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TargetProstaglandin reductase 2(Human)
National Health Research Institutes

US Patent
LigandPNGBDBM616833(US20230279008, Compound 1 | 6-(4-chlorobenzyl)-2-(...)
Affinity DataEC50:  874nMAssay Description:Exemplary compounds thus prepared were evaluated for their efficacy in inhibiting PTGR2. In vitro enzyme activity was measured to determine the half ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2023
Entry Details
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TargetProstaglandin reductase 2(Human)
National Health Research Institutes

US Patent
LigandPNGBDBM616834(US20230279008, Compound 2 | (S)-6-isopropyl-2-((2-...)
Affinity DataEC50:  112nMAssay Description:Exemplary compounds thus prepared were evaluated for their efficacy in inhibiting PTGR2. In vitro enzyme activity was measured to determine the half ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2023
Entry Details
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TargetProstaglandin reductase 2(Human)
National Health Research Institutes

US Patent
LigandPNGBDBM616835(US20230279008, Compound 3 | 6-(2-fluorobenzyl)-5-m...)
Affinity DataEC50:  23.3nMAssay Description:Exemplary compounds thus prepared were evaluated for their efficacy in inhibiting PTGR2. In vitro enzyme activity was measured to determine the half ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2023
Entry Details
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TargetProstaglandin reductase 2(Human)
National Health Research Institutes

US Patent
LigandPNGBDBM616836(US20230279008, Compound 5 | 6-(2-fluoro-4-methoxyb...)
Affinity DataEC50:  40.5nMAssay Description:Exemplary compounds thus prepared were evaluated for their efficacy in inhibiting PTGR2. In vitro enzyme activity was measured to determine the half ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2023
Entry Details
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TargetProstaglandin reductase 2(Human)
National Health Research Institutes

US Patent
LigandPNGBDBM616837(US20230279008, Compound 6 | 6-(3-chloro-2-fluorobe...)
Affinity DataEC50:  300nMAssay Description:Exemplary compounds thus prepared were evaluated for their efficacy in inhibiting PTGR2. In vitro enzyme activity was measured to determine the half ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2023
Entry Details
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TargetProstaglandin reductase 2(Human)
National Health Research Institutes

US Patent
LigandPNGBDBM616838(US20230279008, Compound 7 | 5-methyl-2-(1-(4-pheny...)
Affinity DataEC50:  7nMAssay Description:Exemplary compounds thus prepared were evaluated for their efficacy in inhibiting PTGR2. In vitro enzyme activity was measured to determine the half ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2023
Entry Details
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TargetProstaglandin reductase 2(Human)
National Health Research Institutes

US Patent
LigandPNGBDBM616839(US20230279008, Compound 10 | 6-(3-fluorobenzyl)-5-...)
Affinity DataEC50:  77.4nMAssay Description:Exemplary compounds thus prepared were evaluated for their efficacy in inhibiting PTGR2. In vitro enzyme activity was measured to determine the half ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2023
Entry Details
Go to US Patent

TargetProstaglandin reductase 2(Human)
National Health Research Institutes

US Patent
LigandPNGBDBM616840(US20230279008, Compound 11 | 6-(3-chlorobenzyl)-5-...)
Affinity DataEC50:  61.4nMAssay Description:Exemplary compounds thus prepared were evaluated for their efficacy in inhibiting PTGR2. In vitro enzyme activity was measured to determine the half ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2023
Entry Details
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TargetProstaglandin reductase 2(Human)
National Health Research Institutes

US Patent
LigandPNGBDBM616841(US20230279008, Compound 12 | 6-(3-chlorobenzyl)-5-...)
Affinity DataEC50:  233nMAssay Description:Exemplary compounds thus prepared were evaluated for their efficacy in inhibiting PTGR2. In vitro enzyme activity was measured to determine the half ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2023
Entry Details
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TargetProstaglandin reductase 2(Human)
National Health Research Institutes

US Patent
LigandPNGBDBM616842(US20230279008, Compound 13 | 5-methyl-2-(1-(4-phen...)
Affinity DataEC50:  19.2nMAssay Description:Exemplary compounds thus prepared were evaluated for their efficacy in inhibiting PTGR2. In vitro enzyme activity was measured to determine the half ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2023
Entry Details
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TargetProstaglandin reductase 2(Human)
National Health Research Institutes

