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TargetIntegrin alpha-1/beta-1 [T112H](Human)
University of Pennsylvania

LigandPNGBDBM19053((2S)-2-{[(2R)-1-(benzenesulfonyl)pyrrolidin-2-yl]f...)
Affinity DataAssay Description:Flat bottom microtiter plates (96-well) were coated with soluble type I collagen. Unoccupied protein binding sites on the wells were blocked with bov...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetIntegrin alpha-1/beta-1 [T112H](Human)
University of Pennsylvania

LigandPNGBDBM19057((2S)-3-({[(4-aminophenyl)methyl]carbamoyl}amino)-2...)
Affinity DataAssay Description:Flat bottom microtiter plates (96-well) were coated with soluble type I collagen. Unoccupied protein binding sites on the wells were blocked with bov...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetIntegrin alpha-1/beta-1 [T112H](Human)
University of Pennsylvania

LigandPNGBDBM19063((2S)-3-[(benzylcarbamoyl)amino]-2-{[(2S)-1-[(3,5-d...)
Affinity DataAssay Description:Flat bottom microtiter plates (96-well) were coated with soluble type I collagen. Unoccupied protein binding sites on the wells were blocked with bov...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetIntegrin alpha-1/beta-1 [T112H](Human)
University of Pennsylvania

LigandPNGBDBM19066((2S)-3-[(benzylcarbamoyl)amino]-2-{[(2S)-1-[(3,5-d...)
Affinity DataAssay Description:Flat bottom microtiter plates (96-well) were coated with soluble type I collagen. Unoccupied protein binding sites on the wells were blocked with bov...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetIntegrin alpha-1/beta-1 [T112H](Human)
University of Pennsylvania

LigandPNGBDBM19068((2S)-3-[(benzylcarbamoyl)amino]-2-{[(2S)-1-(naphth...)
Affinity DataAssay Description:Flat bottom microtiter plates (96-well) were coated with soluble type I collagen. Unoccupied protein binding sites on the wells were blocked with bov...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM20319(3-[(4-tert-butylphenyl)methyl]-1-[2-(4-methanesulf...)
Affinity DataEC50:  1.80E+3nMpH: 7.4 T: 2°CAssay Description:Binding assay mixtures were set up and contained [3H] RTX, various concentrations of competing ligands, and rVR1-transfected CHO cells. Nonspecific b...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine/threonine-protein kinase MRCK alpha(Human)
National Cancer Institute-Bethesda

LigandPNGBDBM92594(Phorbol ester (PDBU))
Affinity DataKd:  10.3nMpH: 7.4 T: 2°CAssay Description:[3H]PDBu binding to the C1 domains of MRCK alpha/beta and PKC alpha/delta was measured using the polyethylene glycol precipitation assay.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine/threonine-protein kinase MRCK beta(Human)
National Cancer Institute-Bethesda

LigandPNGBDBM92594(Phorbol ester (PDBU))
Affinity DataKd:  17nMpH: 7.4 T: 2°CAssay Description:[3H]PDBu binding to the C1 domains of MRCK alpha/beta and PKC alpha/delta was measured using the polyethylene glycol precipitation assay.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProtein kinase C alpha type(Human)
National Cancer Institute-Bethesda

LigandPNGBDBM92594(Phorbol ester (PDBU))
Affinity DataKd:  3.40nMpH: 7.4 T: 2°CAssay Description:[3H]PDBu binding to the C1 domains of MRCK alpha/beta and PKC alpha/delta was measured using the polyethylene glycol precipitation assay.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProtein kinase C delta type(Human)
National Cancer Institute-Bethesda

LigandPNGBDBM92594(Phorbol ester (PDBU))
Affinity DataKd:  0.177nMpH: 7.4 T: 2°CAssay Description:[3H]PDBu binding to the C1 domains of MRCK alpha/beta and PKC alpha/delta was measured using the polyethylene glycol precipitation assay.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSurvival motor neuron protein(Human)
Indiana University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50242551(CHEMBL4081345)
Affinity DataEC50:  720nMAssay Description:Stabilization of human SMN protein expressed in HEK293 cells expressing SMN2 promoter after 24 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSurvival motor neuron protein(Human)
Indiana University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50242552(CHEMBL4087521)
Affinity DataEC50:  1.12E+4nMAssay Description:Stabilization of human SMN protein expressed in HEK293 cells expressing SMN2 promoter after 24 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSurvival motor neuron protein(Human)
Indiana University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50242553(CHEMBL4074761)
Affinity DataEC50:  3.56E+3nMAssay Description:Stabilization of human SMN protein expressed in HEK293 cells expressing SMN2 promoter after 24 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSurvival motor neuron protein(Human)
Indiana University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50242554(CHEMBL4092778)
Affinity DataEC50:  1.93E+3nMAssay Description:Stabilization of human SMN protein expressed in HEK293 cells expressing SMN2 promoter after 24 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSurvival motor neuron protein(Human)
Indiana University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50242555(CHEMBL4100508)
Affinity DataEC50:  8.80E+3nMAssay Description:Stabilization of human SMN protein expressed in HEK293 cells expressing SMN2 promoter after 24 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSurvival motor neuron protein(Human)
Indiana University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50242559(CHEMBL4091509)
Affinity DataEC50:  170nMAssay Description:Stabilization of human SMN protein expressed in HEK293 cells expressing SMN2 promoter after 24 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSurvival motor neuron protein(Human)
Indiana University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50242560(CHEMBL4081226)
Affinity DataEC50:  2.60E+3nMAssay Description:Stabilization of human SMN protein expressed in HEK293 cells expressing SMN2 promoter after 24 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSurvival motor neuron protein(Human)
Indiana University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50242561(CHEMBL4060907)
Affinity DataEC50:  780nMAssay Description:Stabilization of human SMN protein expressed in HEK293 cells expressing SMN2 promoter after 24 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSurvival motor neuron protein(Human)
Indiana University School of Medicine

