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TargetDelta-type opioid receptor(Mouse)
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50059997(7 beta-Spirobenzocyclohexylnaltrexone | CHEMBL1016...)
Affinity DataKi:  0.00190nMAssay Description:Inhibition of [3H]-NTI binding to Opioid receptor delta 1 from mouse brain membranes.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDelta-type opioid receptor(Mouse)
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50059994(7 alpha-Spirobenzocyclohexylnaltrexone | CHEMBL105...)
Affinity DataKi:  0.00410nMAssay Description:Inhibition of [3H]-NTI binding to Opioid receptor delta 1 from mouse brain membranes.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PAK 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50148931(CHEMBL3770186)
Affinity DataKi:  0.0230nMAssay Description:Inhibition of full length recombinant human N-terminal GST/His6-tagged PAK1 expressed in sf9 insect cells using tetra LRRWSLG as substrate preincubat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
Xiamen University

Curated by ChEMBL
LigandPNGBDBM50358166(CHEMBL1921842)
Affinity DataKd:  0.0280nMAssay Description:Binding affinity to kappa opioid receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMed
TargetEstrogen receptor(Human)TBA
LigandPNGBDBM774097(3-(5S,7R)-5-(2,6-difluoro-4-(((S)-1-(3-fluoropropy...)
Affinity DataIC50: 0.0500nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
TBA
Entry Details
US Patent

TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Xiamen University

Curated by ChEMBL
LigandPNGBDBM50049750(CHEMBL59986 | (S)-3-(azetidin-2-ylmethoxy)pyridine...)
Affinity DataKi:  0.0500nMAssay Description:Binding affinity to nACh alpha4beta2 receptor (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMed
TargetMu-type opioid receptor(Human)
Xiamen University

Curated by ChEMBL
LigandPNGBDBM50008984(N-(1-Phenethyl-piperidin-4-yl)-N-phenyl-propionami...)
Affinity DataKi:  0.0510nMAssay Description:Binding affinity to mu-opioid receptor (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetStimulator of interferon genes protein(Human)
Jacobio Pharmaceuticals Co.

US Patent
LigandPNGBDBM730218(US20250108123, Example II-1)
Affinity DataIC50: 0.0600nMAssay Description:Cisbio Bioassays' human STING WT binding assay (#64BDSTGPEG & 64BDSTGPEH, Cisbio) is for quantitative measurement of human STING WT ligand using ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/18/2025
Entry Details
US Patent

TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Xiamen University

Curated by ChEMBL
LigandPNGBDBM50621981(CHEMBL5412811)
Affinity DataKi:  0.0600nMAssay Description:Binding affinity to nACh alpha6beta2 receptor (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMed
TargetEstrogen receptor(Human)TBA
LigandPNGBDBM774108(2,2-Difluoro-3-((5R,7R)-5-(4-(((S)-1-(3-fluoroprop...)
Affinity DataIC50: 0.0700nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
TBA
Entry Details
US Patent

LigandPNGBDBM50632513(CHEMBL5415661)
Affinity DataKi: <0.0700nMAssay Description:Inhibition of full length human recombinant HPK1 expressed in baculovirus-infected insect cells using 5-FAM-KRRALSSLRA-COOH peptide as substrate prei...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetEstrogen receptor(Human)TBA
LigandPNGBDBM774107(2,2-Difluoro-3-((5R,7R)-5-(4-((1-(3-fluoropropyl)a...)
Affinity DataIC50: 0.0700nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
TBA
Entry Details
US Patent

TargetStimulator of interferon genes protein(Human)
Jacobio Pharmaceuticals Co.

