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TargetBeta-secretase 1(Human)
Purdue University

LigandPNGBDBM16254(N2-[(2R,4S,5S)-5-{[N-{[(2,5-dimethyl-1,3-oxazol-4-...)
Affinity DataKi:  0.120nM ΔG°:  -58.9kJ/molepH: 4.5 T: 2°CAssay Description:Enzyme activities were assayed by monitoring the hydrolysis of substrate in the presence or absence of inhibitor compounds. The hydrolysis was record...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2007
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Purdue University

LigandPNGBDBM50042296(CHEMBL3352906)
Affinity DataKi:  0.25nMAssay Description:Inhibition of recombinant BACE1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2016
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Purdue University

LigandPNGBDBM16253((3,5-dimethyl-1H-pyrazol-1-yl)methyl N-[(1R)-1-{[(...)
Affinity DataKi:  0.300nM ΔG°:  -56.5kJ/molepH: 4.5 T: 2°CAssay Description:Enzyme activities were assayed by monitoring the hydrolysis of substrate in the presence or absence of inhibitor compounds. The hydrolysis was record...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2007
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Purdue University

LigandPNGBDBM16253((3,5-dimethyl-1H-pyrazol-1-yl)methyl N-[(1R)-1-{[(...)
Affinity DataKi:  0.300nMAssay Description:Inhibition of recombinant BACE1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2016
Entry Details Article
PubMed
TargetBeta-secretase 2(Human)
Purdue University

LigandPNGBDBM16250(CHEMBL290001 | tert-butyl N-[(1S)-1-{[(1S)-1-{[(1R...)
Affinity DataKi:  1.20nM ΔG°:  -53.0kJ/molepH: 4.5 T: 2°CAssay Description:Enzyme activities were assayed by monitoring the hydrolysis of substrate in the presence or absence of inhibitor compounds. The hydrolysis was record...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2007
Entry Details Article
PubMed
TargetCathepsin D(Human)
Purdue University

Curated by ChEMBL
LigandPNGBDBM50042296(CHEMBL3352906)
Affinity DataKi:  1.30nMAssay Description:Inhibition of Cathepsin D (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2016
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Purdue University

LigandPNGBDBM50042285(CHEMBL3361302)
Affinity DataKi:  1.60nMAssay Description:Inhibition of recombinant BACE1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2016
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Purdue University

LigandPNGBDBM16047(EVNXXAEF | N-{(2R,4S,5S)-5-[(L-alpha-glutamyl-L-va...)
Affinity DataKi:  1.60nM ΔG°:  -52.2kJ/molepH: 4.5 T: 2°CAssay Description:Enzyme activities were assayed by monitoring the hydrolysis of substrate in the presence or absence of inhibitor compounds. The hydrolysis was record...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2007
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Purdue University

LigandPNGBDBM16250(CHEMBL290001 | tert-butyl N-[(1S)-1-{[(1S)-1-{[(1R...)
Affinity DataKi:  2.5nM ΔG°:  -51.1kJ/molepH: 4.5 T: 2°CAssay Description:Enzyme activities were assayed by monitoring the hydrolysis of substrate in the presence or absence of inhibitor compounds. The hydrolysis was record...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2007
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Purdue University

LigandPNGBDBM16252((3,5-dimethyl-1H-pyrazol-1-yl)methyl N-[(1R)-1-{[(...)
Affinity DataKi:  4.40nM ΔG°:  -49.6kJ/molepH: 4.5 T: 2°CAssay Description:Enzyme activities were assayed by monitoring the hydrolysis of substrate in the presence or absence of inhibitor compounds. The hydrolysis was record...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2007
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Purdue University

LigandPNGBDBM50042297(CHEMBL3361313)
Affinity DataKi:  11nMAssay Description:Inhibition of recombinant BACE1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2016
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Purdue University

LigandPNGBDBM16251((3,5-dimethyl-1H-pyrazol-1-yl)methyl N-[(1S)-1-{[(...)
Affinity DataKi:  14nM ΔG°:  -46.6kJ/molepH: 4.5 T: 2°CAssay Description:Enzyme activities were assayed by monitoring the hydrolysis of substrate in the presence or absence of inhibitor compounds. The hydrolysis was record...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2007
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Purdue University

LigandPNGBDBM16270((2R,4S,5S)-N-[(1S)-1-(benzylcarbamoyl)-2-methylpro...)
Affinity DataKi:  14.2nM ΔG°:  -46.6kJ/molepH: 4.5 T: 2°CAssay Description:Enzyme activities were assayed by monitoring the hydrolysis of substrate in the presence or absence of inhibitor compounds. The hydrolysis was record...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/8/2007
Entry Details Article
PubMed
TargetCathepsin D(Human)
Purdue University