Curated by ChEMBL
LigandPNGBDBM56067(MLS000087329 | 5-propan-2-yl-N-(3-pyridinyl)-3-iso...)
Affinity DataEC50:  9.90E+3nMAssay Description:Stabilization of human SMN protein expressed in HEK293 cells expressing SMN2 promoter after 24 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSurvival motor neuron protein(Human)
Indiana University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50242562(CHEMBL4085268)
Affinity DataEC50:  360nMAssay Description:Stabilization of human SMN protein expressed in HEK293 cells expressing SMN2 promoter after 24 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSurvival motor neuron protein(Human)
Indiana University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50242563(CHEMBL4097356)
Affinity DataEC50:  1.80E+3nMAssay Description:Stabilization of human SMN protein expressed in HEK293 cells expressing SMN2 promoter after 24 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSurvival motor neuron protein(Human)
Indiana University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50242564(CHEMBL4079330)
Affinity DataEC50:  5.40E+3nMAssay Description:Stabilization of human SMN protein expressed in HEK293 cells expressing SMN2 promoter after 24 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSurvival motor neuron protein(Human)
Indiana University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50242569(CHEMBL4068510)
Affinity DataEC50:  7.30E+3nMAssay Description:Stabilization of human SMN protein expressed in HEK293 cells expressing SMN2 promoter after 24 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSurvival motor neuron protein(Human)
Indiana University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50242570(CHEMBL4081762)
Affinity DataEC50:  2.80E+3nMAssay Description:Stabilization of human SMN protein expressed in HEK293 cells expressing SMN2 promoter after 24 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSurvival motor neuron protein(Human)
Indiana University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50242571(CHEMBL4059844)
Affinity DataEC50:  6.20E+3nMAssay Description:Stabilization of human SMN protein expressed in HEK293 cells expressing SMN2 promoter after 24 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSurvival motor neuron protein(Human)
Indiana University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50242572(CHEMBL4098258)
Affinity DataEC50:  260nMAssay Description:Stabilization of human SMN protein expressed in HEK293 cells expressing SMN2 promoter after 24 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSurvival motor neuron protein(Human)
Indiana University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50242573(CHEMBL4068807)
Affinity DataEC50:  280nMAssay Description:Stabilization of human SMN protein expressed in HEK293 cells expressing SMN2 promoter after 24 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSurvival motor neuron protein(Human)
Indiana University School of Medicine

