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TargetOxidized purine nucleoside triphosphate hydrolase(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50548115(CHEMBL4778773)
Affinity DataIC50:  0.0800nMAssay Description:Inhibition of MTH1 (unknown origin) using 8-oxo-dGTP as substrate preincubated for 15 mins followed by substrate addition and measured after 20 mins ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50094464(CHEMBL3590107 | US10525036, Example SCH772984 | US...)
Affinity DataIC50: <0.300nMAssay Description:Inhibition of MEK U911-activated ERK2 (unknown origin) using Erktide as substrate preincubated with enzyme for 20 mins prior to substrate addition by...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50094465(CHEMBL3590106 | US10525036, Example BVD-523 | US10...)
Affinity DataIC50: <0.300nMAssay Description:Inhibition of MEK U911-activated ERK2 (unknown origin) using Erktide as substrate preincubated with enzyme for 20 mins prior to substrate addition by...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50094464(CHEMBL3590107 | US10525036, Example SCH772984 | US...)
Affinity DataIC50: <0.300nMAssay Description:Inhibition of MEK U911-activated ERK2 (unknown origin) using Erktide as substrate preincubated with enzyme for 20 mins prior to substrate addition by...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50094465(CHEMBL3590106 | US10525036, Example BVD-523 | US10...)
Affinity DataIC50: <0.300nMAssay Description:Inhibition of MEK U911-activated ERK2 (unknown origin) using Erktide as substrate preincubated with enzyme for 20 mins prior to substrate addition by...More data for this Ligand-Target Pair
TargetOxidized purine nucleoside triphosphate hydrolase(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50548110(CHEMBL4747532)
Affinity DataIC50:  0.300nMAssay Description:Inhibition of MTH1 (unknown origin) using 8-oxo-dGTP as substrate preincubated for 15 mins followed by substrate addition and measured after 20 mins ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetOxidized purine nucleoside triphosphate hydrolase(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50162074(CHEMBL3792684)
Affinity DataIC50:  0.5nMAssay Description:Inhibition of MTH1 (unknown origin) using 8-oxo-dGTP as substrate preincubated for 15 mins followed by substrate addition and measured after 20 mins ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOxidized purine nucleoside triphosphate hydrolase(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50548117(CHEMBL4776026)
Affinity DataIC50:  0.5nMAssay Description:Inhibition of MTH1 (unknown origin) using 8-oxo-dGTP as substrate preincubated for 15 mins followed by substrate addition and measured after 20 mins ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetOxidized purine nucleoside triphosphate hydrolase(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50162075(CHEMBL3794167)
Affinity DataIC50:  0.5nMAssay Description:Inhibition of MTH1 (unknown origin) using 8-oxo-dGTP as substrate preincubated for 15 mins followed by substrate addition and measured after 20 mins ...More data for this Ligand-Target Pair
TargetOxidized purine nucleoside triphosphate hydrolase(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50548124(CHEMBL4784602)
Affinity DataIC50:  0.800nMAssay Description:Inhibition of MTH1 (unknown origin) using 8-oxo-dGTP as substrate preincubated for 15 mins followed by substrate addition and measured after 20 mins ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetOxidized purine nucleoside triphosphate hydrolase(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50548109(CHEMBL4783492)
Affinity DataIC50:  0.900nMAssay Description:Inhibition of MTH1 (unknown origin) using 8-oxo-dGTP as substrate preincubated for 15 mins followed by substrate addition and measured after 20 mins ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetOxidized purine nucleoside triphosphate hydrolase(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50548121(CHEMBL4754128)
Affinity DataIC50:  1.40nMAssay Description:Inhibition of MTH1 (unknown origin) using 8-oxo-dGTP as substrate preincubated for 15 mins followed by substrate addition and measured after 20 mins ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetOxidized purine nucleoside triphosphate hydrolase(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50548119(CHEMBL4749068)
Affinity DataIC50:  2nMAssay Description:Inhibition of MTH1 (unknown origin) using 8-oxo-dGTP as substrate preincubated for 15 mins followed by substrate addition and measured after 20 mins ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50094471(CHEMBL3590120)
Affinity DataIC50:  3nMAssay Description:Inhibition of MEK U911-activated ERK2 (unknown origin) using Erktide as substrate preincubated with enzyme for 20 mins prior to substrate addition by...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOxidized purine nucleoside triphosphate hydrolase(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50152124(CHEMBL3782004)
Affinity DataIC50:  3nMAssay Description:Inhibition of MTH1 (unknown origin) using 8-oxo-dGTP as substrate preincubated for 15 mins followed by substrate addition and measured after 20 mins ...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50094471(CHEMBL3590120)
Affinity DataIC50:  3.10nMAssay Description:Inhibition of MEK U911-activated ERK2 (unknown origin) using Erktide as substrate preincubated with enzyme for 20 mins prior to substrate addition by...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50094464(CHEMBL3590107 | US10525036, Example SCH772984 | US...)