Curated by ChEMBL
LigandPNGBDBM16252((3,5-dimethyl-1H-pyrazol-1-yl)methyl N-[(1R)-1-{[(...)
Affinity DataKi:  15nM ΔG°:  -46.5kJ/molepH: 4.5 T: 2°CAssay Description:Enzyme activities were assayed by monitoring the hydrolysis of substrate in the presence or absence of inhibitor compounds. The hydrolysis was record...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2007
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Purdue University

LigandPNGBDBM50042295(CHEMBL3361312)
Affinity DataKi:  17nMAssay Description:Inhibition of recombinant BACE1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2016
Entry Details Article
PubMed
TargetCathepsin D(Human)
Purdue University

Curated by ChEMBL
LigandPNGBDBM16251((3,5-dimethyl-1H-pyrazol-1-yl)methyl N-[(1S)-1-{[(...)
Affinity DataKi:  25nM ΔG°:  -45.1kJ/molepH: 4.5 T: 2°CAssay Description:Enzyme activities were assayed by monitoring the hydrolysis of substrate in the presence or absence of inhibitor compounds. The hydrolysis was record...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2007
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Purdue University

LigandPNGBDBM16271((2R,4S,5S)-N-[(1S)-1-(benzylcarbamoyl)-2-methylpro...)
Affinity DataKi:  25.1nM ΔG°:  -45.1kJ/molepH: 4.5 T: 2°CAssay Description:Enzyme activities were assayed by monitoring the hydrolysis of substrate in the presence or absence of inhibitor compounds. The hydrolysis was record...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/8/2007
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Purdue University

LigandPNGBDBM16263(prop-2-en-1-yl N-[(1S)-1-{[(1S)-1-{[(1R,3S,4S)-1-{...)
Affinity DataKi:  26.6nM ΔG°:  -45.0kJ/molepH: 4.5 T: 2°CAssay Description:Enzyme activities were assayed by monitoring the hydrolysis of substrate in the presence or absence of inhibitor compounds. The hydrolysis was record...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/8/2007
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Purdue University

LigandPNGBDBM16267((2R,4S,5S)-N-[(1S)-1-(benzylcarbamoyl)-2-methylpro...)
Affinity DataKi:  28.4nM ΔG°:  -44.8kJ/molepH: 4.5 T: 2°CAssay Description:Enzyme activities were assayed by monitoring the hydrolysis of substrate in the presence or absence of inhibitor compounds. The hydrolysis was record...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/8/2007
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Purdue University

LigandPNGBDBM50042298(CHEMBL3361314)
Affinity DataKi:  29nMAssay Description:Inhibition of recombinant BACE1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2016
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Purdue University

LigandPNGBDBM50042294(CHEMBL3361311)
Affinity DataKi:  32nMAssay Description:Inhibition of recombinant BACE1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2016
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Purdue University

LigandPNGBDBM50042286(CHEMBL3361303)
Affinity DataKi:  40nMAssay Description:Inhibition of recombinant BACE1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2016
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Purdue University

LigandPNGBDBM16266(but-3-en-1-yl N-[(1S)-1-{[(1S)-1-{[(1R,3S,4S)-1-{[...)
Affinity DataKi:  61.4nM ΔG°:  -42.8kJ/molepH: 4.5 T: 2°CAssay Description:Enzyme activities were assayed by monitoring the hydrolysis of substrate in the presence or absence of inhibitor compounds. The hydrolysis was record...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/8/2007
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Purdue University

LigandPNGBDBM50042288(CHEMBL3361305)
Affinity DataKi:  63nMAssay Description:Inhibition of recombinant BACE1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2016
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Purdue University

LigandPNGBDBM50042292(CHEMBL3361309)
Affinity DataKi:  64nMAssay Description:Inhibition of recombinant BACE1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2016
Entry Details Article
PubMed
TargetBeta-secretase 2(Human)
Purdue University

LigandPNGBDBM50042296(CHEMBL3352906)
Affinity DataKi:  71nMAssay Description:Inhibition of memapsin 1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2016
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Purdue University

LigandPNGBDBM16264((2R,4S,5S)-N-[(1S)-1-(benzylcarbamoyl)-2-methylpro...)
Affinity DataKi:  87.2nM ΔG°:  -41.9kJ/molepH: 4.5 T: 2°CAssay Description:Enzyme activities were assayed by monitoring the hydrolysis of substrate in the presence or absence of inhibitor compounds. The hydrolysis was record...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/8/2007
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Purdue University

LigandPNGBDBM16268((2R,4S,5S)-N-[(1S)-1-(benzylcarbamoyl)-2-methylpro...)
Affinity DataKi:  108nM ΔG°:  -41.4kJ/molepH: 4.5 T: 2°CAssay Description:Enzyme activities were assayed by monitoring the hydrolysis of substrate in the presence or absence of inhibitor compounds. The hydrolysis was record...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/8/2007
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Purdue University

