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TargetPotassium voltage-gated channel subfamily H member 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50275364(N-(2-amino-5-(thiophen-2-yl)phenyl)-6-(2-oxo-3-oxa...)
Affinity DataEC50: >3.00E+4nMAssay Description:Activity at human ERG expressed in CHO cells by patch-clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50275885(6-(2-acetyl-2,8-diazaspiro[4.5]decan-8-yl)-N-(2-am...)
Affinity DataEC50:  1.01E+4nMAssay Description:Activity at human ERG expressed in CHO cells by patch-clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50275986(6-(2-acetyl-2,7-diazaspiro[4.5]decan-7-yl)-N-(2-am...)
Affinity DataEC50:  1.00E+4nMAssay Description:Activity at human ERG expressed in CHO cells by patch-clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50275985(6-(2-acetyl-2,7-diazaspiro[3.5]nonan-7-yl)-N-(2-am...)
Affinity DataEC50:  1.01E+4nMAssay Description:Activity at human ERG expressed in CHO cells by patch-clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50275984(6-(7-acetyl-2,7-diazaspiro[4.4]nonan-2-yl)-N-(2-am...)
Affinity DataEC50:  1.03E+4nMAssay Description:Activity at human ERG expressed in CHO cells by patch-clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50275941(N-(2-amino-5-(thiophen-2-yl)phenyl)-6-(2-(2-hydrox...)
Affinity DataEC50:  6.50E+3nMAssay Description:Activity at human ERG expressed in CHO cells by patch-clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50275888(N-(2-amino-5-(thiophen-2-yl)phenyl)-6-(2-(pyrimidi...)
Affinity DataEC50:  3.35E+3nMAssay Description:Activity at human ERG expressed in CHO cells by patch-clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50275887(N-(2-amino-5-(thiophen-2-yl)phenyl)-6-(2-(methylsu...)
Affinity DataEC50:  3.30E+3nMAssay Description:Activity at human ERG expressed in CHO cells by patch-clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50275886(8-(5-(2-amino-5-(thiophen-2-yl)phenylcarbamoyl)pyr...)
Affinity DataEC50:  5.00E+3nMAssay Description:Activity at human ERG expressed in CHO cells by patch-clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50275770(N-(2-amino-5-(thiophen-2-yl)phenyl)-6-(2,8-diazasp...)
Affinity DataEC50:  1.00E+4nMAssay Description:Activity at human ERG expressed in CHO cells by patch-clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50276028(N-(2-amino-5-(thiophen-2-yl)phenyl)-6-(1-oxo-2,8-d...)
Affinity DataEC50:  1.80E+4nMAssay Description:Activity at human ERG expressed in CHO cells by patch-clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetHepatocyte growth factor receptor(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50427138(CHEMBL2323775 | MK-8033)
Affinity DataKd:  10nMAssay Description:Binding affinity to unphosphorylated c-MET kinase domain (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetHepatocyte growth factor receptor(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50427138(CHEMBL2323775 | MK-8033)
Affinity DataKd:  3.20nMAssay Description:Binding affinity to phosphorylated c-MET kinase domain (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetHepatocyte growth factor receptor(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50427143(CHEMBL2323783)
Affinity DataIC50: 1nMAssay Description:Inhibition of c-MET (unknown origin)-catalyzed N-biotinylated EQEDEPEGDYFEWLECONH2 phosphorylation by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetHepatocyte growth factor receptor(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50427138(CHEMBL2323775 | MK-8033)
Affinity DataIC50: 1nMAssay Description:Inhibition of c-MET (unknown origin)-catalyzed N-biotinylated EQEDEPEGDYFEWLECONH2 phosphorylation by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetHepatocyte growth factor receptor(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50427155(CHEMBL2323770)
Affinity DataIC50: 1nMAssay Description:Inhibition of c-MET (unknown origin)-catalyzed N-biotinylated EQEDEPEGDYFEWLECONH2 phosphorylation by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetHepatocyte growth factor receptor(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50347659(CHEMBL1802916 | MK-2461)
Affinity DataIC50: 2nMAssay Description:Inhibition of c-MET (unknown origin)-catalyzed N-biotinylated EQEDEPEGDYFEWLECONH2 phosphorylation by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetHepatocyte growth factor receptor(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50427172(CHEMBL2323777)
Affinity DataIC50: 2nMAssay Description:Inhibition of c-MET (unknown origin)-catalyzed N-biotinylated EQEDEPEGDYFEWLECONH2 phosphorylation by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetHepatocyte growth factor receptor(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50347658(CHEMBL1802917)
