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TargetCollagenase 3(Human)
French Alternative Energies and Atomic Energy Commission

LigandPNGBDBM16596(N,N -bis(4-fluoro-3-methylbenzyl)pyrimidine-4,6-di...)
Affinity DataIC50: 0.670nMpH: 6.8 T: 2°CAssay Description:Enzyme assay using human matrix metalloproteases or ADAMTS.More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCollagenase 3(Human)
French Alternative Energies and Atomic Energy Commission

LigandPNGBDBM50265079(CHEMBL496942 | 4-{[1-METHYL-2,4-DIOXO-6-(3-PHENYLP...)
Affinity DataIC50: 0.670nMpH: 6.8 T: 2°CAssay Description:Enzyme assay using human matrix metalloproteases or ADAMTS.More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetMacrophage metalloelastase(Human)
French Alternative Energies and Atomic Energy Commission

LigandPNGBDBM92442(MMP Inhibitor, 2)
Affinity DataIC50: 1.40nMpH: 6.8 T: 2°CAssay Description:Enzyme assay using human matrix metalloproteases or ADAMTS.More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2012
Entry Details Article
PubMed
TargetNeutrophil collagenase(Human)
French Alternative Energies and Atomic Energy Commission

LigandPNGBDBM27878(MMP Inhibitor, 7 | 13-(carbamoylmethyl)-3-oxo-N-[(...)
Affinity DataIC50: 7.40nMpH: 6.8 T: 2°CAssay Description:Enzyme assay using human matrix metalloproteases or ADAMTS.More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCollagenase 3(Human)
French Alternative Energies and Atomic Energy Commission

LigandPNGBDBM27878(MMP Inhibitor, 7 | 13-(carbamoylmethyl)-3-oxo-N-[(...)
Affinity DataIC50: 25nMpH: 6.8 T: 2°CAssay Description:Enzyme assay using human matrix metalloproteases or ADAMTS.More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2012
Entry Details Article
PubMed
TargetCollagenase 3(Human)
French Alternative Energies and Atomic Energy Commission

LigandPNGBDBM92444(MMP Inhibitor, 6)
Affinity DataIC50: 33.4nMpH: 6.8 T: 2°CAssay Description:Enzyme assay using human matrix metalloproteases or ADAMTS.More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2012
Entry Details Article
PubMed
TargetNeutrophil collagenase(Human)
French Alternative Energies and Atomic Energy Commission

LigandPNGBDBM92442(MMP Inhibitor, 2)
Affinity DataIC50: 37nMpH: 6.8 T: 2°CAssay Description:Enzyme assay using human matrix metalloproteases or ADAMTS.More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2012
Entry Details Article
PubMed
TargetCollagenase 3(Human)
French Alternative Energies and Atomic Energy Commission

LigandPNGBDBM92442(MMP Inhibitor, 2)
Affinity DataIC50: 46nMpH: 6.8 T: 2°CAssay Description:Enzyme assay using human matrix metalloproteases or ADAMTS.More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2012
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
French Alternative Energies and Atomic Energy Commission

LigandPNGBDBM92442(MMP Inhibitor, 2)
Affinity DataIC50: 66nMpH: 6.8 T: 2°CAssay Description:Enzyme assay using human matrix metalloproteases or ADAMTS.More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2012
Entry Details Article
PubMed
TargetStromelysin-1(Human)
French Alternative Energies and Atomic Energy Commission

LigandPNGBDBM92442(MMP Inhibitor, 2)
Affinity DataIC50: 300nMpH: 6.8 T: 2°CAssay Description:Enzyme assay using human matrix metalloproteases or ADAMTS.More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2012
Entry Details Article
PubMed
TargetMatrix metalloproteinase-9(Human)
French Alternative Energies and Atomic Energy Commission

LigandPNGBDBM92442(MMP Inhibitor, 2)
Affinity DataIC50: 300nMpH: 6.8 T: 2°CAssay Description:Enzyme assay using human matrix metalloproteases or ADAMTS.More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2012
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
French Alternative Energies and Atomic Energy Commission

LigandPNGBDBM92442(MMP Inhibitor, 2)
Affinity DataIC50: 2.00E+3nMpH: 6.8 T: 2°CAssay Description:Enzyme assay using human matrix metalloproteases or ADAMTS.More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2012
Entry Details Article
PubMed
TargetMatrilysin(Human)
French Alternative Energies and Atomic Energy Commission

LigandPNGBDBM92442(MMP Inhibitor, 2)
Affinity DataIC50: 2.00E+3nMpH: 6.8 T: 2°CAssay Description:Enzyme assay using human matrix metalloproteases or ADAMTS.More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2012
Entry Details Article
PubMed
TargetMatrix metalloproteinase-14(Human)
French Alternative Energies and Atomic Energy Commission

