containing protein 2(Human)
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50239423(CHEMBL4081831)
Affinity DataEC50:  20nMAssay Description:Induction of cIAP1 degradation in human MDA-MB-231 cells after 2 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/22/2019
Entry Details Article
PubMed
TargetBaculoviral IAP repeat-containing protein 2(Human)
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM156137(US9018214, 188)
Affinity DataEC50:  240nMAssay Description:Induction of cIAP1 degradation in human MDA-MB-231 cells after 2 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/22/2019
Entry Details Article
PubMed
TargetBaculoviral IAP repeat-containing protein 2(Human)
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50239424(CHEMBL4090609)
Affinity DataEC50:  24nMAssay Description:Induction of cIAP1 degradation in human MDA-MB-231 cells after 2 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/22/2019
Entry Details Article
PubMed
TargetBaculoviral IAP repeat-containing protein 2(Human)
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM156183(US9018214, 234)
Affinity DataEC50:  2.5nMAssay Description:Induction of cIAP1 degradation in human MDA-MB-231 cells after 2 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/22/2019
Entry Details Article
PubMed
TargetBaculoviral IAP repeat-containing protein 2(Human)
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM156189(US9018214, 240)
Affinity DataEC50:  2.40nMAssay Description:Induction of cIAP1 degradation in human MDA-MB-231 cells after 2 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/22/2019
Entry Details Article
PubMed
TargetE3 ubiquitin-protein ligase XIAP(Human)
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50239424(CHEMBL4090609)
Affinity DataEC50:  32nMAssay Description:Inhibition of full length FLAG-tagged XIAP (unknown origin) interaction with full length untagged caspase-9 expressed in HEK293 cells after 2 hrs by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/22/2019
Entry Details Article
PubMed
TargetE3 ubiquitin-protein ligase XIAP(Human)
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50239423(CHEMBL4081831)
Affinity DataEC50:  17nMAssay Description:Inhibition of full length FLAG-tagged XIAP (unknown origin) interaction with full length untagged caspase-9 expressed in HEK293 cells after 2 hrs by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/22/2019
Entry Details Article
PubMed
TargetE3 ubiquitin-protein ligase XIAP(Human)
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50441356(CHEMBL2431768)
Affinity DataEC50:  35nMAssay Description:Inhibition of full length FLAG-tagged XIAP (unknown origin) interaction with full length untagged caspase-9 expressed in HEK293 cells after 2 hrs by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/22/2019
Entry Details Article
PubMed
TargetBaculoviral IAP repeat-containing protein 2(Human)
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM156139(US9018214, 190)
Affinity DataEC50:  150nMAssay Description:Induction of cIAP1 degradation in human MDA-MB-231 cells after 2 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/22/2019
Entry Details Article
PubMed
TargetBaculoviral IAP repeat-containing protein 2(Human)
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50239425(CHEMBL4064619)
Affinity DataEC50:  0.320nMAssay Description:Induction of cIAP1 degradation in human MDA-MB-231 cells after 2 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/22/2019
Entry Details Article
PubMed
TargetE3 ubiquitin-protein ligase XIAP(Human)
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM156152(US9018214, 203)
Affinity DataEC50:  17nMAssay Description:Inhibition of full length FLAG-tagged XIAP (unknown origin) interaction with full length untagged caspase-9 expressed in HEK293 cells after 2 hrs by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/22/2019
Entry Details Article
PubMed
TargetE3 ubiquitin-protein ligase XIAP(Human)
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50239425(CHEMBL4064619)
Affinity DataEC50:  5.10nMAssay Description:Inhibition of full length FLAG-tagged XIAP (unknown origin) interaction with full length untagged caspase-9 expressed in HEK293 cells after 2 hrs by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/22/2019
Entry Details Article
PubMed
TargetBaculoviral IAP repeat-containing protein 2(Human)
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50239421(CHEMBL4092217)
Affinity DataEC50:  2.30nMAssay Description:Induction of cIAP1 degradation in human MDA-MB-231 cells after 2 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/22/2019
Entry Details Article
PubMed
TargetE3 ubiquitin-protein ligase XIAP(Human)
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50393505(CHEMBL2158051)
Affinity DataEC50:  34nMAssay Description:Antagonist activity at full-length FLAG-tagged XIAP (unknown origin) transfected in HEK293 cells assessed as inhibition of interaction with caspase 9...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/15/2016
Entry Details Article
PubMed
TargetE3 ubiquitin-protein ligase XIAP(Human)
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM156012(US9018214, 63)
Affinity DataEC50:  140nMAssay Description:Antagonist activity at full-length FLAG-tagged XIAP (unknown origin) transfected in HEK293 cells assessed as inhibition of interaction with caspase 9...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/15/2016
Entry Details Article
PubMed
TargetDiscoidin domain-containing receptor 2(Human)
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50112617(CHEMBL3608786)
Affinity DataEC50:  8.70nMAssay Description:Inhibition of collagen I-induced DDR2 (unknown origin) phosphorylation expressed in HEK293 cells after 16 hrs by mesoscale discovery assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetE3 ubiquitin-protein ligase XIAP(Human)
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50239422(CHEMBL234346)
Affinity DataIC50: 0.0170nMAssay Description:Inhibition of SMAC-derived peptide abuRPFK (5 and 6FAM)-amide interaction with XIAP BIR3 domain (unknown origin) by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/22/2019
Entry Details Article
PubMed
TargetCholecystokinin receptor type A(Rat)
James Black Foundation

