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TargetALK tyrosine kinase receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50018836(CHEMBL3286826)
Affinity DataIC50: 0.110nMAssay Description:Inhibition of wild type human EML4-fused ALK expressed in mouse NIH-3T3 cells assessed as phosphorylated ALK level after 1 hr by sandwich ELISAMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetALK tyrosine kinase receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50018835(CHEMBL3286825)
Affinity DataIC50: 0.180nMAssay Description:Inhibition of wild type human EML4-fused ALK expressed in mouse NIH-3T3 cells assessed as phosphorylated ALK level after 1 hr by sandwich ELISAMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetALK tyrosine kinase receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50018830(CHEMBL3286830 | US10543199, Compound PF-06463922 |...)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of human EML4-fused ALK F1174L mutant expressed in mouse NIH-3T3 cells assessed as phospho-ALK level after 1 hr by sandwich ELISAMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetALK tyrosine kinase receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50018833(CHEMBL3286823)
Affinity DataIC50: 0.210nMAssay Description:Inhibition of wild type human EML4-fused ALK expressed in mouse NIH-3T3 cells assessed as phosphorylated ALK level after 1 hr by sandwich ELISAMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetALK tyrosine kinase receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50018838(CHEMBL3286828)
Affinity DataIC50: 0.340nMAssay Description:Inhibition of wild type human EML4-fused ALK expressed in mouse NIH-3T3 cells assessed as phosphorylated ALK level after 1 hr by sandwich ELISAMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetALK tyrosine kinase receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50018815(CHEMBL3286820)
Affinity DataIC50: 0.700nMAssay Description:Inhibition of wild type human EML4-fused ALK expressed in mouse NIH-3T3 cells assessed as phosphorylated ALK level after 1 hr by sandwich ELISAMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetALK tyrosine kinase receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50018836(CHEMBL3286826)
Affinity DataIC50: 0.75nMAssay Description:Inhibition of human EML4-fused ALK L1196M mutant expressed in mouse NIH-3T3 cells assessed as phospho-ALK level after 1 hr by sandwich ELISAMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetALK tyrosine kinase receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50448785(CHEMBL3128069)
Affinity DataIC50: 0.760nMAssay Description:Inhibition of wild type human EML4-fused ALK expressed in mouse NIH-3T3 cells assessed as phosphorylated ALK level after 1 hr by sandwich ELISAMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetALK tyrosine kinase receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50448785(CHEMBL3128069)
Affinity DataIC50: 0.800nMAssay Description:Inhibition of human wild type EML4-fused ALK expressed in mouse NIH-3T3 cells assessed as phosphorylated ALK level after 1 hr by sandwich ELISAMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetALK tyrosine kinase receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50018829(CHEMBL3286819)
Affinity DataIC50: 0.900nMAssay Description:Inhibition of wild type human EML4-fused ALK expressed in mouse NIH-3T3 cells assessed as phosphorylated ALK level after 1 hr by sandwich ELISAMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistone-lysine N-methyltransferase EZH2(Human)
Pfizer

US Patent
LigandPNGBDBM50246962(CHEMBL4080043 | US10570121, Example 1)
Affinity DataIC50: 1nMAssay Description:A. Compound preparation1. Prepare 10 mM stock solutions in 100% DMSO from solid material2. Serial dilute 10 mM compound stocks either 2 or 3-fold in ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetHistone-lysine N-methyltransferase EZH2(Human)
Pfizer

US Patent
LigandPNGBDBM50246944(CHEMBL4080606 | US10570121, Example 38)
Affinity DataIC50: 1nMAssay Description:A. Compound preparation1. Prepare 10 mM stock solutions in 100% DMSO from solid material2. Serial dilute 10 mM compound stocks either 2 or 3-fold in ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM50246932(CHEMBL4073864 | US10570121, Example 112)
Affinity DataIC50: 1nMAssay Description:A. Compound preparation1. Prepare 10 mM stock solutions in 100% DMSO from solid material2. Serial dilute 10 mM compound stocks either 2 or 3-fold in ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM435691(US10570121, Example 198 | US10570121, Example 197)
Affinity DataIC50: 1nMAssay Description:A. Compound preparation1. Prepare 10 mM stock solutions in 100% DMSO from solid material2. Serial dilute 10 mM compound stocks either 2 or 3-fold in ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetALK tyrosine kinase receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50018828(CHEMBL3286818)
Affinity DataIC50: 1nMAssay Description:Inhibition of wild type human EML4-fused ALK expressed in mouse NIH-3T3 cells assessed as phosphorylated ALK level after 1 hr by sandwich ELISAMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetALK tyrosine kinase receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50018830(CHEMBL3286830 | US10543199, Compound PF-06463922 |...)
Affinity DataIC50: 1.30nMAssay Description:Inhibition of wild type human EML4-fused ALK expressed in mouse NIH-3T3 cells assessed as phosphorylated ALK level after 1 hr by sandwich ELISAMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetALK tyrosine kinase receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50018837(CHEMBL3286827)
Affinity DataIC50: 1.30nMAssay Description:Inhibition of wild type human EML4-fused ALK expressed in mouse NIH-3T3 cells assessed as phosphorylated ALK level after 1 hr by sandwich ELISAMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetALK tyrosine kinase receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50018833(CHEMBL3286823)
Affinity DataIC50: 1.40nMAssay Description:Inhibition of human EML4-fused ALK L1196M mutant expressed in mouse NIH-3T3 cells assessed as phospho-ALK level after 1 hr by sandwich ELISAMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetALK tyrosine kinase receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50018830(CHEMBL3286830 | US10543199, Compound PF-06463922 |...)
Affinity DataIC50: 1.60nMAssay Description:Inhibition of human EML4-fused ALK C1156Y mutant expressed in mouse NIH-3T3 cells assessed as phospho-ALK level after 1 hr by sandwich ELISAMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetALK tyrosine kinase receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50018838(CHEMBL3286828)
Affinity DataIC50: 1.90nMAssay Description:Inhibition of human EML4-fused ALK L1196M mutant expressed in mouse NIH-3T3 cells assessed as phospho-ALK level after 1 hr by sandwich ELISAMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetHistone-lysine N-methyltransferase EZH2(Human)
Pfizer

