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TargetOxysterols receptor LXR-beta(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50167698(13-hydroxy-2,6-dimethyl-(2S,7R)-tricyclo[8.4.0.02,...)
Affinity DataEC50: <3nMAssay Description:Effective concentration for cofactor association with recombinant liver X receptor-betaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2012
Entry Details Article
PubMed
TargetOxysterols receptor LXR-beta(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50126018({3-chloro-4-[(3-{[7-propyl-3-(trifluoromethyl)-1,2...)
Affinity DataEC50:  1.08E+3nMAssay Description:Effective concentration against liver X receptor-beta in HEK293 cell transactivation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2012
Entry Details Article
PubMed
TargetOxysterols receptor LXR-alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50126018({3-chloro-4-[(3-{[7-propyl-3-(trifluoromethyl)-1,2...)
Affinity DataEC50:  35nMAssay Description:Effective concentration for cofactor association with recombinant liver X receptor-alphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetOxysterols receptor LXR-beta(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50167694(2,6-dimethyl-13-methylcarbonyloxy-(2S)-tricyclo[8....)
Affinity DataEC50:  10nMAssay Description:Effective concentration against liver X receptor-beta in HEK293 cell transactivation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2012
Entry Details Article
PubMed
TargetOxysterols receptor LXR-beta(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50167698(13-hydroxy-2,6-dimethyl-(2S,7R)-tricyclo[8.4.0.02,...)
Affinity DataEC50:  1nMAssay Description:Effective concentration against liver X receptor-beta in HEK293 cell transactivation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2012
Entry Details Article
PubMed
TargetOxysterols receptor LXR-alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50167698(13-hydroxy-2,6-dimethyl-(2S,7R)-tricyclo[8.4.0.02,...)
Affinity DataEC50:  1nMAssay Description:Effective concentration against liver X receptor-alpha in HEK293 cell transactivation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2012
Entry Details Article
PubMed
TargetOxysterols receptor LXR-alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50167696(12-hydroxypodocarpa-8,11,13-trien-16-oic acid | (1...)
Affinity DataEC50: >5.00E+4nMAssay Description:Effective concentration for cofactor association with recombinant liver X receptor-alphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2012
Entry Details Article
PubMed
TargetOxysterols receptor LXR-alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM20177((1S,2R,5S,10S,11S,14R,15S)-14-[(2S,3R)-3-hydroxy-6...)
Affinity DataEC50:  1.50E+4nMAssay Description:Effective concentration for cofactor association with recombinant liver X receptor-alphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2012
Entry Details Article
PubMed
TargetOxysterols receptor LXR-alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50167698(13-hydroxy-2,6-dimethyl-(2S,7R)-tricyclo[8.4.0.02,...)
Affinity DataEC50:  1nMAssay Description:Effective concentration for cofactor association with recombinant liver X receptor-alphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2012
Entry Details Article
PubMed
TargetOxysterols receptor LXR-beta(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50167697((4aS,10aR)-6-Hydroxy-1,4a-dimethyl-1,2,3,4,4a,9,10...)
Affinity DataEC50:  1nMAssay Description:Effective concentration for cofactor association with recombinant liver X receptor-betaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2012
Entry Details Article
PubMed
TargetOxysterols receptor LXR-alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50126018({3-chloro-4-[(3-{[7-propyl-3-(trifluoromethyl)-1,2...)
Affinity DataEC50:  35nMAssay Description:Effective concentration for cofactor association with recombinant liver X receptor-alphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetOxysterols receptor LXR-beta(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50167696(12-hydroxypodocarpa-8,11,13-trien-16-oic acid | (1...)
Affinity DataEC50: >5.00E+4nMAssay Description:Effective concentration for cofactor association with recombinant liver X receptor-betaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2012
Entry Details Article
PubMed
TargetOxysterols receptor LXR-beta(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50167697((4aS,10aR)-6-Hydroxy-1,4a-dimethyl-1,2,3,4,4a,9,10...)
Affinity DataEC50: <3nMAssay Description:Effective concentration against liver X receptor-beta in HEK293 cell transactivation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2012
Entry Details Article
PubMed
TargetOxysterols receptor LXR-beta(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50167694(2,6-dimethyl-13-methylcarbonyloxy-(2S)-tricyclo[8....)
Affinity DataEC50:  2nMAssay Description:Effective concentration for cofactor association with recombinant liver X receptor-betaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2012