LigandPNGBDBM92442(MMP Inhibitor, 2)
Affinity DataIC50: 2.00E+3nMpH: 6.8 T: 2°CAssay Description:Enzyme assay using human matrix metalloproteases or ADAMTS.More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2012
Entry Details Article
PubMed
TargetStromelysin-1(Human)
French Alternative Energies and Atomic Energy Commission

LigandPNGBDBM27878(MMP Inhibitor, 7 | 13-(carbamoylmethyl)-3-oxo-N-[(...)
Affinity DataIC50: 2.50E+3nMpH: 6.8 T: 2°CAssay Description:Enzyme assay using human matrix metalloproteases or ADAMTS.More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2012
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
French Alternative Energies and Atomic Energy Commission

LigandPNGBDBM27878(MMP Inhibitor, 7 | 13-(carbamoylmethyl)-3-oxo-N-[(...)
Affinity DataIC50: 1.00E+4nMpH: 6.8 T: 2°CAssay Description:Enzyme assay using human matrix metalloproteases or ADAMTS.More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2012
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
French Alternative Energies and Atomic Energy Commission

LigandPNGBDBM27878(MMP Inhibitor, 7 | 13-(carbamoylmethyl)-3-oxo-N-[(...)
Affinity DataIC50: 1.00E+4nMpH: 6.8 T: 2°CAssay Description:Enzyme assay using human matrix metalloproteases or ADAMTS.More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2012
Entry Details Article
PubMed
TargetMatrilysin(Human)
French Alternative Energies and Atomic Energy Commission

LigandPNGBDBM27878(MMP Inhibitor, 7 | 13-(carbamoylmethyl)-3-oxo-N-[(...)
Affinity DataIC50: 1.00E+4nMpH: 6.8 T: 2°CAssay Description:Enzyme assay using human matrix metalloproteases or ADAMTS.More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2012
Entry Details Article
PubMed
TargetMatrix metalloproteinase-9(Human)
French Alternative Energies and Atomic Energy Commission

LigandPNGBDBM27878(MMP Inhibitor, 7 | 13-(carbamoylmethyl)-3-oxo-N-[(...)
Affinity DataIC50: 1.00E+4nMpH: 6.8 T: 2°CAssay Description:Enzyme assay using human matrix metalloproteases or ADAMTS.More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2012
Entry Details Article
PubMed
TargetMacrophage metalloelastase(Human)
French Alternative Energies and Atomic Energy Commission

LigandPNGBDBM27878(MMP Inhibitor, 7 | 13-(carbamoylmethyl)-3-oxo-N-[(...)
Affinity DataIC50: 1.00E+4nMpH: 6.8 T: 2°CAssay Description:Enzyme assay using human matrix metalloproteases or ADAMTS.More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2012
Entry Details Article
PubMed
TargetMatrix metalloproteinase-14(Human)
French Alternative Energies and Atomic Energy Commission

LigandPNGBDBM27878(MMP Inhibitor, 7 | 13-(carbamoylmethyl)-3-oxo-N-[(...)
Affinity DataIC50: 1.00E+4nMpH: 6.8 T: 2°CAssay Description:Enzyme assay using human matrix metalloproteases or ADAMTS.More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2012
Entry Details Article
PubMed
TargetCollagenase 3(Human)
French Alternative Energies and Atomic Energy Commission

LigandPNGBDBM50259948(CHEMBL4096462)
Affinity DataKi:  0.00800nMAssay Description:Inhibition of human MMP13 catalytic domain using Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 fluorogenic substrate by spectrophotometric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/8/2020
Entry Details Article
PubMed
TargetMast cell carboxypeptidase A(Rat)
Universitat Aut£Noma De Barcelona

Curated by ChEMBL
LigandPNGBDBM50530230(CHEMBL4445882)
Affinity DataKi:  0.0170nMAssay Description:Inhibition of rat CPA3 using AAFP as substrate preincubated for 45 mins measured at 30 sec intervals for 15 mins by UV/vis-spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetMast cell carboxypeptidase A(Rat)
Universitat Aut£Noma De Barcelona

Curated by ChEMBL
LigandPNGBDBM50530230(CHEMBL4445882)
Affinity DataKi:  0.0170nMAssay Description:Inhibition of rat CPA3 using AAFP as substrate preincubated for 45 mins measured at 30 sec intervals for 15 mins by UV/vis-spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetCarboxypeptidase A1(Human)
Universitat Aut£Noma De Barcelona

Curated by ChEMBL
LigandPNGBDBM50530229(CHEMBL4460840)
Affinity DataKi:  0.0400nMAssay Description:Inhibition of human CPA1 using AAFP as substrate preincubated for 45 mins to 2 hrs measured at 30 sec intervals for 15 mins by UV/vis-spectrophotomet...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCarboxypeptidase A1(Human)
Universitat Aut£Noma De Barcelona

