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TargetBile acid receptor(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50301769(isopropyl 2-cyano-4,4-dimethyl-6-(tetrahydro-2H-py...)
Affinity DataEC50:  3.30E+3nMAssay Description:Agonist activity at gal4-tagged human FXR-ligand binding domain expressed in human HEK293 cells by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
TargetToll-like receptor 7(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50063497(CHEMBL3398485)
Affinity DataEC50:  150nMAssay Description:Activation of human TLR7 expressed in HEK293 cells after 24 hrs by NFkappaB-mediated SEAP reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/8/2016
Entry Details Article
PubMed
TargetToll-like receptor 4(Human)
Inimmune

Curated by ChEMBL
LigandPNGBDBM50630274(CHEMBL5434803)
Affinity DataEC50:  24nMAssay Description:Agonist activity at TLR4 in human PBMC cells assessed as induction of MIP-1beta release incubated for 20 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
TargetOxysterols receptor LXR-beta(Human)
Wyeth Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50305494(4-(3-(3-chloro-5-(methylsulfonyl)phenoxy)phenyl)-8...)
Affinity DataEC50:  5.10E+3nMAssay Description:Agonist activity at human recombinant LXRalpha ligand binding domain in human HuH7 cells co-transfected with fused Gal4-DBD by transactivation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetToll-like receptor 4(Mouse)
Inimmune

Curated by ChEMBL
LigandPNGBDBM50630274(CHEMBL5434803)
Affinity DataEC50:  3.70nMAssay Description:Agonist activity at TLR4 in mouse RAW264.7 cells assessed as induction of MIP-1beta release incubated for 24 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
TargetToll-like receptor 4(Human)
Inimmune

Curated by ChEMBL
LigandPNGBDBM50630281(CHEMBL5407900)
Affinity DataEC50:  2.60nMAssay Description:Agonist activity at TLR4 in human PBMC cells assessed as induction of TNFalpha release incubated for 20 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
TargetBile acid receptor(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50301754(isopropyl 2-cyano-6-(3-fluorobenzoyl)-4,4-dimethyl...)
Affinity DataEC50:  2.5nMAssay Description:Agonist activity at gal4-tagged human FXR-ligand binding domain expressed in human HEK293 cells by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
TargetToll-like receptor 7(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50544842(CHEMBL4632802)
Affinity DataEC50:  2.31E+4nMAssay Description:Agonist activity at human TLR7 expressed in HEK293 cells assessed as induction of NFKappaB activity after 24 hrs by SEAP reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetOxysterols receptor LXR-beta(Human)
Wyeth Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50316094(3-Ethyl-2-[3'-(methylsulfonyl)biphenyl-4-yl]-5-(tr...)
Affinity DataEC50:  2.02E+3nMAssay Description:Agonist activity at human recombinant LXRbeta ligand binding domain in human HuH7 cells co-transfected with fused Gal4-DBD by transactivation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetBromodomain-containing protein 4(Human)
Gsk

Curated by ChEMBL
LigandPNGBDBM50544597(GSK778)
Affinity DataKd:  1.26E+3nMAssay Description:Binding affinity to BRD4 BD2 (333 to 460 residues) (unknown origin) by surface plasmon resonance methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetOxysterols receptor LXR-beta(Human)
Wyeth Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50305494(4-(3-(3-chloro-5-(methylsulfonyl)phenoxy)phenyl)-8...)
Affinity DataEC50:  1.09E+4nMAssay Description:Agonist activity at human LXRalpha in HEK293 cells assessed as Gal4 transactivationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetToll-like receptor 8(Human)
University of Montana

Curated by ChEMBL
LigandPNGBDBM50544843(CHEMBL4638683)
Affinity DataEC50:  2.53E+3nMAssay Description:Agonist activity at human TLR8 expressed in HEK293 cells assessed as induction of NFKappaB activity after 24 hrs by SEAP reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetToll-like receptor 4(Human)
Inimmune

Curated by ChEMBL
LigandPNGBDBM50630283(CHEMBL5423611)
Affinity DataEC50:  0.110nMAssay Description:Agonist activity at TLR4 in human PBMC cells assessed as induction of MIP-1beta release incubated for 20 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
TargetBromodomain-containing protein 4(Human)
Gsk