Affinity DataIC50: 3nMAssay Description:Inhibition of c-MET (unknown origin)-catalyzed N-biotinylated EQEDEPEGDYFEWLECONH2 phosphorylation by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetHepatocyte growth factor receptor(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50427151(CHEMBL2323774)
Affinity DataIC50: 3nMAssay Description:Inhibition of c-MET (unknown origin)-catalyzed N-biotinylated EQEDEPEGDYFEWLECONH2 phosphorylation by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetHepatocyte growth factor receptor(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50427153(CHEMBL2323772)
Affinity DataIC50: 3nMAssay Description:Inhibition of c-MET (unknown origin)-catalyzed N-biotinylated EQEDEPEGDYFEWLECONH2 phosphorylation by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetHepatocyte growth factor receptor(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50427154(CHEMBL2323771)
Affinity DataIC50: 3nMAssay Description:Inhibition of c-MET (unknown origin)-catalyzed N-biotinylated EQEDEPEGDYFEWLECONH2 phosphorylation by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetHistone deacetylase 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50278466(pyridin-3-ylmethyl 4-(2-amino-5-(thiophen-2-yl)phe...)
Affinity DataIC50: 3.5nMAssay Description:Inhibition of HDAC1More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetHistone deacetylase 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM27774(N-[2-amino-5-(thiophen-2-yl)phenyl]-4-{1,8-diazasp...)
Affinity DataIC50: 4nMpH: 8.0 T: 2°CAssay Description:The Fluor-de-Lys HDAC activity assay kit (Biomol) was used. Purified recombinant HDAC enzyme was incubated with Fluor-de-Lys substrate in the presenc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2009
Entry Details Article
PubMed
TargetHepatocyte growth factor receptor(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50347681(CHEMBL1802829)
Affinity DataIC50: 4nMAssay Description:Inhibition of c-MET (unknown origin)-catalyzed N-biotinylated EQEDEPEGDYFEWLECONH2 phosphorylation by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetHepatocyte growth factor receptor(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50427156(CHEMBL2323769)
Affinity DataIC50: 5nMAssay Description:Inhibition of c-MET (unknown origin)-catalyzed N-biotinylated EQEDEPEGDYFEWLECONH2 phosphorylation by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetHistone deacetylase 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM19412(pyridin-3-ylmethyl N-[(4-{[2-amino-5-(thiophen-2-y...)
Affinity DataIC50: 6nMAssay Description:Inhibition of HDAC2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetHistone deacetylase 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50275941(N-(2-amino-5-(thiophen-2-yl)phenyl)-6-(2-(2-hydrox...)
Affinity DataIC50: 6nMAssay Description:Inhibition of human HDAC1 expressed in mammalian cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetHepatocyte growth factor receptor(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50427157(CHEMBL2324128)
Affinity DataIC50: 6nMAssay Description:Inhibition of c-MET (unknown origin)-catalyzed N-biotinylated EQEDEPEGDYFEWLECONH2 phosphorylation by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetHistone deacetylase 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50016941(CHEMBL3286732)
Affinity DataIC50: 6nMAssay Description:Inhibition of FLAG-tagged full-length human recombinant HDAC1 expressed in HEK293F cells using acetyl-lysine containing peptide as substrate preincub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2015
Entry Details Article
PubMed
TargetHistone deacetylase 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50278467(ethyl 4-(2-amino-5-(thiophen-2-yl)phenylcarbamoyl)...)
Affinity DataIC50: 6.5nMAssay Description:Inhibition of HDAC1More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetHistone deacetylase 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50229197(ethyl 4-((2-amino-5-(thiophen-2-yl)phenyl)carbamoy...)
Affinity DataIC50: 7nMAssay Description:Inhibition of HDAC1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetHistone deacetylase 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50275363(N-(2-amino-5-(thiophen-2-yl)phenyl)-6-(2-oxo-1,3,8...)
Affinity DataIC50: 7nMAssay Description:Inhibition of human HDAC1 expressed in mammalian cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetHistone deacetylase 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50278377(methyl 4-(2-amino-5-(thiophen-2-yl)phenylcarbamoyl...)
