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TargetNon-specific protein-tyrosine kinase [T818I](Human)
Dana-Farber Cancer Institute

US Patent
LigandPNGBDBM50328136(6-(1H-pyrazol-4-yl)-N-(4-(trifluoromethoxy)phenyl)...)
Affinity DatapH: 7.5Assay Description:In vitro kinase assays were carried out by using recombinant murine c-abl containing SH3, SH2 and kinase domains (residues 46-531) and full length im...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/7/2018
Entry Details
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TargetSerine/threonine-protein kinase pim-3(Human)
Harvard Medical School

LigandPNGBDBM81550(Furan thiazolidinediones, A47)
Affinity DataKd:  13nMAssay Description:In vitro biochemical assays were performed in parallel to determine the most potent tool compound.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/3/2011
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 7(Human)
Harvard Medical School

LigandPNGBDBM50337134(US9266890, IV-6 | Scaffold, B46 | CHEMBL1673046 | ...)
Affinity DataKd:  80nMAssay Description:In vitro biochemical assays were performed in parallel to determine the most potent tool compound.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/3/2011
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetActivated CDC42 kinase 1(Human)
Harvard Medical School

LigandPNGBDBM50337126(US9266890, IV-2 | CHEMBL1672987 | Scaffold, B19 | ...)
Affinity DataKd:  15nMAssay Description:In vitro biochemical assays were performed in parallel to determine the most potent tool compound.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/3/2011
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PLK1(Human)
Dana-Farber Cancer Institute

US Patent
LigandPNGBDBM209393(US9266890, I-1)
Affinity DataKd:  49nMAssay Description:In vitro Plk1 binding assay: Ambit Kd values in nanomolar. Kd values generated by Ambit binding assay over a concentration range of the compound.More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/23/2017
Entry Details
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TargetSerine/threonine-protein kinase PLK1(Human)
Dana-Farber Cancer Institute

US Patent
LigandPNGBDBM50435736(US9266890, I-3 | CHEMBL2392552)
Affinity DataKd:  0.570nMAssay Description:In vitro Plk1 binding assay: Ambit Kd values in nanomolar. Kd values generated by Ambit binding assay over a concentration range of the compound.More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/23/2017
Entry Details
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TargetSerine/threonine-protein kinase PLK1(Human)
Dana-Farber Cancer Institute

US Patent
LigandPNGBDBM209397(US9266890, I-6)
Affinity DataKd:  19nMAssay Description:In vitro Plk1 binding assay: Ambit Kd values in nanomolar. Kd values generated by Ambit binding assay over a concentration range of the compound.More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/23/2017
Entry Details
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TargetSerine/threonine-protein kinase PLK1(Human)
Dana-Farber Cancer Institute

US Patent
LigandPNGBDBM209398(US9266890, I-7)
Affinity DataKd:  36nMAssay Description:In vitro Plk1 binding assay: Ambit Kd values in nanomolar. Kd values generated by Ambit binding assay over a concentration range of the compound.More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/23/2017
Entry Details
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TargetSerine/threonine-protein kinase PLK1(Human)
Dana-Farber Cancer Institute

US Patent
LigandPNGBDBM209399(US9266890, I-8)
Affinity DataKd:  35nMAssay Description:In vitro Plk1 binding assay: Ambit Kd values in nanomolar. Kd values generated by Ambit binding assay over a concentration range of the compound.More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/23/2017
Entry Details
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TargetSerine/threonine-protein kinase PLK1(Human)
Dana-Farber Cancer Institute

US Patent
LigandPNGBDBM36486(US9266890, I-10 | Scaffold, B13 | 9-Cyclopentyl-2-...)
Affinity DataKd:  47nMAssay Description:In vitro Plk1 binding assay: Ambit Kd values in nanomolar. Kd values generated by Ambit binding assay over a concentration range of the compound.More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/23/2017
Entry Details
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TargetSerine/threonine-protein kinase PLK1(Human)
Dana-Farber Cancer Institute