Curated by ChEMBL
LigandPNGBDBM50526964(CHEMBL4438171)
Affinity DataKd:  5nMAssay Description:Displacement of Alexa Fluor 647 labelled ligand from recombinant human N-terminal His6-tagged BRD4 BD1 (1 to 477 residues)/BD2 Y390A mutant incubated...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetToll-like receptor 4(Human)
Inimmune

Curated by ChEMBL
LigandPNGBDBM50630281(CHEMBL5407900)
Affinity DataEC50:  7.90nMAssay Description:Agonist activity at human TLR4 in human HEK-Blue hTLR4 cells assessed as NF-kappaB activation incubated for 48 hrs by SEAP reporter gene based Quanti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
TargetToll-like receptor 4(Human)
Inimmune

Curated by ChEMBL
LigandPNGBDBM50630279(CHEMBL5422378)
Affinity DataEC50:  40nMAssay Description:Agonist activity at TLR4 in human MONO-MAC-6 cells assessed as induction of MIP-1beta release incubated for 24 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
TargetToll-like receptor 4(Mouse)
Inimmune

Curated by ChEMBL
LigandPNGBDBM50630282(CHEMBL5407887)
Affinity DataEC50:  0.0400nMAssay Description:Agonist activity at TLR4 in mouse RAW264.7 cells assessed as induction of MIP-1beta release incubated for 24 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
TargetToll-like receptor 4(Human)
Inimmune

Curated by ChEMBL
LigandPNGBDBM50630281(CHEMBL5407900)
Affinity DataEC50:  0.140nMAssay Description:Agonist activity at TLR4 in human PBMC cells assessed as induction of RANTES release incubated for 20 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
TargetToll-like receptor 4(Human)
Inimmune

Curated by ChEMBL
LigandPNGBDBM50630278(CHEMBL5432710)
Affinity DataEC50:  8.80nMAssay Description:Agonist activity at TLR4 in human PBMC cells assessed as induction of IL-1beta release incubated for 20 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
TargetBile acid receptor(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50306716(Isopropyl 3-{4-[2-(Dimethylamino)ethoxy]benzoyl}-1...)
Affinity DataEC50:  439nMAssay Description:Agonist activity at human FXR-LBD expressed in HEL293 cells by Gal4-luciferase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetToll-like receptor 4(Human)
Inimmune

Curated by ChEMBL
LigandPNGBDBM50630279(CHEMBL5422378)
Affinity DataEC50:  116nMAssay Description:Agonist activity at TLR4 in human PBMC cells assessed as induction of TNFalpha release incubated for 20 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
TargetToll-like receptor 8(Human)
University of Montana

Curated by ChEMBL
LigandPNGBDBM50063496(CHEMBL3398484)
Affinity DataEC50:  3.26E+5nMAssay Description:Agonist activity at human TLR8 expressed in HEK293 cells assessed as induction of NFKappaB activity after 24 hrs by SEAP reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50301760(isopropyl 2-cyano-4,4-dimethyl-6-(thiophene-2-carb...)
Affinity DataEC50:  16nMAssay Description:Agonist activity at gal4-tagged human FXR-ligand binding domain expressed in human HEK293 cells by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50306723(Isopropyl 1,1-Dimethyl-3-{4-[3-(4-methylpiperazin-...)
Affinity DataEC50:  194nMAssay Description:Agonist activity at human FXR-LBD expressed in HEL293 cells by Gal4-luciferase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetBile acid receptor(Mouse)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50306714(Isopropyl 1,1-Dimethyl-3-[4-(3-morpholin-4-ylpropo...)
Affinity DataEC50:  108nMAssay Description:Agonist activity at mouse FXR-LBD expressed in HEL293 cells by Gal4-luciferase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetToll-like receptor 4(Mouse)
Inimmune