Curated by ChEMBL
LigandPNGBDBM50530229(CHEMBL4460840)
Affinity DataKi:  0.0400nMAssay Description:Inhibition of human CPA1 using AAFP as substrate preincubated for 45 mins to 2 hrs measured at 30 sec intervals for 15 mins by UV/vis-spectrophotomet...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCarboxypeptidase A1(Human)
Universitat Aut£Noma De Barcelona

Curated by ChEMBL
LigandPNGBDBM50530230(CHEMBL4445882)
Affinity DataKi:  0.0700nMAssay Description:Inhibition of human CPA1 using AAFP as substrate measured at pre-steady state by spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetCarboxypeptidase A1(Human)
Universitat Aut£Noma De Barcelona

Curated by ChEMBL
LigandPNGBDBM50530230(CHEMBL4445882)
Affinity DataKi:  0.0700nMAssay Description:Inhibition of human CPA1 using AAFP as substrate measured at pre-steady state by spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetCarboxypeptidase A1(Human)
Universitat Aut£Noma De Barcelona

Curated by ChEMBL
LigandPNGBDBM50530235(CHEMBL4436298)
Affinity DataKi:  0.0800nMAssay Description:Inhibition of human CPA1 using AAFP as substrate preincubated for 45 mins to 2 hrs measured at 30 sec intervals for 15 mins by UV/vis-spectrophotomet...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetCarboxypeptidase A1(Human)
Universitat Aut£Noma De Barcelona

Curated by ChEMBL
LigandPNGBDBM50530235(CHEMBL4436298)
Affinity DataKi:  0.0800nMAssay Description:Inhibition of human CPA1 using AAFP as substrate preincubated for 45 mins to 2 hrs measured at 30 sec intervals for 15 mins by UV/vis-spectrophotomet...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetCarboxypeptidase A1(Human)
Universitat Aut£Noma De Barcelona

Curated by ChEMBL
LigandPNGBDBM50530231(CHEMBL4528407)
Affinity DataKi:  0.0870nMAssay Description:Inhibition of human CPA1 using AAFP as substrate preincubated for 45 mins to 2 hrs measured at 30 sec intervals for 15 mins by UV/vis-spectrophotomet...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCarboxypeptidase A1(Human)
Universitat Aut£Noma De Barcelona

Curated by ChEMBL
LigandPNGBDBM50530231(CHEMBL4528407)
Affinity DataKi:  0.0870nMAssay Description:Inhibition of human CPA1 using AAFP as substrate preincubated for 45 mins to 2 hrs measured at 30 sec intervals for 15 mins by UV/vis-spectrophotomet...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCarboxypeptidase A1(Human)
Universitat Aut£Noma De Barcelona

Curated by ChEMBL
LigandPNGBDBM50530230(CHEMBL4445882)
Affinity DataKi:  0.0890nMAssay Description:Inhibition of human CPA1 using AAFP as substrate preincubated for 45 mins to 2 hrs measured at 30 sec intervals for 15 mins by UV/vis-spectrophotomet...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetCarboxypeptidase A1(Human)
Universitat Aut£Noma De Barcelona

Curated by ChEMBL
LigandPNGBDBM50530230(CHEMBL4445882)
Affinity DataKi:  0.0890nMAssay Description:Inhibition of human CPA1 using AAFP as substrate preincubated for 45 mins to 2 hrs measured at 30 sec intervals for 15 mins by UV/vis-spectrophotomet...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetCarboxypeptidase A1(Human)
Universitat Aut£Noma De Barcelona

Curated by ChEMBL
LigandPNGBDBM50530228(CHEMBL4483485)
Affinity DataKi:  0.107nMAssay Description:Inhibition of human CPA1 using AAFP as substrate preincubated for 45 mins to 2 hrs measured at 30 sec intervals for 15 mins by UV/vis-spectrophotomet...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCarboxypeptidase A1(Human)
Universitat Aut£Noma De Barcelona

Curated by ChEMBL
LigandPNGBDBM50530228(CHEMBL4483485)
Affinity DataKi:  0.107nMAssay Description:Inhibition of human CPA1 using AAFP as substrate preincubated for 45 mins to 2 hrs measured at 30 sec intervals for 15 mins by UV/vis-spectrophotomet...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCarboxypeptidase B(Human)
Universitat Aut£Noma De Barcelona

Curated by ChEMBL
LigandPNGBDBM50530229(CHEMBL4460840)
Affinity DataKi:  0.120nMAssay Description:Inhibition of human CPB1 using AAFA as substrate preincubated for 45 mins to 2 hrs measured at 30 sec intervals for 15 mins by UV/vis-spectrophotomet...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetCarboxypeptidase B(Human)
Universitat Aut£Noma De Barcelona