US Patent
LigandPNGBDBM616843(US20230279008, Compound 15 | 6-(3-fluoro-4-methoxy...)
Affinity DataEC50:  64.5nMAssay Description:Exemplary compounds thus prepared were evaluated for their efficacy in inhibiting PTGR2. In vitro enzyme activity was measured to determine the half ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2023
Entry Details
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TargetProstaglandin reductase 2(Human)
National Health Research Institutes

US Patent
LigandPNGBDBM616844(US20230279008, Compound 16 | 6-(3,4-difluorobenzyl...)
Affinity DataEC50:  16.5nMAssay Description:Exemplary compounds thus prepared were evaluated for their efficacy in inhibiting PTGR2. In vitro enzyme activity was measured to determine the half ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2023
Entry Details
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TargetProstaglandin reductase 2(Human)
National Health Research Institutes

US Patent
LigandPNGBDBM616845(US20230279008, Compound 17 | 5-methyl-6-(4-methylb...)
Affinity DataEC50:  104nMAssay Description:Exemplary compounds thus prepared were evaluated for their efficacy in inhibiting PTGR2. In vitro enzyme activity was measured to determine the half ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2023
Entry Details
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TargetProstaglandin reductase 2(Human)
National Health Research Institutes

US Patent
LigandPNGBDBM616846(US20230279008, Compound 18 | 6-(4-methoxybenzyl)-5...)
Affinity DataEC50:  280nMAssay Description:Exemplary compounds thus prepared were evaluated for their efficacy in inhibiting PTGR2. In vitro enzyme activity was measured to determine the half ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2023
Entry Details
Go to US Patent

TargetProstaglandin reductase 2(Human)
National Health Research Institutes

US Patent
LigandPNGBDBM616847(US20230279008, Compound 19 | 6-(4-fluorobenzyl)-5-...)
Affinity DataEC50:  56.9nMAssay Description:Exemplary compounds thus prepared were evaluated for their efficacy in inhibiting PTGR2. In vitro enzyme activity was measured to determine the half ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2023
Entry Details
Go to US Patent

TargetProstaglandin reductase 2(Human)
National Health Research Institutes

US Patent
LigandPNGBDBM616848(US20230279008, Compound 20 | 6-(4-chlorobenzyl)-5-...)
Affinity DataEC50:  161nMAssay Description:Exemplary compounds thus prepared were evaluated for their efficacy in inhibiting PTGR2. In vitro enzyme activity was measured to determine the half ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2023
Entry Details
Go to US Patent

TargetProstaglandin reductase 2(Human)
National Health Research Institutes

US Patent
LigandPNGBDBM616849(US20230279008, Compound 26 | 6-(3-chlorobenzyl)-5-...)
Affinity DataEC50:  530nMAssay Description:Exemplary compounds thus prepared were evaluated for their efficacy in inhibiting PTGR2. In vitro enzyme activity was measured to determine the half ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2023
Entry Details
Go to US Patent

TargetProstaglandin reductase 2(Human)
National Health Research Institutes

US Patent
LigandPNGBDBM616850(US20230279008, Compound 28 | (S)-2-((2-(4-(2-metho...)
Affinity DataEC50:  108nMAssay Description:Exemplary compounds thus prepared were evaluated for their efficacy in inhibiting PTGR2. In vitro enzyme activity was measured to determine the half ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2023
Entry Details
Go to US Patent

TargetProstaglandin reductase 2(Human)
National Health Research Institutes

US Patent
LigandPNGBDBM616851(US20230279008, Compound 32 | 6-(3-chlorobenzyl)-2-...)
Affinity DataEC50:  174nMAssay Description:Exemplary compounds thus prepared were evaluated for their efficacy in inhibiting PTGR2. In vitro enzyme activity was measured to determine the half ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2023
Entry Details
Go to US Patent

TargetProstaglandin reductase 2(Human)
National Health Research Institutes

US Patent
LigandPNGBDBM616852(US20230279008, Compound 34 | 6-(3-chlorobenzyl)-5-...)
Affinity DataEC50:  427nMAssay Description:Exemplary compounds thus prepared were evaluated for their efficacy in inhibiting PTGR2. In vitro enzyme activity was measured to determine the half ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2023
Entry Details
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TargetProstaglandin reductase 2(Human)
National Health Research Institutes

