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TargetAmyloid-beta precursor protein(Human)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50173647(4-[(E)-2-(4-Methylamino-phenyl)-vinyl]-phenol | [3...)
Affinity DataKd:  2.40nMAssay Description:Binding affinity to Beta amyloid aggregates in Alzheimer's disease patient brainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2020
Entry Details Article
PubMed
TargetCalmodulin-domain protein kinase 1(Toxoplasma gondii)
University of Washington

Curated by ChEMBL
LigandPNGBDBM416558(US10307425, Example 24 | US10632122, Example 24)
Affinity DataEC50:  430nMAssay Description:Inhibition of wild type hemagglutinin-tagged Toxoplasma gondii RH CDPK1 assessed as parasite growth inhibition infected in human foreskin fibroblasts...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
TargetCalmodulin-domain protein kinase 1(Toxoplasma gondii)
University of Washington

Curated by ChEMBL
LigandPNGBDBM416559(US10307425, Example 25 | US10632122, Example 25)
Affinity DataEC50:  470nMAssay Description:Inhibition of wild type hemagglutinin-tagged Toxoplasma gondii RH CDPK1 assessed as parasite growth inhibition infected in human foreskin fibroblasts...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
University of Washington

Curated by ChEMBL
LigandPNGBDBM50148749(CHEMBL3770313 | US9518026, Example 70 | US9956214,...)
Affinity DataEC50:  2.28E+4nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/29/2018
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
University of Washington

Curated by ChEMBL
LigandPNGBDBM50148648(CHEMBL3770743 | US9518026, Example 54 | US9956214,...)
Affinity DataEC50: >3.00E+4nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/29/2018
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
University of Washington

Curated by ChEMBL
LigandPNGBDBM50446178(CHEMBL3108913 | US9518026, Example 3 | US9956214, ...)
Affinity DataEC50: >3.00E+4nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/29/2018
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
University of Washington

Curated by ChEMBL
LigandPNGBDBM50446179(CHEMBL3109011 | US9518026, Example 39 | US9956214,...)
Affinity DataEC50: >3.00E+4nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/29/2018
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
University of Washington

Curated by ChEMBL
LigandPNGBDBM50148652(CHEMBL3770802 | US9518026, Example 57 | US9956214,...)
Affinity DataEC50:  1.41E+4nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/29/2018
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
University of Washington

Curated by ChEMBL
LigandPNGBDBM50200557(CHEMBL3908956)
Affinity DataEC50: >3.00E+4nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/29/2018
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
University of Washington

Curated by ChEMBL
LigandPNGBDBM50446172(CHEMBL3108997 | US9518026, Example 24 | US9956214,...)
Affinity DataEC50: >1.00E+4nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/29/2018
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
University of Washington

Curated by ChEMBL
LigandPNGBDBM50148632(CHEMBL3770409 | US9518026, Example 40 | US9956214,...)
Affinity DataEC50:  1.88E+4nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/29/2018
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
University of Washington

Curated by ChEMBL
LigandPNGBDBM50148728(CHEMBL3770425 | US9518026, Example 65 | US9956214,...)
Affinity DataEC50: >3.00E+4nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/29/2018
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
University of Washington

