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TargetKinesin-like protein KIF11(Human)
Merck Research Laboratories

LigandPNGBDBM50293756(KSP Inhibitor, 4a | CHEMBL561696 | 2-(4-(methylthi...)
Affinity DataKd:  2.00E+3nMAssay Description:Binding assay using temperature-dependent circular dichroism (TdCD). In TdCD, the loss of protein secondary structure was monitored as a function of...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetKinesin-like protein KIF11(Human)
Merck Research Laboratories

LigandPNGBDBM50293753(KSP Inhibitor, 4b | CHEMBL565195 | 2-(4-(methylsul...)
Affinity DataKd:  2.50E+3nMAssay Description:Binding assay using temperature-dependent circular dichroism (TdCD). In TdCD, the loss of protein secondary structure was monitored as a function of...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetKinesin-like protein KIF11(Human)
Merck Research Laboratories

LigandPNGBDBM92864(KSP Inhibitor, 4c)
Affinity DataKd:  1.40E+4nMAssay Description:Binding assay using temperature-dependent circular dichroism (TdCD). In TdCD, the loss of protein secondary structure was monitored as a function of...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetKinesin-like protein KIF11(Human)
Merck Research Laboratories

LigandPNGBDBM92865(KSP Inhibitor, 4d)
Affinity DataKd:  5.00E+3nMAssay Description:Binding assay using temperature-dependent circular dichroism (TdCD). In TdCD, the loss of protein secondary structure was monitored as a function of...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetKinesin-like protein KIF11(Human)
Merck Research Laboratories

LigandPNGBDBM50293744(KSP Inhibitor, 4e | CHEMBL563643 | 2-(4-sulfamoylp...)
Affinity DataKd:  600nMAssay Description:Binding assay using temperature-dependent circular dichroism (TdCD). In TdCD, the loss of protein secondary structure was monitored as a function of...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetKinesin-like protein KIF11(Human)
Merck Research Laboratories

LigandPNGBDBM50293759(CHEMBL563846 | KSP Inhibitor, 4f | 2-(4-methoxyphe...)
Affinity DataKd:  1.20E+3nMAssay Description:Binding assay using temperature-dependent circular dichroism (TdCD). In TdCD, the loss of protein secondary structure was monitored as a function of...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetKinesin-like protein KIF11(Human)
Merck Research Laboratories

LigandPNGBDBM92866(KSP Inhibitor, 4g)
Affinity DataKd:  3.40E+3nMAssay Description:Binding assay using temperature-dependent circular dichroism (TdCD). In TdCD, the loss of protein secondary structure was monitored as a function of...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetCytochrome P450 3A4(Human)
Cytokinetics

Curated by ChEMBL
LigandPNGBDBM50575174(Mavacamten)
Affinity DataEC50:  2.20E+3nMAssay Description:Induction of CYP3A4 in human hepatocytes assessed as mRNA expression incubated for 3 days by RT-RTPCR analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 2B6(Human)
Cytokinetics

Curated by ChEMBL
LigandPNGBDBM50575174(Mavacamten)
Affinity DataEC50:  5.10E+3nMAssay Description:Induction of CYP2B6 in human hepatocytes assessed as mRNA expression incubated for 3 days by RT-RTPCR analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPeroxisome proliferator-activated receptor gamma(Human)
Bayer Research Center

Curated by ChEMBL
LigandPNGBDBM50216934(2-((S)-5-(2-(2-(3-fluorophenyl)-5-methyloxazol-4-y...)
Affinity DataEC50:  13nMAssay Description:Agonist activity at GST-tagged human PPARdelta by FRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPeroxisome proliferator-activated receptor gamma(Human)
Bayer Research Center

Curated by ChEMBL
LigandPNGBDBM50216935(2-(3,3-dimethyl-5-(2-(5-methyl-2-phenyloxazol-4-yl...)
Affinity DataEC50:  6.48E+3nMAssay Description:Agonist activity at GST-tagged human PPARdelta by FRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPeroxisome proliferator-activated receptor alpha(Human)
Bayer Research Center

Curated by ChEMBL
LigandPNGBDBM50216936((S)-2-(5-(2-(2-(4-ethylphenyl)-1,4-dimethyl-1H-imi...)
Affinity DataEC50:  1.00E+4nMAssay Description:Agonist activity at PPARalpha by FRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPeroxisome proliferator-activated receptor alpha(Human)
Bayer Research Center

