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TargetProstaglandin E2 receptor EP3 subtype(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50414549(CHEMBL563480)
Affinity DataEC50: >2.51E+4nMAssay Description:Agonist activity at human EP3 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Stanford University

Curated by ChEMBL
LigandPNGBDBM36609(Rapamycin C-7, analog 4 | SIROLIMUS | US11603377, ...)
Affinity DataIC50: 0.100nMAssay Description:Inhibition of mTOR kinase expressed in human HEK293 cells by Western blot analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50282363(4-[2-Butyl-5-((E)-2-carboxy-3-thiophen-2-yl-propen...)
Affinity DataIC50: 0.160nMAssay Description:Tested for inhibition of [125I]- AII specific binding to rat mesenteric arteries, expressed as IC50More data for this Ligand-Target Pair
In DepthDetails Article

LigandPNGBDBM50011977((E)-3-[2-n-butyl-1-{(4-carboxyphenyl)methyl}-1H-im...)
Affinity DataIC50: 1nMAssay Description:Tested for inhibition of [125I]- AII specific binding to rat mesenteric arteries, expressed as IC50More data for this Ligand-Target Pair
In DepthDetails Article

LigandPNGBDBM50048078(4-[2-Butyl-5-((E)-2-carboxy-3-thiophen-2-yl-propen...)
Affinity DataIC50: 1nMAssay Description:Tested for inhibition of [125I]- AII specific binding to rat mesenteric arteries, expressed as IC50More data for this Ligand-Target Pair
In DepthDetails Article

TargetType-1 angiotensin II receptor(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50282362(4-[2-Butyl-5-((E)-2-carboxy-3-thiophen-2-yl-propen...)
Affinity DataIC50: 1.20nMAssay Description:Tested for Angiotensin II receptor, type 1 affinity in the absence of BSAMore data for this Ligand-Target Pair
In DepthDetails Article

LigandPNGBDBM50011975(4-[2-Butyl-5-(2-carboxy-3-thiophen-2-yl-propenyl)-...)
Affinity DataIC50: 1.5nMAssay Description:Tested for inhibition of [125I]- AII specific binding to rat mesenteric arteries, expressed as IC50More data for this Ligand-Target Pair
In DepthDetails Article

TargetType-1 angiotensin II receptor(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50011977((E)-3-[2-n-butyl-1-{(4-carboxyphenyl)methyl}-1H-im...)
Affinity DataIC50: 2nMAssay Description:Tested for Angiotensin II receptor, type 1 affinity in the absence of bovine serum albumin (BSA)More data for this Ligand-Target Pair
In DepthDetails Article

TargetType-1 angiotensin II receptor(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50284297(4-(2-Butyl-5-{[(R)-1-carboxy-2-(1H-indol-3-yl)-eth...)
Affinity DataIC50: 2.90nMAssay Description:Tested for inhibition of Angiotensin II specific binding to Angiotensin II receptor, type 1 in the recombinant human AT-1 receptor expressed in LhAT-...More data for this Ligand-Target Pair
In DepthDetails Article

TargetSerine/threonine-protein kinase mTOR(Human)
Stanford University

Curated by ChEMBL
LigandPNGBDBM50260264(C-16-(S)-3-methylindolerapamycin | CHEMBL503885)
Affinity DataIC50: 5nMAssay Description:Inhibition of mTOR kinase expressed in human HEK293 cells by Western blot analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetType-1 angiotensin II receptor(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50011977((E)-3-[2-n-butyl-1-{(4-carboxyphenyl)methyl}-1H-im...)
Affinity DataIC50: 7.30nMAssay Description:Tested for Angiotensin II receptor, type 1 affinity in the presence of 0.25% bovine serum albumin (BSA)More data for this Ligand-Target Pair
In DepthDetails Article

