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TargetOxysterols receptor LXR-alpha(Human)
University of Perugia

Curated by ChEMBL
LigandPNGBDBM50257928(CHEMBL4070016)
Affinity DataEC50:  1.50E+3nMAssay Description:Activation of GAL4 fused human LXR alpha expressed in HEK293 cells after 24 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2019
Entry Details Article
PubMed
TargetOxysterols receptor LXR-alpha(Human)
University of Perugia

Curated by ChEMBL
LigandPNGBDBM50257929(CHEMBL4097209)
Affinity DataEC50:  4.11E+3nMAssay Description:Activation of GAL4 fused human LXR alpha expressed in HEK293 cells after 24 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2019
Entry Details Article
PubMed
TargetOxysterols receptor LXR-alpha(Human)
University of Perugia

Curated by ChEMBL
LigandPNGBDBM50257930(CHEMBL4061349)
Affinity DataEC50:  1.64E+4nMAssay Description:Activation of GAL4 fused human LXR alpha expressed in HEK293 cells after 24 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2019
Entry Details Article
PubMed
TargetOxysterols receptor LXR-alpha(Human)
University of Perugia

Curated by ChEMBL
LigandPNGBDBM20177((1S,2R,5S,10S,11S,14R,15S)-14-[(2S,3R)-3-hydroxy-6...)
Affinity DataEC50:  6.71E+3nMAssay Description:Activation of GAL4 fused human LXR alpha expressed in HEK293 cells after 24 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2019
Entry Details Article
PubMed
TargetOxysterols receptor LXR-alpha(Human)
University of Perugia

Curated by ChEMBL
LigandPNGBDBM50257931(CHEMBL4073435)
Affinity DataEC50:  5.58E+3nMAssay Description:Activation of GAL4 fused human LXR alpha expressed in HEK293 cells after 24 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2019
Entry Details Article
PubMed
TargetOxysterols receptor LXR-alpha(Human)
University of Perugia

Curated by ChEMBL
LigandPNGBDBM50257932(CHEMBL4085972)
Affinity DataEC50:  1.58E+4nMAssay Description:Activation of GAL4 fused human LXR alpha expressed in HEK293 cells after 24 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2019
Entry Details Article
PubMed
TargetOxysterols receptor LXR-alpha(Human)
University of Perugia

Curated by ChEMBL
LigandPNGBDBM50257933(CHEMBL4086897)
Affinity DataEC50:  6.61E+3nMAssay Description:Activation of GAL4 fused human LXR alpha expressed in HEK293 cells after 24 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2019
Entry Details Article
PubMed
TargetOxysterols receptor LXR-alpha(Human)
University of Perugia

Curated by ChEMBL
LigandPNGBDBM50257934(CHEMBL4104778)
Affinity DataEC50:  8.07E+3nMAssay Description:Activation of GAL4 fused human LXR alpha expressed in HEK293 cells after 24 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2019
Entry Details Article
PubMed
TargetOxysterols receptor LXR-alpha(Human)
University of Perugia

Curated by ChEMBL
LigandPNGBDBM50257935(CHEMBL4067156)
Affinity DataEC50:  3.20E+3nMAssay Description:Activation of GAL4 fused human LXR alpha expressed in HEK293 cells after 24 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2019
Entry Details Article
PubMed
TargetOxysterols receptor LXR-alpha(Human)
University of Perugia

Curated by ChEMBL
LigandPNGBDBM50257936(CHEMBL4059545)
Affinity DataEC50:  8.51E+3nMAssay Description:Activation of GAL4 fused human LXR alpha expressed in HEK293 cells after 24 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2019
Entry Details Article
PubMed
TargetOxysterols receptor LXR-beta(Human)
University of Perugia

Curated by ChEMBL
LigandPNGBDBM20177((1S,2R,5S,10S,11S,14R,15S)-14-[(2S,3R)-3-hydroxy-6...)
Affinity DataEC50:  4.75E+3nMAssay Description:Activation of GAL4 fused human LXR beta expressed in HEK293 cells after 24 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2019
Entry Details Article
PubMed
TargetOxysterols receptor LXR-beta(Human)
University of Perugia