US Patent
LigandPNGBDBM616853(US20230279008, Compound 46 | 2-((2-oxo-2-(4-(thiaz...)
Affinity DataEC50:  119nMAssay Description:Exemplary compounds thus prepared were evaluated for their efficacy in inhibiting PTGR2. In vitro enzyme activity was measured to determine the half ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2023
Entry Details
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TargetProstaglandin reductase 2(Human)
National Health Research Institutes

US Patent
LigandPNGBDBM616854(US20230279008, Compound 47 | 6-(3-chlorobenzyl)-5-...)
Affinity DataEC50:  546nMAssay Description:Exemplary compounds thus prepared were evaluated for their efficacy in inhibiting PTGR2. In vitro enzyme activity was measured to determine the half ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2023
Entry Details
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TargetProstaglandin reductase 2(Human)
National Health Research Institutes

US Patent
LigandPNGBDBM616855(US20230279008, Compound 48 | 6-isopropyl-2-((2-oxo...)
Affinity DataEC50:  129nMAssay Description:Exemplary compounds thus prepared were evaluated for their efficacy in inhibiting PTGR2. In vitro enzyme activity was measured to determine the half ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2023
Entry Details
Go to US Patent

TargetProstaglandin reductase 2(Human)
National Health Research Institutes

US Patent
LigandPNGBDBM616856(US20230279008, Compound 53 | (R)-6-isopropyl-2-((2...)
Affinity DataEC50:  207nMAssay Description:Exemplary compounds thus prepared were evaluated for their efficacy in inhibiting PTGR2. In vitro enzyme activity was measured to determine the half ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2023
Entry Details
Go to US Patent

TargetProstaglandin reductase 2(Human)
National Health Research Institutes

US Patent
LigandPNGBDBM616857(US20230279008, Compound 54 | 6-(4-fluorobenzyl)-5-...)
Affinity DataEC50:  248nMAssay Description:Exemplary compounds thus prepared were evaluated for their efficacy in inhibiting PTGR2. In vitro enzyme activity was measured to determine the half ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2023
Entry Details
Go to US Patent

TargetProstaglandin reductase 2(Human)
National Health Research Institutes

US Patent
LigandPNGBDBM616858(US20230279008, Compound 63 | 2-((2-(4-(2-ethoxyphe...)
Affinity DataEC50:  164nMAssay Description:Exemplary compounds thus prepared were evaluated for their efficacy in inhibiting PTGR2. In vitro enzyme activity was measured to determine the half ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2023
Entry Details
Go to US Patent

