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TargetTrifunctional purine biosynthetic protein adenosine-3(Human)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50393640(CHEMBL2158681)
Affinity DataIC50: 1.79nMAssay Description:Inhibition of GARFTase in human IGROV1 cells assessed as reduction in [14C]glycine incorporation into [14C]formyl GAR incubated for 15 hrs in complet...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetTrifunctional purine biosynthetic protein adenosine-3(Human)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50393639(CHEMBL2158682)
Affinity DataIC50: 2.03nMAssay Description:Inhibition of GARFTase in human IGROV1 cells assessed as reduction in [14C]glycine incorporation into [14C]formyl GAR incubated for 15 hrs in complet...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetTrifunctional purine biosynthetic protein adenosine-3(Human)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50442985(CHEMBL3086865)
Affinity DataIC50: 2.90nMAssay Description:In situ inhibition of GRAFTase in human KB cells assessed as incorporation of [14C]-glycine into [14C]-formyl GAR preincubated for 30 mins followed b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetTrifunctional purine biosynthetic protein adenosine-3(Human)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50306576((S)-2-({5-[4-(2-Amino-4-oxo-4,7-dihydro-3H-pyrrolo...)
Affinity DataIC50: 3.46nMAssay Description:Inhibition of GARFTase in human IGROV1 cells assessed as reduction in [14C]glycine incorporation into [14C]formyl GAR incubated for 15 hrs in complet...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetTrifunctional purine biosynthetic protein adenosine-3(Human)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50442984(CHEMBL3086866 | AGF147)
Affinity DataIC50: 5.5nMAssay Description:In situ inhibition of GRAFTase in human KB cells assessed as incorporation of [14C]-glycine into [14C]-formyl GAR preincubated for 30 mins followed b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetTrifunctional purine biosynthetic protein adenosine-3(Human)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50005518(CHEMBL142806 | (S)-2-{(R)-4-[2-((R)-2-Amino-4-oxo-...)
Affinity DataIC50: 5.77nMAssay Description:Inhibition of GARFTase in human IGROV1 cells assessed as reduction in [14C]glycine incorporation into [14C]formyl GAR incubated for 15 hrs in complet...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetTrifunctional purine biosynthetic protein adenosine-3(Human)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50171511(N-{4-[4-(2-Amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-...)
Affinity DataIC50: 6.80nMAssay Description:Inhibition of GARFTase in human KB cells assessed as inhibition of [14C]glycine incorporation into [14C]formylGAR in presence of azaserineMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetTrifunctional purine biosynthetic protein adenosine-3(Human)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50272272(N-{4-[5-(2-Amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-...)
Affinity DataIC50: 7.20nMAssay Description:Inhibition of GARFTase in human KB cells assessed as inhibition of [14C]glycine incorporation into [14C]formylGAR in presence of azaserineMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2012
Entry Details Article
PubMed
TargetTrifunctional purine biosynthetic protein adenosine-3(Human)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50272273(N-{4-[6-(2-Amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-...)
Affinity DataIC50: 8.60nMAssay Description:Inhibition of GARFTase in human KB cells assessed as inhibition of [14C]glycine incorporation into [14C]formylGAR in presence of azaserineMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2012
Entry Details Article
PubMed
TargetTrifunctional purine biosynthetic protein adenosine-3(Human)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50442983(CHEMBL3086867)
Affinity DataIC50: 9.60nMAssay Description:In situ inhibition of GRAFTase in human KB cells assessed as incorporation of [14C]-glycine into [14C]-formyl GAR preincubated for 30 mins followed b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
TargetTrifunctional purine biosynthetic protein adenosine-3(Human)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50249877((S)-2-(4-(4-(2-amino-4-oxo-3,4-dihydrothieno[2,3-d...)
Affinity DataIC50: 13nMAssay Description:Inhibition of GARFTase in human KB cells assessed as inhibition of incorporation of [14C]glycine into [14C]formyl GAR after 30 mins in presence of az...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTrifunctional purine biosynthetic protein adenosine-3(Human)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM22590(5,10-dideazatetrahydrofolic acid | DDF | (2S)-2-[(...)
Affinity DataIC50: 14nMAssay Description:Inhibition of GARFTase in human KB cells assessed as inhibition of incorporation of [14C]glycine into [14C]formyl GAR after 30 mins in presence of az...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTrifunctional purine biosynthetic protein adenosine-3(Human)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50005518(CHEMBL142806 | (S)-2-{(R)-4-[2-((R)-2-Amino-4-oxo-...)
