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LigandPNGBDBM50504138(CHEMBL1424006)
Affinity DataKd:  5.01E+4nMAssay Description:Binding affinity to His6/FLAG-tagged TEV fused ATAD2 bromodomain (950 to 1148 residues) (unknown origin) expressed in Escherichia coli BL21(DE3) cell...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetBromodomain and PHD finger-containing protein 3(Human)
University of Strathclyde

Curated by ChEMBL
LigandPNGBDBM50514857(CHEMBL4449894)
Affinity DataKd:  126nMAssay Description:Binding affinity to human partial length BRPF3 (E588 to G701 residues) expressed in bacterial expression system by BROMOscan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetSphingosine 1-phosphate receptor 1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50419203(CHEMBL1836214)
Affinity DataEC50:  7.94nMAssay Description:Agonist activity at human S1P1 receptor expressed in CHO-K1 EDG1 cells expressing beta-arrestin 2 after 105 mins by chemi-luminescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
LigandPNGBDBM50098249(CHEMBL3590388)
Affinity DataKd:  3.16E+3nMAssay Description:Binding affinity to FLAG-6His-Tev-ATAD2 (950 to 1148) (unknown origin) expressed in Escherichia coli BL21 (DE3) by SPR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/25/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50098305(CHEMBL3590405)
Affinity DataKd:  63nMAssay Description:Binding affinity to FLAG-6His-Tev-ATAD2 (950 to 1148) (unknown origin) expressed in Escherichia coli BL21 (DE3) by SPR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/25/2016
Entry Details Article
PubMed
TargetSphingosine 1-phosphate receptor 5(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50354138(CHEMBL1836215)
Affinity DataEC50:  19.9nMAssay Description:Agonist activity at human S1P5 receptor expressed in CHO-K1 aequorin cells assessed as calcium accumulation of by luminescence assay in presence of c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
TargetProtein polybromo-1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50098311(CHEMBL3590408)
Affinity DataKd: <1.00E+5nMAssay Description:Binding affinity to PBRM1 in human HUT78 cells incubated for 45 mins by mass spectrometry based bromosphere chemoproteomic assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/25/2016
Entry Details Article
PubMed
TargetSphingosine 1-phosphate receptor 1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM23165(CHEMBL366208 | [(2S)-2-amino-3-hydroxy-2-[2-(4-oct...)
Affinity DataEC50:  20nMAssay Description:Agonist activity at human S1P1 receptor expressed in CHO-K1 EDG1 cells by beta-arrestin recruitment assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2017
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetPeregrin(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50189403(CHEMBL3828191)
Affinity DataKd:  0.316nMAssay Description:Inhibition of human BRPF1 by BROMOscan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2017
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50098252(CHEMBL3590394)
Affinity DataKd:  3.20E+3nMAssay Description:Binding affinity to FLAG-6His-Tev-ATAD2 (950 to 1148) (unknown origin) expressed in Escherichia coli BL21 (DE3) by SPR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/25/2016
Entry Details Article
PubMed
TargetBromodomain-containing protein 9(Human)
University of Strathclyde

Curated by ChEMBL
LigandPNGBDBM50455480(CHEMBL4218735)
Affinity DataKd: <3.02E+4nMAssay Description:Binding affinity to human partial length DNA-tagged BRD9 isoform 1 expressed in bacteria by BROMOscan methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetHistone acetyltransferase KAT2B(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50098305(CHEMBL3590405)
Affinity DataKd: <1.00E+5nMAssay Description:Binding affinity to KAT2B in human HUT78 cells incubated for 45 mins by mass spectrometry based bromosphere chemoproteomic assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/25/2016
Entry Details Article
PubMed
TargetBromodomain-containing protein 2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50560174(GSK789)
Affinity DataKd:  4nMAssay Description:Binding affinity to full length BRD2 BD1 in human HuT78 cell lysates incubated for 45 mins by liquid chromatography-mass spectrometry based chemoprot...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetBromodomain-containing protein 3(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50560174(GSK789)
Affinity DataKd:  4nMAssay Description:Binding affinity to full length BRD3 BD1 in human HuT78 cell lysates incubated for 45 mins by liquid chromatography-mass spectrometry based chemoprot...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetBromodomain-containing protein 4(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50098250(CHEMBL3590389)
Affinity DataKd:  1.59E+3nMAssay Description:Binding affinity to BRD4 in human HUT78 cells incubated for 45 mins by mass spectrometry based bromosphere chemoproteomic assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/25/2016
Entry Details Article
PubMed
TargetSphingosine 1-phosphate receptor 3(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50149558(CHEMBL3771116)
Affinity DataEC50: <3.16E+4nMAssay Description:Agonist activity at human S1P3 receptor expressed in RBL cells by [35S]GTP-gammaS accumulation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2017
Entry Details Article
PubMed
TargetTranscription activator BRG1(Human)
University of Strathclyde

Curated by ChEMBL
LigandPNGBDBM50455480(CHEMBL4218735)
Affinity DataKd: <3.02E+4nMAssay Description:Binding affinity to human partial length DNA-tagged SMARCA4 expressed in bacteria by BROMOscan methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetTranscription initiation factor TFIID subunit 1(Human)
University of Strathclyde

