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TargetEpidermal growth factor receptor(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50322823((S)-N-(4-(3-chloro-4-fluorophenylamino)-7-(tetrahy...)
Affinity DataIC50: 0.570nMAssay Description:Inhibition of EGFR exon 19 deletion activating mutant phosphorylation in human PC9 cells after 2 hrs by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetEpidermal growth factor receptor(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM112499(DACOMITINIB | US8623883, No. 2 | WO2022090481, Exa...)
Affinity DataIC50: 0.630nMAssay Description:Inhibition of EGFR exon 19 deletion activating mutant phosphorylation in human PC9 cells after 2 hrs by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetSodium-dependent dopamine transporter(Human)
Massachusetts College of Pharmacy and Health Sciences

Curated by ChEMBL
LigandPNGBDBM50202396((RS/SR)-2-[1-(3,4-dichlorophenyl)butyl]piperidine ...)
Affinity DataKi:  0.970nMAssay Description:Displacement of [125I]RTI-55 from human DAT expressing HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/9/2012
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Human)
Massachusetts College of Pharmacy and Health Sciences

Curated by ChEMBL
LigandPNGBDBM50202396((RS/SR)-2-[1-(3,4-dichlorophenyl)butyl]piperidine ...)
Affinity DataKi:  0.970nMAssay Description:Displacement of [125I]RTI-55 from human DAT expressing HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/9/2012
Entry Details Article
PubMed
TargetHistone-lysine N-methyltransferase EZH2(Human)
Constellation Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50563820(CHEMBL4779123)
Affinity DataIC50: 1nMAssay Description:Inhibition of wild-type EZH2 in PRC2 complex (unknown origin) using RKQLATKAARK(Me3)SAPATGGVKKP-NH2 peptide substrate preincubated for 30 mins follow...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetHistone-lysine N-methyltransferase EZH2(Human)
Constellation Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50563822(CHEMBL4779426)
Affinity DataIC50: 1nMAssay Description:Inhibition of wild-type EZH2 in PRC2 complex (unknown origin) using RKQLATKAARK(Me3)SAPATGGVKKP-NH2 peptide substrate preincubated for 30 mins follow...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetHistone-lysine N-methyltransferase EZH2(Human)
Constellation Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50563823(CHEMBL4799137)
Affinity DataIC50: 1nMAssay Description:Inhibition of wild-type EZH2 in PRC2 complex (unknown origin) using RKQLATKAARK(Me3)SAPATGGVKKP-NH2 peptide substrate preincubated for 30 mins follow...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetHistone-lysine N-methyltransferase EZH2(Human)
Constellation Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50563825(CHEMBL4794859)
Affinity DataIC50: 1nMAssay Description:Inhibition of wild-type EZH2 in PRC2 complex (unknown origin) using RKQLATKAARK(Me3)SAPATGGVKKP-NH2 peptide substrate preincubated for 30 mins follow...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Human)
Massachusetts College of Pharmacy and Health Sciences

Curated by ChEMBL
LigandPNGBDBM50202400((RR/SS)-2-[1-(3,4-dichlorophenyl)-3-methylbutyl]-p...)
Affinity DataKi:  1nMAssay Description:Displacement of [125I]RTI-55 from human DAT expressing HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/9/2012
Entry Details Article
PubMed
TargetHistone-lysine N-methyltransferase EZH2(Human)
Constellation Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50017293(CHEMBL3287735 | US10647700, Compound GSK126)
Affinity DataIC50: 1nMAssay Description:Inhibition of EZH2 (unknown origin) using biotinylated nucleosome, H3K27me3 activator and [3H]-SAM incubated for 60 mins by top-count based methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2016
Entry Details Article
PubMed
TargetHistone-lysine N-methyltransferase EZH2(Human)
Constellation Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50563825(CHEMBL4794859)
Affinity DataIC50: 1nMAssay Description:Inhibition of EZH2 Y641F mutant in PRC2 complex (unknown origin) using RKQLATKAARK(Me3)SAPATGGVKKP-NH2 peptide substrate preincubated for 30 mins fol...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetHistone-lysine N-methyltransferase EZH2(Human)
Constellation Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM172038(US10647700, Compound EPZ6438 | BDBM190183 | US1015...)
Affinity DataIC50: 1nMAssay Description:Inhibition of EZH2 (unknown origin) using biotinylated nucleosome, H3K27me3 activator and [3H]-SAM incubated for 60 mins by top-count based methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2016
Entry Details Article
PubMed
TargetHistone-lysine N-methyltransferase EZH2(Human)
Constellation Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM172038(US10647700, Compound EPZ6438 | BDBM190183 | US1015...)
Affinity DataIC50: 1nMAssay Description:Inhibition of EZH2 Y641N mutant (unknown origin) using biotinylated nucleosome, H3K27me3 activator and [3H]-SAM incubated for 60 mins by top-count ba...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2016
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Human)
Massachusetts College of Pharmacy and Health Sciences