Entry Details Article
PubMed
TargetOxysterols receptor LXR-alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50167694(2,6-dimethyl-13-methylcarbonyloxy-(2S)-tricyclo[8....)
Affinity DataEC50:  2nMAssay Description:Effective concentration for cofactor association with recombinant liver X receptor-alphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2012
Entry Details Article
PubMed
TargetOxysterols receptor LXR-alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50126018({3-chloro-4-[(3-{[7-propyl-3-(trifluoromethyl)-1,2...)
Affinity DataEC50:  1.79E+3nMAssay Description:Effective concentration against liver X receptor-alpha in HEK293 cell transactivation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetOxysterols receptor LXR-alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50167694(2,6-dimethyl-13-methylcarbonyloxy-(2S)-tricyclo[8....)
Affinity DataEC50:  10nMAssay Description:Effective concentration against liver X receptor-alpha in HEK293 cell transactivation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2012
Entry Details Article
PubMed
TargetOxysterols receptor LXR-beta(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM20177((1S,2R,5S,10S,11S,14R,15S)-14-[(2S,3R)-3-hydroxy-6...)
Affinity DataEC50:  1.50E+4nMAssay Description:Effective concentration for cofactor association with recombinant liver X receptor-betaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2012
Entry Details Article
PubMed
TargetOxysterols receptor LXR-alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50167699(1-((9R,10S)-6-Hydroxy-1,4a-dimethyl-1,2,3,4,4a,9,1...)
Affinity DataEC50:  320nMAssay Description:Effective concentration for cofactor association with recombinant liver X receptor-alphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2012
Entry Details Article
PubMed
TargetOxysterols receptor LXR-alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50167697((4aS,10aR)-6-Hydroxy-1,4a-dimethyl-1,2,3,4,4a,9,10...)
Affinity DataEC50:  1nMAssay Description:Effective concentration for cofactor association with recombinant liver X receptor-alphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2012
Entry Details Article
PubMed
TargetOxysterols receptor LXR-alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50167697((4aS,10aR)-6-Hydroxy-1,4a-dimethyl-1,2,3,4,4a,9,10...)
Affinity DataEC50: <3nMAssay Description:Effective concentration against liver X receptor-alpha in HEK293 cell transactivation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2012
Entry Details Article
PubMed
TargetOxysterols receptor LXR-beta(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50126018({3-chloro-4-[(3-{[7-propyl-3-(trifluoromethyl)-1,2...)
Affinity DataEC50:  16nMAssay Description:Effective concentration for cofactor association with recombinant liver X receptor-betaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2012
Entry Details Article
PubMed
TargetOxysterols receptor LXR-beta(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50167697((4aS,10aR)-6-Hydroxy-1,4a-dimethyl-1,2,3,4,4a,9,10...)
Affinity DataIC50: 1nMAssay Description:Displacement of [3H2]-F3-methyl AA (1) from liver X receptor-beta in SPA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2012
Entry Details Article
PubMed
TargetOxysterols receptor LXR-alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50167697((4aS,10aR)-6-Hydroxy-1,4a-dimethyl-1,2,3,4,4a,9,10...)
Affinity DataIC50: 1nMAssay Description:Displacement of [3H2]-F3-methyl AA (1) from liver X receptor-alpha in SPA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2012
Entry Details Article
PubMed
TargetOxysterols receptor LXR-beta(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50167698(13-hydroxy-2,6-dimethyl-(2S,7R)-tricyclo[8.4.0.02,...)
Affinity DataIC50: 1nMAssay Description:Displacement of [3H2]-F3-methyl AA (1) from liver X receptor-beta in SPA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2012
Entry Details Article
PubMed
TargetOxysterols receptor LXR-beta(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50167694(2,6-dimethyl-13-methylcarbonyloxy-(2S)-tricyclo[8....)
Affinity DataIC50: 2nMAssay Description:Displacement of [3H2]-F3-methyl AA (1) from liver X receptor-beta in SPA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2012
Entry Details Article
PubMed
TargetOxysterols receptor LXR-alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50167698(13-hydroxy-2,6-dimethyl-(2S,7R)-tricyclo[8.4.0.02,...)
Affinity DataIC50: 2nMAssay Description:Displacement of [3H2]-F3-methyl AA (1) from liver X receptor-alpha in SPA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2012
Entry Details Article
PubMed
TargetOxysterols receptor LXR-alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50167694(2,6-dimethyl-13-methylcarbonyloxy-(2S)-tricyclo[8....)
Affinity DataIC50: 2nMAssay Description:Displacement of [3H2]-F3-methyl AA (1) from liver X receptor-alpha in SPA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2012
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Industrial Technology Research Institute

