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TargetMucolipin-2(Human)
Arkuda Therapeutics

Curated by ChEMBL
LigandPNGBDBM50625881(CHEMBL5414380)
Affinity DataEC50:  1.87E+3nMAssay Description:Agonist activity at human TRPML1 expressed in HEK293 cells incubated for 1 hr by FLIPR assayMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetPresenilin-1(Human)
Forum Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50577504(CHEMBL4849643)
Affinity DataEC50:  26nMAssay Description:Modulation of gamma-secretase in human H4 cells expressing human wild type APP751 assessed as reduction in amyloid beta42 level incubated overnight b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Forum Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50577525(CHEMBL4848062)
Affinity DataEC50:  9nMAssay Description:Modulation of gamma-secretase in human H4 cells expressing human wild type APP751 assessed as reduction in amyloid beta42 level incubated overnight b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Forum Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50577518(CHEMBL4855120)
Affinity DataEC50:  10nMAssay Description:Modulation of gamma-secretase in human H4 cells expressing human wild type APP751 assessed as reduction in amyloid beta42 level incubated overnight b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Forum Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50577510(CHEMBL4858970)
Affinity DataEC50:  13nMAssay Description:Modulation of gamma-secretase in human H4 cells expressing human wild type APP751 assessed as reduction in amyloid beta42 level incubated overnight b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Forum Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50577500(CHEMBL4848262)
Affinity DataEC50:  34nMAssay Description:Modulation of gamma-secretase in human H4 cells expressing human wild type APP751 assessed as reduction in amyloid beta42 level incubated overnight b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Forum Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50577523(CHEMBL4869387)
Affinity DataEC50:  14nMAssay Description:Modulation of gamma-secretase in human H4 cells expressing human wild type APP751 assessed as reduction in amyloid beta42 level incubated overnight b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Forum Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50577511(CHEMBL4864477)
Affinity DataEC50:  8nMAssay Description:Modulation of gamma-secretase in human H4 cells expressing human wild type APP751 assessed as reduction in amyloid beta42 level incubated overnight b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Forum Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50577524(CHEMBL4862666)
Affinity DataEC50:  5nMAssay Description:Modulation of gamma-secretase in human H4 cells expressing human wild type APP751 assessed as reduction in amyloid beta42 level incubated overnight b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetMucolipin-2(Human)
Arkuda Therapeutics

Curated by ChEMBL
LigandPNGBDBM50625886(CHEMBL5428833)
Affinity DataEC50:  481nMAssay Description:Agonist activity at human TRPML1 expressed in HEK293 cells incubated for 1 hr by FLIPR assayMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetPresenilin-1(Human)
Forum Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50577493(CHEMBL4865935)
Affinity DataEC50:  97nMAssay Description:Modulation of gamma-secretase in human H4 cells expressing human wild type APP751 assessed as reduction in amyloid beta42 level incubated overnight b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Forum Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50577512(CHEMBL4873343)
Affinity DataEC50:  14nMAssay Description:Modulation of gamma-secretase in human H4 cells expressing human wild type APP751 assessed as reduction in amyloid beta42 level incubated overnight b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Forum Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50577513(CHEMBL4865396)
Affinity DataEC50:  13nMAssay Description:Modulation of gamma-secretase in human H4 cells expressing human wild type APP751 assessed as reduction in amyloid beta42 level incubated overnight b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Forum Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50577517(CHEMBL4878938)
Affinity DataEC50:  23nMAssay Description:Modulation of gamma-secretase in human H4 cells expressing human wild type APP751 assessed as reduction in amyloid beta42 level incubated overnight b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetMucolipin-2(Human)
Arkuda Therapeutics

Curated by ChEMBL
LigandPNGBDBM50625879(CHEMBL5424688)
Affinity DataEC50:  3.69E+4nMAssay Description:Agonist activity at human TRPML1 expressed in HEK293 cells incubated for 1 hr by FLIPR assayMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetPresenilin-1(Human)
Forum Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50577496(CHEMBL4859045)
Affinity DataEC50:  97nMAssay Description:Modulation of gamma-secretase in human H4 cells expressing human wild type APP751 assessed as reduction in amyloid beta42 level incubated overnight b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetMucolipin-2(Human)
Arkuda Therapeutics

Curated by ChEMBL
LigandPNGBDBM50625876(CHEMBL5422473)
Affinity DataEC50: >4.88E+4nMAssay Description:Agonist activity at human TRPML1 expressed in HEK293 cells incubated for 1 hr by FLIPR assayMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetMucolipin-2(Human)
Arkuda Therapeutics