Curated by ChEMBL
LigandPNGBDBM50257930(CHEMBL4061349)
Affinity DataEC50:  1.27E+4nMAssay Description:Activation of GAL4 fused human LXR beta expressed in HEK293 cells after 24 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2019
Entry Details Article
PubMed
TargetOxysterols receptor LXR-beta(Human)
University of Perugia

Curated by ChEMBL
LigandPNGBDBM50257929(CHEMBL4097209)
Affinity DataEC50:  7.20E+3nMAssay Description:Activation of GAL4 fused human LXR beta expressed in HEK293 cells after 24 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2019
Entry Details Article
PubMed
TargetOxysterols receptor LXR-beta(Human)
University of Perugia

Curated by ChEMBL
LigandPNGBDBM50257928(CHEMBL4070016)
Affinity DataEC50:  1.96E+3nMAssay Description:Activation of GAL4 fused human LXR beta expressed in HEK293 cells after 24 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2019
Entry Details Article
PubMed
TargetOxysterols receptor LXR-beta(Human)
University of Perugia

Curated by ChEMBL
LigandPNGBDBM50257937(CHEMBL4094610)
Affinity DataEC50:  2.31E+3nMAssay Description:Activation of GAL4 fused human LXR beta expressed in HEK293 cells after 24 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2019
Entry Details Article
PubMed
TargetOxysterols receptor LXR-beta(Human)
University of Perugia

Curated by ChEMBL
LigandPNGBDBM50257933(CHEMBL4086897)
Affinity DataEC50:  1.96E+3nMAssay Description:Activation of GAL4 fused human LXR beta expressed in HEK293 cells after 24 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2019
Entry Details Article
PubMed
TargetOxysterols receptor LXR-alpha(Human)
University of Perugia

Curated by ChEMBL
LigandPNGBDBM50257938(CHEMBL4089508)
Affinity DataEC50:  2.09E+3nMAssay Description:Activation of GAL4 fused human LXR alpha expressed in HEK293 cells after 24 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2019
Entry Details Article
PubMed
TargetOxysterols receptor LXR-alpha(Human)
University of Perugia

Curated by ChEMBL
LigandPNGBDBM50257939(CHEMBL4078083)
Affinity DataEC50:  1.45E+4nMAssay Description:Activation of GAL4 fused human LXR alpha expressed in HEK293 cells after 24 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2019
Entry Details Article
PubMed
TargetOxysterols receptor LXR-alpha(Human)
University of Perugia

Curated by ChEMBL
LigandPNGBDBM50257937(CHEMBL4094610)
Affinity DataEC50:  6.93E+3nMAssay Description:Activation of GAL4 fused human LXR alpha expressed in HEK293 cells after 24 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2019
Entry Details Article
PubMed
TargetOxysterols receptor LXR-beta(Human)
University of Perugia

Curated by ChEMBL
LigandPNGBDBM50257938(CHEMBL4089508)
Affinity DataEC50:  3.79E+3nMAssay Description:Activation of GAL4 fused human LXR beta expressed in HEK293 cells after 24 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2019
Entry Details Article
PubMed
TargetOxysterols receptor LXR-beta(Human)
University of Perugia

Curated by ChEMBL
LigandPNGBDBM50257935(CHEMBL4067156)
Affinity DataEC50:  2.70E+3nMAssay Description:Activation of GAL4 fused human LXR beta expressed in HEK293 cells after 24 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2019
Entry Details Article
PubMed
TargetOxysterols receptor LXR-beta(Human)
University of Perugia