US Patent
LigandPNGBDBM730205(4,4'-((propane-1,3-diylbis(oxy))bis(6-methoxyisoin...)
Affinity DataIC50: 0.100nMAssay Description:Cisbio Bioassays' human STING WT binding assay (#64BDSTGPEG & 64BDSTGPEH, Cisbio) is for quantitative measurement of human STING WT ligand using ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/18/2025
Entry Details
US Patent

TargetEstrogen receptor(Human)TBA
LigandPNGBDBM774094((S)—N-(3,5-difluoro-4-((5S,7R)-7-methyl-6-(2,2,2-t...)
Affinity DataIC50: 0.100nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
TBA
Entry Details
US Patent

TargetEstrogen receptor(Human)TBA
LigandPNGBDBM774017((S)-1-(3-fluoropropyl)-N-(4-((5R,7R)-7-methyl-6-(2...)
Affinity DataIC50: 0.140nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
TBA
Entry Details
US Patent

TargetD(3) dopamine receptor(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50007518(3-Chloro-5-ethyl-N-((S)-1-ethyl-pyrrolidin-2-ylmet...)
Affinity DataKi:  0.160nMAssay Description:Compound was measured for its ability to compete with [125I]NCQ298 binding to the human Dopamine receptor D3 transfected in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2012
Entry Details Article
PubMed
TargetDipeptidyl peptidase 4(Human)
East China University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM420962(US10479798, Compound 21)
Affinity DataKd:  0.177nMAssay Description:Binding affinity to DPP4 (unknown origin) expressed in baculovirus expressing systemMore data for this Ligand-Target Pair
Ligand InfoPDBSimilars
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetStimulator of interferon genes protein(Human)
Jacobio Pharmaceuticals Co.

US Patent
LigandPNGBDBM730221(US20250108123, Example II-4)
Affinity DataIC50: 0.180nMAssay Description:Cisbio Bioassays' human STING WT binding assay (#64BDSTGPEG & 64BDSTGPEH, Cisbio) is for quantitative measurement of human STING WT ligand using ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/18/2025
Entry Details
US Patent

TargetStimulator of interferon genes protein(Human)
Jacobio Pharmaceuticals Co.

US Patent
LigandPNGBDBM730235(US20250108123, Example II-20)
Affinity DataIC50: 0.190nMAssay Description:Cisbio Bioassays' human STING WT binding assay (#64BDSTGPEG & 64BDSTGPEH, Cisbio) is for quantitative measurement of human STING WT ligand using ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/18/2025
Entry Details
US Patent

TargetEstrogen receptor(Human)TBA
LigandPNGBDBM774104((5S,7R)-5-(2,6-difluoro-4-(((S)-1-(3-fluoropropyl)...)
Affinity DataIC50: 0.190nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
TBA
Entry Details
US Patent

TargetStimulator of interferon genes protein(Human)
Jacobio Pharmaceuticals Co.

US Patent
LigandPNGBDBM730232(US20250108123, Example II-17)
Affinity DataIC50: 0.190nMAssay Description:Cisbio Bioassays' human STING WT binding assay (#64BDSTGPEG & 64BDSTGPEH, Cisbio) is for quantitative measurement of human STING WT ligand using ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/18/2025
Entry Details
US Patent

TargetDelta-type opioid receptor(Human)
Xiamen University

Curated by ChEMBL
LigandPNGBDBM50001714(2-[3-cyclopropylmethyl-11-hydroxy-15-methoxy-13-ox...)
Affinity DataKi:  0.200nMAssay Description:Binding affinity to delta opioid receptor (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMed
TargetMu-type opioid receptor(Human)
Xiamen University

Curated by ChEMBL
LigandPNGBDBM50001714(2-[3-cyclopropylmethyl-11-hydroxy-15-methoxy-13-ox...)
Affinity DataKi:  0.200nMAssay Description:Binding affinity to mu-opioid receptor (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMed
TargetD(3) dopamine receptor(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM21397(8-[4-(4-fluorophenyl)-4-oxidanylidene-butyl]-1-phe...)
Affinity DataKi:  0.25nMAssay Description:Displacement of [125I]iodosulpiride from human Dopamine receptor D3 expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2012
Entry Details Article
PubMed
TargetEstrogen receptor(Human)TBA
LigandPNGBDBM774098(N—((S-1-(3-fluoropropyl)pyrrolidin-3-yl)-6-((5S,7R...)
Affinity DataIC50: 0.270nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
TBA
Entry Details
US Patent

