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TargetFree fatty acid receptor 1(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50244053(CHEMBL4083678)
Affinity DataEC50:  7.68E+3nMAssay Description:Agonist activity at human GPR40 expressed in CHOA12 cells assessed as induction of Ca2+ mobilization by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/21/2019
Entry Details Article
PubMed
TargetFree fatty acid receptor 1(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50267118(CHEMBL4096887)
Affinity DataEC50:  150nMAssay Description:Agonist activity at human GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2020
Entry Details Article
PubMed
TargetFree fatty acid receptor 1(Mouse)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50267021(CHEMBL4091669)
Affinity DataEC50: >3.30E+4nMAssay Description:Agonist activity at GPR40 in mouse STC1 cells assessed as induction of GLP-1 secretion measured after 1 hr by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2020
Entry Details Article
PubMed
TargetPeroxisome proliferator-activated receptor gamma(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50614650(CHEMBL5285235)
Affinity DataEC50: >4.80E+4nMAssay Description:Transactivation of PPARgamma (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetGrowth hormone secretagogue receptor type 1(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

LigandPNGBDBM21950(2-{5-[(1S)-1-(2-amino-2-methylpropanamido)-2-(benz...)
Affinity DataEC50:  7.90nMpH: 7.2 T: 2°CAssay Description:The functional FLIPR assay was developed from H4 glioma cells in which expression of the endogenous human GHS receptor was enhanced by RAGE-activatio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2008
Entry Details Article
PubMed
TargetCannabinoid receptor 1(Rat)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50356013(CHEMBL1911375 | CHEMBL1911374)
Affinity DataKd:  29.1nMAssay Description:Binding affinity to rat brain CB1 receptor after 90 mins by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/20/2012
Entry Details Article
PubMed
TargetGlucagon receptor(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50301952((3S,6S,9S,12S,15S,21S)-21-(2-((S)-2-amino-3-(1H-im...)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at glucagon receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/26/2012
Entry Details Article
PubMed
TargetGrowth hormone secretagogue receptor type 1(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

LigandPNGBDBM50366689(GHRELIN)
Affinity DataEC50:  1.41nMAssay Description:Inhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2012
Entry Details Article
PubMed
TargetFree fatty acid receptor 1(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50267113(CHEMBL4105565)
Affinity DataEC50:  4.60E+3nMAssay Description:Agonist activity at human GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2020
Entry Details Article
PubMed
TargetMotilin receptor(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50143037(CHEMBL411576 | MOTILIN)
Affinity DataEC50:  0.150nMAssay Description:In vitro effective concentration towards human motilin receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2012
Entry Details Article
PubMed
TargetFree fatty acid receptor 1(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50244013(CHEMBL4103854)
Affinity DataEC50:  450nMAssay Description:Agonist activity at human GPR40 expressed in CHOA12 cells assessed as induction of Ca2+ mobilization by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/21/2019
Entry Details Article
PubMed
TargetFree fatty acid receptor 1(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50244092(CHEMBL4066815)
Affinity DataEC50:  150nMAssay Description:Agonist activity at human GPR40 expressed in CHOA12 cells assessed as induction of Ca2+ mobilization by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/21/2019
Entry Details Article
PubMed
TargetPeroxisome proliferator-activated receptor gamma(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50614652(CHEMBL5266348)
Affinity DataEC50: >4.70E+4nMAssay Description:Transactivation of PPARgamma (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetMotilin receptor(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50143031(8'N-[1-carbamoyl-3-phenyl-(1R)-propyl]-2'-benzo[d]...)
Affinity DataEC50: >1.00E+4nMAssay Description:In vitro effective concentration towards human motilin receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2012
Entry Details Article
PubMed
TargetFree fatty acid receptor 1(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50244067(CHEMBL4075946)
Affinity DataEC50:  510nMAssay Description:Agonist activity at human GPR40 expressed in CHOA12 cells assessed as induction of Ca2+ mobilization by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/21/2019
Entry Details Article
PubMed
TargetFree fatty acid receptor 1(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50267017(CHEMBL4093180)
Affinity DataEC50:  1.30E+3nMAssay Description:Agonist activity at human GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2020
Entry Details Article
PubMed
TargetFree fatty acid receptor 1(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50267083(CHEMBL4088190)
Affinity DataEC50: >3.30E+4nMAssay Description:Agonist activity at human GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2020
Entry Details Article
PubMed
TargetCoagulation factor XI(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50458533(CHEMBL4206890)
Affinity DataKd:  1.40E+6nMAssay Description:Inhibition of human factor 11a assessed as reduction in para-nitroanilide releasee using pyroGlu-Pro-Arg-pNA.HCl substrate by by chromogenic assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetGrowth hormone secretagogue receptor type 1(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

