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TargetStimulator of interferon genes protein(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM453553(US10730849, Example 18)
Affinity DataEC50:  1.25E+4nMAssay Description:The individual compounds described in the Examples herein are defined as STING agonists by (i) binding to the STING protein as evidenced by a reducti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2021
Entry Details
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LigandPNGBDBM574001(US11453697, Example 319 | 2-amino-9- [(5R,7R,8R,12...)
Affinity DataEC50:  7.30nMAssay Description:The compounds were serially titrated by the Hamilton STARPlus CORE in a 96-well plate (Greiner, #651201) using a 1:3 ten-point dose response format. ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2022
Entry Details
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TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Emd Serono Research & Development Institute

Curated by ChEMBL
LigandPNGBDBM548727(WO2022098806, Compound 1-123)
Affinity DataEC50:  11nMAssay Description:Inhibition of human HPK1 in anti-humanCD3/anti-humanCD28 stimulated human CD3-positive T cells assessed as increase in IL-2 release incubated for 48 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetFree fatty acid receptor 4(Mouse)
Merck

Curated by ChEMBL
LigandPNGBDBM50203658(CHEMBL3973101)
Affinity DataEC50:  7nMAssay Description:Agonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/10/2018
Entry Details Article
PubMed
TargetFree fatty acid receptor 4(Mouse)
Merck

Curated by ChEMBL
LigandPNGBDBM50203668(CHEMBL3934450)
Affinity DataEC50:  264nMAssay Description:Agonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/10/2018
Entry Details Article
PubMed
TargetStimulator of interferon genes protein(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM453537(US10730849, Example 2)
Affinity DataEC50:  9.59E+3nMAssay Description:The individual compounds described in the Examples herein are defined as STING agonists by (i) binding to the STING protein as evidenced by a reducti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2021
Entry Details
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TargetStimulator of interferon genes protein(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM453567((S)-4-(6-bromo-5- chlorobenzo[b]thiophen- 2-yl)-2-...)
Affinity DataEC50:  3.63E+3nMAssay Description:The individual compounds described in the Examples herein are defined as STING agonists by (i) binding to the STING protein as evidenced by a reducti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2021
Entry Details
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TargetStimulator of interferon genes protein(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM453570(US10730849, Example 35)
Affinity DataEC50:  7.67E+3nMAssay Description:The individual compounds described in the Examples herein are defined as STING agonists by (i) binding to the STING protein as evidenced by a reducti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2021
Entry Details
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LigandPNGBDBM573949(US11453697, Example 134 | US11453697, Example 136 ...)
Affinity DataEC50:  253nMAssay Description:The compounds were serially titrated by the Hamilton STARPlus CORE in a 96-well plate (Greiner, #651201) using a 1:3 ten-point dose response format. ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2022
Entry Details
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LigandPNGBDBM574006(US11453697, Example 333 | 9,9'-[(5S,7R,8R,12aR,14R...)
Affinity DataEC50:  45.9nMAssay Description:The compounds were serially titrated by the Hamilton STARPlus CORE in a 96-well plate (Greiner, #651201) using a 1:3 ten-point dose response format. ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2022
Entry Details
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TargetStimulator of interferon genes protein [H232R](ZEBOV)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM574008(US11453697, Example 62 | 2-amino-9- [(5S,7R,8R,12a...)
Affinity DataEC50:  2.60nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2022
Entry Details
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Target3-oxoacyl-[acyl-carrier-protein] synthase 2(Staphylococcus aureus)
Colorado State University

Curated by ChEMBL
LigandPNGBDBM50532305(CHEMBL4458874)
Affinity DataKd:  9.20E+4nMAssay Description:Binding affinity to Staphylococcus aureus wild type FabF expressed in Escherichia coli BL21 (DE3) PlysS cells by intrinsic tryptophan fluorescence qu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetArginase-1(Human)
Quantitative Biosciences

Curated by ChEMBL
LigandPNGBDBM50577476(CHEMBL4852406)
Affinity DataEC50:  1.40E+4nMAssay Description:Inhibition of human ARG1 in HEK293 cells by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetArginase-1(Human)
Quantitative Biosciences

Curated by ChEMBL
LigandPNGBDBM50561036(CHEMBL4778978)
Affinity DataEC50:  6.90E+3nMAssay Description:Inhibition of human ARG1 in HEK293 cells by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Emd Serono Research & Development Institute

Curated by ChEMBL
LigandPNGBDBM50618966(CHEMBL5411794)
Affinity DataEC50:  39nMAssay Description:Inhibition of human HPK1 in anti-humanCD3/anti-humanCD28 stimulated human CD3-positive T cells assessed as increase in IL-2 release incubated for 48 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
LifeMine Therapeutics