Curated by ChEMBL
LigandPNGBDBM4814(SUNITINIB MALATE | CHEMBL535 | N-[2-(diethylamino)...)
Affinity DataIC50: 3nMAssay Description:Inhibition of FLT3 by time resolved fluorescence methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Industrial Technology Research Institute

Curated by ChEMBL
LigandPNGBDBM50328416((Z)-3-((4-(3-(dimethylamino)propoxy)-3-methylazule...)
Affinity DataIC50: 5nMAssay Description:Inhibition of FLT3 by time resolved fluorescence methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
National Tsing Hua University

Curated by ChEMBL
LigandPNGBDBM50349120(CHEMBL1807196)
Affinity DataIC50: 6nMAssay Description:Inhibition of RET kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Industrial Technology Research Institute

Curated by ChEMBL
LigandPNGBDBM50328406((Z)-3-((4-(3-(dimethylamino)propoxy)-3-methylazule...)
Affinity DataIC50: 12nMAssay Description:Inhibition of FLT3 by time resolved fluorescence methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetOxysterols receptor LXR-beta(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50167700((1S,4aS,10aR)-6-Hydroxy-1,4a-dimethyl-1,2,3,4,4a,9...)
Affinity DataIC50: 12nMAssay Description:Displacement of [3H2]-F3-methyl AA (1) from liver X receptor-beta in SPA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2012
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Industrial Technology Research Institute

Curated by ChEMBL
LigandPNGBDBM50328417((Z)-4,5-difluoro-3-((3-methyl-4-(3-morpholinopropo...)
Affinity DataIC50: 12nMAssay Description:Inhibition of FLT3 by time resolved fluorescence methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Industrial Technology Research Institute

Curated by ChEMBL
LigandPNGBDBM50328419((Z)-3-((4-(3-(diethylamino)propoxy)-3-methylazulen...)
Affinity DataIC50: 14nMAssay Description:Inhibition of FLT3 by time resolved fluorescence methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetOxysterols receptor LXR-alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50167700((1S,4aS,10aR)-6-Hydroxy-1,4a-dimethyl-1,2,3,4,4a,9...)
Affinity DataIC50: 14nMAssay Description:Effective concentration against liver X receptor-alpha in HEK293 cell transactivation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2012
Entry Details Article
PubMed
TargetMast/stem cell growth factor receptor Kit(Human)
Industrial Technology Research Institute

Curated by ChEMBL
LigandPNGBDBM4814(SUNITINIB MALATE | CHEMBL535 | N-[2-(diethylamino)...)
Affinity DataIC50: 15nMAssay Description:Inhibition of c-Kit autophosphorylation in human Kasumi-1 cells by Western blot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Industrial Technology Research Institute