Affinity DataIC50: 7nMAssay Description:Inhibition of HDAC1More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetHistone deacetylase 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50374057(CHEMBL407560)
Affinity DataIC50: 7nMAssay Description:Inhibition of HDAC1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetHistone deacetylase 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM19423(N-[2-amino-5-(thiophen-2-yl)phenyl]-4-acetamidoben...)
Affinity DataIC50: 7nMAssay Description:Inhibition of HDAC1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
LigandPNGBDBM50427138(CHEMBL2323775 | MK-8033)
Affinity DataIC50: 7nMAssay Description:Inhibition of RON (unknown origin) by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
LigandPNGBDBM50347681(CHEMBL1802829)
Affinity DataIC50: 7nMAssay Description:Inhibition of RON (unknown origin) by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetHistone deacetylase 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50278515(diethyl(4-(2-amino-5-(thiophen-2-yl)phenylcarbamoy...)
Affinity DataIC50: 7.70nMAssay Description:Inhibition of HDAC1More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetHistone deacetylase 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM27773(N-(2-amino-5-phenylphenyl)-4-{1,8-diazaspiro[4.5]d...)
Affinity DataIC50: 8nMpH: 8.0 T: 2°CAssay Description:The Fluor-de-Lys HDAC activity assay kit (Biomol) was used. Purified recombinant HDAC enzyme was incubated with Fluor-de-Lys substrate in the presenc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2009
Entry Details Article
PubMed
TargetHistone deacetylase 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM27775(N-[2-amino-5-(thiophen-3-yl)phenyl]-4-{1,8-diazasp...)
Affinity DataIC50: 8nMpH: 8.0 T: 2°CAssay Description:The Fluor-de-Lys HDAC activity assay kit (Biomol) was used. Purified recombinant HDAC enzyme was incubated with Fluor-de-Lys substrate in the presenc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2009
Entry Details Article
PubMed
TargetHistone deacetylase 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM27782(N-(2-amino-5-phenylphenyl)-4-{1,8-diazaspiro[4.5]d...)
Affinity DataIC50: 8nMpH: 8.0 T: 2°CAssay Description:The Fluor-de-Lys HDAC activity assay kit (Biomol) was used. Purified recombinant HDAC enzyme was incubated with Fluor-de-Lys substrate in the presenc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2009
Entry Details Article
PubMed
TargetHistone deacetylase 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50229204([4-(4-amino-biphenyl-3-ylcarbamoyl)-benzyl]-carbam...)
Affinity DataIC50: 8nMAssay Description:Inhibition of HDAC1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetHistone deacetylase 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50275770(N-(2-amino-5-(thiophen-2-yl)phenyl)-6-(2,8-diazasp...)
Affinity DataIC50: 8nMAssay Description:Inhibition of human HDAC1 expressed in mammalian cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetHistone deacetylase 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50275887(N-(2-amino-5-(thiophen-2-yl)phenyl)-6-(2-(methylsu...)
Affinity DataIC50: 8nMAssay Description:Inhibition of human HDAC1 expressed in mammalian cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetHistone deacetylase 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50275986(6-(2-acetyl-2,7-diazaspiro[4.5]decan-7-yl)-N-(2-am...)
Affinity DataIC50: 8nMAssay Description:Inhibition of human HDAC1 expressed in mammalian cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetHistone deacetylase 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50275364(N-(2-amino-5-(thiophen-2-yl)phenyl)-6-(2-oxo-3-oxa...)
Affinity DataIC50: 8nMAssay Description:Inhibition of human HDAC1 expressed in mammalian cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetHepatocyte growth factor receptor(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50427144(CHEMBL2323782)
Affinity DataIC50: 8nMAssay Description:Inhibition of c-MET (unknown origin)-catalyzed N-biotinylated EQEDEPEGDYFEWLECONH2 phosphorylation by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetHepatocyte growth factor receptor(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50427152(CHEMBL2323773)
Affinity DataIC50: 8nMAssay Description:Inhibition of c-MET (unknown origin)-catalyzed N-biotinylated EQEDEPEGDYFEWLECONH2 phosphorylation by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetHistone deacetylase 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50229194(N-(2-amino-5-(thiophen-2-yl)phenyl)-4-(propionamid...)
Affinity DataIC50: 9nMAssay Description:Inhibition of HDAC1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
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