TargetSerine/threonine-protein kinase mTOR(Human)
Stanford University

Curated by ChEMBL
LigandPNGBDBM50260265(C-16-(S)-7-methylindolerapamycin | AP-21967 | CHEM...)
Affinity DataIC50: 10nMAssay Description:Inhibition of mTOR kinase expressed in human HEK293 cells by Western blot analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50282362(4-[2-Butyl-5-((E)-2-carboxy-3-thiophen-2-yl-propen...)
Affinity DataIC50: 12nMAssay Description:Tested for inhibition of [125I]- AII specific binding to rat mesenteric arteries, expressed as IC50More data for this Ligand-Target Pair
In DepthDetails Article

Target1-deoxy-D-xylulose 5-phosphate reductoisomerase, apicoplastic(Plasmodium falciparum (isolate 3D7))
George Washington University

Curated by ChEMBL
LigandPNGBDBM50459311(CHEMBL1922604 | FR900098)
Affinity DataIC50: 23nMAssay Description:Inhibition of Plasmodium falciparum DXR assessed as reduction in NADPH oxidation in presence of DOXP by UV-visible spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target1-deoxy-D-xylulose 5-phosphate reductoisomerase, apicoplastic(Plasmodium falciparum (isolate 3D7))
George Washington University

Curated by ChEMBL
LigandPNGBDBM50459311(CHEMBL1922604 | FR900098)
Affinity DataIC50: 24nMAssay Description:Inhibition of Plasmodium falciparum DXRMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetType-1 angiotensin II receptor(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50282362(4-[2-Butyl-5-((E)-2-carboxy-3-thiophen-2-yl-propen...)
Affinity DataIC50: 31nMAssay Description:Tested for Angiotensin II receptor, type 1 affinity in the presence of 0.25% BSAMore data for this Ligand-Target Pair
In DepthDetails Article

Target1-deoxy-D-xylulose 5-phosphate reductoisomerase, apicoplastic(Plasmodium falciparum (isolate 3D7))
George Washington University

Curated by ChEMBL
LigandPNGBDBM50028309(Fosmidomycin Sodium)
Affinity DataIC50: 34nMAssay Description:Inhibition of Plasmodium falciparum DXRMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50048076(4-[2-Butyl-5-((E)-2-carboxy-3-thiophen-2-yl-propen...)
Affinity DataIC50: 35nMAssay Description:Tested for inhibition of [125I]- AII specific binding to rat mesenteric arteries, expressed as IC50More data for this Ligand-Target Pair
In DepthDetails Article

TargetType-1 angiotensin II receptor(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50284298(4-(2-Butyl-5-{[(S)-1-carboxy-2-(1H-indol-3-yl)-eth...)
Affinity DataIC50: 48.3nMAssay Description:Tested for inhibition of Angiotensin II specific binding to Angiotensin II receptor, type 1 in the recombinant human AT-1 receptor expressed in LhAT-...More data for this Ligand-Target Pair
In DepthDetails Article

Target1-deoxy-D-xylulose 5-phosphate reductoisomerase, apicoplastic(Plasmodium falciparum (isolate 3D7))
George Washington University

Curated by ChEMBL
LigandPNGBDBM50028309(Fosmidomycin Sodium)
Affinity DataIC50: 64nMAssay Description:Inhibition of Plasmodium falciparum DXR assessed as reduction in NADPH oxidation in presence of DOXP by UV-visible spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target1-deoxy-D-xylulose 5-phosphate reductoisomerase, apicoplastic(Plasmodium falciparum (isolate 3D7))
George Washington University

Curated by ChEMBL
LigandPNGBDBM50459310(CHEMBL4207168)
Affinity DataIC50: 92nMAssay Description:Inhibition of Plasmodium falciparum DXR assessed as reduction in NADPH oxidation in presence of DOXP by UV-visible spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target1-deoxy-D-xylulose 5-phosphate reductoisomerase(Staphylococcus hyicus subsp. chromogenes)
THE GEORGE WASHINGTON UNIVERSITY, A CONGRESSIONALLY CHARTERED NOT-FOR-PROFIT CORPORATION; WASHINGTON UNIVERSITY