Curated by ChEMBL
LigandPNGBDBM50216937((S)-2-(5-(2-(2-(4-chlorophenyl)-5-methylthiazol-4-...)
Affinity DataEC50:  1.00E+4nMAssay Description:Agonist activity at PPARalpha by FRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPeroxisome proliferator-activated receptor gamma(Human)
Bayer Research Center

Curated by ChEMBL
LigandPNGBDBM50216939({(S)-5-[2-(2-biphenyl-4-yl-5-methyl-oxazol-4-yl)-e...)
Affinity DataEC50:  6nMAssay Description:Agonist activity at GST-tagged human PPARdelta by FRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPeroxisome proliferator-activated receptor gamma(Human)
Bayer Research Center

Curated by ChEMBL
LigandPNGBDBM50216943(2-((S)-5-(2-(2-(3-fluorophenyl)-5-methylthiazol-4-...)
Affinity DataEC50:  47nMAssay Description:Agonist activity at GST-tagged human PPARdelta by FRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPeroxisome proliferator-activated receptor gamma(Human)
Bayer Research Center

Curated by ChEMBL
LigandPNGBDBM50216940(2-((S)-5-(2-(2-(benzo[d][1,3]dioxol-5-yl)-5-methyl...)
Affinity DataEC50:  5nMAssay Description:Agonist activity at GST-tagged human PPARdelta by FRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPeroxisome proliferator-activated receptor gamma(Human)
Bayer Research Center

Curated by ChEMBL
LigandPNGBDBM50216941((S)-2-(5-(2-(2-(4-isopropylphenyl)-5-methyloxazol-...)
Affinity DataEC50:  1nMAssay Description:Agonist activity at GST-tagged human PPARdelta by FRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPeroxisome proliferator-activated receptor gamma(Human)
Bayer Research Center

Curated by ChEMBL
LigandPNGBDBM50216938((S)-2-(5-(2-(2-(4-methoxyphenyl)-1,5-dimethyl-1H-i...)
Affinity DataEC50:  1.00E+4nMAssay Description:Agonist activity at GST-tagged human PPARdelta by FRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPeroxisome proliferator-activated receptor gamma(Human)
Bayer Research Center

Curated by ChEMBL
LigandPNGBDBM50216944((S)-2-(6-(2-(5-methyl-2-phenyloxazol-4-yl)ethoxy)-...)
Affinity DataEC50:  3.14E+3nMAssay Description:Agonist activity at GST-tagged human PPARdelta by FRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPeroxisome proliferator-activated receptor gamma(Human)
Bayer Research Center

Curated by ChEMBL
LigandPNGBDBM50176631(2-(5-(2-(5-methyl-2-phenyloxazol-4-yl)ethoxy)-2,3-...)
Affinity DataEC50:  590nMAssay Description:Agonist activity at GST-tagged human PPARdelta by FRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPeroxisome proliferator-activated receptor gamma(Human)
Bayer Research Center

Curated by ChEMBL
LigandPNGBDBM50216947((S)-2-(5-(2-(5-ethyl-2-p-tolyloxazol-4-yl)ethoxy)-...)
Affinity DataEC50:  5nMAssay Description:Agonist activity at GST-tagged human PPARdelta by FRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPeroxisome proliferator-activated receptor gamma(Human)
Bayer Research Center

Curated by ChEMBL
LigandPNGBDBM50216945((S)-2-(5-(2-(2-(4-chlorophenyl)-5-methyloxazol-4-y...)
Affinity DataEC50:  3nMAssay Description:Agonist activity at GST-tagged human PPARdelta by FRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPeroxisome proliferator-activated receptor alpha(Human)
Bayer Research Center

Curated by ChEMBL
LigandPNGBDBM50216946((S)-2-(5-(2-(5-ethyl-2-(4-ethylphenyl)oxazol-4-yl)...)
Affinity DataEC50:  2.53E+3nMAssay Description:Agonist activity at PPARalpha by FRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPeroxisome proliferator-activated receptor alpha(Human)
Bayer Research Center

Curated by ChEMBL
LigandPNGBDBM50216938((S)-2-(5-(2-(2-(4-methoxyphenyl)-1,5-dimethyl-1H-i...)
Affinity DataEC50:  1.00E+4nMAssay Description:Agonist activity at PPARalpha by FRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPeroxisome proliferator-activated receptor gamma(Human)
Bayer Research Center

Curated by ChEMBL
LigandPNGBDBM50216948((S)-2-(5-(2-(2-(4-ethylphenyl)-5-methyloxazol-4-yl...)
Affinity DataEC50:  3nMAssay Description:Agonist activity at GST-tagged human PPARdelta by FRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPeroxisome proliferator-activated receptor gamma(Human)
Bayer Research Center