Affinity DataIC50: 14nMAssay Description:Inhibition of GARFTase in human KB cells assessed as inhibition of [14C]glycine incorporation into [14C]formylGAR in presence of azaserineMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2012
Entry Details Article
PubMed
TargetTrifunctional purine biosynthetic protein adenosine-3(Human)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50249876(N-{4-[3-(2-Amino-4-oxo-3,4-dihydrothieno[2,3-d]pyr...)
Affinity DataIC50: 14nMAssay Description:Inhibition of GARFTase in human KB cells assessed as inhibition of incorporation of [14C]glycine into [14C]formyl GAR after 30 mins in presence of az...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTrifunctional purine biosynthetic protein adenosine-3(Human)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50171513((S)-2-(4-(3-(2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[...)
Affinity DataIC50: 18nMAssay Description:Inhibition of GARFTase in human KB cells assessed as inhibition of [14C]glycine incorporation into [14C]formylGAR in presence of azaserineMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2012
Entry Details Article
PubMed
TargetTrifunctional purine biosynthetic protein adenosine-3(Human)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50249953(N-{4-[5-(2-Amino-4-oxo-3,4-dihydrothieno[2,3-d]pyr...)
Affinity DataIC50: 24nMAssay Description:Inhibition of GARFTase in human KB cells assessed as inhibition of incorporation of [14C]glycine into [14C]formyl GAR after 30 mins in presence of az...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTrifunctional purine biosynthetic protein adenosine-3(Human)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50249954(N-{4-[6-(2-Amino-4-oxo-3,4-dihydrothieno[2,3-d]pyr...)
Affinity DataIC50: 27nMAssay Description:Inhibition of GARFTase in human KB cells assessed as inhibition of incorporation of [14C]glycine into [14C]formyl GAR after 30 mins in presence of az...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTrifunctional purine biosynthetic protein adenosine-3(Human)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM18796((2S)-2-{[4-(2-{2-amino-4-oxo-1H,4H,7H-pyrrolo[2,3-...)
Affinity DataIC50: 30nMAssay Description:Inhibition of GARFTase in human KB cells assessed as inhibition of incorporation of [14C]glycine into [14C]formyl GAR after 30 mins in presence of az...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTrifunctional purine biosynthetic protein adenosine-3(Human)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM18796((2S)-2-{[4-(2-{2-amino-4-oxo-1H,4H,7H-pyrrolo[2,3-...)
Affinity DataIC50: 30nMAssay Description:Inhibition of GARFTase in human KB cells assessed as inhibition of [14C]glycine incorporation into [14C]formylGAR in presence of azaserineMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2012
Entry Details Article
PubMed
TargetTrifunctional purine biosynthetic protein adenosine-3(Human)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50249875(N-{4-[2-(2-Amino-4-oxo-3,4-dihydrothieno[2,3-d]pyr...)
Affinity DataIC50: 32nMAssay Description:Inhibition of GARFTase in human KB cells assessed as inhibition of incorporation of [14C]glycine into [14C]formyl GAR after 30 mins in presence of az...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTrifunctional purine biosynthetic protein adenosine-3(Mouse)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50306576((S)-2-({5-[4-(2-Amino-4-oxo-4,7-dihydro-3H-pyrrolo...)
Affinity DataIC50: 60nMAssay Description:Inhibition of mouse recombinant GARFtase assessed as FGAR formation by spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2012
Entry Details Article
PubMed
TargetTrifunctional purine biosynthetic protein adenosine-3(Mouse)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50171511(N-{4-[4-(2-Amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-...)
Affinity DataIC50: 150nMAssay Description:Inhibition of mouse recombinant GARFTaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetTrifunctional purine biosynthetic protein adenosine-3(Human)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50306576((S)-2-({5-[4-(2-Amino-4-oxo-4,7-dihydro-3H-pyrrolo...)
Affinity DataIC50: 630nMAssay Description:Inhibition of GARFtase in human KB cells assessed as [14C]glycine incorporation in to [14C]FGAR in folate free RPMI medium with 2 nM LCV by in-situas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2012
Entry Details Article
PubMed
TargetTrifunctional purine biosynthetic protein adenosine-3(Mouse)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM22590(5,10-dideazatetrahydrofolic acid | DDF | (2S)-2-[(...)