Curated by ChEMBL
LigandPNGBDBM50514856(CHEMBL4465880)
Affinity DataKd:  63nMAssay Description:Binding affinity to human partial length TAF1 bromodomain 2 (D1521 to D1656 residues) expressed in bacterial expression system by BROMOscan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetSphingosine 1-phosphate receptor 5(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM23165(CHEMBL366208 | [(2S)-2-amino-3-hydroxy-2-[2-(4-oct...)
Affinity DataEC50:  63.1nMAssay Description:Agonist activity at human S1P5 receptor expressed in CHO-K1 aequorin cells assessed as calcium accumulation of by luminescence assay in presence of c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
TargetSphingosine 1-phosphate receptor 1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50149562(CHEMBL3770966)
Affinity DataEC50:  158nMAssay Description:Agonist activity at human S1P1 receptor expressed in CHO-K1 EDG1 cells by beta-arrestin recruitment assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2017
Entry Details Article
PubMed
TargetBromodomain-containing protein 4(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50544597(GSK778)
Affinity DataKd:  1.26E+3nMAssay Description:Binding affinity to BRD4 BD2 (333 to 460 residues) (unknown origin) by surface plasmon resonance methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetSphingosine 1-phosphate receptor 3(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM23165(CHEMBL366208 | [(2S)-2-amino-3-hydroxy-2-[2-(4-oct...)
Affinity DataEC50:  5.01nMAssay Description:Agonist activity at human S1P3 receptor expressed in RBL cells assessed as [35S]GTPgammaS binding after 3 hrs by radiometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetSphingosine 1-phosphate receptor 1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50149575(CHEMBL3771070)
Affinity DataEC50: <3.16E+4nMAssay Description:Agonist activity at human S1P1 receptor expressed in RH7777 cells by [35S]GTP-gammaS accumulation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2017
Entry Details Article
PubMed
LigandPNGBDBM50504143(CHEMBL1602822)
Affinity DataKd:  2.00E+4nMAssay Description:Binding affinity to His6/FLAG-tagged TEV fused ATAD2 bromodomain (950 to 1148 residues) (unknown origin) expressed in Escherichia coli BL21(DE3) cell...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetSphingosine 1-phosphate receptor 1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50419202(CHEMBL1836169)
Affinity DataEC50:  5.62nMAssay Description:Agonist activity at human S1P1 receptor expressed in CHO-K1 EDG1 cells expressing beta-arrestin 2 after 105 mins by chemi-luminescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
LigandPNGBDBM50560174(GSK789)
Affinity DataKd:  1.58E+4nMAssay Description:Binding affinity to human partial length BAZ2A (M1792 to L1905 residues) expressed in bacterial expression system by BROMOscan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetBromodomain-containing protein 2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50560174(GSK789)
Affinity DataKd:  2.51E+4nMAssay Description:Binding affinity to human partial length BRD2 bromodomain 2 isoform 1 (E348 to D455 residues) expressed in bacterial expression system by BROMOscan a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetSphingosine 1-phosphate receptor 1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50149588(CHEMBL3770302)
Affinity DataEC50:  63nMAssay Description:Agonist activity at human S1P1 receptor expressed in RH7777 cells by [35S]GTP-gammaS accumulation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2017
Entry Details Article
PubMed
TargetSphingosine 1-phosphate receptor 3(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50149555(CHEMBL3770278)
Affinity DataEC50: <3.16E+4nMAssay Description:Agonist activity at human S1P3 receptor expressed in RBL cells by [35S]GTP-gammaS accumulation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2017
Entry Details Article
PubMed
TargetBromodomain testis-specific protein(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50560174(GSK789)
Affinity DataKd:  10nMAssay Description:Binding affinity to full length BRDT BD1 in human HuT78 cell lysates incubated for 45 mins by liquid chromatography-mass spectrometry based chemoprot...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetATPase family AAA domain-containing protein 2B(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50098311(CHEMBL3590408)
Affinity DataKd:  100nMAssay Description:Binding affinity to ATAD2B in human HUT78 cells incubated for 45 mins by mass spectrometry based bromosphere chemoproteomic assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/25/2016
Entry Details Article
PubMed
TargetSphingosine 1-phosphate receptor 1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50149589(CHEMBL3770772)
Affinity DataEC50:  2.51E+4nMAssay Description:Agonist activity at human S1P1 receptor expressed in RH7777 cells by [35S]GTP-gammaS accumulation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2017
Entry Details Article
PubMed
TargetSphingosine 1-phosphate receptor 3(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50149557(CHEMBL3769716)
Affinity DataEC50: <3.16E+4nMAssay Description:Agonist activity at human S1P3 receptor expressed in RBL cells by [35S]GTP-gammaS accumulation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2017
Entry Details Article
PubMed
TargetATPase family AAA domain-containing protein 2B(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50560174(GSK789)
Affinity DataKd:  1.58E+4nMAssay Description:Binding affinity to human partial length ATAD2B (Q955 to R1082 residues) expressed in bacterial expression system by BROMOscan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetTranscription activator BRG1(Human)
University of Strathclyde