Curated by ChEMBL
LigandPNGBDBM50446177(CHEMBL3108991 | US9518026, Example 18 | US9956214,...)
Affinity DataEC50: >3.00E+4nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/29/2018
Entry Details Article
PubMed
LigandPNGBDBM28365(CHEMBL512355 | N-[4-(2-cyanoethyl)cyclohexyl]-N-cy...)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of 11beta-HSD1 in human adipocytesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2012
Entry Details Article
PubMed
LigandPNGBDBM50248471(1,1,1-trifluoro-2-(4-((R)-2-methyl-4-((1-(pyridin-...)
Affinity DataIC50: 0.400nMAssay Description:Inhibition of full length human recombinant 11beta-HSD1 expressed in baculovirus insect cell system assessed as conversion of [3H]cortisone to [3H]co...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50248519(1,1,1-trifluoro-2-(4-((R)-2-methyl-4-((1-(pyridin-...)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of full length human recombinant 11beta-HSD1 expressed in baculovirus insect cell system assessed as conversion of [3H]cortisone to [3H]co...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50248472(1,1,1-trifluoro-2-(4-((R)-2-methyl-4-((1-(pyridin-...)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of full length human recombinant 11beta-HSD1 expressed in baculovirus insect cell system assessed as conversion of [3H]cortisone to [3H]co...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50248521(1,1,1-trifluoro-2-(4-((R)-2-methyl-4-((1-(pyridin-...)
Affinity DataIC50: 0.600nMAssay Description:Inhibition of full length human recombinant 11beta-HSD1 expressed in baculovirus insect cell system assessed as conversion of [3H]cortisone to [3H]co...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50248518(1,1,1-trifluoro-2-(4-((R)-2-methyl-4-((1-(pyridin-...)
Affinity DataIC50: 0.600nMAssay Description:Inhibition of full length human recombinant 11beta-HSD1 expressed in baculovirus insect cell system assessed as conversion of [3H]cortisone to [3H]co...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50248569((1-(((R)-3-methyl-4-(4-((S)-1,1,1-trifluoro-2-hydr...)
Affinity DataIC50: 0.700nMAssay Description:Inhibition of full length human recombinant 11beta-HSD1 expressed in baculovirus insect cell system assessed as conversion of [3H]cortisone to [3H]co...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM28365(CHEMBL512355 | N-[4-(2-cyanoethyl)cyclohexyl]-N-cy...)
Affinity DataIC50: 0.700nMAssay Description:Inhibition of human cloned 11beta-HSD1 by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2012
Entry Details Article
PubMed
LigandPNGBDBM50243635(N-((1r,4S)-4-(4-cyanophenyl)cyclohexyl)-N-cyclopro...)
Affinity DataIC50: 0.700nMAssay Description:Inhibition of human cloned 11beta-HSD1 by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2012
Entry Details Article
PubMed
TargetCalmodulin-domain protein kinase 1(Toxoplasma gondii)
University of Washington

Curated by ChEMBL
LigandPNGBDBM416551(US10307425, Example 17 | US10632122, Example 17)
Affinity DataIC50: 0.800nMAssay Description:Inhibition of recombinant Toxoplasma gondii CDPK1 using Biotin-C6-PLARTLSVAGLPGKK as substrate after 90 mins in presence of ATP by luciferase reporte...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
LigandPNGBDBM50248520(1,1,1-trifluoro-2-(4-((R)-2-methyl-4-((1-(pyridin-...)
Affinity DataIC50: 0.800nMAssay Description:Inhibition of full length human recombinant 11beta-HSD1 expressed in baculovirus insect cell system assessed as conversion of [3H]cortisone to [3H]co...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50243632((S)-N-Cyclohexyl-4-(1,1,1-trifluoro-2-hydroxypropa...)
Affinity DataIC50: 0.800nMAssay Description:Inhibition of human cloned 11beta-HSD1 by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2012
Entry Details Article
PubMed
TargetCalmodulin-domain protein kinase 1(Toxoplasma gondii)
University of Washington

Curated by ChEMBL
LigandPNGBDBM416560(US10307425, Example 26 | US10632122, Example 26)
Affinity DataIC50: 0.900nMAssay Description:Inhibition of recombinant Toxoplasma gondii CDPK1 using Biotin-C6-PLARTLSVAGLPGKK as substrate after 90 mins in presence of ATP by luciferase reporte...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
LigandPNGBDBM50248469(2-(4-((R)-4-(2,2-difluoro-2-(pyridin-4-yl)ethyl)-2...)
Affinity DataIC50: 0.900nMAssay Description:Inhibition of full length human recombinant 11beta-HSD1 expressed in baculovirus insect cell system assessed as conversion of [3H]cortisone to [3H]co...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetCalmodulin-domain protein kinase 1(Toxoplasma gondii)
University of Washington