Affinity DataIC50: 780nMAssay Description:Inhibition of mouse recombinant GARFTaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTrifunctional purine biosynthetic protein adenosine-3(Mouse)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50005518(CHEMBL142806 | (S)-2-{(R)-4-[2-((R)-2-Amino-4-oxo-...)
Affinity DataIC50: 780nMAssay Description:Inhibition of mouse recombinant GARFtase assessed as FGAR formation by spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2012
Entry Details Article
PubMed
TargetTrifunctional purine biosynthetic protein adenosine-3(Mouse)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50005518(CHEMBL142806 | (S)-2-{(R)-4-[2-((R)-2-Amino-4-oxo-...)
Affinity DataIC50: 780nMAssay Description:Inhibition of mouse recombinant GARFTaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2012
Entry Details Article
PubMed
TargetTrifunctional purine biosynthetic protein adenosine-3(Human)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50272231((S)-2-(4-((2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of GARFTase in human KB cells assessed as inhibition of [14C]glycine incorporation into [14C]formylGAR in presence of azaserineMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2012
Entry Details Article
PubMed
TargetTrifunctional purine biosynthetic protein adenosine-3(Mouse)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50272272(N-{4-[5-(2-Amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-...)
Affinity DataIC50: 2.26E+3nMAssay Description:Inhibition of mouse recombinant GARFTaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2012
Entry Details Article
PubMed
TargetTrifunctional purine biosynthetic protein adenosine-3(Mouse)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50171513((S)-2-(4-(3-(2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[...)
Affinity DataIC50: 2.44E+3nMAssay Description:Inhibition of mouse recombinant GARFTaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2012
Entry Details Article
PubMed
TargetTrifunctional purine biosynthetic protein adenosine-3(Mouse)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50272273(N-{4-[6-(2-Amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-...)
Affinity DataIC50: 2.51E+3nMAssay Description:Inhibition of mouse recombinant GARFTaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2012
Entry Details Article
PubMed
TargetTrifunctional purine biosynthetic protein adenosine-3(Mouse)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50306577((S)-2-({5-[5-(2-Amino-4-oxo-4,7-dihydro-3H-pyrrolo...)
Affinity DataIC50: 3.31E+3nMAssay Description:Inhibition of mouse recombinant GARFtase assessed as FGAR formation by spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2012
Entry Details Article
PubMed
TargetTrifunctional purine biosynthetic protein adenosine-3(Mouse)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50249877((S)-2-(4-(4-(2-amino-4-oxo-3,4-dihydrothieno[2,3-d...)
Affinity DataIC50: 5.51E+3nMAssay Description:Inhibition of mouse recombinant GARFTaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTrifunctional purine biosynthetic protein adenosine-3(Human)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50171511(N-{4-[4-(2-Amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-...)
Affinity DataIC50: 6.80E+3nMAssay Description:Inhibition of GARFtase in human KB cells assessed as [14C]glycine incorporation in to [14C]FGAR in folate free RPMI medium with 2 nM LCV by in-situas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetTrifunctional purine biosynthetic protein adenosine-3(Human)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50306577((S)-2-({5-[5-(2-Amino-4-oxo-4,7-dihydro-3H-pyrrolo...)
Affinity DataIC50: 7.65E+3nMAssay Description:Inhibition of GARFtase in human KB cells assessed as [14C]glycine incorporation in to [14C]FGAR in folate free RPMI medium with 2 nM LCV by in-situas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2012
Entry Details Article
PubMed
TargetTrifunctional purine biosynthetic protein adenosine-3(Mouse)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50249876(N-{4-[3-(2-Amino-4-oxo-3,4-dihydrothieno[2,3-d]pyr...)
Affinity DataIC50: 8.52E+3nMAssay Description:Inhibition of mouse recombinant GARFTaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTrifunctional purine biosynthetic protein adenosine-3(Human)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50249877((S)-2-(4-(4-(2-amino-4-oxo-3,4-dihydrothieno[2,3-d...)
Affinity DataIC50: 1.33E+4nMAssay Description:Inhibition of GARFtase in human KB cells assessed as [14C]glycine incorporation in to [14C]FGAR in folate free RPMI medium with 2 nM LCV by in-situas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2012
Entry Details Article
PubMed
TargetTrifunctional purine biosynthetic protein adenosine-3(Human)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50005518(CHEMBL142806 | (S)-2-{(R)-4-[2-((R)-2-Amino-4-oxo-...)