US Patent
LigandPNGBDBM50459310(CHEMBL4207168)
Affinity DataIC50: 170nMAssay Description:Oxidation of NADPH to NADP+ as a result of substrate turnover was monitored at 340 nm in a POLARstar Omega microplate reader (BMG Labtech). The stand...More data for this Ligand-Target Pair
In DepthDetails
US Patent

Target1-deoxy-D-xylulose 5-phosphate reductoisomerase, apicoplastic(Plasmodium falciparum (isolate 3D7))
George Washington University

Curated by ChEMBL
LigandPNGBDBM50445564(CHEMBL3103256)
Affinity DataIC50: 206nMAssay Description:Inhibition of Plasmodium falciparum DXR assessed as reduction in NADPH oxidation in presence of DOXP by UV-visible spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetType-1 angiotensin II receptor(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50284295(4-{2-Butyl-5-[(carboxymethyl-amino)-methyl]-imidaz...)
Affinity DataIC50: 298nMAssay Description:Tested for inhibition of Angiotensin II specific binding to Angiotensin II receptor, type 1 in the recombinant human AT-1 receptor expressed in LhAT-...More data for this Ligand-Target Pair
In DepthDetails Article

Target1-deoxy-D-xylulose 5-phosphate reductoisomerase(Staphylococcus hyicus subsp. chromogenes)
THE GEORGE WASHINGTON UNIVERSITY, A CONGRESSIONALLY CHARTERED NOT-FOR-PROFIT CORPORATION; WASHINGTON UNIVERSITY

US Patent
LigandPNGBDBM701271(US12122799, Compound Fosmidomycin)
Affinity DataIC50: 340nMAssay Description:Oxidation of NADPH to NADP+ as a result of substrate turnover was monitored at 340 nm in a POLARstar Omega microplate reader (BMG Labtech). The stand...More data for this Ligand-Target Pair
Ligand InfoSimilars
In DepthDetails
US Patent

Target1-deoxy-D-xylulose 5-phosphate reductoisomerase(Staphylococcus hyicus subsp. chromogenes)
THE GEORGE WASHINGTON UNIVERSITY, A CONGRESSIONALLY CHARTERED NOT-FOR-PROFIT CORPORATION; WASHINGTON UNIVERSITY

US Patent
LigandPNGBDBM50459311(CHEMBL1922604 | FR900098)
Affinity DataIC50: 360nMAssay Description:Oxidation of NADPH to NADP+ as a result of substrate turnover was monitored at 340 nm in a POLARstar Omega microplate reader (BMG Labtech). The stand...More data for this Ligand-Target Pair
In DepthDetails
US Patent

Target1-deoxy-D-xylulose 5-phosphate reductoisomerase()
THE GEORGE WASHINGTON UNIVERSITY, A CONGRESSIONALLY CHARTERED NOT-FOR-PROFIT CORPORATION; WASHINGTON UNIVERSITY

US Patent
LigandPNGBDBM50459310(CHEMBL4207168)
Affinity DataIC50: 410nMAssay Description:Oxidation of NADPH to NADP+ as a result of substrate turnover was monitored at 340 nm in a POLARstar Omega microplate reader (BMG Labtech). The stand...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetType-1 angiotensin II receptor(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50048069(3-(3-Benzyl-2-butyl-3H-imidazol-4-yl)-2-thiophen-2...)
Affinity DataIC50: 440nMAssay Description:Tested for binding affinity to Angiotensin II receptor, type 1More data for this Ligand-Target Pair
In DepthDetails Article

Target1-deoxy-D-xylulose 5-phosphate reductoisomerase()
THE GEORGE WASHINGTON UNIVERSITY, A CONGRESSIONALLY CHARTERED NOT-FOR-PROFIT CORPORATION; WASHINGTON UNIVERSITY