US Patent
LigandPNGBDBM209401(US9266890, I-11)
Affinity DataKd:  200nMAssay Description:In vitro Plk1 binding assay: Ambit Kd values in nanomolar. Kd values generated by Ambit binding assay over a concentration range of the compound.More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/23/2017
Entry Details
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TargetSerine/threonine-protein kinase PLK1(Human)
Dana-Farber Cancer Institute

US Patent
LigandPNGBDBM209402(US9266890, I-12)
Affinity DataKd:  8nMAssay Description:In vitro Plk1 binding assay: Ambit Kd values in nanomolar. Kd values generated by Ambit binding assay over a concentration range of the compound.More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/23/2017
Entry Details
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TargetSerine/threonine-protein kinase PLK1(Human)
Dana-Farber Cancer Institute

US Patent
LigandPNGBDBM209414(US9266890, I-24)
Affinity DataKd:  18nMAssay Description:In vitro Plk1 binding assay: Ambit Kd values in nanomolar. Kd values generated by Ambit binding assay over a concentration range of the compound.More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/23/2017
Entry Details
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TargetMitogen-activated protein kinase 7(Human)
Harvard Medical School

LigandPNGBDBM209410(US9266890, I-20)
Affinity DataKd:  550nMAssay Description:In vitro Erk5 binding assay: Ambit Kd values in nanomolar. Kd values generated by Ambit binding assay over a concentration range of the compound.More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/23/2017
Entry Details
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TargetMitogen-activated protein kinase 7(Human)
Harvard Medical School

LigandPNGBDBM209414(US9266890, I-24)
Affinity DataKd:  320nMAssay Description:In vitro Erk5 binding assay: Ambit Kd values in nanomolar. Kd values generated by Ambit binding assay over a concentration range of the compound.More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/23/2017
Entry Details
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TargetMitogen-activated protein kinase 7(Human)
Harvard Medical School

LigandPNGBDBM50337126(US9266890, IV-2 | CHEMBL1672987 | Scaffold, B19 | ...)
Affinity DataKd:  670nMAssay Description:In vitro Erk5 binding assay: Ambit Kd values in nanomolar. Kd values generated by Ambit binding assay over a concentration range of the compound.More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/23/2017
Entry Details
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TargetMitogen-activated protein kinase 7(Human)
Harvard Medical School

LigandPNGBDBM50337127(US9266890, IV-1 | 2-(2-methoxy-4-(4-methylpiperazi...)
Affinity DataKd:  19nMAssay Description:In vitro Erk5 binding assay: Ambit Kd values in nanomolar. Kd values generated by Ambit binding assay over a concentration range of the compound.More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/23/2017
Entry Details
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TargetMitogen-activated protein kinase 7(Human)
Harvard Medical School

LigandPNGBDBM50337128(US9266890, IV-7 | 2-((4-(4-hydroxypiperidin-1-yl)-...)
Affinity DataKd:  57nMAssay Description:In vitro Erk5 binding assay: Ambit Kd values in nanomolar. Kd values generated by Ambit binding assay over a concentration range of the compound.More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/23/2017
Entry Details
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TargetMitogen-activated protein kinase 7(Human)
Harvard Medical School

LigandPNGBDBM50337134(US9266890, IV-6 | Scaffold, B46 | CHEMBL1673046 | ...)
Affinity DataKd:  80nMAssay Description:In vitro Erk5 binding assay: Ambit Kd values in nanomolar. Kd values generated by Ambit binding assay over a concentration range of the compound.More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/23/2017
Entry Details
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PDB3D3D Structure (crystal)
TargetMitogen-activated protein kinase 7(Human)
Harvard Medical School

LigandPNGBDBM209448(US9266890, IV-8)
Affinity DataKd:  50nMAssay Description:In vitro Erk5 binding assay: Ambit Kd values in nanomolar. Kd values generated by Ambit binding assay over a concentration range of the compound.More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/23/2017
Entry Details
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TargetD-3-phosphoglycerate dehydrogenase(Human)
Peking University