Affinity DataIC50: 1.40E+4nMAssay Description:Inhibition of GARFtase in human KB cells assessed as [14C]glycine incorporation in to [14C]FGAR in folate free RPMI medium with 2 nM LCV by in-situas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2012
Entry Details Article
PubMed
TargetTrifunctional purine biosynthetic protein adenosine-3(Mouse)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM18796((2S)-2-{[4-(2-{2-amino-4-oxo-1H,4H,7H-pyrrolo[2,3-...)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of mouse recombinant GARFTaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTrifunctional purine biosynthetic protein adenosine-3(Mouse)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM18796((2S)-2-{[4-(2-{2-amino-4-oxo-1H,4H,7H-pyrrolo[2,3-...)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of mouse recombinant GARFtase assessed as FGAR formation by spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2012
Entry Details Article
PubMed
TargetTrifunctional purine biosynthetic protein adenosine-3(Mouse)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM18796((2S)-2-{[4-(2-{2-amino-4-oxo-1H,4H,7H-pyrrolo[2,3-...)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of mouse recombinant GARFTaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2012
Entry Details Article
PubMed
TargetTrifunctional purine biosynthetic protein adenosine-3(Mouse)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50272231((S)-2-(4-((2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,...)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of mouse recombinant GARFTaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2012
Entry Details Article
PubMed
TargetTrifunctional purine biosynthetic protein adenosine-3(Mouse)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50249954(N-{4-[6-(2-Amino-4-oxo-3,4-dihydrothieno[2,3-d]pyr...)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of mouse recombinant GARFTaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTrifunctional purine biosynthetic protein adenosine-3(Mouse)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50249953(N-{4-[5-(2-Amino-4-oxo-3,4-dihydrothieno[2,3-d]pyr...)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of mouse recombinant GARFTaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTrifunctional purine biosynthetic protein adenosine-3(Mouse)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50249875(N-{4-[2-(2-Amino-4-oxo-3,4-dihydrothieno[2,3-d]pyr...)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of mouse recombinant GARFTaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetTrifunctional purine biosynthetic protein adenosine-3(Human)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM18796((2S)-2-{[4-(2-{2-amino-4-oxo-1H,4H,7H-pyrrolo[2,3-...)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of GARFtase in human KB cells assessed as [14C]glycine incorporation in to [14C]FGAR in folate free RPMI medium with 2 nM LCV by in-situas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2012
Entry Details Article
PubMed
TargetTrifunctional purine biosynthetic protein adenosine-3(Mouse)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50171511(N-{4-[4-(2-Amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-...)
Affinity DataIC50: 1.50E+5nMAssay Description:Inhibition of mouse recombinant GARFtase assessed as FGAR formation by spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetTrifunctional purine biosynthetic protein adenosine-3(Mouse)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50249877((S)-2-(4-(4-(2-amino-4-oxo-3,4-dihydrothieno[2,3-d...)
Affinity DataIC50: 5.51E+6nMAssay Description:Inhibition of mouse recombinant GARFtase assessed as FGAR formation by spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2012
Entry Details Article
PubMed
TargetProton-coupled folate transporter(Human)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM18796((2S)-2-{[4-(2-{2-amino-4-oxo-1H,4H,7H-pyrrolo[2,3-...)
Affinity DataKi:  94nMpH: 5.5Assay Description:Inhibition of [3H]MTX transport at human PCFT expressed in Chinese hamster R2 cells at pH 5.5 by Dixon plotMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetProton-coupled folate transporter(Human)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM18796((2S)-2-{[4-(2-{2-amino-4-oxo-1H,4H,7H-pyrrolo[2,3-...)
Affinity DataKi:  96nMpH: 5.5Assay Description:Displacement of [3H]MTX from human PCFT expressed in Chinese hamster R2 cells at pH 5.5 by Dixon plotMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2012
Entry Details Article
PubMed
TargetProton-coupled folate transporter(Human)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50306577((S)-2-({5-[5-(2-Amino-4-oxo-4,7-dihydro-3H-pyrrolo...)
Affinity DataKi:  100nMpH: 5.5Assay Description:Displacement of [3H]MTX from human PCFT expressed in Chinese hamster R2 cells at pH 5.5 by Dixon plotMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2012
Entry Details Article
PubMed
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