Curated by ChEMBL
LigandPNGBDBM50216949(2-((S)-5-(2-(5-methyl-2-m-tolyloxazol-4-yl)ethoxy)...)
Affinity DataEC50:  64nMAssay Description:Agonist activity at GST-tagged human PPARdelta by FRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPeroxisome proliferator-activated receptor gamma(Human)
Bayer Research Center

Curated by ChEMBL
LigandPNGBDBM50216951((S)-2-(5-(2-(2-(4-fluorophenyl)-5-methyloxazol-4-y...)
Affinity DataEC50:  7nMAssay Description:Agonist activity at GST-tagged human PPARdelta by FRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPeroxisome proliferator-activated receptor alpha(Human)
Bayer Research Center

Curated by ChEMBL
LigandPNGBDBM50216943(2-((S)-5-(2-(2-(3-fluorophenyl)-5-methylthiazol-4-...)
Affinity DataEC50:  6.53E+3nMAssay Description:Agonist activity at PPARalpha by FRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPeroxisome proliferator-activated receptor alpha(Human)
Bayer Research Center

Curated by ChEMBL
LigandPNGBDBM50216950(2-((S)-5-(2-(2-(3-cyanophenyl)-5-methyloxazol-4-yl...)
Affinity DataEC50:  1.00E+4nMAssay Description:Agonist activity at PPARalpha by FRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPeroxisome proliferator-activated receptor alpha(Human)
Bayer Research Center

Curated by ChEMBL
LigandPNGBDBM50216953(2-((S)-5-(2-(5-methyl-2-m-tolylthiazol-4-yl)ethoxy...)
Affinity DataEC50:  6.79E+3nMAssay Description:Agonist activity at PPARalpha by FRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPeroxisome proliferator-activated receptor alpha(Human)
Bayer Research Center

Curated by ChEMBL
LigandPNGBDBM50216954((S)-2-(5-(2-(2-phenyl-5-propyloxazol-4-yl)ethoxy)-...)
Affinity DataEC50:  1.00E+4nMAssay Description:Agonist activity at PPARalpha by FRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPeroxisome proliferator-activated receptor alpha(Human)
Bayer Research Center

Curated by ChEMBL
LigandPNGBDBM50176631(2-(5-(2-(5-methyl-2-phenyloxazol-4-yl)ethoxy)-2,3-...)
Affinity DataEC50:  130nMAssay Description:Agonist activity at PPARalpha by FRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPeroxisome proliferator-activated receptor alpha(Human)
Bayer Research Center

Curated by ChEMBL
LigandPNGBDBM50216957((S)-2-(5-(2-(2-(4-tert-butylphenyl)-5-methyloxazol...)
Affinity DataEC50:  546nMAssay Description:Agonist activity at PPARalpha by FRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPeroxisome proliferator-activated receptor gamma(Human)
Bayer Research Center

Curated by ChEMBL
LigandPNGBDBM50216955((S)-2-(5-(2-(5-phenethyl-2-phenyloxazol-4-yl)ethox...)
Affinity DataEC50:  607nMAssay Description:Agonist activity at GST-tagged human PPARdelta by FRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPeroxisome proliferator-activated receptor gamma(Human)
Bayer Research Center

Curated by ChEMBL
LigandPNGBDBM50176673(2-methoxy-2-(5-(2-(5-methyl-2-phenyloxazol-4-yl)et...)
Affinity DataEC50:  4.40E+3nMAssay Description:Agonist activity at GST-tagged human PPARdelta by FRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPeroxisome proliferator-activated receptor gamma(Human)
Bayer Research Center

Curated by ChEMBL
LigandPNGBDBM50216956((S)-2-(5-(2-(5-methyl-2-p-tolyloxazol-4-yl)ethoxy)...)
Affinity DataEC50:  4nMAssay Description:Agonist activity at GST-tagged human PPARdelta by FRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPeroxisome proliferator-activated receptor gamma(Human)
Bayer Research Center

Curated by ChEMBL
LigandPNGBDBM50216958((S)-2-(5-(2-(1,5-dimethyl-2-phenyl-1H-imidazol-4-y...)
Affinity DataEC50:  1.00E+4nMAssay Description:Agonist activity at GST-tagged human PPARdelta by FRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPeroxisome proliferator-activated receptor alpha(Human)
Bayer Research Center