Curated by ChEMBL
LigandPNGBDBM50625870(CHEMBL5428524)
Affinity DataEC50: >4.88E+4nMAssay Description:Agonist activity at human TRPML1 expressed in HEK293 cells incubated for 1 hr by FLIPR assayMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetMucolipin-2(Human)
Arkuda Therapeutics

Curated by ChEMBL
LigandPNGBDBM50625875(CHEMBL5415347)
Affinity DataEC50: >4.88E+4nMAssay Description:Agonist activity at human TRPML1 expressed in HEK293 cells incubated for 1 hr by FLIPR assayMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetPresenilin-1(Human)
Forum Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50577515(CHEMBL4872778)
Affinity DataEC50:  21nMAssay Description:Modulation of gamma-secretase in human H4 cells expressing human wild type APP751 assessed as reduction in amyloid beta42 level incubated overnight b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetMucolipin-2(Human)
Arkuda Therapeutics

Curated by ChEMBL
LigandPNGBDBM50625877(CHEMBL5409056)
Affinity DataEC50: >4.88E+4nMAssay Description:Agonist activity at human TRPML1 expressed in HEK293 cells incubated for 1 hr by FLIPR assayMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetPresenilin-1(Human)
Forum Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50236004(CHEMBL4101809)
Affinity DataEC50:  35nMAssay Description:Modulation of gamma-secretase in human H4 cells expressing human wild type APP751 assessed as reduction in amyloid beta42 level incubated overnight b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Forum Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50577498(CHEMBL4846662)
Affinity DataEC50:  74nMAssay Description:Modulation of gamma-secretase in human H4 cells expressing human wild type APP751 assessed as reduction in amyloid beta42 level incubated overnight b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Forum Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50577494(CHEMBL4855113)
Affinity DataEC50:  60nMAssay Description:Modulation of gamma-secretase in human H4 cells expressing human wild type APP751 assessed as reduction in amyloid beta42 level incubated overnight b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetMucolipin-2(Human)
Arkuda Therapeutics

Curated by ChEMBL
LigandPNGBDBM50625873(CHEMBL5430756)
Affinity DataEC50:  2.24E+4nMAssay Description:Agonist activity at human TRPML1 expressed in HEK293 cells incubated for 1 hr by FLIPR assayMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetPresenilin-1(Human)
Forum Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50577521(CHEMBL4851284)
Affinity DataEC50:  16nMAssay Description:Modulation of gamma-secretase in human H4 cells expressing human wild type APP751 assessed as reduction in amyloid beta42 level incubated overnight b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Forum Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50577519(CHEMBL4849599)
Affinity DataEC50:  75nMAssay Description:Modulation of gamma-secretase in human H4 cells expressing human wild type APP751 assessed as reduction in amyloid beta42 level incubated overnight b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetMucolipin-2(Human)
Arkuda Therapeutics

Curated by ChEMBL
LigandPNGBDBM50625880(CHEMBL5396548)
Affinity DataEC50:  2.11E+3nMAssay Description:Agonist activity at human TRPML1 expressed in HEK293 cells incubated for 1 hr by FLIPR assayMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetMucolipin-2(Human)
Arkuda Therapeutics

Curated by ChEMBL
LigandPNGBDBM50625869(CHEMBL5432101)
Affinity DataEC50:  675nMAssay Description:Agonist activity at human TRPML1 expressed in HEK293 cells incubated for 1 hr by FLIPR assayMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetPresenilin-1(Human)
Forum Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50577508(CHEMBL4848661)
Affinity DataEC50:  10nMAssay Description:Modulation of gamma-secretase in human H4 cells expressing human wild type APP751 assessed as reduction in amyloid beta42 level incubated overnight b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M3(Human)
Arkuda Therapeutics

Curated by ChEMBL
LigandPNGBDBM50370682(SOLIFENACIN)
Affinity DataEC50:  24nMAssay Description:Antagonist activity at M3 receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetNociceptin receptor(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM21842(OFQ 1-17 | N/OFQ | (2S)-2-[(2S)-2-[(2S)-2-[(2S)-2-...)
Affinity DataEC50:  0.0800nMAssay Description:Compound was evaluated for increase in [35S]GTP-gamma-S, binding for human ORL1 receptor carried out in CHO cell membranes; Nd: no dataMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/6/2012
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Forum Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50577516(CHEMBL4855162)
Affinity DataEC50:  19nMAssay Description:Modulation of gamma-secretase in human H4 cells expressing human wild type APP751 assessed as reduction in amyloid beta42 level incubated overnight b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Forum Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50577501(CHEMBL4851690)
Affinity DataEC50:  10nMAssay Description:Modulation of gamma-secretase in human H4 cells expressing human wild type APP751 assessed as reduction in amyloid beta42 level incubated overnight b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetMucolipin-2(Human)
Arkuda Therapeutics

