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LigandPNGBDBM50239500(CHEMBL4066705 | US10329302, Example 337 | US107935...)
Affinity DataIC50: 0.100nMAssay Description:Inhibition of N-terminal His6-tagged human full length IRAK4 preincubated for 20 mins followed by biotinylated-AGAGRDKYKTLRQIR substrate addition in ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/22/2019
Entry Details Article
PubMed
LigandPNGBDBM50239499(CHEMBL4081711 | US10329302, Example 344 | US107935...)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of N-terminal His6-tagged human full length IRAK4 preincubated for 20 mins followed by biotinylated-AGAGRDKYKTLRQIR substrate addition in ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/22/2019
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50239498(CHEMBL4093120 | US10329302, Example 189 | US107935...)
Affinity DataIC50: 0.300nMAssay Description:Inhibition of N-terminal His6-tagged human full length IRAK4 preincubated for 20 mins followed by biotinylated-AGAGRDKYKTLRQIR substrate addition in ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/22/2019
Entry Details Article
PubMed
LigandPNGBDBM50239507(CHEMBL4091434 | US10329302, Example 246 | US107935...)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of N-terminal His6-tagged human full length IRAK4 preincubated for 20 mins followed by biotinylated-AGAGRDKYKTLRQIR substrate addition in ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/22/2019
Entry Details Article
PubMed
LigandPNGBDBM50239508(CHEMBL4085199 | US10329302, Example 309 | US107935...)
Affinity DataIC50: 0.600nMAssay Description:Inhibition of N-terminal His6-tagged human full length IRAK4 preincubated for 20 mins followed by biotinylated-AGAGRDKYKTLRQIR substrate addition in ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/22/2019
Entry Details Article
PubMed
TargetCarbonic anhydrase 2(Human)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM11390(2-(3-hydroxyphenyl)-3-(morpholin-4-ylmethyl)-1,1-d...)
Affinity DataIC50: 1.20nMAssay Description:Concentration which produces 50% inhibition of human Carbonic anhydrase IIMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2020
Entry Details Article
PubMed
LigandPNGBDBM50239493(CHEMBL4103497 | US10329302, Example 312 | US107935...)
Affinity DataIC50: 1.30nMAssay Description:Inhibition of N-terminal His6-tagged human full length IRAK4 preincubated for 20 mins followed by biotinylated-AGAGRDKYKTLRQIR substrate addition in ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/22/2019
Entry Details Article
PubMed
TargetCarbonic anhydrase 2(Human)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM11392((4R)-4-amino-2-(3-methoxypropyl)-1,1-dioxo-2H,3H,4...)
Affinity DataIC50: 1.30nMAssay Description:Concentration which produces 50% inhibition of human Carbonic anhydrase IIMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2020
Entry Details Article
PubMed
LigandPNGBDBM50239491(CHEMBL4083655 | US10329302, Example 173 | US107935...)
Affinity DataIC50: 1.30nMAssay Description:Inhibition of N-terminal His6-tagged human full length IRAK4 preincubated for 20 mins followed by biotinylated-AGAGRDKYKTLRQIR substrate addition in ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/22/2019
Entry Details Article
PubMed
TargetCarbonic anhydrase 2(Human)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM11391(2-(3-Methoxyphenyl)-3-[(4-morpholinyl)methyl]-2H-t...)
Affinity DataIC50: 1.30nMAssay Description:Concentration which produces 50% inhibition of human Carbonic anhydrase IIMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2020
Entry Details Article
PubMed
LigandPNGBDBM50239506(CHEMBL4071526 | US10329302, Example 188 | US107935...)
Affinity DataIC50: 1.90nMAssay Description:Inhibition of N-terminal His6-tagged human full length IRAK4 preincubated for 20 mins followed by biotinylated-AGAGRDKYKTLRQIR substrate addition in ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/22/2019
Entry Details Article
PubMed
TargetFocal adhesion kinase 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50246060(CHEMBL472212 | N-methyl-N-(2-((2-(2-oxoindolin-5-y...)