Curated by ChEMBL
LigandPNGBDBM50630281(CHEMBL5407900)
Affinity DataEC50:  0.150nMAssay Description:Agonist activity at mouse TLR4 in human HEK-Blue mTLR4 cells assessed as NF-kappaB activation incubated for 48 hrs by SEAP reporter gene based Quanti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
TargetMitogen-activated protein kinase 14(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50361469(CHEMBL1938764)
Affinity DataKd:  3.30nMAssay Description:Binding affinity to p38alpha MAPK by surface plasmon resonance methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetBile acid receptor(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50306726(Isopropyl 1,1-Dimethyl-3-[3-(2-piperidin-1-ylethox...)
Affinity DataEC50:  894nMAssay Description:Agonist activity at human FXR-LBD expressed in HEL293 cells by Gal4-luciferase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetToll-like receptor 4(Mouse)
Inimmune

Curated by ChEMBL
LigandPNGBDBM50630282(CHEMBL5407887)
Affinity DataEC50:  0.680nMAssay Description:Agonist activity at mouse TLR4 in human HEK-Blue mTLR4 cells assessed as NF-kappaB activation incubated for 48 hrs by SEAP reporter gene based Quanti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
TargetTransient receptor potential cation channel subfamily A member 1(Human)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50203070(1-methyl-3-(2-oxopropylidene)indolin-2-one | CHEMB...)
Affinity DataEC50:  800nMAssay Description:Activation of TRPA1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetToll-like receptor 8(Human)
University of Montana

Curated by ChEMBL
LigandPNGBDBM50544839(CHEMBL4636713)
Affinity DataEC50:  2.13E+3nMAssay Description:Agonist activity at human TLR8 expressed in HEK293 cells assessed as induction of NFKappaB activity after 24 hrs by SEAP reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetToll-like receptor 8(Human)
University of Montana

Curated by ChEMBL
LigandPNGBDBM50544840(CHEMBL4646208)
Affinity DataEC50:  1.30E+4nMAssay Description:Agonist activity at human TLR8 expressed in HEK293 cells assessed as induction of NFKappaB activity after 24 hrs by SEAP reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetToll-like receptor 7(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50544846(CHEMBL4645696)
Affinity DataEC50: >5.00E+5nMAssay Description:Agonist activity at human TLR7 expressed in HEK293 cells assessed as induction of NFKappaB activity after 24 hrs by SEAP reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetToll-like receptor 4(Human)
Inimmune

Curated by ChEMBL
LigandPNGBDBM50630278(CHEMBL5432710)
Affinity DataEC50:  1.60nMAssay Description:Agonist activity at TLR4 in human PBMC cells assessed as induction of MIP-1beta release incubated for 20 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
TargetInsulin receptor(Mouse)
Telik

Curated by ChEMBL
LigandPNGBDBM50377966(CHEMBL1627108)
Affinity DataEC50: >2.00E+5nMAssay Description:Activation of insulin receptor tyrosine kinase in mouse 3T3-L1 cells assessed as increase in 2-deoxy-D-[14C]glucose transport in presence of insulinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2012
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50301758(isopropyl 6-(3-chlorobenzoyl)-2-cyano-4,4-dimethyl...)
Affinity DataEC50:  12nMAssay Description:Agonist activity at gal4-tagged human FXR-ligand binding domain expressed in human HEK293 cells by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
TargetToll-like receptor 4(Human)
Inimmune

Curated by ChEMBL
LigandPNGBDBM50630283(CHEMBL5423611)
Affinity DataEC50:  0.130nMAssay Description:Agonist activity at TLR4 in human PBMC cells assessed as induction of RANTES release incubated for 20 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Revolution Medicines

Curated by ChEMBL
LigandPNGBDBM50616040(CHEMBL5418335)
Affinity DataEC50: <10nMAssay Description:Inhibition of recombinant human EmGFP fused FKBP12/GST-tagged human mTOR (1360 to 2549 residues) FRB domain incubated for 1 hrs by LanthaScreen based...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetToll-like receptor 4(Human)
Inimmune