US Patent
LigandPNGBDBM50246953(CHEMBL4090352 | US10570121, Example 3)
Affinity DataIC50: 2nMAssay Description:A. Compound preparation1. Prepare 10 mM stock solutions in 100% DMSO from solid material2. Serial dilute 10 mM compound stocks either 2 or 3-fold in ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetHistone-lysine N-methyltransferase EZH2(Human)
Pfizer

US Patent
LigandPNGBDBM50246933(CHEMBL4094432 | US10570121, Example 165)
Affinity DataIC50: 2nMAssay Description:A. Compound preparation1. Prepare 10 mM stock solutions in 100% DMSO from solid material2. Serial dilute 10 mM compound stocks either 2 or 3-fold in ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM50246933(CHEMBL4094432 | US10570121, Example 165)
Affinity DataIC50: 2nMAssay Description:A. Compound preparation1. Prepare 10 mM stock solutions in 100% DMSO from solid material2. Serial dilute 10 mM compound stocks either 2 or 3-fold in ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM50246944(CHEMBL4080606 | US10570121, Example 38)
Affinity DataIC50: 2nMAssay Description:A. Compound preparation1. Prepare 10 mM stock solutions in 100% DMSO from solid material2. Serial dilute 10 mM compound stocks either 2 or 3-fold in ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM50246941(CHEMBL4062421 | US10570121, Example 51)
Affinity DataIC50: 2nMAssay Description:A. Compound preparation1. Prepare 10 mM stock solutions in 100% DMSO from solid material2. Serial dilute 10 mM compound stocks either 2 or 3-fold in ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM435562(US10570121, Example 73 | US10570121, Example 72)
Affinity DataIC50: 2nMAssay Description:A. Compound preparation1. Prepare 10 mM stock solutions in 100% DMSO from solid material2. Serial dilute 10 mM compound stocks either 2 or 3-fold in ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM435574(US10570121, Example 85 | US10570121, Example 84)
Affinity DataIC50: 2nMAssay Description:A. Compound preparation1. Prepare 10 mM stock solutions in 100% DMSO from solid material2. Serial dilute 10 mM compound stocks either 2 or 3-fold in ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM435577(US10570121, Example 87)
Affinity DataIC50: 2nMAssay Description:A. Compound preparation1. Prepare 10 mM stock solutions in 100% DMSO from solid material2. Serial dilute 10 mM compound stocks either 2 or 3-fold in ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM50246939(CHEMBL4072089 | US10570121, Example 110)
Affinity DataIC50: 2nMAssay Description:A. Compound preparation1. Prepare 10 mM stock solutions in 100% DMSO from solid material2. Serial dilute 10 mM compound stocks either 2 or 3-fold in ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM435660(US10570121, Example 167 | US10570121, Example 166)
Affinity DataIC50: 2nMAssay Description:A. Compound preparation1. Prepare 10 mM stock solutions in 100% DMSO from solid material2. Serial dilute 10 mM compound stocks either 2 or 3-fold in ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM435694(US10570121, Example 201 | US10570121, Example 200)
Affinity DataIC50: 2nMAssay Description:A. Compound preparation1. Prepare 10 mM stock solutions in 100% DMSO from solid material2. Serial dilute 10 mM compound stocks either 2 or 3-fold in ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetLeukocyte tyrosine kinase receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50448785(CHEMBL3128069)
Affinity DataIC50: 2nMAssay Description:Inhibition of LTK (unknown origin) using Km levels of ATPMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein kinase Fer(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50448785(CHEMBL3128069)
Affinity DataIC50: 2nMAssay Description:Inhibition of FER (unknown origin) using Km levels of ATPMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetALK tyrosine kinase receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50018835(CHEMBL3286825)
Affinity DataIC50: 2.10nMAssay Description:Inhibition of human EML4-fused ALK L1196M mutant expressed in mouse NIH-3T3 cells assessed as phospho-ALK level after 1 hr by sandwich ELISAMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50246927(CHEMBL4060447 | US10570121, Example 127)
Affinity DataIC50: 2.20nMAssay Description:A. Compound preparation1. Prepare 10 mM stock solutions in 100% DMSO from solid material2. Serial dilute 10 mM compound stocks either 2 or 3-fold in ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetLeukocyte tyrosine kinase receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50018830(CHEMBL3286830 | US10543199, Compound PF-06463922 |...)