Affinity DataIC50: 2nMAssay Description:Inhibition of full-length C-terminal his-tagged human FAK pre-incubated with enzyme for 1 h prior to the addition of 500 uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
LigandPNGBDBM50239499(CHEMBL4081711 | US10329302, Example 344 | US107935...)
Affinity DataIC50: 2nMAssay Description:Inhibition of IRAK4 in human whole blood assessed as reduction R848-induced IL-6 secretion by measuring plasma protein binding corrected IC50 preincu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/22/2019
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50239499(CHEMBL4081711 | US10329302, Example 344 | US107935...)
Affinity DataIC50: 2nMAssay Description:Inhibition of IRAK4 in human PBMC assessed as reduction in R848-stimulated TNF alpha production by measuring plasma protein binding corrected IC50 af...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/22/2019
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50239499(CHEMBL4081711 | US10329302, Example 344 | US107935...)
Affinity DataIC50: 2nMAssay Description:Inhibition of IRAK4 in human PBMC assessed as reduction in R848-stimulated TNF alpha production after 3 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/22/2019
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetTyrosine-protein kinase SYK(Human)
Pfizer

LigandPNGBDBM92626(Pyrido analog, 3)
Affinity DataIC50: 2.10nMpH: 7.4 T: 2°CAssay Description:A Lance TR-FRET assay (Perkin Elmer) was used to measure and compare the potency of compounds against Syk kinase domain.More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50239497(CHEMBL4084228 | US10329302, Example 271 | US107935...)
Affinity DataIC50: 2.40nMAssay Description:Inhibition of N-terminal His6-tagged human full length IRAK4 preincubated for 20 mins followed by biotinylated-AGAGRDKYKTLRQIR substrate addition in ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/22/2019
Entry Details Article
PubMed
LigandPNGBDBM50239492(CHEMBL4070515 | US10329302, Example 211 | US107935...)
Affinity DataIC50: 2.70nMAssay Description:Inhibition of N-terminal His6-tagged human full length IRAK4 preincubated for 20 mins followed by biotinylated-AGAGRDKYKTLRQIR substrate addition in ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/22/2019
Entry Details Article
PubMed
TargetCarbonic anhydrase 2(Human)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM10885((4R)-4-(ethylamino)-2-(3-methoxypropyl)-1,1-dioxo-...)
Affinity DataIC50: 3.20nMAssay Description:Concentration which produces 50% inhibition of human Carbonic anhydrase IIMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50239505(CHEMBL4061801 | US10329302, Example 248 | US107935...)
Affinity DataIC50: 3.70nMAssay Description:Inhibition of N-terminal His6-tagged human full length IRAK4 preincubated for 20 mins followed by biotinylated-AGAGRDKYKTLRQIR substrate addition in ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/22/2019
Entry Details Article
PubMed
TargetCarbonic anhydrase 4(Human)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM11390(2-(3-hydroxyphenyl)-3-(morpholin-4-ylmethyl)-1,1-d...)
Affinity DataIC50: 4.30nMAssay Description:Concentration which produces 50% Inhibition of human Carbonic anhydrase IVMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2020
Entry Details Article
PubMed
LigandPNGBDBM50239488(CHEMBL4092338 | US10329302, Example 26 | US1079357...)
Affinity DataIC50: 4.60nMAssay Description:Inhibition of N-terminal His6-tagged human full length IRAK4 preincubated for 20 mins followed by biotinylated-AGAGRDKYKTLRQIR substrate addition in ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/22/2019
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50239496(CHEMBL4075552 | US10329302, Example 264 | US107935...)
Affinity DataIC50: 4.80nMAssay Description:Inhibition of N-terminal His6-tagged human full length IRAK4 preincubated for 20 mins followed by biotinylated-AGAGRDKYKTLRQIR substrate addition in ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/22/2019
Entry Details Article
PubMed
LigandPNGBDBM50239504(CHEMBL4061890 | US10329302, Example 262 | US107935...)