LigandPNGBDBM209925(PKUMDL-WQ-2201)
Affinity DataKd:  6.69E+4nMpH: 7.4Assay Description:The binding affinities of compounds towards PHGDH were assayed using the SPR-based Biacore T200 instrument (GE Healthcare). PHGDH was immobilized on ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/27/2017
Entry Details Article
PubMed
TargetD-3-phosphoglycerate dehydrogenase(Human)
Peking University

LigandPNGBDBM209926(PKUMDL-WQ-2202)
Affinity DataKd:  2.90E+4nMpH: 7.4Assay Description:The binding affinities of compounds towards PHGDH were assayed using the SPR-based Biacore T200 instrument (GE Healthcare). PHGDH was immobilized on ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/27/2017
Entry Details Article
PubMed
TargetD-3-phosphoglycerate dehydrogenase(Human)
Peking University

LigandPNGBDBM209927(PKUMDL-WQ-2203)
Affinity DataKd:  7.22E+3nMpH: 7.4Assay Description:The binding affinities of compounds towards PHGDH were assayed using the SPR-based Biacore T200 instrument (GE Healthcare). PHGDH was immobilized on ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/27/2017
Entry Details Article
PubMed
Target1-phosphatidylinositol 3-phosphate 5-kinase(Human)
Xiamen University

US Patent
LigandPNGBDBM557256(US11352354, Example V-c-1)
Affinity DataKd:  1.30E+5nMAssay Description:1. Preparation of magnetic beads: biotin-labeled small molecule ligand and avidin-coated magnetic beads were allowed to interact at room temperature ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/10/2022
Entry Details
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Target1-phosphatidylinositol 3-phosphate 5-kinase(Human)
Xiamen University

US Patent
LigandPNGBDBM557257(US11352354, Example V-c-2)
Affinity DataKd:  2.00E+6nMAssay Description:1. Preparation of magnetic beads: biotin-labeled small molecule ligand and avidin-coated magnetic beads were allowed to interact at room temperature ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/10/2022
Entry Details
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Target1-phosphatidylinositol 3-phosphate 5-kinase(Human)
Xiamen University

US Patent
LigandPNGBDBM557258(US11352354, Example V-c-10)
Affinity DataKd:  3.50E+6nMAssay Description:1. Preparation of magnetic beads: biotin-labeled small molecule ligand and avidin-coated magnetic beads were allowed to interact at room temperature ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/10/2022
Entry Details
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Target1-phosphatidylinositol 3-phosphate 5-kinase(Human)
Xiamen University

US Patent
LigandPNGBDBM557259(US11352354, Example V-c-11)
Affinity DataKd:  7.00E+5nMAssay Description:1. Preparation of magnetic beads: biotin-labeled small molecule ligand and avidin-coated magnetic beads were allowed to interact at room temperature ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/10/2022
Entry Details
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Target1-phosphatidylinositol 3-phosphate 5-kinase(Human)
Xiamen University

US Patent
LigandPNGBDBM557260(US11352354, Example V-c-12)
Affinity DataKd: >3.00E+7nMAssay Description:1. Preparation of magnetic beads: biotin-labeled small molecule ligand and avidin-coated magnetic beads were allowed to interact at room temperature ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/10/2022
Entry Details
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Target1-phosphatidylinositol 3-phosphate 5-kinase(Human)
Xiamen University

US Patent
LigandPNGBDBM557261(US11352354, Example V-c-13)
Affinity DataKd:  1.60E+4nMAssay Description:1. Preparation of magnetic beads: biotin-labeled small molecule ligand and avidin-coated magnetic beads were allowed to interact at room temperature ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/10/2022
Entry Details
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Target1-phosphatidylinositol 3-phosphate 5-kinase(Human)
Xiamen University

US Patent
LigandPNGBDBM557262(US11352354, Example V-c-14)
Affinity DataKd:  2.00E+4nMAssay Description:1. Preparation of magnetic beads: biotin-labeled small molecule ligand and avidin-coated magnetic beads were allowed to interact at room temperature ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/10/2022
Entry Details
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Target1-phosphatidylinositol 3-phosphate 5-kinase(Human)
Xiamen University