Curated by ChEMBL
LigandPNGBDBM50625874(CHEMBL5423474)
Affinity DataEC50: >4.88E+4nMAssay Description:Agonist activity at human TRPML1 expressed in HEK293 cells incubated for 1 hr by FLIPR assayMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetMucolipin-2(Human)
Arkuda Therapeutics

Curated by ChEMBL
LigandPNGBDBM50625883(CHEMBL5432025)
Affinity DataEC50:  1.07E+3nMAssay Description:Agonist activity at human TRPML1 expressed in HEK293 cells incubated for 1 hr by FLIPR assayMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetMucolipin-2(Human)
Arkuda Therapeutics

Curated by ChEMBL
LigandPNGBDBM50625890(CHEMBL5418881)
Affinity DataEC50:  1.41E+3nMAssay Description:Agonist activity at human TRPML1 expressed in HEK293 cells incubated for 1 hr by FLIPR assayMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetMucolipin-2(Human)
Arkuda Therapeutics

Curated by ChEMBL
LigandPNGBDBM50625871(CHEMBL5407879)
Affinity DataEC50:  1.24E+4nMAssay Description:Agonist activity at human TRPML1 expressed in HEK293 cells incubated for 1 hr by FLIPR assayMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetPresenilin-1(Human)
Forum Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50577514(CHEMBL4868749)
Affinity DataEC50:  10nMAssay Description:Modulation of gamma-secretase in human H4 cells expressing human wild type APP751 assessed as reduction in amyloid beta42 level incubated overnight b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M3(Human)
Arkuda Therapeutics

Curated by ChEMBL
LigandPNGBDBM50609447(CHEMBL5284728)
Affinity DataEC50:  1.70E+4nMAssay Description:Antagonist activity at M3 receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetPresenilin-1(Human)
Forum Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50577507(CHEMBL4871709)
Affinity DataEC50:  23nMAssay Description:Modulation of gamma-secretase in human H4 cells expressing human wild type APP751 assessed as reduction in amyloid beta42 level incubated overnight b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetMucolipin-2(Human)
Arkuda Therapeutics

Curated by ChEMBL
LigandPNGBDBM50625885(CHEMBL5419801)
Affinity DataEC50:  885nMAssay Description:Agonist activity at human TRPML1 expressed in HEK293 cells incubated for 1 hr by FLIPR assayMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetMucolipin-2(Human)
Arkuda Therapeutics

Curated by ChEMBL
LigandPNGBDBM50625882(CHEMBL5440040)
Affinity DataEC50:  6.50E+3nMAssay Description:Agonist activity at human TRPML1 expressed in HEK293 cells incubated for 1 hr by FLIPR assayMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetPresenilin-1(Human)
Forum Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50577509(CHEMBL4850647)
Affinity DataEC50:  10nMAssay Description:Modulation of gamma-secretase in human H4 cells expressing human wild type APP751 assessed as reduction in amyloid beta42 level incubated overnight b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Forum Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50577522(CHEMBL4848087)
Affinity DataEC50:  8nMAssay Description:Modulation of gamma-secretase in human H4 cells expressing human wild type APP751 assessed as reduction in amyloid beta42 level incubated overnight b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Forum Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50577503(CHEMBL4878673)
Affinity DataEC50:  197nMAssay Description:Modulation of gamma-secretase in human H4 cells expressing human wild type APP751 assessed as reduction in amyloid beta42 level incubated overnight b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Forum Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50577499(CHEMBL4872582)
Affinity DataEC50:  39nMAssay Description:Modulation of gamma-secretase in human H4 cells expressing human wild type APP751 assessed as reduction in amyloid beta42 level incubated overnight b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetMucolipin-2(Human)
Arkuda Therapeutics

Curated by ChEMBL
LigandPNGBDBM50625878(CHEMBL5406419)
Affinity DataEC50:  2.60E+4nMAssay Description:Agonist activity at human TRPML1 expressed in HEK293 cells incubated for 1 hr by FLIPR assayMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetPresenilin-1(Human)
Forum Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50577495(CHEMBL4866858)
Affinity DataEC50:  450nMAssay Description:Modulation of gamma-secretase in human H4 cells expressing human wild type APP751 assessed as reduction in amyloid beta42 level incubated overnight b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetPresenilin-1(Human)
Forum Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50577505(CHEMBL4863683)
Affinity DataEC50:  23nMAssay Description:Modulation of gamma-secretase in human H4 cells expressing human wild type APP751 assessed as reduction in amyloid beta42 level incubated overnight b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
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