Curated by ChEMBL
LigandPNGBDBM50645816(CHEMBL5583972)
Affinity DataEC50:  3.00E+3nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetStimulator of interferon genes protein(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM453545(US10730849, Example 10)
Affinity DataEC50:  2.00E+4nMAssay Description:The individual compounds described in the Examples herein are defined as STING agonists by (i) binding to the STING protein as evidenced by a reducti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2021
Entry Details
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LigandPNGBDBM573930(US11453697, Example 100 | US11453697, Example 101 ...)
Affinity DataEC50:  16.7nMAssay Description:The compounds were serially titrated by the Hamilton STARPlus CORE in a 96-well plate (Greiner, #651201) using a 1:3 ten-point dose response format. ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2022
Entry Details
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TargetStimulator of interferon genes protein [H232R](ZEBOV)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM573867(US11453697, Example 32 | 2-amino-9- [(5R,7R,8R,12a...)
Affinity DataEC50:  25nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2022
Entry Details
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TargetStimulator of interferon genes protein [H232R](ZEBOV)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM574159(US11453697, Example 324 | 2-amino-9-[(5R,7R,8R,12a...)
Affinity DataEC50:  10.7nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2022
Entry Details
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TargetFree fatty acid receptor 4(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50203665(CHEMBL3985939)
Affinity DataEC50:  149nMAssay Description:Agonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/10/2018
Entry Details Article
PubMed
TargetFree fatty acid receptor 4(Mouse)
Merck

Curated by ChEMBL
LigandPNGBDBM50203652(CHEMBL3909872)
Affinity DataEC50:  16nMAssay Description:Agonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/10/2018
Entry Details Article
PubMed
TargetStimulator of interferon genes protein(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM453585(US10730849, Example 50)
Affinity DataEC50:  890nMAssay Description:The individual compounds described in the Examples herein are defined as STING agonists by (i) binding to the STING protein as evidenced by a reducti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2021
Entry Details
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LigandPNGBDBM573840(US11453697, Example 4 | (5R,7R,8R,12aR,14R,15R,15a...)
Affinity DataEC50:  22nMAssay Description:The compounds were serially titrated by the Hamilton STARPlus CORE in a 96-well plate (Greiner, #651201) using a 1:3 ten-point dose response format. ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2022
Entry Details
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LigandPNGBDBM573849(US11453697, Example 13 | 2-amino-9- [(5R,7R,8R,12a...)
Affinity DataEC50:  1.5nMAssay Description:The compounds were serially titrated by the Hamilton STARPlus CORE in a 96-well plate (Greiner, #651201) using a 1:3 ten-point dose response format. ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2022
Entry Details
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LigandPNGBDBM573989(US11453697, Example 307 | 2-amino-9-[(2R,5R,7R,8S,...)
Affinity DataEC50: <1nMAssay Description:The compounds were serially titrated by the Hamilton STARPlus CORE in a 96-well plate (Greiner, #651201) using a 1:3 ten-point dose response format. ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2022
Entry Details
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TargetStimulator of interferon genes protein [H232R](ZEBOV)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM573877(US11453697, Example 72 | 2-amino-9- [(5R,7R,8R,12a...)
Affinity DataEC50: <1nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2022
Entry Details
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LigandPNGBDBM457772(2-amino-9-[(1R,6R,8R,9S,14R,16R,17R,18R)-16- (6-am...)
Affinity DataEC50:  3.60nMAssay Description:16 nM of [3H] c-GAMP ligand was prepared by diluting into assay buffer, and 50 uL of this working stock was manually added to each well of the assay ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/4/2021
Entry Details
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TargetStimulator of interferon genes protein [H232R](ZEBOV)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM574040(US11453697, Example 165 | 2-amino-9-[(5R,7R,8S,12a...)
Affinity DataEC50:  463nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2022
Entry Details
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Target3-oxoacyl-[acyl-carrier-protein] synthase 2(Staphylococcus aureus)
Colorado State University

Curated by ChEMBL
LigandPNGBDBM214777(TLM18)
Affinity DataKd:  1.07E+5nMAssay Description:Binding affinity to Staphylococcus aureus wild type FabF expressed in Escherichia coli BL21 (DE3) PlysS cells by intrinsic tryptophan fluorescence qu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
LifeMine Therapeutics

Curated by ChEMBL
LigandPNGBDBM50645819(CHEMBL5591069)
Affinity DataEC50:  870nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
LifeMine Therapeutics

Curated by ChEMBL
LigandPNGBDBM50645814(CHEMBL5590401)
Affinity DataEC50:  2.89E+3nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetStimulator of interferon genes protein(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM453564((S)-4-(6-bromo-5- methylbenzo[b] thiophen-2-yl)- 2...)
Affinity DataEC50:  2.00E+4nMAssay Description:The individual compounds described in the Examples herein are defined as STING agonists by (i) binding to the STING protein as evidenced by a reducti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2021
Entry Details
Go to US Patent