Curated by ChEMBL
LigandPNGBDBM50257939(CHEMBL4078083)
Affinity DataEC50:  6.02E+3nMAssay Description:Activation of GAL4 fused human LXR beta expressed in HEK293 cells after 24 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/24/2019
Entry Details Article
PubMed
LigandPNGBDBM50118359((2-Chloro-7,7-dioxo-4,7-dihydro-1,7-dithia-4,6-dia...)
Affinity DataEC50:  190nMAssay Description:Activity at Kir6.2/SUR1 KATP channels expressed in HEK293 cells assessed as repolarization of tolbutamide-induced membrane depolarizationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM86248(NSC_3019 | CAS_364-98-7 | diazoxide)
Affinity DataEC50:  3.10E+4nMAssay Description:Activity at Kir6.2/SUR1 KATP channels expressed in HEK293 cells assessed as activation of K+ currentsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50210318(6-chloro-4-hydroxy-2-oxo-N-1,3-thiazol-2-yl-2H-chr...)
Affinity DataEC50: >3.00E+4nMAssay Description:Activity at Kir6.2/SUR1 KATP channels expressed in HEK293 cells assessed as repolarization of tolbutamide-induced membrane depolarizationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50210319(4-amino-6-methoxy-2-(trifluoromethyl)quinoline-3-c...)
Affinity DataEC50:  1.50E+4nMAssay Description:Activity at Kir6.2/SUR1 KATP channels expressed in HEK293 cells assessed as repolarization of tolbutamide-induced membrane depolarizationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50210320([(2Z)-4-(4-fluorophenyl)-2-[(4-fluorophenyl)imino]...)
Affinity DataEC50:  2.10E+4nMAssay Description:Activity at Kir6.2/SUR1 KATP channels expressed in HEK293 cells assessed as repolarization of tolbutamide-induced membrane depolarizationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50118359((2-Chloro-7,7-dioxo-4,7-dihydro-1,7-dithia-4,6-dia...)
Affinity DataEC50:  450nMAssay Description:Activity at Kir6.2/SUR1 KATP channels expressed in HEK293 cells assessed as activation of K+ currentsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50210321(5-methoxy-2-piperidin-1-yl-1H-benzimidazole | CHEM...)
Affinity DataEC50: >3.00E+4nMAssay Description:Activity at Kir6.2/SUR1 KATP channels expressed in HEK293 cells assessed as repolarization of tolbutamide-induced membrane depolarizationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM86248(NSC_3019 | CAS_364-98-7 | diazoxide)
Affinity DataEC50:  3.30E+4nMAssay Description:Activity at Kir6.2/SUR1 KATP channels expressed in HEK293 cells assessed as repolarization of tolbutamide-induced membrane depolarizationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50130735((7-chloro-1,1-dioxo-1,4-dihydro-benzo[1,2,4]thiadi...)
Affinity DataEC50:  250nMAssay Description:Activity at Kir6.2/SUR1 KATP channels expressed in HEK293 cells assessed as repolarization of tolbutamide-induced membrane depolarizationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50210322(N-[1-(2-pyrrolidin-1-ylethyl)-1H-benzimidazol-2-yl...)
Affinity DataEC50: >3.00E+4nMAssay Description:Activity at Kir6.2/SUR1 KATP channels expressed in HEK293 cells assessed as repolarization of tolbutamide-induced membrane depolarizationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50210324(6-phenylpteridin-4(3H)-one | CHEMBL228035)
Affinity DataEC50: >3.00E+4nMAssay Description:Activity at Kir6.2/SUR1 KATP channels expressed in HEK293 cells assessed as repolarization of tolbutamide-induced membrane depolarizationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50210323(2-{[(4-chlorophenyl)sulfonyl]amino}benzamide | CHE...)
Affinity DataEC50: >3.00E+4nMAssay Description:Activity at Kir6.2/SUR1 KATP channels expressed in HEK293 cells assessed as repolarization of tolbutamide-induced membrane depolarizationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50210325(3-oxo-5,6-diphenyl-2,3-dihydropyridazine-4-carboni...)
Affinity DataEC50: >3.00E+4nMAssay Description:Activity at Kir6.2/SUR1 KATP channels expressed in HEK293 cells assessed as repolarization of tolbutamide-induced membrane depolarizationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM56470(2-(2-imino-3-methyl-1-benzimidazolyl)-1-thiophen-2...)
Affinity DataEC50: >3.00E+4nMAssay Description:Activity at Kir6.2/SUR1 KATP channels expressed in HEK293 cells assessed as repolarization of tolbutamide-induced membrane depolarizationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
University of Perugia

Curated by ChEMBL
LigandPNGBDBM8610(24F2-1,25(OH)D3 | Ketoconazole (k) | KTZ | 1-[4-(4...)
Affinity DataIC50: 1nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using testosterone as substrate after 5 mins by LC-MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/22/2017
Entry Details Article
PubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
University of Perugia