LigandPNGBDBM50235852(2-(5-((S)-2-(2-(pyridin-3-yl)benzyloxy)-1-(2-amino...)
Affinity DataEC50:  1.18nMAssay Description:Inhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2012
Entry Details Article
PubMed
TargetPeroxisome proliferator-activated receptor gamma(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50614640(CHEMBL5287383)
Affinity DataEC50: >4.80E+4nMAssay Description:Transactivation of PPARgamma (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetGlucagon-like peptide 1 receptor(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50301932((3S,6S,9S,12S,15S,21S)-21-((S)-2-((S)-2-amino-3-(1...)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at human GLP1R expressed in CHO cells assessed as stimulation of intracellular [3H]cAMP accumulation after 30 mins by scintillation ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/26/2012
Entry Details Article
PubMed
TargetFree fatty acid receptor 1(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50244004(CHEMBL4088375)
Affinity DataEC50:  6.27E+3nMAssay Description:Agonist activity at human GPR40 expressed in CHOA12 cells assessed as induction of Ca2+ mobilization by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/21/2019
Entry Details Article
PubMed
TargetFree fatty acid receptor 1(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50244084(CHEMBL4089881)
Affinity DataEC50:  2.83E+3nMAssay Description:Agonist activity at human GPR40 expressed in CHOA12 cells assessed as induction of Ca2+ mobilization by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/21/2019
Entry Details Article
PubMed
TargetFree fatty acid receptor 1(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50244024(CHEMBL4081072)
Affinity DataEC50:  210nMAssay Description:Agonist activity at human GPR40 expressed in CHOA12 cells assessed as induction of Ca2+ mobilization by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/21/2019
Entry Details Article
PubMed
TargetPeroxisome proliferator-activated receptor gamma(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50614651(CHEMBL5268798)
Affinity DataEC50: >4.70E+4nMAssay Description:Transactivation of PPARgamma (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetFree fatty acid receptor 1(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50244066(CHEMBL4083365)
Affinity DataEC50:  210nMAssay Description:Positive allosteric modulation of human GPR40 expressed in HEK293 cells assessed as cAMP accumulationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetPeroxisome proliferator-activated receptor gamma(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50244066(CHEMBL4083365)
Affinity DataEC50:  4.40E+3nMAssay Description:Transactivation of PPARgamma (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetFree fatty acid receptor 1(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50614669(CHEMBL5274396)
Affinity DataEC50:  240nMAssay Description:Positive allosteric modulation of human GPR40 by calcium based FLIPR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetGlucagon-like peptide 1 receptor(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50301952((3S,6S,9S,12S,15S,21S)-21-(2-((S)-2-amino-3-(1H-im...)
Affinity DataEC50:  0.0870nMAssay Description:Agonist activity at human GLP1R expressed in CHO cells assessed as stimulation of intracellular [3H]cAMP accumulation after 30 mins by scintillation ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/26/2012
Entry Details Article
PubMed
TargetFree fatty acid receptor 1(Mouse)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50267044(CHEMBL4069764)
Affinity DataEC50:  710nMAssay Description:Agonist activity at GPR40 in mouse STC1 cells assessed as induction of GLP-1 secretion measured after 1 hr by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2020
Entry Details Article
PubMed
TargetPeroxisome proliferator-activated receptor gamma(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50614655(CHEMBL5281753)
Affinity DataEC50: >4.70E+4nMAssay Description:Transactivation of PPARgamma (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetGrowth hormone secretagogue receptor type 1(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

LigandPNGBDBM50235844((S)-2-(5-(2-(3,5-bis(trifluoromethyl)benzyloxy)-1-...)
Affinity DataEC50:  34nMAssay Description:Inhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2012
Entry Details Article
PubMed
TargetFree fatty acid receptor 1(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50267030(CHEMBL4090240)
Affinity DataEC50:  110nMAssay Description:Agonist activity at human GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2020
Entry Details Article
PubMed
TargetFree fatty acid receptor 1(Mouse)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50267119(CHEMBL1532576)
Affinity DataEC50: >3.30E+4nMAssay Description:Agonist activity at mouse GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2020
Entry Details Article
PubMed
TargetGrowth hormone secretagogue receptor type 1(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