Curated by ChEMBL
LigandPNGBDBM50202400((RR/SS)-2-[1-(3,4-dichlorophenyl)-3-methylbutyl]-p...)
Affinity DataKi:  1nMAssay Description:Displacement of [125I]RTI-55 from human DAT expressing HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/9/2012
Entry Details Article
PubMed
TargetHistone-lysine N-methyltransferase EZH2(Human)
Constellation Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50110357(CHEMBL3605455)
Affinity DataIC50: 1nMAssay Description:Inhibition of EZH2 (unknown origin) using biotinylated nucleosome, H3K27me3 activator and [3H]-SAM incubated for 60 mins by top-count based methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2016
Entry Details Article
PubMed
TargetHistone-lysine N-methyltransferase EZH2(Human)
Constellation Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50110359(CHEMBL3605453)
Affinity DataIC50: 1nMAssay Description:Inhibition of EZH2 (unknown origin) using biotinylated nucleosome, H3K27me3 activator and [3H]-SAM incubated for 60 mins by top-count based methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2016
Entry Details Article
PubMed
TargetHistone-lysine N-methyltransferase EZH2(Human)
Constellation Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50110355(CHEMBL3605457)
Affinity DataIC50: 1nMAssay Description:Inhibition of wild-type EZH2 in PRC2 complex (unknown origin) using RKQLATKAARK(Me3)SAPATGGVKKP-NH2 peptide substrate preincubated for 30 mins follow...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetHistone-lysine N-methyltransferase EZH2(Human)
Constellation Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50563818(CHEMBL4781657)
Affinity DataIC50: 1nMAssay Description:Inhibition of wild-type EZH2 in PRC2 complex (unknown origin) using RKQLATKAARK(Me3)SAPATGGVKKP-NH2 peptide substrate preincubated for 30 mins follow...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Human)
Massachusetts College of Pharmacy and Health Sciences

Curated by ChEMBL
LigandPNGBDBM50202391((RS/SR)-methyl 2-(3,4-dichlorophenyl)-2-(piperidin...)
Affinity DataKi:  1.40nMAssay Description:Displacement of [125I]RTI-55 from human DAT expressing HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/9/2012
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Human)
Massachusetts College of Pharmacy and Health Sciences

Curated by ChEMBL
LigandPNGBDBM50202391((RS/SR)-methyl 2-(3,4-dichlorophenyl)-2-(piperidin...)
Affinity DataKi:  1.40nMAssay Description:Displacement of [125I]RTI-55 from human DAT expressing HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/9/2012
Entry Details Article
PubMed
TargetHistone-lysine N-methyltransferase EZH2(Human)
Constellation Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50563826(CHEMBL4782143)
Affinity DataIC50: 1.60nMAssay Description:Inhibition of wild-type EZH2 in PRC2 complex (unknown origin) using RKQLATKAARK(Me3)SAPATGGVKKP-NH2 peptide substrate preincubated for 30 mins follow...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetHistone-lysine N-methyltransferase EZH2(Human)
Constellation Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50563818(CHEMBL4781657)
Affinity DataIC50: 1.70nMAssay Description:Inhibition of EZH2 Y641F mutant in PRC2 complex (unknown origin) using RKQLATKAARK(Me3)SAPATGGVKKP-NH2 peptide substrate preincubated for 30 mins fol...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetHistone-lysine N-methyltransferase EZH2(Human)
Constellation Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50563822(CHEMBL4779426)
Affinity DataIC50: 1.70nMAssay Description:Inhibition of EZH2 Y641F mutant in PRC2 complex (unknown origin) using RKQLATKAARK(Me3)SAPATGGVKKP-NH2 peptide substrate preincubated for 30 mins fol...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetHistone-lysine N-methyltransferase EZH2(Human)
Constellation Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50563827(CHEMBL4797333)
Affinity DataIC50: 1.80nMAssay Description:Inhibition of wild-type EZH2 in PRC2 complex (unknown origin) using RKQLATKAARK(Me3)SAPATGGVKKP-NH2 peptide substrate preincubated for 30 mins follow...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetHistone-lysine N-methyltransferase EZH2(Human)
Constellation Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50017293(CHEMBL3287735 | US10647700, Compound GSK126)
Affinity DataIC50: 2nMAssay Description:Inhibition of EZH2 Y641N mutant (unknown origin) using biotinylated nucleosome, H3K27me3 activator and [3H]-SAM incubated for 60 mins by top-count ba...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2016
Entry Details Article
PubMed
TargetHistone-lysine N-methyltransferase EZH2(Human)
Constellation Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50110355(CHEMBL3605457)
Affinity DataIC50: 2nMAssay Description:Inhibition of EZH2 (unknown origin) using biotinylated nucleosome, H3K27me3 activator and [3H]-SAM incubated for 60 mins by top-count based methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2016
Entry Details Article
PubMed
TargetMacrophage colony-stimulating factor 1 receptor(Human)
Astrazeneca R&D Boston