Curated by ChEMBL
LigandPNGBDBM1803(2-amino-6-[(3-bromo-5-methylbenzene)sulfonyl]benzo...)
Affinity DataIC50: 3nMAssay Description:Inhibitory concentration against Reverse transcriptaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/23/2013
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
University of Perugia

Curated by ChEMBL
LigandPNGBDBM8610(24F2-1,25(OH)D3 | Ketoconazole (k) | KTZ | 1-[4-(4...)
Affinity DataIC50: 4nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using midazolam as substrate after 4 mins by LC-MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/22/2017
Entry Details Article
PubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
University of Perugia

Curated by ChEMBL
LigandPNGBDBM1804(2-amino-6-[(3-chloro-5-methylbenzene)sulfonyl]benz...)
Affinity DataIC50: 5nMAssay Description:Inhibitory concentration against Reverse transcriptaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/23/2013
Entry Details Article
PubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
University of Perugia

Curated by ChEMBL
LigandPNGBDBM1802(2-amino-6-[(3,5-dimethylbenzene)sulfonyl]benzonitr...)
Affinity DataIC50: 7.10nMAssay Description:Inhibitory concentration against Reverse transcriptaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/23/2013
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCytochrome P450 2D6(Human)
University of Perugia

Curated by ChEMBL
LigandPNGBDBM50121975((6-Methoxy-quinolin-4-yl)-(5-vinyl-1-aza-bicyclo[2...)
Affinity DataIC50: 9nMAssay Description:Inhibition of CYP2D6 in human liver microsomes using dextromethorphan as substrate after 10 mins by LC-MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/22/2017
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
University of Perugia

Curated by ChEMBL
LigandPNGBDBM1805(2-amino-6-[(3-methoxy-5-methylbenzene)sulfonyl]ben...)
Affinity DataIC50: 10nMAssay Description:Inhibitory concentration against Reverse transcriptaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/23/2013
Entry Details Article
PubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
University of Perugia

Curated by ChEMBL
LigandPNGBDBM1778(2-amino-6-(naphthalene-2-sulfonyl)benzonitrile | 2...)
Affinity DataIC50: 30nMAssay Description:Inhibitory concentration against Reverse transcriptaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/23/2013
Entry Details Article
PubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
University of Perugia

Curated by ChEMBL
LigandPNGBDBM1801(2-amino-6-[(3,5-dichlorobenzene)sulfonyl]benzonitr...)
Affinity DataIC50: 30nMAssay Description:Inhibitory concentration against Reverse transcriptaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/23/2013
Entry Details Article
PubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
University of Perugia

Curated by ChEMBL
LigandPNGBDBM1806(2-amino-6-{[3-methoxy-5-(trifluoromethyl)benzene]s...)
Affinity DataIC50: 40nMAssay Description:Inhibitory concentration against Reverse transcriptaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/23/2013
Entry Details Article
PubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
University of Perugia

Curated by ChEMBL
LigandPNGBDBM1751(2-amino-6-[(3,5-dichlorophenyl)sulfanyl]benzonitri...)
Affinity DataIC50: 120nMAssay Description:Inhibitory concentration against Reverse transcriptaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/23/2013
Entry Details Article
PubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
University of Perugia

Curated by ChEMBL
LigandPNGBDBM1753(2-amino-6-[(3-methoxy-5-methylphenyl)sulfanyl]benz...)
Affinity DataIC50: 141nMAssay Description:Inhibitory concentration against Reverse transcriptaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/23/2013
Entry Details Article
PubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
University of Perugia

Curated by ChEMBL
LigandPNGBDBM1792(2-amino-6-[(3-bromobenzene)sulfonyl]benzonitrile |...)
Affinity DataIC50: 200nMAssay Description:Inhibitory concentration against Reverse transcriptaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/23/2013
Entry Details Article
PubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
University of Perugia

Curated by ChEMBL
LigandPNGBDBM1786(2-amino-6-[(3-methylbenzene)sulfonyl]benzonitrile ...)
Affinity DataIC50: 200nMAssay Description:Inhibitory concentration against Reverse transcriptaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/23/2013
Entry Details Article
PubMed
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