Curated by ChEMBL
LigandPNGBDBM416558(US10307425, Example 24 | US10632122, Example 24)
Affinity DataIC50: 1nMAssay Description:Inhibition of recombinant Toxoplasma gondii CDPK1 using Biotin-C6-PLARTLSVAGLPGKK as substrate after 90 mins in presence of ATP by luciferase reporte...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
LigandPNGBDBM50248310((R)-1-(4-tert-butylphenylsulfonyl)-2-methyl-4-(3-(...)
Affinity DataIC50: 1nMAssay Description:Inhibition of full length human recombinant 11beta-HSD1 expressed in baculovirus insect cell system assessed as conversion of [3H]cortisone to [3H]co...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetCalmodulin-domain protein kinase 1(Toxoplasma gondii)
University of Washington

Curated by ChEMBL
LigandPNGBDBM50534390(CHEMBL4455656)
Affinity DataIC50: 1.10nMAssay Description:Inhibition of recombinant Toxoplasma gondii CDPK1 using Biotin-C6-PLARTLSVAGLPGKK as substrate after 90 mins in presence of ATP by luciferase reporte...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
LigandPNGBDBM50248470(2-(4-((R)-4-(2,2-difluoro-2-(pyridin-3-yl)ethyl)-2...)
Affinity DataIC50: 1.10nMAssay Description:Inhibition of full length human recombinant 11beta-HSD1 expressed in baculovirus insect cell system assessed as conversion of [3H]cortisone to [3H]co...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetCalmodulin-domain protein kinase 1(Toxoplasma gondii)
University of Washington

Curated by ChEMBL
LigandPNGBDBM416552(US10307425, Example 18 | US10632122, Example 18)
Affinity DataIC50: 1.20nMAssay Description:Inhibition of recombinant Toxoplasma gondii CDPK1 using Biotin-C6-PLARTLSVAGLPGKK as substrate after 90 mins in presence of ATP by luciferase reporte...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
LigandPNGBDBM50248568(4-(1-(((3R)-3-methyl-4-(4-(1,1,1-trifluoro-2-hydro...)
Affinity DataIC50: 1.20nMAssay Description:Inhibition of full length human recombinant 11beta-HSD1 expressed in baculovirus insect cell system assessed as conversion of [3H]cortisone to [3H]co...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetCalmodulin-domain protein kinase 1(Toxoplasma gondii)
University of Washington

Curated by ChEMBL
LigandPNGBDBM416553(US10307425, Example 19 | US10632122, Example 19)
Affinity DataIC50: 1.30nMAssay Description:Inhibition of recombinant Toxoplasma gondii CDPK1 using Biotin-C6-PLARTLSVAGLPGKK as substrate after 90 mins in presence of ATP by luciferase reporte...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
TargetGlutamate carboxypeptidase 2(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM50544832(CHEMBL4636677)
Affinity DataIC50: 1.30nMAssay Description:Displacement of [125I]MIP-1095 from PSMA in human PC3-PIP cells after 1 hr by gamma counter analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
LigandPNGBDBM50248427(1,1,1-trifluoro-2-(4-((R)-2-methyl-4-(2-(pyridin-3...)
Affinity DataIC50: 1.30nMAssay Description:Inhibition of full length human recombinant 11beta-HSD1 expressed in baculovirus insect cell system assessed as conversion of [3H]cortisone to [3H]co...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50243595((S)-N-Cyclohexyl-4-(1,1,1-trifluoro-2-hydroxypropa...)
Affinity DataIC50: 1.30nMAssay Description:Inhibition of human recombinant 11beta-HSD1 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2012
Entry Details Article
PubMed
LigandPNGBDBM50243633(N-cyclopropyl-N-((1r,4S)-4-phenylcyclohexyl)-4-((S...)
Affinity DataIC50: 1.30nMAssay Description:Inhibition of human cloned 11beta-HSD1 by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2012
Entry Details Article
PubMed
LigandPNGBDBM28365(CHEMBL512355 | N-[4-(2-cyanoethyl)cyclohexyl]-N-cy...)
Affinity DataIC50: 1.30nMAssay Description:Inhibition of human recombinant 11beta-HSD1 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2012
Entry Details Article
PubMed
LigandPNGBDBM28361(N-cyclopropyl-N-[4-(pyridin-3-yl)cyclohexyl]-4-[(2...)
Affinity DataIC50: 1.40nMAssay Description:Inhibition of human cloned 11beta-HSD1 by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2012
Entry Details Article
PubMed
TargetCalmodulin-domain protein kinase 1(Toxoplasma gondii)
University of Washington