Curated by ChEMBL
LigandPNGBDBM50255518(4-(3,4-dichlorophenylamino)-7-methoxy-6-(4-methylp...)
Affinity DataIC50: 2nMAssay Description:Inhibition of CSF1RMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetHistone-lysine N-methyltransferase EZH2(Human)
Constellation Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50110356(CHEMBL3605456)
Affinity DataIC50: 2nMAssay Description:Inhibition of EZH2 (unknown origin) using biotinylated nucleosome, H3K27me3 activator and [3H]-SAM incubated for 60 mins by top-count based methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2016
Entry Details Article
PubMed
TargetHistone-lysine N-methyltransferase EZH2(Human)
Constellation Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50110358(CHEMBL3605454)
Affinity DataIC50: 2nMAssay Description:Inhibition of EZH2 (unknown origin) using biotinylated nucleosome, H3K27me3 activator and [3H]-SAM incubated for 60 mins by top-count based methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2016
Entry Details Article
PubMed
TargetHistone-lysine N-methyltransferase EZH2(Human)
Constellation Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50563817(CHEMBL4787149)
Affinity DataIC50: 2nMAssay Description:Inhibition of wild-type EZH2 in PRC2 complex (unknown origin) using RKQLATKAARK(Me3)SAPATGGVKKP-NH2 peptide substrate preincubated for 30 mins follow...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetHistone-lysine N-methyltransferase EZH2(Human)
Constellation Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50541920(Lirametostat | Cpi-1205)
Affinity DataIC50: 2.20nMAssay Description:Inhibition of wild-type EZH2 in PRC2 complex (unknown origin) using RKQLATKAARK(Me3)SAPATGGVKKP-NH2 peptide substrate preincubated for 30 mins follow...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetHistone-lysine N-methyltransferase EZH2(Human)
Constellation Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50563824(CHEMBL4777385)
Affinity DataIC50: 2.30nMAssay Description:Inhibition of wild-type EZH2 in PRC2 complex (unknown origin) using RKQLATKAARK(Me3)SAPATGGVKKP-NH2 peptide substrate preincubated for 30 mins follow...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Human)
Massachusetts College of Pharmacy and Health Sciences

Curated by ChEMBL
LigandPNGBDBM50202404((RS/SR)-2-[1-(3,4-dichlorophenyl)pentyl]piperidine...)
Affinity DataKi:  2.30nMAssay Description:Displacement of [125I]RTI-55 from human DAT expressing HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/9/2012
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Human)
Massachusetts College of Pharmacy and Health Sciences

Curated by ChEMBL
LigandPNGBDBM50202404((RS/SR)-2-[1-(3,4-dichlorophenyl)pentyl]piperidine...)
Affinity DataKi:  2.30nMAssay Description:Displacement of [125I]RTI-55 from human DAT expressing HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/9/2012
Entry Details Article
PubMed
TargetSmoothened homolog(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50388706(CHEMBL2059863)
Affinity DataIC50: 2.40nMAssay Description:Inhibition of Smo expressed in mouse NIH/3T3 cells after 20 hrs by Gli reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed
TargetHistone-lysine N-methyltransferase EZH2(Human)
Constellation Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50563823(CHEMBL4799137)
Affinity DataIC50: 2.5nMAssay Description:Inhibition of EZH2 Y641F mutant in PRC2 complex (unknown origin) using RKQLATKAARK(Me3)SAPATGGVKKP-NH2 peptide substrate preincubated for 30 mins fol...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetHistone-lysine N-methyltransferase EZH2(Human)
Constellation Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50563819(CHEMBL4800227)
Affinity DataIC50: 2.5nMAssay Description:Inhibition of wild-type EZH2 in PRC2 complex (unknown origin) using RKQLATKAARK(Me3)SAPATGGVKKP-NH2 peptide substrate preincubated for 30 mins follow...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetSmoothened homolog(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50388707(CHEMBL2059864)
Affinity DataIC50: 2.60nMAssay Description:Inhibition of Smo expressed in mouse NIH/3T3 cells after 20 hrs by Gli reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Human)
Massachusetts College of Pharmacy and Health Sciences