Curated by ChEMBL
LigandPNGBDBM48569(N-(3-chlorophenyl)-5-propan-2-yl-1,2-oxazole-3-car...)
Affinity DataEC50:  860nMAssay Description:Stabilization of human SMN protein expressed in HEK293 cells expressing SMN2 promoter after 24 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSurvival motor neuron protein(Human)
Indiana University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50242574(CHEMBL4062299)
Affinity DataEC50:  1.80E+3nMAssay Description:Stabilization of human SMN protein expressed in HEK293 cells expressing SMN2 promoter after 24 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSurvival motor neuron protein(Human)
Indiana University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50242586(CHEMBL4092581)
Affinity DataEC50:  500nMAssay Description:Stabilization of human SMN protein expressed in HEK293 cells expressing SMN2 promoter after 24 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSurvival motor neuron protein(Human)
Indiana University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50242587(CHEMBL4097866)
Affinity DataEC50:  290nMAssay Description:Stabilization of human SMN protein expressed in HEK293 cells expressing SMN2 promoter after 24 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSurvival motor neuron protein(Human)
Indiana University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50242588(CHEMBL4090149)
Affinity DataEC50:  1.60E+3nMAssay Description:Stabilization of human SMN protein expressed in HEK293 cells expressing SMN2 promoter after 24 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSurvival motor neuron protein(Human)
Indiana University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50242589(CHEMBL4062125)
Affinity DataEC50:  5.50E+3nMAssay Description:Stabilization of human SMN protein expressed in HEK293 cells expressing SMN2 promoter after 24 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSurvival motor neuron protein(Human)
Indiana University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50242590(CHEMBL4089219)
Affinity DataEC50:  9.90E+3nMAssay Description:Stabilization of human SMN protein expressed in HEK293 cells expressing SMN2 promoter after 24 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSurvival motor neuron protein(Human)
Indiana University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50242591(CHEMBL4070751)
Affinity DataEC50:  500nMAssay Description:Stabilization of human SMN protein expressed in HEK293 cells expressing SMN2 promoter after 24 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSurvival motor neuron protein(Human)
Indiana University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50242592(CHEMBL4066153)
Affinity DataEC50:  1.39E+4nMAssay Description:Stabilization of human SMN protein expressed in HEK293 cells expressing SMN2 promoter after 24 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSurvival motor neuron protein(Human)
Indiana University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50242602(CHEMBL4073693)
Affinity DataEC50:  1.50E+3nMAssay Description:Stabilization of human SMN protein expressed in HEK293 cells expressing SMN2 promoter after 24 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSurvival motor neuron protein(Human)
Indiana University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50242603(CHEMBL4099244)
Affinity DataEC50:  260nMAssay Description:Stabilization of human SMN protein expressed in HEK293 cells expressing SMN2 promoter after 24 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSurvival motor neuron protein(Human)
Indiana University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50242604(CHEMBL4063645)
Affinity DataEC50:  1.40E+3nMAssay Description:Stabilization of human SMN protein expressed in HEK293 cells expressing SMN2 promoter after 24 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSurvival motor neuron protein(Human)
Indiana University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50242605(CHEMBL4089637)
Affinity DataEC50:  3.60E+3nMAssay Description:Stabilization of human SMN protein expressed in HEK293 cells expressing SMN2 promoter after 24 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSurvival motor neuron protein(Human)
Indiana University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50242606(CHEMBL4071219)
Affinity DataEC50:  340nMAssay Description:Stabilization of human SMN protein expressed in HEK293 cells expressing SMN2 promoter after 24 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSurvival motor neuron protein(Human)
Indiana University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50242607(CHEMBL4084011)
Affinity DataEC50:  1.80E+3nMAssay Description:Stabilization of human SMN protein expressed in HEK293 cells expressing SMN2 promoter after 24 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSurvival motor neuron protein(Human)
Indiana University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50242574(CHEMBL4062299)
Affinity DataEC50:  1.80E+3nMAssay Description:Stabilization of human SMN protein expressed in HEK293 cells expressing SMN2 promoter after 24 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target3-phosphoinositide-dependent protein kinase 1(Human)
Brigham Young University

Curated by ChEMBL
LigandPNGBDBM103938(US8569511, 1)
Affinity DataEC50:  76nMAssay Description:Inhibition of PDK1 mediated PI3K/Akt/mTOR pathway activation in human AN3CA cells assessed as reduction in ribosomal p70S6 protein phosphorylation af...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target3-phosphoinositide-dependent protein kinase 1(Human)
Brigham Young University

Curated by ChEMBL
LigandPNGBDBM103939(US8569511, 2)
Affinity DataEC50:  77nMAssay Description:Inhibition of PDK1 mediated PI3K/Akt/mTOR pathway activation in human AN3CA cells assessed as reduction in ribosomal p70S6 protein phosphorylation af...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAmyloid-beta precursor protein(Human)
University of Pennsylvania

Curated by ChEMBL
LigandPNGBDBM50173647(4-[(E)-2-(4-Methylamino-phenyl)-vinyl]-phenol | [3...)
Affinity DataKd:  2.40nMAssay Description:Binding affinity to Beta amyloid aggregates in Alzheimer's disease patient brainMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAdenosine receptor A3(Human)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50496303(CHEMBL3125715)
Affinity DataEC50:  27nMAssay Description:Partial agonist activity at recombinant human adenosine A3 receptor expressed in CHO cells assessed as stimulation of forskolin-induced intracellular...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAdenosine receptor A3(Human)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50496304(CHEMBL3125712)
Affinity DataEC50:  46nMAssay Description:Partial agonist activity at recombinant human adenosine A3 receptor expressed in CHO cells assessed as stimulation of forskolin-induced intracellular...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAdenosine receptor A3(Human)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50496308(CHEMBL3125714)
Affinity DataEC50:  20nMAssay Description:Partial agonist activity at recombinant human adenosine A3 receptor expressed in CHO cells assessed as stimulation of forskolin-induced intracellular...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAdenosine receptor A3(Human)
Seoul National University

Curated by ChEMBL
LigandPNGBDBM50496310(CHEMBL3125713)
Affinity DataEC50:  16nMAssay Description:Partial agonist activity at recombinant human adenosine A3 receptor expressed in CHO cells assessed as stimulation of forskolin-induced intracellular...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
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