US Patent
LigandPNGBDBM557263(US11352354, Example V-c-15)
Affinity DataKd:  1.40E+5nMAssay Description:1. Preparation of magnetic beads: biotin-labeled small molecule ligand and avidin-coated magnetic beads were allowed to interact at room temperature ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/10/2022
Entry Details
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Target1-phosphatidylinositol 3-phosphate 5-kinase(Human)
Xiamen University

US Patent
LigandPNGBDBM557264(US11352354, Example V-c-16)
Affinity DataKd:  1.10E+5nMAssay Description:1. Preparation of magnetic beads: biotin-labeled small molecule ligand and avidin-coated magnetic beads were allowed to interact at room temperature ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/10/2022
Entry Details
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Target1-phosphatidylinositol 3-phosphate 5-kinase(Human)
Xiamen University

US Patent
LigandPNGBDBM557265(US11352354, Example V-c-17)
Affinity DataKd:  6.40E+5nMAssay Description:1. Preparation of magnetic beads: biotin-labeled small molecule ligand and avidin-coated magnetic beads were allowed to interact at room temperature ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/10/2022
Entry Details
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Target1-phosphatidylinositol 3-phosphate 5-kinase(Human)
Xiamen University

US Patent
LigandPNGBDBM557266(US11352354, Example V-c-18)
Affinity DataKd:  6.40E+3nMAssay Description:1. Preparation of magnetic beads: biotin-labeled small molecule ligand and avidin-coated magnetic beads were allowed to interact at room temperature ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/10/2022
Entry Details
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Target1-phosphatidylinositol 3-phosphate 5-kinase(Human)
Xiamen University

US Patent
LigandPNGBDBM557267(US11352354, Example V-c-19)
Affinity DataKd:  1.60E+4nMAssay Description:1. Preparation of magnetic beads: biotin-labeled small molecule ligand and avidin-coated magnetic beads were allowed to interact at room temperature ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/10/2022
Entry Details
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Target1-phosphatidylinositol 3-phosphate 5-kinase(Human)
Xiamen University

US Patent
LigandPNGBDBM557267(US11352354, Example V-c-19)
Affinity DataKd:  1.50E+4nMAssay Description:1. Preparation of magnetic beads: biotin-labeled small molecule ligand and avidin-coated magnetic beads were allowed to interact at room temperature ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/10/2022
Entry Details
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Target1-phosphatidylinositol 3-phosphate 5-kinase(Human)
Xiamen University

US Patent
LigandPNGBDBM557268(US11352354, Example V-c-20)
Affinity DataKd:  1.00E+6nMAssay Description:1. Preparation of magnetic beads: biotin-labeled small molecule ligand and avidin-coated magnetic beads were allowed to interact at room temperature ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/10/2022
Entry Details
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Target1-phosphatidylinositol 3-phosphate 5-kinase(Human)
Xiamen University

US Patent
LigandPNGBDBM557269(US11352354, Example V-c-21)
Affinity DataKd:  9.10E+5nMAssay Description:1. Preparation of magnetic beads: biotin-labeled small molecule ligand and avidin-coated magnetic beads were allowed to interact at room temperature ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/10/2022
Entry Details
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Target1-phosphatidylinositol 3-phosphate 5-kinase(Human)
Xiamen University

US Patent
LigandPNGBDBM557270(US11352354, Example V-c-22)
Affinity DataKd:  2.10E+7nMAssay Description:1. Preparation of magnetic beads: biotin-labeled small molecule ligand and avidin-coated magnetic beads were allowed to interact at room temperature ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/10/2022
Entry Details
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Target1-phosphatidylinositol 3-phosphate 5-kinase(Human)
Xiamen University

US Patent
LigandPNGBDBM557271(US11352354, Example V-c-23)
Affinity DataKd:  3.30E+4nMAssay Description:1. Preparation of magnetic beads: biotin-labeled small molecule ligand and avidin-coated magnetic beads were allowed to interact at room temperature ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/10/2022
Entry Details
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Target1-phosphatidylinositol 3-phosphate 5-kinase(Human)
Xiamen University