TargetEstrogen receptor(Human)TBA
LigandPNGBDBM774105(1-(3-Fluoropropyl)-N-(4-((5R,7R)-7-methyl-6-(2,2,2...)
Affinity DataIC50: 0.270nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
TBA
Entry Details
US Patent

TargetKappa-type opioid receptor(Human)
Xiamen University

Curated by ChEMBL
LigandPNGBDBM50621977(CHEMBL5404473)
Affinity DataKi:  0.280nMAssay Description:Binding affinity to kappa opioid receptor (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMed
TargetKappa-type opioid receptor(Human)
Xiamen University

Curated by ChEMBL
LigandPNGBDBM50621978(CHEMBL5428920)
Affinity DataKi:  0.280nMAssay Description:Binding affinity to kappa opioid receptor (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMed
TargetStimulator of interferon genes protein(Human)
Jacobio Pharmaceuticals Co.

US Patent
LigandPNGBDBM665306(US20240116909, Example 10 | 4-(5-(3-((2-(3-carboxy...)
Affinity DataIC50: 0.280nMAssay Description:Cisbio Bioassays' human STING WT binding assay (#64BDSTGPEG & 64BDSTGPEH, Cisbio) is for quantitative measurement of human STING WT ligand using ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2025
Entry Details
US Patent

TargetStimulator of interferon genes protein(Human)
Jacobio Pharmaceuticals Co.

US Patent
LigandPNGBDBM730212(US20250108123, Example I-9)
Affinity DataIC50: 0.320nMAssay Description:Cisbio Bioassays' human STING WT binding assay (#64BDSTGPEG & 64BDSTGPEH, Cisbio) is for quantitative measurement of human STING WT ligand using ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/18/2025
Entry Details
US Patent

TargetStimulator of interferon genes protein(Human)
Jacobio Pharmaceuticals Co.

US Patent
LigandPNGBDBM730222(sodium (S)-4-(5-(3-((2-((S)-3-carboxylatobutanoyl)...)
Affinity DataIC50: 0.320nMAssay Description:Cisbio Bioassays' human STING WT binding assay (#64BDSTGPEG & 64BDSTGPEH, Cisbio) is for quantitative measurement of human STING WT ligand using ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/18/2025
Entry Details
US Patent

TargetEstrogen receptor(Human)TBA
LigandPNGBDBM774100(2,2-Difluoro-3-((5S,7R)-5-(3-fluoro-5-(((S)-1-(3-f...)
Affinity DataIC50: 0.350nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
TBA
Entry Details
US Patent

TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Xiamen University

Curated by ChEMBL
LigandPNGBDBM50621984(CHEMBL5404578)
Affinity DataKi:  0.360nMAssay Description:Binding affinity to nACh alpha6beta2 receptor (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMed
LigandPNGBDBM50632506(CHEMBL5423993)
Affinity DataKi:  0.360nMAssay Description:Inhibition of full length human recombinant HPK1 expressed in baculovirus-infected insect cells using 5-FAM-KRRALSSLRA-COOH peptide as substrate prei...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetStimulator of interferon genes protein(Human)
Jacobio Pharmaceuticals Co.