Affinity DataIC50: 5.90nMAssay Description:Inhibition of N-terminal His6-tagged human full length IRAK4 preincubated for 20 mins followed by biotinylated-AGAGRDKYKTLRQIR substrate addition in ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/22/2019
Entry Details Article
PubMed
TargetProtein-tyrosine kinase 2-beta(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50402996(CHEMBL2207440)
Affinity DataIC50: 6.40nMAssay Description:Inhibition of human recombinant C-terminal His-tagged PYK2 using ATP as substrate incubated for 1 hr prior to substrate additionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
LigandPNGBDBM50239500(CHEMBL4066705 | US10329302, Example 337 | US107935...)
Affinity DataIC50: 6.5nMAssay Description:Inhibition of IRAK4 in human PBMC assessed as reduction in R848-stimulated TNF alpha production after 3 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/22/2019
Entry Details Article
PubMed
TargetCarbonic anhydrase 4(Human)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM11391(2-(3-Methoxyphenyl)-3-[(4-morpholinyl)methyl]-2H-t...)
Affinity DataIC50: 7.40nMAssay Description:Concentration which produces 50% Inhibition of human Carbonic anhydrase IVMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2020
Entry Details Article
PubMed
LigandPNGBDBM50239489(CHEMBL4100091 | US10329302, Example 121 | US107935...)
Affinity DataIC50: 7.60nMAssay Description:Inhibition of N-terminal His6-tagged human full length IRAK4 preincubated for 20 mins followed by biotinylated-AGAGRDKYKTLRQIR substrate addition in ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/22/2019
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50239507(CHEMBL4091434 | US10329302, Example 246 | US107935...)
Affinity DataIC50: 9nMAssay Description:Inhibition of IRAK4 in human PBMC assessed as reduction in R848-stimulated TNF alpha production after 3 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/22/2019
Entry Details Article
PubMed
TargetProtein-tyrosine kinase 2-beta(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50246060(CHEMBL472212 | N-methyl-N-(2-((2-(2-oxoindolin-5-y...)
Affinity DataIC50: 11nMAssay Description:Inhibition of human recombinant N-terminal His-6-tagged thrombin cleavable fused PYK2 catalytic domain (residues Pro-416 to Glu-692) expressed in Sf9...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50239494(CHEMBL4079243 | US10329302, Example 340 | US107935...)
Affinity DataIC50: 12nMAssay Description:Inhibition of N-terminal His6-tagged human full length IRAK4 preincubated for 20 mins followed by biotinylated-AGAGRDKYKTLRQIR substrate addition in ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/22/2019
Entry Details Article
PubMed
TargetProtein-tyrosine kinase 2-beta(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50402999(CHEMBL2207441)
Affinity DataIC50: 13nMAssay Description:Inhibition of human recombinant C-terminal His-tagged PYK2 using ATP as substrate incubated for 1 hr prior to substrate additionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
LigandPNGBDBM50239498(CHEMBL4093120 | US10329302, Example 189 | US107935...)
Affinity DataIC50: 13nMAssay Description:Inhibition of IRAK4 in human PBMC assessed as reduction in R848-stimulated TNF alpha production after 3 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/22/2019
Entry Details Article
PubMed
LigandPNGBDBM50239508(CHEMBL4085199 | US10329302, Example 309 | US107935...)
Affinity DataIC50: 17nMAssay Description:Inhibition of IRAK4 in human PBMC assessed as reduction in R848-stimulated TNF alpha production after 3 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/22/2019
Entry Details Article
PubMed
LigandPNGBDBM50239490(CHEMBL4073250 | US10329302, Example 122 | US117024...)
Affinity DataIC50: 24nMAssay Description:Inhibition of N-terminal His6-tagged human full length IRAK4 preincubated for 20 mins followed by biotinylated-AGAGRDKYKTLRQIR substrate addition in ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/22/2019
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetProtein-tyrosine kinase 2-beta(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50403004(CHEMBL2207439)
Affinity DataIC50: 25nMAssay Description:Inhibition of human recombinant C-terminal His-tagged PYK2 using ATP as substrate incubated for 1 hr prior to substrate additionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
LigandPNGBDBM50239493(CHEMBL4103497 | US10329302, Example 312 | US107935...)