LigandPNGBDBM16269(pent-4-en-1-yl N-[(1S)-1-{[(1S)-1-{[(1R,3S,4S)-1-{...)
Affinity DataKi:  112nM ΔG°:  -41.3kJ/molepH: 4.5 T: 2°CAssay Description:Enzyme activities were assayed by monitoring the hydrolysis of substrate in the presence or absence of inhibitor compounds. The hydrolysis was record...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/8/2007
Entry Details Article
PubMed
TargetCathepsin D(Human)
Purdue University

Curated by ChEMBL
LigandPNGBDBM16253((3,5-dimethyl-1H-pyrazol-1-yl)methyl N-[(1R)-1-{[(...)
Affinity DataKi:  131nM ΔG°:  -40.9kJ/molepH: 4.5 T: 2°CAssay Description:Enzyme activities were assayed by monitoring the hydrolysis of substrate in the presence or absence of inhibitor compounds. The hydrolysis was record...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2007
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Purdue University

LigandPNGBDBM50042290(CHEMBL3361307)
Affinity DataKi:  148nMAssay Description:Inhibition of recombinant BACE1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2016
Entry Details Article
PubMed
TargetBeta-secretase 2(Human)
Purdue University

LigandPNGBDBM16252((3,5-dimethyl-1H-pyrazol-1-yl)methyl N-[(1R)-1-{[(...)
Affinity DataKi:  161nM ΔG°:  -40.3kJ/molepH: 4.5 T: 2°CAssay Description:Enzyme activities were assayed by monitoring the hydrolysis of substrate in the presence or absence of inhibitor compounds. The hydrolysis was record...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2007
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Purdue University

LigandPNGBDBM50042293(CHEMBL3361310)
Affinity DataKi:  192nMAssay Description:Inhibition of recombinant BACE1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2016
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Purdue University

LigandPNGBDBM50042291(CHEMBL3361308)
Affinity DataKi:  201nMAssay Description:Inhibition of recombinant BACE1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2016
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Purdue University

LigandPNGBDBM16265((2R,4S,5S)-N-[(1S)-1-(benzylcarbamoyl)-2-methylpro...)
Affinity DataKi:  218nM ΔG°:  -39.6kJ/molepH: 4.5 T: 2°CAssay Description:Enzyme activities were assayed by monitoring the hydrolysis of substrate in the presence or absence of inhibitor compounds. The hydrolysis was record...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/8/2007
Entry Details Article
PubMed
TargetCathepsin D(Human)
Purdue University

Curated by ChEMBL
LigandPNGBDBM16254(N2-[(2R,4S,5S)-5-{[N-{[(2,5-dimethyl-1,3-oxazol-4-...)
Affinity DataKi:  304nM ΔG°:  -38.7kJ/molepH: 4.5 T: 2°CAssay Description:Enzyme activities were assayed by monitoring the hydrolysis of substrate in the presence or absence of inhibitor compounds. The hydrolysis was record...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2007
Entry Details Article
PubMed
TargetBeta-secretase 2(Human)
Purdue University

LigandPNGBDBM16253((3,5-dimethyl-1H-pyrazol-1-yl)methyl N-[(1R)-1-{[(...)
Affinity DataKi:  356nM ΔG°:  -38.3kJ/molepH: 4.5 T: 2°CAssay Description:Enzyme activities were assayed by monitoring the hydrolysis of substrate in the presence or absence of inhibitor compounds. The hydrolysis was record...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2007
Entry Details Article
PubMed
TargetBeta-secretase 2(Human)
Purdue University

LigandPNGBDBM16254(N2-[(2R,4S,5S)-5-{[N-{[(2,5-dimethyl-1,3-oxazol-4-...)
Affinity DataKi:  458nM ΔG°:  -37.6kJ/molepH: 4.5 T: 2°CAssay Description:Enzyme activities were assayed by monitoring the hydrolysis of substrate in the presence or absence of inhibitor compounds. The hydrolysis was record...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2007
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Purdue University

LigandPNGBDBM50042289(CHEMBL3361306)
Affinity DataKi:  471nMAssay Description:Inhibition of recombinant BACE1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2016
Entry Details Article
PubMed
TargetBeta-secretase 2(Human)
Purdue University

LigandPNGBDBM16251((3,5-dimethyl-1H-pyrazol-1-yl)methyl N-[(1S)-1-{[(...)
Affinity DataKi:  811nM ΔG°:  -36.2kJ/molepH: 4.5 T: 2°CAssay Description:Enzyme activities were assayed by monitoring the hydrolysis of substrate in the presence or absence of inhibitor compounds. The hydrolysis was record...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2007
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Purdue University

LigandPNGBDBM50042287(CHEMBL3361304)
Affinity DataKi:  1.64E+3nMAssay Description:Inhibition of recombinant BACE1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2016
Entry Details Article
PubMed