Curated by ChEMBL
LigandPNGBDBM4814(SUNITINIB MALATE | CHEMBL535 | N-[2-(diethylamino)...)
Affinity DataIC50: 16nMAssay Description:Inhibition of FLT3 autophosphorylation in human RS4-11 cells by Western blot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetPlatelet-derived growth factor receptor beta(Human)
Industrial Technology Research Institute

Curated by ChEMBL
LigandPNGBDBM4814(SUNITINIB MALATE | CHEMBL535 | N-[2-(diethylamino)...)
Affinity DataIC50: 17nMAssay Description:Inhibition of PDGFRbeta autophosphorylation by cell based Western blot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Industrial Technology Research Institute

Curated by ChEMBL
LigandPNGBDBM50328418((Z)-4,5-difluoro-3-((3-methyl-4-(3-(piperidin-1-yl...)
Affinity DataIC50: 17nMAssay Description:Inhibition of FLT3 by time resolved fluorescence methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Industrial Technology Research Institute

Curated by ChEMBL
LigandPNGBDBM50328415((Z)-3-((4-(2-(4-(dimethylamino)piperidin-1-yl)etho...)
Affinity DataIC50: 18nMAssay Description:Inhibition of FLT3 by time resolved fluorescence methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Industrial Technology Research Institute

Curated by ChEMBL
LigandPNGBDBM50328403((Z)-5-fluoro-3-((3-methyl-4-(2-morpholinoethoxy)az...)
Affinity DataIC50: 19nMAssay Description:Inhibition of FLT3 by time resolved fluorescence methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Industrial Technology Research Institute

Curated by ChEMBL
LigandPNGBDBM50328401((Z)-5-fluoro-3-((3-fluoroazulen-1-yl)methylene)ind...)
Affinity DataIC50: 23nMAssay Description:Inhibition of FLT3 by time resolved fluorescence methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetOxysterols receptor LXR-beta(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50126018({3-chloro-4-[(3-{[7-propyl-3-(trifluoromethyl)-1,2...)
Affinity DataIC50: 25nMAssay Description:Displacement of [3H2]-F3-methyl AA (1) from liver X receptor-beta in SPA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2012
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Industrial Technology Research Institute

Curated by ChEMBL
LigandPNGBDBM50328405((E)-3-((4-(3-(dimethylamino)propoxy)-3-methylazule...)
Affinity DataIC50: 25nMAssay Description:Inhibition of FLT3 by time resolved fluorescence methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetPlatelet-derived growth factor receptor beta(Human)
Industrial Technology Research Institute

Curated by ChEMBL
LigandPNGBDBM50328414(E/Z-(S)-5-fluoro-3-((4-(2-(2-(hydroxymethyl)pyrrol...)
Affinity DataIC50: 28nMAssay Description:Inhibition of PDGFRbeta autophosphorylation by cell based Western blot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetOxysterols receptor LXR-beta(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50167695(13-[13-hydroxy-2,6-dimethyl-(2S,6S,7R)-tricyclo[8....)
Affinity DataIC50: 29nMAssay Description:Displacement of [3H2]-F3-methyl AA (1) from liver X receptor-beta in SPA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2012
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Industrial Technology Research Institute

Curated by ChEMBL
LigandPNGBDBM50328407((E)-3-((4-(3-(diethylamino)propoxy)-3-methylazulen...)
Affinity DataIC50: 30nMAssay Description:Inhibition of FLT3 by time resolved fluorescence methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetOxysterols receptor LXR-alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50126018({3-chloro-4-[(3-{[7-propyl-3-(trifluoromethyl)-1,2...)
Affinity DataIC50: 35nMAssay Description:Displacement of [3H2]-F3-methyl AA (1) from liver X receptor-alpha in SPA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
National Tsing Hua University

Curated by ChEMBL
LigandPNGBDBM50349119(CHEMBL1807197)
Affinity DataIC50: 36nMAssay Description:Inhibition of RET kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
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