Affinity DataIC50: 28nMAssay Description:Inhibition of IRAK4 in human PBMC assessed as reduction in R848-stimulated TNF alpha production after 3 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/22/2019
Entry Details Article
PubMed
LigandPNGBDBM50239495(CHEMBL4076912 | US10329302, Example 247 | US107935...)
Affinity DataIC50: 29nMAssay Description:Inhibition of N-terminal His6-tagged human full length IRAK4 preincubated for 20 mins followed by biotinylated-AGAGRDKYKTLRQIR substrate addition in ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/22/2019
Entry Details Article
PubMed
LigandPNGBDBM50239506(CHEMBL4071526 | US10329302, Example 188 | US107935...)
Affinity DataIC50: 30nMAssay Description:Inhibition of IRAK4 in human PBMC assessed as reduction in R848-stimulated TNF alpha production after 3 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/22/2019
Entry Details Article
PubMed
TargetProtein-tyrosine kinase 2-beta(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50403003(CHEMBL2207823)
Affinity DataIC50: 31nMAssay Description:Inhibition of human recombinant C-terminal His-tagged PYK2 using ATP as substrate incubated for 1 hr prior to substrate additionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
LigandPNGBDBM50239491(CHEMBL4083655 | US10329302, Example 173 | US107935...)
Affinity DataIC50: 37nMAssay Description:Inhibition of IRAK4 in human PBMC assessed as reduction in R848-stimulated TNF alpha production after 3 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/22/2019
Entry Details Article
PubMed
TargetCarbonic anhydrase 4(Human)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM10885((4R)-4-(ethylamino)-2-(3-methoxypropyl)-1,1-dioxo-...)
Affinity DataIC50: 45nMAssay Description:Concentration which produces 50% Inhibition of human Carbonic anhydrase IVMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2020
Entry Details Article
PubMed
LigandPNGBDBM50239492(CHEMBL4070515 | US10329302, Example 211 | US107935...)
Affinity DataIC50: 52nMAssay Description:Inhibition of IRAK4 in human PBMC assessed as reduction in R848-stimulated TNF alpha production after 3 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/22/2019
Entry Details Article
PubMed
LigandPNGBDBM50239497(CHEMBL4084228 | US10329302, Example 271 | US107935...)
Affinity DataIC50: 52nMAssay Description:Inhibition of IRAK4 in human PBMC assessed as reduction in R848-stimulated TNF alpha production after 3 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/22/2019
Entry Details Article
PubMed
TargetProtein-tyrosine kinase 2-beta(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50402991(CHEMBL2207428)
Affinity DataIC50: 57nMAssay Description:Inhibition of human recombinant C-terminal His-tagged PYK2 using ATP as substrate incubated for 1 hr prior to substrate additionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetProtein-tyrosine kinase 2-beta(Mouse)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50402999(CHEMBL2207441)
Affinity DataIC50: 62nMAssay Description:Inhibition of PYK2 in mouse NIH-3T3 cells by LI-COR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetProtein-tyrosine kinase 2-beta(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50403001(CHEMBL2207438)
Affinity DataIC50: 69nMAssay Description:Inhibition of human recombinant C-terminal His-tagged PYK2 using ATP as substrate incubated for 1 hr prior to substrate additionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
LigandPNGBDBM50239509(CHEMBL4086222)
Affinity DataIC50: 72nMAssay Description:Inhibition of N-terminal His6-tagged human full length IRAK4 preincubated for 20 mins followed by biotinylated-AGAGRDKYKTLRQIR substrate addition in ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/22/2019
Entry Details Article
PubMed
TargetProtein-tyrosine kinase 2-beta(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50403002(CHEMBL2207430)
Affinity DataIC50: 75nMAssay Description:Inhibition of human recombinant C-terminal His-tagged PYK2 using ATP as substrate incubated for 1 hr prior to substrate additionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetProtein-tyrosine kinase 2-beta(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50402990(CHEMBL2207427)
Affinity DataIC50: 78nMAssay Description:Inhibition of human recombinant C-terminal His-tagged PYK2 using ATP as substrate incubated for 1 hr prior to substrate additionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
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