Curated by ChEMBL
LigandPNGBDBM50098311(CHEMBL3590408)
Affinity DataKd:  2.00E+4nMAssay Description:Binding affinity to SMARCA4 in human HUT78 cells incubated for 45 mins by mass spectrometry based bromosphere chemoproteomic assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/25/2016
Entry Details Article
PubMed
TargetSphingosine 1-phosphate receptor 1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50149558(CHEMBL3771116)
Affinity DataEC50:  794nMAssay Description:Agonist activity at human S1P1 receptor expressed in CHO-K1 EDG1 cells by beta-arrestin recruitment assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2017
Entry Details Article
PubMed
TargetSphingosine 1-phosphate receptor 3(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50149571(CHEMBL3771073)
Affinity DataEC50: <3.16E+4nMAssay Description:Agonist activity at human S1P3 receptor expressed in RBL cells by [35S]GTP-gammaS accumulation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2017
Entry Details Article
PubMed
TargetSphingosine 1-phosphate receptor 1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50149564(CHEMBL3769584)
Affinity DataEC50:  13nMAssay Description:Agonist activity at human S1P1 receptor expressed in RH7777 cells by [35S]GTP-gammaS accumulation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2017
Entry Details Article
PubMed
TargetSphingosine 1-phosphate receptor 3(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50149563(CHEMBL3770368)
Affinity DataEC50: <3.16E+4nMAssay Description:Agonist activity at human S1P3 receptor expressed in RBL cells by [35S]GTP-gammaS accumulation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2017
Entry Details Article
PubMed
LigandPNGBDBM50098252(CHEMBL3590394)
Affinity DataKd:  3.16E+3nMAssay Description:Binding affinity to FLAG-6His-Tev-ATAD2 (950 to 1148) (unknown origin) expressed in Escherichia coli BL21 (DE3) by SPR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/25/2016
Entry Details Article
PubMed
TargetBromodomain-containing protein 7(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50098311(CHEMBL3590408)
Affinity DataKd:  3.16E+4nMAssay Description:Binding affinity to BRD7 in human HUT78 cells incubated for 45 mins by mass spectrometry based bromosphere chemoproteomic assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/25/2016
Entry Details Article
PubMed
LigandPNGBDBM50514857(CHEMBL4449894)
Affinity DataKd:  10nMAssay Description:Binding affinity to human partial length ATAD2A (Q981 to R1108 residues) expressed in bacterial expression system by BROMOscan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetProtein polybromo-1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50455480(CHEMBL4218735)
Affinity DataKd: <3.02E+4nMAssay Description:Binding affinity to human partial length DNA-tagged PBRM1 BD5 expressed in bacteria by BROMOscan methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
LigandPNGBDBM50098311(CHEMBL3590408)
Affinity DataKd:  200nMAssay Description:Binding affinity to FLAG-6His-Tev-ATAD2 (950 to 1148) (unknown origin) expressed in Escherichia coli BL21 (DE3) by SPR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/25/2016
Entry Details Article
PubMed
TargetTranscription initiation factor TFIID subunit 1(Human)
University of Strathclyde

Curated by ChEMBL
LigandPNGBDBM50098311(CHEMBL3590408)
Affinity DataKd:  1.26E+3nMAssay Description:Binding affinity to TAF1 in human HUT78 cells incubated for 45 mins by mass spectrometry based bromosphere chemoproteomic assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/25/2016
Entry Details Article
PubMed
LigandPNGBDBM50504167(CHEMBL2138220)
Affinity DataKd:  7.94E+3nMAssay Description:Binding affinity to His6/FLAG-tagged TEV fused ATAD2 bromodomain (950 to 1148 residues) (unknown origin) expressed in Escherichia coli BL21(DE3) cell...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetBromodomain-containing protein 3(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50098250(CHEMBL3590389)
Affinity DataKd:  2.00E+3nMAssay Description:Binding affinity to BRD3 in human HUT78 cells incubated for 45 mins by mass spectrometry based bromosphere chemoproteomic assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/25/2016
Entry Details Article
PubMed
TargetSphingosine 1-phosphate receptor 3(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50127666(CHEMBL3628839)
Affinity DataEC50: <3.16E+4nMAssay Description:Agonist activity at S1P3 receptor (unknown origin) expressed in RBL membranes assessed as GTPgammaS binding after 3 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2016
Entry Details Article
PubMed
LigandPNGBDBM50504155(CHEMBL1731756)
Affinity DataKd:  5.01E+4nMAssay Description:Binding affinity to His6/FLAG-tagged TEV fused ATAD2 bromodomain (950 to 1148 residues) (unknown origin) expressed in Escherichia coli BL21(DE3) cell...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
LigandPNGBDBM50098311(CHEMBL3590408)
Affinity DataKd: <1.00E+5nMAssay Description:Binding affinity to BAZ2B in human HUT78 cells incubated for 45 mins by mass spectrometry based bromosphere chemoproteomic assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/25/2016
Entry Details Article
PubMed
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