Affinity DataIC50: 2.70nMAssay Description:Inhibition of LTK (unknown origin) by TR-FRET-based Z'-LYTE assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50246962(CHEMBL4080043 | US10570121, Example 1)
Affinity DataIC50: 3nMAssay Description:A. Compound preparation1. Prepare 10 mM stock solutions in 100% DMSO from solid material2. Serial dilute 10 mM compound stocks either 2 or 3-fold in ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM435551(US10570121, Example 71 | US10570121, Example 61)
Affinity DataIC50: 3nMAssay Description:A. Compound preparation1. Prepare 10 mM stock solutions in 100% DMSO from solid material2. Serial dilute 10 mM compound stocks either 2 or 3-fold in ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM50246967(CHEMBL4080228 | US10570121, Example 81)
Affinity DataIC50: 3nMAssay Description:A. Compound preparation1. Prepare 10 mM stock solutions in 100% DMSO from solid material2. Serial dilute 10 mM compound stocks either 2 or 3-fold in ...More data for this Ligand-Target Pair
In DepthDetails
US Patent
PDB3D3D Structure (crystal)
LigandPNGBDBM435609(US10570121, Example 119 | US10570121, Example 118)
Affinity DataIC50: 3nMAssay Description:A. Compound preparation1. Prepare 10 mM stock solutions in 100% DMSO from solid material2. Serial dilute 10 mM compound stocks either 2 or 3-fold in ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM50246940(CHEMBL4071056 | US10570121, Example 137)
Affinity DataIC50: 3nMAssay Description:A. Compound preparation1. Prepare 10 mM stock solutions in 100% DMSO from solid material2. Serial dilute 10 mM compound stocks either 2 or 3-fold in ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM435642(US10570121, Example 150 | US10570121, Example 151 ...)
Affinity DataIC50: 3nMAssay Description:A. Compound preparation1. Prepare 10 mM stock solutions in 100% DMSO from solid material2. Serial dilute 10 mM compound stocks either 2 or 3-fold in ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM435689(US10570121, Example 196 | US10570121, Example 195)
Affinity DataIC50: 3nMAssay Description:A. Compound preparation1. Prepare 10 mM stock solutions in 100% DMSO from solid material2. Serial dilute 10 mM compound stocks either 2 or 3-fold in ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetTyrosine-protein kinase Fer(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50018830(CHEMBL3286830 | US10543199, Compound PF-06463922 |...)
Affinity DataIC50: 3.30nMAssay Description:Inhibition of FER (unknown origin) by TR-FRET-based Z'-LYTE assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM435640(US10570121, Example 147 | US10570121, Example 146)
Affinity DataIC50: 3.5nMAssay Description:A. Compound preparation1. Prepare 10 mM stock solutions in 100% DMSO from solid material2. Serial dilute 10 mM compound stocks either 2 or 3-fold in ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM50246953(CHEMBL4090352 | US10570121, Example 3)
Affinity DataIC50: 4nMAssay Description:A. Compound preparation1. Prepare 10 mM stock solutions in 100% DMSO from solid material2. Serial dilute 10 mM compound stocks either 2 or 3-fold in ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetHistone-lysine N-methyltransferase EZH2(Human)
Pfizer

US Patent
LigandPNGBDBM435513(US10570121, Example 24)
Affinity DataIC50: 4nMAssay Description:A. Compound preparation1. Prepare 10 mM stock solutions in 100% DMSO from solid material2. Serial dilute 10 mM compound stocks either 2 or 3-fold in ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetHistone-lysine N-methyltransferase EZH2(Human)
Pfizer

US Patent
LigandPNGBDBM50246963(CHEMBL4072040 | US10570121, Example 30)
Affinity DataIC50: 4nMAssay Description:A. Compound preparation1. Prepare 10 mM stock solutions in 100% DMSO from solid material2. Serial dilute 10 mM compound stocks either 2 or 3-fold in ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetHistone-lysine N-methyltransferase EZH2(Human)
Pfizer

US Patent
LigandPNGBDBM50246944(CHEMBL4080606 | US10570121, Example 38)
Affinity DataIC50: 4nMAssay Description:A. Compound preparation1. Prepare 10 mM stock solutions in 100% DMSO from solid material2. Serial dilute 10 mM compound stocks either 2 or 3-fold in ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM435546(US10570121, Example 56)
Affinity DataIC50: 4nMAssay Description:A. Compound preparation1. Prepare 10 mM stock solutions in 100% DMSO from solid material2. Serial dilute 10 mM compound stocks either 2 or 3-fold in ...More data for this Ligand-Target Pair
In DepthDetails
US Patent

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