Curated by ChEMBL
LigandPNGBDBM50202402((RS/SR)-2-[1-(3-chlorophenyl)-3-methylbutyl]piperi...)
Affinity DataIC50: 2.80nMAssay Description:Inhibition of [3H]DA uptake at human DAT expressing HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/9/2012
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Human)
Massachusetts College of Pharmacy and Health Sciences

Curated by ChEMBL
LigandPNGBDBM50202402((RS/SR)-2-[1-(3-chlorophenyl)-3-methylbutyl]piperi...)
Affinity DataIC50: 2.80nMAssay Description:Inhibition of [3H]DA uptake at human DAT expressing HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/9/2012
Entry Details Article
PubMed
TargetHistone-lysine N-methyltransferase EZH2(Human)
Constellation Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50110355(CHEMBL3605457)
Affinity DataIC50: 2.80nMAssay Description:Inhibition of EZH2 Y641F mutant in PRC2 complex (unknown origin) using RKQLATKAARK(Me3)SAPATGGVKKP-NH2 peptide substrate preincubated for 30 mins fol...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed
TargetCasein kinase II subunit alpha(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50437434(CHEMBL2409175)
Affinity DataIC50: 3nMAssay Description:Inhibition of recombinant human full length N-terminal His6-tagged CK2alpha expressed in Sf21 insect cells using CK2tide as substrate treated for 20 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetBromodomain-containing protein 9 [134-239](Human)
Genentech

US Patent
LigandPNGBDBM321438(3-[6-[(E)-but-2-enyl]-2-methyl-7-oxo-1H-pyrrolo[2,...)
Affinity DataIC50: 3nMAssay Description:His/Flag epitope tagged BRD9134-239 was cloned, expressed, and purified to homogeneity. BRD9 binding and inhibition was assessed by monitoring the en...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/16/2019
Entry Details
US Patent

TargetCasein kinase II subunit alpha(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50388781(CHEMBL2062585)
Affinity DataIC50: 3nMAssay Description:Inhibition of recombinant human full length N-terminal His6-tagged CK2alpha expressed in Sf21 insect cells using CK2tide as substrate treated for 20 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetHomeodomain-interacting protein kinase 2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50460939(CHEMBL4228654)
Affinity DataIC50: 3nMAssay Description:Inhibition of HIPK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetMacrophage colony-stimulating factor 1 receptor(Human)
Astrazeneca R&D Boston

Curated by ChEMBL
LigandPNGBDBM50255594(4-(2,3-dichlorophenylamino)-7-fluoro-6-(4-methylpi...)
Affinity DataIC50: 3nMAssay Description:Inhibition of CSF1RMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetBromodomain-containing protein 9 [134-239](Human)
Genentech

US Patent
LigandPNGBDBM321429((E)-1-(4-(6-(but-2-en-1-yl)-2-methyl-7-oxo-6,7-dih...)
Affinity DataIC50: 3nMAssay Description:His/Flag epitope tagged BRD9134-239 was cloned, expressed, and purified to homogeneity. BRD9 binding and inhibition was assessed by monitoring the en...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/16/2019
Entry Details
US Patent

TargetMacrophage colony-stimulating factor 1 receptor(Human)
Astrazeneca R&D Boston

Curated by ChEMBL
LigandPNGBDBM50255517(4-(2,4-dichlorophenylamino)-7-methoxy-6-(4-methylp...)
Affinity DataIC50: 3nMAssay Description:Inhibition of CSF1RMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetMacrophage colony-stimulating factor 1 receptor(Human)
Astrazeneca R&D Boston

Curated by ChEMBL
LigandPNGBDBM50244783(2-chloro-5-[(3,5-dimethylbenzoyl)amino]-N-1,3-thia...)
Affinity DataIC50: 3nMAssay Description:Inhibition of CSF1RMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetBromodomain-containing protein 9 [134-239](Human)
Genentech

US Patent
LigandPNGBDBM321430(6-[(E)-but-2-enyl]-4-[3-isopropoxy-4-(morpholine-4...)
Affinity DataIC50: 3nMAssay Description:His/Flag epitope tagged BRD9134-239 was cloned, expressed, and purified to homogeneity. BRD9 binding and inhibition was assessed by monitoring the en...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/16/2019
Entry Details
US Patent

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