Affinity DataIC50:  4nMAssay Description:Inhibition of ERK2 in human A375 cells harboring B-RAF V600E mutant assessed as decrease in phospho-ERK2 level after 2 hrs by Cellomics ArrayScanTM V...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50094304(CHEMBL3590118 | US9796700, Compound I-108)
Affinity DataIC50:  5.40nMAssay Description:Inhibition of MEK U911-activated ERK2 (unknown origin) using Erktide as substrate preincubated with enzyme for 20 mins prior to substrate addition by...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50094471(CHEMBL3590120)
Affinity DataIC50:  6.70nMAssay Description:Inhibition of ERK2 in human A375 cells harboring B-RAF V600E mutant assessed as decrease in phospho-ERK2 level after 2 hrs by Cellomics ArrayScanTM V...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50094470(CHEMBL3590121)
Affinity DataIC50:  6.90nMAssay Description:Inhibition of MEK U911-activated ERK2 (unknown origin) using Erktide as substrate preincubated with enzyme for 20 mins prior to substrate addition by...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50094312(CHEMBL3590110)
Affinity DataIC50:  7.5nMAssay Description:Inhibition of MEK U911-activated ERK2 (unknown origin) using Erktide as substrate preincubated with enzyme for 20 mins prior to substrate addition by...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50094470(CHEMBL3590121)
Affinity DataIC50:  8.5nMAssay Description:Inhibition of MEK U911-activated ERK2 (unknown origin) using Erktide as substrate preincubated with enzyme for 20 mins prior to substrate addition by...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50094304(CHEMBL3590118 | US9796700, Compound I-108)
Affinity DataIC50:  8.5nMAssay Description:Inhibition of MEK U911-activated ERK2 (unknown origin) using Erktide as substrate preincubated with enzyme for 20 mins prior to substrate addition by...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOxidized purine nucleoside triphosphate hydrolase(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50548118(CHEMBL4758926)
Affinity DataIC50:  9nMAssay Description:Inhibition of MTH1 (unknown origin) using 8-oxo-dGTP as substrate preincubated for 15 mins followed by substrate addition and measured after 20 mins ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetOxidized purine nucleoside triphosphate hydrolase(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50548107(CHEMBL4799076)
Affinity DataIC50:  9nMAssay Description:Inhibition of MTH1 (unknown origin) using 8-oxo-dGTP as substrate preincubated for 15 mins followed by substrate addition and measured after 20 mins ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50094468(CHEMBL3590123)
Affinity DataIC50:  9.90nMAssay Description:Inhibition of MEK U911-activated ERK2 (unknown origin) using Erktide as substrate preincubated with enzyme for 20 mins prior to substrate addition by...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOxidized purine nucleoside triphosphate hydrolase(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50255420(4-(4-chloro-2-fluorophenylamino)-6,7-dimethoxyquin...)
Affinity DataIC50:  13nMAssay Description:Inhibition of MTH1 (unknown origin) using 8-oxo-dGTP as substrate preincubated for 15 mins followed by substrate addition and measured after 20 mins ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50094468(CHEMBL3590123)
Affinity DataIC50:  13nMAssay Description:Inhibition of MEK U911-activated ERK2 (unknown origin) using Erktide as substrate preincubated with enzyme for 20 mins prior to substrate addition by...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50094312(CHEMBL3590110)
Affinity DataIC50:  17nMAssay Description:Inhibition of MEK U911-activated ERK2 (unknown origin) using Erktide as substrate preincubated with enzyme for 20 mins prior to substrate addition by...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50094304(CHEMBL3590118 | US9796700, Compound I-108)
Affinity DataIC50:  19nMAssay Description:Inhibition of ERK2 in human A375 cells harboring B-RAF V600E mutant assessed as decrease in phospho-ERK2 level after 2 hrs by Cellomics ArrayScanTM V...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOxidized purine nucleoside triphosphate hydrolase(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50548112(CHEMBL4791612)
Affinity DataIC50:  21nMAssay Description:Inhibition of MTH1 (unknown origin) using 8-oxo-dGTP as substrate preincubated for 15 mins followed by substrate addition and measured after 20 mins ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50094470(CHEMBL3590121)
Affinity DataIC50:  22nMAssay Description:Inhibition of ERK2 in human A375 cells harboring B-RAF V600E mutant assessed as decrease in phospho-ERK2 level after 2 hrs by Cellomics ArrayScanTM V...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50094466(CHEMBL3590125)