US Patent
LigandPNGBDBM557272(US11352354, Example V-c-24)
Affinity DataKd: >3.00E+7nMAssay Description:1. Preparation of magnetic beads: biotin-labeled small molecule ligand and avidin-coated magnetic beads were allowed to interact at room temperature ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/10/2022
Entry Details
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Target1-phosphatidylinositol 3-phosphate 5-kinase(Human)
Xiamen University

US Patent
LigandPNGBDBM557273(US11352354, Example V-c-38)
Affinity DataKd: >3.00E+7nMAssay Description:1. Preparation of magnetic beads: biotin-labeled small molecule ligand and avidin-coated magnetic beads were allowed to interact at room temperature ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/10/2022
Entry Details
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Target1-phosphatidylinositol 3-phosphate 5-kinase(Human)
Xiamen University

US Patent
LigandPNGBDBM557274(US11352354, Example V-c-39)
Affinity DataKd: >3.00E+7nMAssay Description:1. Preparation of magnetic beads: biotin-labeled small molecule ligand and avidin-coated magnetic beads were allowed to interact at room temperature ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/10/2022
Entry Details
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Target1-phosphatidylinositol 3-phosphate 5-kinase(Human)
Xiamen University

US Patent
LigandPNGBDBM557275(US11352354, Example V-c-4)
Affinity DataKd:  3.30E+4nMAssay Description:1. Preparation of magnetic beads: biotin-labeled small molecule ligand and avidin-coated magnetic beads were allowed to interact at room temperature ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/10/2022
Entry Details
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Target1-phosphatidylinositol 3-phosphate 5-kinase(Human)
Xiamen University

US Patent
LigandPNGBDBM557276(US11352354, Example V-c-40)
Affinity DataKd:  3.80E+5nMAssay Description:1. Preparation of magnetic beads: biotin-labeled small molecule ligand and avidin-coated magnetic beads were allowed to interact at room temperature ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/10/2022
Entry Details
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Target1-phosphatidylinositol 3-phosphate 5-kinase(Human)
Xiamen University

US Patent
LigandPNGBDBM557277(US11352354, Example V-c-41)
Affinity DataKd: >3.00E+7nMAssay Description:1. Preparation of magnetic beads: biotin-labeled small molecule ligand and avidin-coated magnetic beads were allowed to interact at room temperature ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/10/2022
Entry Details
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Target1-phosphatidylinositol 3-phosphate 5-kinase(Human)
Xiamen University

US Patent
LigandPNGBDBM557278(US11352354, Example V-c-42)
Affinity DataKd: >3.00E+7nMAssay Description:1. Preparation of magnetic beads: biotin-labeled small molecule ligand and avidin-coated magnetic beads were allowed to interact at room temperature ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/10/2022
Entry Details
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Target1-phosphatidylinositol 3-phosphate 5-kinase(Human)
Xiamen University

US Patent
LigandPNGBDBM557279(US11352354, Example V-c-43)
Affinity DataKd: >3.00E+7nMAssay Description:1. Preparation of magnetic beads: biotin-labeled small molecule ligand and avidin-coated magnetic beads were allowed to interact at room temperature ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/10/2022
Entry Details
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Target1-phosphatidylinositol 3-phosphate 5-kinase(Human)
Xiamen University

US Patent
LigandPNGBDBM557280(US11352354, Example V-c-51)
Affinity DataKd: >3.00E+7nMAssay Description:1. Preparation of magnetic beads: biotin-labeled small molecule ligand and avidin-coated magnetic beads were allowed to interact at room temperature ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/10/2022
Entry Details
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Target1-phosphatidylinositol 3-phosphate 5-kinase(Human)
Xiamen University

US Patent
LigandPNGBDBM557281(US11352354, Example V-c-52)
Affinity DataKd: >3.00E+7nMAssay Description:1. Preparation of magnetic beads: biotin-labeled small molecule ligand and avidin-coated magnetic beads were allowed to interact at room temperature ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/10/2022
Entry Details
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