TargetMelanocortin receptor 4(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50152799((R)-N-((R)-3-(4-chlorophenyl)-1-oxo-1-(4-(2-(1-(pi...)
Affinity DataEC50:  3.80nMAssay Description:Effective concentration against cAMP release in CHO cells expressing human melanocortin-4 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50152814((R)-1,2,3,4-Tetrahydro-isoquinoline-3-carboxylic a...)
Affinity DataEC50:  274nMAssay Description:Effective concentration against cAMP release in CHO cells expressing human melanocortin-4 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50152797((R)-1,2,3,4-Tetrahydro-isoquinoline-3-carboxylic a...)
Affinity DataEC50:  577nMAssay Description:Effective concentration against cAMP release in CHO cells expressing human melanocortin-4 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50152793((R)-1,2,3,4-Tetrahydro-isoquinoline-3-carboxylic a...)
Affinity DataEC50:  40nMAssay Description:Effective concentration against cAMP release in CHO cells expressing human melanocortin-4 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50152822((R)-1,2,3,4-Tetrahydro-isoquinoline-3-carboxylic a...)
Affinity DataEC50:  190nMAssay Description:Effective concentration against cAMP release in CHO cells expressing human melanocortin-4 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50134486(1,2,3,4-Tetrahydro-isoquinoline-3-carboxylic acid ...)
Affinity DataEC50:  80nMAssay Description:Effective concentration against cAMP release in CHO cells expressing human melanocortin-4 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50152802((R)-1,2,3,4-Tetrahydro-isoquinoline-3-carboxylic a...)
Affinity DataEC50:  15nMAssay Description:Effective concentration against cAMP release in CHO cells expressing human melanocortin-4 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50152796(1,2,3,4-Tetrahydro-isoquinoline-3-carboxylic acid ...)
Affinity DataEC50:  34nMAssay Description:Effective concentration against cAMP release in CHO cells expressing human melanocortin-4 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50152803((R)-1,2,3,4-Tetrahydro-isoquinoline-3-carboxylic a...)
Affinity DataEC50:  300nMAssay Description:Effective concentration against cAMP release in CHO cells expressing human melanocortin-4 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50152795(1,2,3,4-Tetrahydro-isoquinoline-3-carboxylic acid ...)
Affinity DataEC50:  12nMAssay Description:Effective concentration against cAMP release in CHO cells expressing human melanocortin-4 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50152805(1,2,3,4-Tetrahydro-isoquinoline-3-carboxylic acid ...)
Affinity DataEC50:  51nMAssay Description:Effective concentration against cAMP release in CHO cells expressing human melanocortin-4 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50152810(1,2,3,4-Tetrahydro-isoquinoline-3-carboxylic acid ...)
Affinity DataEC50:  146nMAssay Description:Effective concentration against cAMP release in CHO cells expressing human melanocortin-4 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50152815((R)-1,2,3,4-Tetrahydro-isoquinoline-3-carboxylic a...)
Affinity DataEC50:  208nMAssay Description:Effective concentration against cAMP release in CHO cells expressing human melanocortin-4 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50152819(3-{2-[4-((R)-3-(4-Chloro-phenyl)-2-{[(R)-oxo-(1,2,...)
Affinity DataEC50:  90nMAssay Description:Effective concentration against cAMP release in CHO cells expressing human melanocortin-4 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50152811(1,2,3,4-Tetrahydro-isoquinoline-3-carboxylic acid ...)
Affinity DataEC50:  91nMAssay Description:Effective concentration against cAMP release in CHO cells expressing human melanocortin-4 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50152799((R)-N-((R)-3-(4-chlorophenyl)-1-oxo-1-(4-(2-(1-(pi...)
Affinity DataEC50:  4.70nMAssay Description:Effective concentration for cAMP release in HEK293 cells expressing human melanocortin-4 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50152804(1,2,3,4-Tetrahydro-isoquinoline-3-carboxylic acid ...)
Affinity DataEC50:  487nMAssay Description:Effective concentration against cAMP release in CHO cells expressing human melanocortin-4 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50152806(1,2,3,4-Tetrahydro-isoquinoline-3-carboxylic acid ...)
Affinity DataEC50:  274nMAssay Description:Effective concentration against cAMP release in CHO cells expressing human melanocortin-4 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50152801((R)-1,2,3,4-Tetrahydro-isoquinoline-3-carboxylic a...)
Affinity DataEC50:  36nMAssay Description:Effective concentration against cAMP release in CHO cells expressing human melanocortin-4 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50139028(1,2,3,4-Tetrahydro-isoquinoline-3-carboxylic acid ...)
Affinity DataEC50:  7nMAssay Description:Effective concentration against cAMP release in CHO cells expressing human melanocortin-4 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50136357(N-[(R)-1-(4-Chloro-benzyl)-2-(4-cyclohexyl-4-[1,2,...)
Affinity DataEC50:  40nMAssay Description:Effective concentration against cAMP release in CHO cells expressing human melanocortin-4 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50152798(CHEMBL182231 | NBI-56453 | 1,2,3,4-Tetrahydro-isoq...)
Affinity DataEC50:  94nMAssay Description:Effective concentration against cAMP release in CHO cells expressing human melanocortin-4 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50152800(1,2,3,4-Tetrahydro-isoquinoline-3-carboxylic acid ...)
Affinity DataEC50:  72nMAssay Description:Effective concentration against cAMP release in CHO cells expressing human melanocortin-4 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50152809(N-[1-[(R)-(R)-2-(4-Butyryl-4-cyclohexyl-piperidin-...)
Affinity DataEC50:  2.90nMAssay Description:Effective concentration against cAMP release in CHO cells expressing human melanocortin-4 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
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