Curated by ChEMBL
LigandPNGBDBM416538(US10307425, Example 4 | US10632122, Example 4)
Affinity DataIC50: 1.5nMAssay Description:Inhibition of recombinant Toxoplasma gondii CDPK1 using Biotin-C6-PLARTLSVAGLPGKK as substrate after 90 mins in presence of ATP by luciferase reporte...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
TargetCalmodulin-domain protein kinase 1(Toxoplasma gondii)
University of Washington

Curated by ChEMBL
LigandPNGBDBM50534383(CHEMBL4517731)
Affinity DataIC50: 1.60nMAssay Description:Inhibition of recombinant Toxoplasma gondii CDPK1 using Biotin-C6-PLARTLSVAGLPGKK as substrate after 90 mins in presence of ATP by luciferase reporte...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
LigandPNGBDBM50248566(1-(((3R)-3-methyl-4-(4-(1,1,1-trifluoro-2-hydroxyp...)
Affinity DataIC50: 1.70nMAssay Description:Inhibition of full length human recombinant 11beta-HSD1 expressed in baculovirus insect cell system assessed as conversion of [3H]cortisone to [3H]co...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50243595((S)-N-Cyclohexyl-4-(1,1,1-trifluoro-2-hydroxypropa...)
Affinity DataIC50: 1.70nMAssay Description:Inhibition of human cloned 11beta-HSD1 by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2012
Entry Details Article
PubMed
TargetCalmodulin-domain protein kinase 1(Toxoplasma gondii)
University of Washington

Curated by ChEMBL
LigandPNGBDBM416554(US10307425, Example 20 | US10632122, Example 20)
Affinity DataIC50: 1.80nMAssay Description:Inhibition of recombinant Toxoplasma gondii CDPK1 using Biotin-C6-PLARTLSVAGLPGKK as substrate after 90 mins in presence of ATP by luciferase reporte...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
TargetCalmodulin-domain protein kinase 1(Toxoplasma gondii)
University of Washington

Curated by ChEMBL
LigandPNGBDBM416556(US10307425, Example 22 | US10632122, Example 22)
Affinity DataIC50: 1.80nMAssay Description:Inhibition of recombinant Toxoplasma gondii CDPK1 using Biotin-C6-PLARTLSVAGLPGKK as substrate after 90 mins in presence of ATP by luciferase reporte...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
TargetCalmodulin-domain protein kinase 1(Toxoplasma gondii)
University of Washington

Curated by ChEMBL
LigandPNGBDBM50534388(CHEMBL4573817)
Affinity DataIC50: 2nMAssay Description:Inhibition of recombinant Toxoplasma gondii CDPK1 using Biotin-C6-PLARTLSVAGLPGKK as substrate after 90 mins in presence of ATP by luciferase reporte...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
TargetCalmodulin-domain protein kinase 1(Toxoplasma gondii)
University of Washington

Curated by ChEMBL
LigandPNGBDBM416559(US10307425, Example 25 | US10632122, Example 25)
Affinity DataIC50: 2nMAssay Description:Inhibition of recombinant Toxoplasma gondii CDPK1 using Biotin-C6-PLARTLSVAGLPGKK as substrate after 90 mins in presence of ATP by luciferase reporte...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
TargetCalmodulin-domain protein kinase 1(Toxoplasma gondii)
University of Washington

Curated by ChEMBL
LigandPNGBDBM50534385(CHEMBL4537636)
Affinity DataIC50: 2nMAssay Description:Inhibition of recombinant Toxoplasma gondii CDPK1 using Biotin-C6-PLARTLSVAGLPGKK as substrate after 90 mins in presence of ATP by luciferase reporte...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
TargetGlutamate carboxypeptidase 2(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM50544834(CHEMBL4636963)
Affinity DataIC50: 2nMAssay Description:Displacement of [125I]MIP-1095 from PSMA in human PC3-PIP cells after 1 hr by gamma counter analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
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