TargetStimulator of interferon genes protein [H232R](ZEBOV)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM573882(US11453697, Example 41 | 2-amino-9- [(5R,7R,8R,12a...)
Affinity DataEC50:  506nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2022
Entry Details
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TargetStimulator of interferon genes protein [H232R](ZEBOV)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM574151(US11453697, Example 283 | 2-amino-9-[(5S,7R,8R,12a...)
Affinity DataEC50:  17.2nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2022
Entry Details
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TargetFree fatty acid receptor 4(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50203676(CHEMBL3897776)
Affinity DataEC50:  170nMAssay Description:Agonist activity at human GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/10/2018
Entry Details Article
PubMed
LigandPNGBDBM457797(US10738074, Example 34)
Affinity DataEC50: <1nMAssay Description:16 nM of [3H] c-GAMP ligand was prepared by diluting into assay buffer, and 50 uL of this working stock was manually added to each well of the assay ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/4/2021
Entry Details
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TargetStimulator of interferon genes protein [H232R](Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM457803(US10738074, Example 30)
Affinity DataEC50:  7.35E+3nMAssay Description:16 nM of [3H] c-GAMP ligand was prepared by diluting into assay buffer, and 50 uL of this working stock was manually added to each well of the assay ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/4/2021
Entry Details
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TargetStimulator of interferon genes protein [H232R](ZEBOV)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM574021(US11453697, Example 111 | US11453697, Example 114 ...)
Affinity DataEC50:  155nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2022
Entry Details
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TargetStimulator of interferon genes protein [H232R](ZEBOV)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM574156(US11453697, Example 288 | 2-amino-9-[(5R,7R,8R,12a...)
Affinity DataEC50:  24.9nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2022
Entry Details
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TargetStimulator of interferon genes protein(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM576120(US11466047, Example 3 | 2-amino-9-[(5S,7R,8R,12aR,...)
Affinity DataEC50:  2nMAssay Description:The compounds were serially titrated by the Hamilton STARPlus CORE in a 96-well plate (Greiner, #651201) using a 1:3 ten-point dose response format. ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2022
Entry Details
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LigandPNGBDBM50547430(CHEMBL4753045)
Affinity DataEC50:  7.30E+3nMAssay Description:Activation of human sGC subunit alpha1/beta1 expressed in CHO cells assessed as cGMP production by CASA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
TargetFree fatty acid receptor 4(Mouse)
Merck

Curated by ChEMBL
LigandPNGBDBM50203669(CHEMBL3974501)
Affinity DataEC50:  1.87E+3nMAssay Description:Agonist activity at mouse GPR120 expressed in CHOK1 cells measured after 60 mins by IP1-HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/10/2018
Entry Details Article
PubMed
TargetStimulator of interferon genes protein(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM453576(US10730849, Example 41)
Affinity DataEC50:  5.70E+3nMAssay Description:The individual compounds described in the Examples herein are defined as STING agonists by (i) binding to the STING protein as evidenced by a reducti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2021
Entry Details
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TargetStimulator of interferon genes protein(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM453549(US10730849, Example 14 | US10730849, Example 25 | ...)
Affinity DataEC50:  8.64E+3nMAssay Description:The individual compounds described in the Examples herein are defined as STING agonists by (i) binding to the STING protein as evidenced by a reducti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2021
Entry Details
Go to US Patent

LigandPNGBDBM573876(US11453697, Example 71 | 2-amino-9- [(5R,7R,8R,12a...)
Affinity DataEC50: <1nMAssay Description:The compounds were serially titrated by the Hamilton STARPlus CORE in a 96-well plate (Greiner, #651201) using a 1:3 ten-point dose response format. ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2022
Entry Details
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TargetStimulator of interferon genes protein [H232R](ZEBOV)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM574086(US11453697, Example 214 | US11453697, Example 217 ...)
Affinity DataEC50:  66.2nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2022
Entry Details
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TargetStimulator of interferon genes protein [H232R](ZEBOV)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM574137(US11453697, Example 269 | 5-amino-3-[(5R,7R,8R,12a...)
Affinity DataEC50:  4.38E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2022
Entry Details
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LigandPNGBDBM50547433(CHEMBL4740488)
Affinity DataEC50:  9.00E+4nMAssay Description:Activation of human sGC subunit alpha1/beta1 expressed in CHO cells assessed as cGMP production by CASA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed
LigandPNGBDBM573902(US11453697, Example 61 | 1-[(5R,7R,8R,12aR,14R,15R...)
Affinity DataEC50:  18.2nMAssay Description:The compounds were serially titrated by the Hamilton STARPlus CORE in a 96-well plate (Greiner, #651201) using a 1:3 ten-point dose response format. ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2022
Entry Details
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