LigandPNGBDBM50235845((S)-2-(5-(2-(2,4-difluorobenzyloxy)-1-(2-amino-2-m...)
Affinity DataEC50:  0.420nMAssay Description:Inhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2012
Entry Details Article
PubMed
TargetFree fatty acid receptor 1(Mouse)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50267061(CHEMBL4060859)
Affinity DataEC50: >1.60E+4nMAssay Description:Agonist activity at GPR40 in mouse STC1 cells assessed as induction of GLP-1 secretion measured after 1 hr by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2020
Entry Details Article
PubMed
TargetFree fatty acid receptor 1(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50614652(CHEMBL5266348)
Affinity DataEC50:  110nMAssay Description:Positive allosteric modulation of human GPR40 by calcium based FLIPR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetGlucagon-like peptide 1 receptor(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50301940((3S,6S,9S,12S,15S,21S)-21-((S)-2-((S)-2-amino-3-(1...)
Affinity DataEC50:  148nMAssay Description:Agonist activity at human GLP1R expressed in CHO cells assessed as stimulation of intracellular [3H]cAMP accumulation after 30 mins by scintillation ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/26/2012
Entry Details Article
PubMed
TargetFree fatty acid receptor 1(Mouse)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50267048(CHEMBL4075190)
Affinity DataEC50: >3.30E+4nMAssay Description:Agonist activity at GPR40 in mouse STC1 cells assessed as induction of GLP-1 secretion measured after 1 hr by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2020
Entry Details Article
PubMed
TargetMotilin receptor(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50344952((2R,3S,4R,5R,8R,9S,10S,11R,12S)-5-ethyl-11-((2S,3R...)
Affinity DataEC50:  4.20nMAssay Description:In vitro effective concentration towards human motilin receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2012
Entry Details Article
PubMed
TargetFree fatty acid receptor 1(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50244023(CHEMBL4097617)
Affinity DataEC50:  1.20E+3nMAssay Description:Agonist activity at human GPR40 expressed in CHOA12 cells assessed as induction of Ca2+ mobilization by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/21/2019
Entry Details Article
PubMed
TargetPeroxisome proliferator-activated receptor gamma(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50244066(CHEMBL4083365)
Affinity DataEC50:  4.40E+3nMAssay Description:Transactivation of human Gal4 fused PPARgamma-LBD expressed in HEK293 cells after 18 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2020
Entry Details Article
PubMed
TargetGlucagon-like peptide 1 receptor(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50301948((3S,6S,9S,12S,15S,21S)-21-((S)-2-((S)-2-amino-3-(1...)
Affinity DataEC50:  7nMAssay Description:Agonist activity at human GLP1R expressed in CHO cells assessed as stimulation of intracellular [3H]cAMP accumulation after 30 mins by scintillation ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/26/2012
Entry Details Article
PubMed
TargetFree fatty acid receptor 1(Mouse)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50267117(CHEMBL4060499)
Affinity DataEC50:  780nMAssay Description:Agonist activity at mouse GPR40 expressed in CHO-A12 cells assessed as increase in intracellular calcium flux measured for 100 secs by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2020
Entry Details Article
PubMed
TargetFree fatty acid receptor 1(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50614656(CHEMBL5268534)
Affinity DataEC50:  69nMAssay Description:Positive allosteric modulation of human GPR40 by calcium based FLIPR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetGrowth hormone secretagogue receptor type 1(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

LigandPNGBDBM50366689(GHRELIN)
Affinity DataEC50:  1.42nMAssay Description:Agonist activity at GHS receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2012
Entry Details Article
PubMed
TargetGrowth hormone secretagogue receptor type 1(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

LigandPNGBDBM21941(2-{5-[(1S)-1-(2-amino-2-methylpropanamido)-2-(benz...)
Affinity DataEC50:  1.90nMpH: 7.2 T: 2°CAssay Description:The functional FLIPR assay was developed from H4 glioma cells in which expression of the endogenous human GHS receptor was enhanced by RAGE-activatio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2008
Entry Details Article
PubMed
TargetFree fatty acid receptor 1(Mouse)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50267027(CHEMBL4094160)
Affinity DataEC50:  740nMAssay Description:Agonist activity at GPR40 in mouse STC1 cells assessed as induction of GLP-1 secretion measured after 1 hr by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2020
Entry Details Article
PubMed
TargetFree fatty acid receptor 1(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50614639(CHEMBL5290988)
Affinity DataEC50:  4.10E+3nMAssay Description:Positive allosteric modulation of human GPR40 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetFree fatty acid receptor 1(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50614641(CHEMBL5275737)
Affinity DataEC50:  180nMAssay Description:Positive allosteric modulation of human GPR40 by calcium based FLIPR analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
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