US Patent
LigandPNGBDBM701271(US12122799, Compound Fosmidomycin)
Affinity DataIC50: 670nMAssay Description:Oxidation of NADPH to NADP+ as a result of substrate turnover was monitored at 340 nm in a POLARstar Omega microplate reader (BMG Labtech). The stand...More data for this Ligand-Target Pair
Ligand InfoSimilars
In DepthDetails
US Patent

Target1-deoxy-D-xylulose 5-phosphate reductoisomerase()
THE GEORGE WASHINGTON UNIVERSITY, A CONGRESSIONALLY CHARTERED NOT-FOR-PROFIT CORPORATION; WASHINGTON UNIVERSITY

US Patent
LigandPNGBDBM50459311(CHEMBL1922604 | FR900098)
Affinity DataIC50: 1.00E+3nMAssay Description:Oxidation of NADPH to NADP+ as a result of substrate turnover was monitored at 340 nm in a POLARstar Omega microplate reader (BMG Labtech). The stand...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetCytochrome P450 3A4(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50372613(CHEMBL410420)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of CYP3A4More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target1-deoxy-D-xylulose 5-phosphate reductoisomerase(Staphylococcus hyicus subsp. chromogenes)
THE GEORGE WASHINGTON UNIVERSITY, A CONGRESSIONALLY CHARTERED NOT-FOR-PROFIT CORPORATION; WASHINGTON UNIVERSITY

US Patent
LigandPNGBDBM701274(US12122799, Compound ERJ-207)
Affinity DataIC50: 1.69E+3nMAssay Description:Oxidation of NADPH to NADP+ as a result of substrate turnover was monitored at 340 nm in a POLARstar Omega microplate reader (BMG Labtech). The stand...More data for this Ligand-Target Pair
Ligand InfoSimilars
In DepthDetails
US Patent

Target1-deoxy-D-xylulose 5-phosphate reductoisomerase, apicoplastic(Plasmodium falciparum (isolate 3D7))
George Washington University

Curated by ChEMBL
LigandPNGBDBM50459307(CHEMBL4215008)
Affinity DataIC50: 2.11E+3nMAssay Description:Inhibition of Plasmodium falciparum DXR assessed as reduction in NADPH oxidation in presence of DOXP by UV-visible spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target1-deoxy-D-xylulose 5-phosphate reductoisomerase, apicoplastic(Plasmodium falciparum (isolate 3D7))
George Washington University

Curated by ChEMBL
LigandPNGBDBM50459312(CHEMBL4210088)
Affinity DataIC50: 2.54E+3nMAssay Description:Inhibition of Plasmodium falciparum DXR assessed as reduction in NADPH oxidation in presence of DOXP by UV-visible spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 3A4(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50372609(CHEMBL401960)
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of CYP3A4More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target1-deoxy-D-xylulose 5-phosphate reductoisomerase()
THE GEORGE WASHINGTON UNIVERSITY, A CONGRESSIONALLY CHARTERED NOT-FOR-PROFIT CORPORATION; WASHINGTON UNIVERSITY

US Patent
LigandPNGBDBM701274(US12122799, Compound ERJ-207)
Affinity DataIC50: 3.31E+3nMAssay Description:Oxidation of NADPH to NADP+ as a result of substrate turnover was monitored at 340 nm in a POLARstar Omega microplate reader (BMG Labtech). The stand...More data for this Ligand-Target Pair
Ligand InfoSimilars
In DepthDetails
US Patent

TargetCytochrome P450 2C9(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50329821(1-(1-(2-chloro-6-fluorobenzyl)-2-oxo-1,2-dihydropy...)
Affinity DataIC50: 3.70E+3nMAssay Description:Inhibition of CYP2C9More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 3A4(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50372611(CHEMBL196478)
Affinity DataIC50: 4.00E+3nMAssay Description:Inhibition of CYP3A4More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 2C19(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50329821(1-(1-(2-chloro-6-fluorobenzyl)-2-oxo-1,2-dihydropy...)
Affinity DataIC50: 4.50E+3nMAssay Description:Inhibition of CYP2C19More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target1-deoxy-D-xylulose 5-phosphate reductoisomerase, apicoplastic(Plasmodium falciparum (isolate 3D7))
George Washington University