Curated by ChEMBL
LigandPNGBDBM50005463(1H-Indole-2-carboxylic acid (1-methyl-2-oxo-5-phen...)
Affinity DataIC50: 0.0800nMAssay Description:Half maximal inhibition of specific binding of [125I]-Bolton-Hunter CCK-8 to Cholecystokinin type A receptor in the rat pancreasMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/15/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetBaculoviral IAP repeat-containing protein 2(Human)
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50450049(CHEMBL4166057)
Affinity DataIC50: 0.100nMAssay Description:Induction of intracellular cIAP1 degradation in human MDA-MB-231 cells after 2 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetBaculoviral IAP repeat-containing protein 2(Human)
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50450044(CHEMBL4167141)
Affinity DataIC50: 0.130nMAssay Description:Induction of intracellular cIAP1 degradation in human MDA-MB-231 cells after 2 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetGastrin/cholecystokinin type B receptor(Mouse)
James Black Foundation

Curated by ChEMBL
LigandPNGBDBM50062005(PD-135666 | 3-[2-(2-Adamantan-2-yl-acetylamino)-3-...)
Affinity DataIC50: 0.150nMAssay Description:Half maximal inhibition of specific binding of [125I]Bolton-Hunter CCK-8 to Cholecystokinin type B receptor in the mouse cerebral cortexMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/15/2012
Entry Details Article
PubMed
TargetBaculoviral IAP repeat-containing protein 2(Human)
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50450038(CHEMBL4171490)
Affinity DataIC50: 0.170nMAssay Description:Induction of intracellular cIAP1 degradation in human MDA-MB-231 cells after 2 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetBaculoviral IAP repeat-containing protein 2(Human)
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50450047(CHEMBL4169478)
Affinity DataIC50: 0.180nMAssay Description:Induction of intracellular cIAP1 degradation in human MDA-MB-231 cells after 2 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetBaculoviral IAP repeat-containing protein 2(Human)
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50450043(CHEMBL4166607)
Affinity DataIC50: 0.190nMAssay Description:Induction of intracellular cIAP1 degradation in human MDA-MB-231 cells after 2 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetBaculoviral IAP repeat-containing protein 2(Human)
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50450037(CHEMBL4164271)
Affinity DataIC50: 0.200nMAssay Description:Induction of intracellular cIAP1 degradation in human MDA-MB-231 cells after 2 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetBaculoviral IAP repeat-containing protein 2(Human)
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50450046(CHEMBL4173974)
Affinity DataIC50: 0.220nMAssay Description:Induction of intracellular cIAP1 degradation in human MDA-MB-231 cells after 2 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetBaculoviral IAP repeat-containing protein 2(Human)
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50239422(CHEMBL234346)
Affinity DataIC50: 0.320nMAssay Description:Inhibition of SMAC-derived peptide abuRPFK (5 and 6FAM)-amide interaction with cIAP1 BIR3 domain (unknown origin) by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/22/2019
Entry Details Article
PubMed
TargetBaculoviral IAP repeat-containing protein 2(Human)
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50239425(CHEMBL4064619)
Affinity DataIC50: 0.320nMAssay Description:Induction of intracellular cIAP1 degradation in human MDA-MB-231 cells after 2 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetBaculoviral IAP repeat-containing protein 2(Human)
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50450039(CHEMBL4160872)
Affinity DataIC50: 0.340nMAssay Description:Induction of intracellular cIAP1 degradation in human MDA-MB-231 cells after 2 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetBaculoviral IAP repeat-containing protein 2(Human)
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50441356(CHEMBL2431768)
Affinity DataIC50: 0.400nMAssay Description:Induction of intracellular cIAP1 degradation in human MDA-MB-231 cells after 2 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetE3 ubiquitin-protein ligase Mdm2(Human)
Astex Therapeutics

US Patent
LigandPNGBDBM427143(1-({[(1R)-2-[(4-chloro-2-methanesulfonylphenyl)met...)
Affinity DataIC50: 0.490nMAssay Description:The ELISA assay was performed in streptavidin coated plates which were preincubated with 200 μl per well of 1 μg ml−1 biotinylated IP...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2020
Entry Details
Go to US Patent

LigandPNGBDBM427143(1-({[(1R)-2-[(4-chloro-2-methanesulfonylphenyl)met...)
Affinity DataIC50: 0.490nMAssay Description:The ELISA assay was performed in streptavidin coated plates which were preincubated with 200 μl per well of 1 μg ml−1 biotinylated IP...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2021
Entry Details
Go to US Patent

TargetE3 ubiquitin-protein ligase Mdm2(Human)
Astex Therapeutics

US Patent
LigandPNGBDBM427127(1-({[(1R)-2-[(4-chloro-2-methanesulfonylphenyl)met...)
Affinity DataIC50: 0.5nMAssay Description:The ELISA assay was performed in streptavidin coated plates which were preincubated with 200 μl per well of 1 μg ml−1 biotinylated IP...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2020
Entry Details
Go to US Patent

LigandPNGBDBM427127(1-({[(1R)-2-[(4-chloro-2-methanesulfonylphenyl)met...)
Affinity DataIC50: 0.5nMAssay Description:The ELISA assay was performed in streptavidin coated plates which were preincubated with 200 μl per well of 1 μg ml−1 biotinylated IP...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2021
Entry Details
Go to US Patent

TargetE3 ubiquitin-protein ligase Mdm2(Human)
Astex Therapeutics

US Patent
LigandPNGBDBM427196(US10544132, Example 137)
Affinity DataIC50: 0.570nMAssay Description:The ELISA assay was performed in streptavidin coated plates which were preincubated with 200 μl per well of 1 μg ml−1 biotinylated IP...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2020
Entry Details
Go to US Patent

LigandPNGBDBM427195(US10544132, Example 136 | US10981898, Example 137 ...)
Affinity DataIC50: 0.570nMAssay Description:The ELISA assay was performed in streptavidin coated plates which were preincubated with 200 μl per well of 1 μg ml−1 biotinylated IP...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2021
Entry Details
Go to US Patent

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