Curated by ChEMBL
LigandPNGBDBM50630275(CHEMBL5417929)
Affinity DataEC50:  6.20nMAssay Description:Agonist activity at human TLR4 in human HEK-Blue hTLR4 cells assessed as NF-kappaB activation incubated for 48 hrs by SEAP reporter gene based Quanti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
TargetBile acid receptor(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50306719(Isopropyl 1,1-Dimethyl-3-{4-[2-(4-methylpiperazin-...)
Affinity DataEC50:  287nMAssay Description:Agonist activity at human FXR-LBD expressed in HEL293 cells by Gal4-luciferase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50306728(Isopropyl 1,1-Dimethyl-3-{3-[2-(4-methylpiperazin-...)
Affinity DataEC50:  2.87E+3nMAssay Description:Agonist activity at human FXR-LBD expressed in HEL293 cells by Gal4-luciferase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
TargetOxysterols receptor LXR-beta(Human)
Wyeth Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM19993(CHEMBL62136 | [3H]T0901317 | T 0901317 | N-[4-(1,1...)
Affinity DataEC50:  140nMAssay Description:Agonist activity at human recombinant LXRalpha ligand binding domain in human HuH7 cells co-transfected with fused Gal4-DBD by transactivation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetToll-like receptor 8(Human)
University of Montana

Curated by ChEMBL
LigandPNGBDBM50544844(CHEMBL4635691)
Affinity DataEC50:  6.19E+5nMAssay Description:Agonist activity at human TLR8 expressed in HEK293 cells assessed as induction of NFKappaB activity after 24 hrs by SEAP reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetToll-like receptor 4(Human)
Inimmune

Curated by ChEMBL
LigandPNGBDBM50630281(CHEMBL5407900)
Affinity DataEC50:  0.130nMAssay Description:Agonist activity at TLR4 in human PBMC cells assessed as induction of MIP-1beta release incubated for 20 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
TargetInsulin receptor(Mouse)
Telik

Curated by ChEMBL
LigandPNGBDBM50253190(3-({7-[(N-{7-[N-(3-Carboxyphenyl)carbamoyl]-2-naph...)
Affinity DataEC50: >2.00E+5nMAssay Description:Activation of insulin receptor tyrosine kinase in mouse 3T3-L1 cells assessed as increase in 2-deoxy-D-[14C]glucose transport in presence of insulinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2012
Entry Details Article
PubMed
TargetToll-like receptor 4(Human)
Inimmune

Curated by ChEMBL
LigandPNGBDBM50630276(CHEMBL5428754)
Affinity DataEC50:  2.60nMAssay Description:Agonist activity at TLR4 in human PBMC cells assessed as induction of IL-1beta release incubated for 20 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
TargetInsulin receptor(Mouse)
Telik

Curated by ChEMBL
LigandPNGBDBM50253169(1,3-bis(5-hydroxy-7-{[3-(hydroxymethyl)phenyl]sulf...)
Affinity DataEC50: >2.00E+5nMAssay Description:Activation of insulin receptor tyrosine kinase in mouse 3T3-L1 cells assessed as increase in 2-deoxy-D-[14C]glucose transport in presence of insulinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2012
Entry Details Article
PubMed
TargetToll-like receptor 8(Human)
University of Montana

Curated by ChEMBL
LigandPNGBDBM50544841(CHEMBL4640501)
Affinity DataEC50:  2.14E+3nMAssay Description:Agonist activity at human TLR8 expressed in HEK293 cells assessed as induction of NFKappaB activity after 24 hrs by SEAP reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetToll-like receptor 4(Mouse)
Inimmune

Curated by ChEMBL
LigandPNGBDBM50630276(CHEMBL5428754)
Affinity DataEC50:  0.430nMAssay Description:Agonist activity at mouse TLR4 in human HEK-Blue mTLR4 cells assessed as NF-kappaB activation incubated for 48 hrs by SEAP reporter gene based Quanti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMed
TargetBile acid receptor(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50306732(Isopropyl 1,1-Dimethyl-3-[3-(3-morpholin-4-ylpropo...)
Affinity DataEC50:  796nMAssay Description:Agonist activity at human FXR-LBD expressed in HEL293 cells by Gal4-luciferase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2010
Entry Details Article
PubMed
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