Curated by ChEMBL
LigandPNGBDBM50530229(CHEMBL4460840)
Affinity DataKi:  0.120nMAssay Description:Inhibition of human CPB1 using AAFA as substrate preincubated for 45 mins to 2 hrs measured at 30 sec intervals for 15 mins by UV/vis-spectrophotomet...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetCarboxypeptidase A1(Human)
Universitat Aut£Noma De Barcelona

Curated by ChEMBL
LigandPNGBDBM50530227(CHEMBL4454162)
Affinity DataKi:  0.129nMAssay Description:Inhibition of human CPA1 using AAFP as substrate preincubated for 45 mins to 2 hrs measured at 30 sec intervals for 15 mins by UV/vis-spectrophotomet...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetCarboxypeptidase A1(Human)
Universitat Aut£Noma De Barcelona

Curated by ChEMBL
LigandPNGBDBM50530227(CHEMBL4454162)
Affinity DataKi:  0.129nMAssay Description:Inhibition of human CPA1 using AAFP as substrate preincubated for 45 mins to 2 hrs measured at 30 sec intervals for 15 mins by UV/vis-spectrophotomet...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetCarboxypeptidase A1(Human)
Universitat Aut£Noma De Barcelona

Curated by ChEMBL
LigandPNGBDBM50530231(CHEMBL4528407)
Affinity DataKi:  0.140nMAssay Description:Inhibition of human CPA1 using AAFP as substrate measured at pre-steady state by spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCarboxypeptidase A1(Human)
Universitat Aut£Noma De Barcelona

Curated by ChEMBL
LigandPNGBDBM50530231(CHEMBL4528407)
Affinity DataKi:  0.140nMAssay Description:Inhibition of human CPA1 using AAFP as substrate measured at pre-steady state by spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCarboxypeptidase A1(Human)
Universitat Aut£Noma De Barcelona

Curated by ChEMBL
LigandPNGBDBM50530227(CHEMBL4454162)
Affinity DataKi:  0.160nMAssay Description:Inhibition of human CPA1 using AAFP as substrate measured at pre-steady state by spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetCarboxypeptidase A1(Human)
Universitat Aut£Noma De Barcelona

Curated by ChEMBL
LigandPNGBDBM50530228(CHEMBL4483485)
Affinity DataKi:  0.160nMAssay Description:Inhibition of human CPA1 using AAFP as substrate measured at pre-steady state by spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCarboxypeptidase A1(Human)
Universitat Aut£Noma De Barcelona

Curated by ChEMBL
LigandPNGBDBM50530228(CHEMBL4483485)
Affinity DataKi:  0.160nMAssay Description:Inhibition of human CPA1 using AAFP as substrate measured at pre-steady state by spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCarboxypeptidase A1(Human)
Universitat Aut£Noma De Barcelona

Curated by ChEMBL
LigandPNGBDBM50530227(CHEMBL4454162)
Affinity DataKi:  0.160nMAssay Description:Inhibition of human CPA1 using AAFP as substrate measured at pre-steady state by spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetMacrophage metalloelastase(Human)
French Alternative Energies and Atomic Energy Commission

LigandPNGBDBM92441(RXP470, Compound 4 | RXP470, 1)
Affinity DataKi:  0.190nM ΔG°:  -55.5kJ/molepH: 6.8 T: 2°CAssay Description:Enzyme assay using matrix metalloproteinases.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2012
Entry Details Article
PubMed
TargetMacrophage metalloelastase(Human)
French Alternative Energies and Atomic Energy Commission

LigandPNGBDBM92441(RXP470, Compound 4 | RXP470, 1)
Affinity DataKi:  0.200nM ΔG°:  -55.4kJ/molepH: 6.8 T: 2°CAssay Description:Enzyme assay using human matrix metalloproteases or ADAMTS.More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2012
Entry Details Article
PubMed
TargetCarboxypeptidase A2(Human)
Universitat Aut£Noma De Barcelona

Curated by ChEMBL
LigandPNGBDBM50530235(CHEMBL4436298)
Affinity DataKi:  0.200nMAssay Description:Inhibition of human CPA2 using AAFP as substrate preincubated for 45 mins to 2 hrs measured at 30 sec intervals for 15 mins by UV/vis-spectrophotomet...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetCarboxypeptidase A2(Human)
Universitat Aut£Noma De Barcelona

Curated by ChEMBL
LigandPNGBDBM50530235(CHEMBL4436298)
Affinity DataKi:  0.200nMAssay Description:Inhibition of human CPA2 using AAFP as substrate preincubated for 45 mins to 2 hrs measured at 30 sec intervals for 15 mins by UV/vis-spectrophotomet...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
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