Affinity DataIC50:  39nMAssay Description:Inhibition of MEK U911-activated ERK2 (unknown origin) using Erktide as substrate preincubated with enzyme for 20 mins prior to substrate addition by...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50094306(CHEMBL3590116)
Affinity DataIC50:  40nMAssay Description:Inhibition of MEK U911-activated ERK2 (unknown origin) using Erktide as substrate preincubated with enzyme for 20 mins prior to substrate addition by...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50094305(CHEMBL3590117)
Affinity DataIC50:  42nMAssay Description:Inhibition of MEK U911-activated ERK2 (unknown origin) using Erktide as substrate preincubated with enzyme for 20 mins prior to substrate addition by...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50094308(CHEMBL3590114)
Affinity DataIC50:  44nMAssay Description:Inhibition of MEK U911-activated ERK2 (unknown origin) using Erktide as substrate preincubated with enzyme for 20 mins prior to substrate addition by...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50094466(CHEMBL3590125)
Affinity DataIC50:  47nMAssay Description:Inhibition of MEK U911-activated ERK2 (unknown origin) using Erktide as substrate preincubated with enzyme for 20 mins prior to substrate addition by...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50094468(CHEMBL3590123)
Affinity DataIC50:  48nMAssay Description:Inhibition of ERK2 in human A375 cells harboring B-RAF V600E mutant assessed as decrease in phospho-ERK2 level after 2 hrs by Cellomics ArrayScanTM V...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50094305(CHEMBL3590117)
Affinity DataIC50:  60nMAssay Description:Inhibition of MEK U911-activated ERK2 (unknown origin) using Erktide as substrate preincubated with enzyme for 20 mins prior to substrate addition by...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50094466(CHEMBL3590125)
Affinity DataIC50:  66nMAssay Description:Inhibition of ERK2 in human A375 cells harboring B-RAF V600E mutant assessed as decrease in phospho-ERK2 level after 2 hrs by Cellomics ArrayScanTM V...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50094467(CHEMBL3590124)
Affinity DataIC50:  72nMAssay Description:Inhibition of ERK2 in human A375 cells harboring B-RAF V600E mutant assessed as decrease in phospho-ERK2 level after 2 hrs by Cellomics ArrayScanTM V...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50094311(CHEMBL3590111)
Affinity DataIC50:  74nMAssay Description:Inhibition of MEK U911-activated ERK2 (unknown origin) using Erktide as substrate preincubated with enzyme for 20 mins prior to substrate addition by...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50094469(CHEMBL3590122)
Affinity DataIC50:  77nMAssay Description:Inhibition of MEK U911-activated ERK2 (unknown origin) using Erktide as substrate preincubated with enzyme for 20 mins prior to substrate addition by...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50094467(CHEMBL3590124)
Affinity DataIC50:  85nMAssay Description:Inhibition of MEK U911-activated ERK2 (unknown origin) using Erktide as substrate preincubated with enzyme for 20 mins prior to substrate addition by...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50094469(CHEMBL3590122)
Affinity DataIC50:  88nMAssay Description:Inhibition of MEK U911-activated ERK2 (unknown origin) using Erktide as substrate preincubated with enzyme for 20 mins prior to substrate addition by...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50094467(CHEMBL3590124)
Affinity DataIC50:  90nMAssay Description:Inhibition of MEK U911-activated ERK2 (unknown origin) using Erktide as substrate preincubated with enzyme for 20 mins prior to substrate addition by...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50094311(CHEMBL3590111)
Affinity DataIC50:  110nMAssay Description:Inhibition of MEK U911-activated ERK2 (unknown origin) using Erktide as substrate preincubated with enzyme for 20 mins prior to substrate addition by...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50094305(CHEMBL3590117)
Affinity DataIC50:  120nMAssay Description:Inhibition of ERK2 in human A375 cells harboring B-RAF V600E mutant assessed as decrease in phospho-ERK2 level after 2 hrs by Cellomics ArrayScanTM V...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50094312(CHEMBL3590110)
Affinity DataIC50:  120nMAssay Description:Inhibition of ERK2 in human A375 cells harboring B-RAF V600E mutant assessed as decrease in phospho-ERK2 level after 2 hrs by Cellomics ArrayScanTM V...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50094468(CHEMBL3590123)
Affinity DataIC50:  120nMAssay Description:Inhibition of MEK1 (unknown origin) autophosphorylation incubated with enzyme for 20 mins prior to ATP addition by ADP Glo kinase assay in presence o...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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