US Patent
LigandPNGBDBM730223(US20250108123, Example II-7)
Affinity DataIC50: 0.360nMAssay Description:Cisbio Bioassays' human STING WT binding assay (#64BDSTGPEG & 64BDSTGPEH, Cisbio) is for quantitative measurement of human STING WT ligand using ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
8/18/2025
Entry Details
US Patent

TargetEstrogen receptor(Human)TBA
LigandPNGBDBM774096(2,2-Difluoro-3-((5S,7R)-5-(5-(((S)-1-(3-fluoroprop...)
Affinity DataIC50: 0.370nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
TBA
Entry Details
US Patent

TargetMu-type opioid receptor(Mouse)
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50059997(7 beta-Spirobenzocyclohexylnaltrexone | CHEMBL1016...)
Affinity DataKi:  0.380nMAssay Description:Inhibition of [3H]DAMGO binding to Opioid receptor mu 1 from mouse brain membranes.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50632512(CHEMBL5437932)
Affinity DataKi:  0.400nMAssay Description:Inhibition of full length human recombinant HPK1 expressed in baculovirus-infected insect cells using 5-FAM-KRRALSSLRA-COOH peptide as substrate prei...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetKappa-type opioid receptor(Human)
Xiamen University

Curated by ChEMBL
LigandPNGBDBM50621979(CHEMBL5405248)
Affinity DataKi:  0.430nMAssay Description:Binding affinity to kappa opioid receptor (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMed
TargetEstrogen receptor(Human)TBA
LigandPNGBDBM774106(N-(1-(3-fluoropropyl)azetidin-3-yl)-6-((5S,7R)-7-m...)
Affinity DataIC50: 0.430nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
TBA
Entry Details
US Patent

TargetEstrogen receptor(Human)TBA
LigandPNGBDBM774095(2,2-Difluoro-3-((5R,7R)-5-(4-(((S)-1-(3-fluoroprop...)
Affinity DataIC50: 0.440nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
TBA
Entry Details
US Patent

TargetEstrogen receptor(Human)TBA
LigandPNGBDBM774099(5-Fluoro-N—((S)-1-(3-fluoropropyl)pyrrolidin-3-yl)...)
Affinity DataIC50: 0.460nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
TBA
Entry Details
US Patent

TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Xiamen University

Curated by ChEMBL
LigandPNGBDBM50621983(CHEMBL5438932)
Affinity DataKi:  0.5nMAssay Description:Binding affinity to nACh alpha6beta2 receptor (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMed
TargetEstrogen receptor(Human)TBA
LigandPNGBDBM774103(2,2-Difluoro-3-((5S,7R)-5-(5-((1-(3-fluoropropyl)a...)
Affinity DataIC50: 0.5nMMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
TBA
Entry Details
US Patent

TargetIndoleamine 2,3-dioxygenase 1(Human)
Fudan University

Curated by ChEMBL
LigandPNGBDBM50285416(CHEMBL4161733)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of IDO1 (unknown origin) by cell-based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetMatrix metalloproteinase-9(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50185884(4-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-2-(4-p-tol...)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of MMP9More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50632510(CHEMBL5418420)
Affinity DataKi:  0.580nMAssay Description:Inhibition of full length human recombinant HPK1 expressed in baculovirus-infected insect cells using 5-FAM-KRRALSSLRA-COOH peptide as substrate prei...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
LigandPNGBDBM50632507(CHEMBL5439912)
Affinity DataKi:  0.590nMAssay Description:Inhibition of full length human recombinant HPK1 expressed in baculovirus-infected insect cells using 5-FAM-KRRALSSLRA-COOH peptide as substrate prei...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetC-X-C chemokine receptor type 2(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50211457(3-(2-((R)-1-(4-sec-butylfuran-2-yl)propylamino)-3,...)
Affinity DataKi:  0.600nMAssay Description:Displacement of [125I]IL8 from human CXCR2 expressed in CHO cells by SPAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTyrosine-protein kinase BTK(Human)
East China University of Science & Technology

Curated by ChEMBL
LigandPNGBDBM50357312(IBRUTINIB | US9181263, 1 | US9108973, Ref 1 | US92...)
Affinity DataIC50: 0.600nMAssay Description:Inhibition of BTK (unknown origin) by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
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