Curated by ChEMBL
LigandPNGBDBM50459308(CHEMBL4202817)
Affinity DataIC50: 4.53E+3nMAssay Description:Inhibition of Plasmodium falciparum DXR assessed as reduction in NADPH oxidation in presence of DOXP by UV-visible spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetType-1 angiotensin II receptor(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50003266(CHEMBL289543 | 3-[2-Butyl-3-(2-chloro-benzyl)-3H-i...)
Affinity DataIC50: 4.53E+3nMAssay Description:Tested for binding affinity to Angiotensin II receptor, type 1More data for this Ligand-Target Pair
In DepthDetails Article

TargetCytochrome P450 1A2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50329821(1-(1-(2-chloro-6-fluorobenzyl)-2-oxo-1,2-dihydropy...)
Affinity DataIC50: 5.70E+3nMAssay Description:Inhibition of CYP1A2More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 3A4(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50372614(CHEMBL209864)
Affinity DataIC50: 7.00E+3nMAssay Description:Inhibition of CYP3A4More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target1-deoxy-D-xylulose 5-phosphate reductoisomerase()
THE GEORGE WASHINGTON UNIVERSITY, A CONGRESSIONALLY CHARTERED NOT-FOR-PROFIT CORPORATION; WASHINGTON UNIVERSITY

US Patent
LigandPNGBDBM701278(US12122799, Compound JXW-573)
Affinity DataIC50: 1.26E+4nMAssay Description:Oxidation of NADPH to NADP+ as a result of substrate turnover was monitored at 340 nm in a POLARstar Omega microplate reader (BMG Labtech). The stand...More data for this Ligand-Target Pair
Ligand InfoSimilars
In DepthDetails
US Patent

Target1-deoxy-D-xylulose 5-phosphate reductoisomerase, apicoplastic(Plasmodium falciparum (isolate 3D7))
George Washington University

Curated by ChEMBL
LigandPNGBDBM50459309(CHEMBL4211531)
Affinity DataIC50: 1.45E+4nMAssay Description:Inhibition of Plasmodium falciparum DXR assessed as reduction in NADPH oxidation in presence of DOXP by UV-visible spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target1-deoxy-D-xylulose 5-phosphate reductoisomerase(Staphylococcus hyicus subsp. chromogenes)
THE GEORGE WASHINGTON UNIVERSITY, A CONGRESSIONALLY CHARTERED NOT-FOR-PROFIT CORPORATION; WASHINGTON UNIVERSITY

US Patent
LigandPNGBDBM701278(US12122799, Compound JXW-573)
Affinity DataIC50: 1.52E+4nMAssay Description:Oxidation of NADPH to NADP+ as a result of substrate turnover was monitored at 340 nm in a POLARstar Omega microplate reader (BMG Labtech). The stand...More data for this Ligand-Target Pair
Ligand InfoSimilars
In DepthDetails
US Patent

TargetCytochrome P450 2D6(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50329821(1-(1-(2-chloro-6-fluorobenzyl)-2-oxo-1,2-dihydropy...)
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 3A4(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50329821(1-(1-(2-chloro-6-fluorobenzyl)-2-oxo-1,2-dihydropy...)
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of CYP3A4More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50384443(CHEMBL1770317)
Affinity DataIC50: 5.01E+4nMAssay Description:Antagonist activity against human EP2 receptor expressed in CHO-K1 cells assessed as inhibition of cAMP production after 4 hrs by FRET signal in LANC...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProstaglandin D2 receptor(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50384443(CHEMBL1770317)
Affinity DataIC50: 5.01E+4nMAssay Description:Binding affinity at human DP receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
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