Curated by ChEMBL
LigandPNGBDBM50216933(2-((S)-5-(2-(5-methyl-2-(3-(trifluoromethyl)phenyl...)
Affinity DataEC50:  1.00E+4nMAssay Description:Agonist activity at PPARalpha by FRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPeroxisome proliferator-activated receptor alpha(Human)
Bayer Research Center

Curated by ChEMBL
LigandPNGBDBM50216934(2-((S)-5-(2-(2-(3-fluorophenyl)-5-methyloxazol-4-y...)
Affinity DataEC50:  1.69E+3nMAssay Description:Agonist activity at PPARalpha by FRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPeroxisome proliferator-activated receptor alpha(Human)
Bayer Research Center

Curated by ChEMBL
LigandPNGBDBM50216959((S)-2-(5-(2-(1,4-dimethyl-2-phenyl-1H-imidazol-5-y...)
Affinity DataEC50:  1.00E+4nMAssay Description:Agonist activity at PPARalpha by FRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPeroxisome proliferator-activated receptor alpha(Human)
Bayer Research Center

Curated by ChEMBL
LigandPNGBDBM50216960((S)-2-(5-(2-(5-methyl-2-p-tolylthiazol-4-yl)ethoxy...)
Affinity DataEC50:  594nMAssay Description:Agonist activity at PPARalpha by FRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPeroxisome proliferator-activated receptor gamma(Human)
Bayer Research Center

Curated by ChEMBL
LigandPNGBDBM50216960((S)-2-(5-(2-(5-methyl-2-p-tolylthiazol-4-yl)ethoxy...)
Affinity DataEC50:  0.800nMAssay Description:Agonist activity at GST-tagged human PPARdelta by FRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPeroxisome proliferator-activated receptor alpha(Human)
Bayer Research Center

Curated by ChEMBL
LigandPNGBDBM50216961((S)-2-(5-(2-(2-(4-methoxyphenyl)-1,4-dimethyl-1H-i...)
Affinity DataEC50:  1.00E+4nMAssay Description:Agonist activity at PPARalpha by FRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPeroxisome proliferator-activated receptor alpha(Human)
Bayer Research Center

Curated by ChEMBL
LigandPNGBDBM50216932(2-((S)-5-(2-(2-(3-chlorophenyl)-5-methyloxazol-4-y...)
Affinity DataEC50:  1.57E+3nMAssay Description:Agonist activity at PPARalpha by FRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPeroxisome proliferator-activated receptor gamma(Human)
Bayer Research Center

Curated by ChEMBL
LigandPNGBDBM50216957((S)-2-(5-(2-(2-(4-tert-butylphenyl)-5-methyloxazol...)
Affinity DataEC50:  21nMAssay Description:Agonist activity at GST-tagged human PPARdelta by FRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPeroxisome proliferator-activated receptor gamma(Human)
Bayer Research Center

Curated by ChEMBL
LigandPNGBDBM50216962((S)-2-(5-(2-(2-(4-isopropylphenyl)-5-methylthiazol...)
Affinity DataEC50:  5nMAssay Description:Agonist activity at GST-tagged human PPARdelta by FRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPeroxisome proliferator-activated receptor gamma(Human)
Bayer Research Center

Curated by ChEMBL
LigandPNGBDBM50216965((S)-2-(5-(2-(5-methyl-2-(4-(trifluoromethoxy)pheny...)
Affinity DataEC50:  2nMAssay Description:Agonist activity at GST-tagged human PPARdelta by FRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPeroxisome proliferator-activated receptor gamma(Human)
Bayer Research Center

Curated by ChEMBL
LigandPNGBDBM50216932(2-((S)-5-(2-(2-(3-chlorophenyl)-5-methyloxazol-4-y...)
Affinity DataEC50:  13nMAssay Description:Agonist activity at GST-tagged human PPARdelta by FRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPeroxisome proliferator-activated receptor alpha(Human)
Bayer Research Center

Curated by ChEMBL
LigandPNGBDBM50216967({(S)-5-[2-(2-biphenyl-4-yl-1,5-dimethyl-1H-imidazo...)
Affinity DataEC50:  1.00E+4nMAssay Description:Agonist activity at PPARalpha by FRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPeroxisome proliferator-activated receptor gamma(Human)
Bayer Research Center

Curated by ChEMBL
LigandPNGBDBM50216964((S)-2-(5-(2-(2-(4-ethoxyphenyl)-5-methylthiazol-4-...)
Affinity DataEC50:  30nMAssay Description:Agonist activity at GST-tagged human PPARdelta by FRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
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