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TargetHistone deacetylase 6(Human)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50578549(CHEMBL4876454)
Affinity DataIC50: 0.00200nMAssay Description:Inhibition of HDAC6 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetApoptosis regulator Bcl-2(Human)
Hunan Provinc

Curated by ChEMBL
LigandPNGBDBM50162774(ABT-199 | Venetoclax | US11420968, Example ABT-199)
Affinity DataKi: <0.0100nMAssay Description:Inhibition of Bcl-2 (unknown origin) by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/8/2020
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM50591813(CHEMBL5206715)
Affinity DataIC50: 0.100nMAssay Description:Inhibition of EGFR del19/T790M mutant (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
LigandPNGBDBM700589(US20240336629, Compound 90B)
Affinity DataIC50: 0.110nMAssay Description:Inhibition of PARP7 (unknown origin) incubated for 1 hr by chemiluminescence based microplate reader assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
TargetEpidermal growth factor receptor(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM50591813(CHEMBL5206715)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of EGFR L858R/T790M mutant (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM50591813(CHEMBL5206715)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of EGFR del19/T790M/C797S mutant (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetBromodomain-containing protein 2(Human)
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM297163(US10112941, Example 279 | 2-{8-Fluoro-3-[4-(2H3)me...)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of BRD2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetMyc proto-oncogene protein(Human)
Bristol Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM445524(US10683290, Example 16 | 2-{7-[4-(2H3)Methyl-1-met...)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of c-MYC (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2023
Entry Details Article
PubMed
LigandPNGBDBM431795(US10550105, Example 661)
Affinity DataKd:  0.220nMAssay Description:Binding affinity to PARP7 (unknown origin) assessed as dissociation constantMore data for this Ligand-Target Pair
Ligand InfoPDBSimilars
In Depth
Date in BDB:
TBA
Entry Details
TargetEpidermal growth factor receptor(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM50591813(CHEMBL5206715)
Affinity DataIC50: 0.300nMAssay Description:Inhibition of EGFR L858R/T790M/C797S mutant (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetBromodomain-containing protein 4 [75-147](Human)
Jacobio Pharmaceuticals

US Patent
LigandPNGBDBM575844(US11466005, Compound 16 | 6-(1,4-Dimethyl-1H-1,2,3...)
Affinity DataIC50: 0.300nMAssay Description:Briefly, 20 nL of compounds were transferred to the 384-well plate by Echo 550 liquid handler (Labcyte, USA), then 5 μL of BRD4(BD1) (Reaction B...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2022
Entry Details
US Patent

TargetBromodomain-containing protein 4 [75-147](Human)
Jacobio Pharmaceuticals

US Patent
LigandPNGBDBM575868(US11466005, Compound 34 | 4-((6-(1,4-dimethyl-1H-1...)
Affinity DataIC50: 0.340nMAssay Description:Briefly, 20 nL of compounds were transferred to the 384-well plate by Echo 550 liquid handler (Labcyte, USA), then 5 μL of BRD4(BD1) (Reaction B...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2022
Entry Details
US Patent

TargetBromodomain-containing protein 4 [75-147](Human)
Jacobio Pharmaceuticals

US Patent
LigandPNGBDBM575845(US11466005, Compound 2 | (S)-2-(6-(3,5-dimethyliso...)
Affinity DataIC50: 0.350nMAssay Description:Briefly, 20 nL of compounds were transferred to the 384-well plate by Echo 550 liquid handler (Labcyte, USA), then 5 μL of BRD4(BD1) (Reaction B...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2022
Entry Details
US Patent

LigandPNGBDBM700540(US20240336629, Compound 67A)
Affinity DataIC50: 0.400nMAssay Description:Inhibition of PARP7 (unknown origin) incubated for 1 hr by chemiluminescence based microplate reader assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
LigandPNGBDBM50643508(CHEMBL5568973)
Affinity DataIC50: 0.400nMAssay Description:Inhibition of PARP7 (unknown origin) incubated for 1 hr by chemiluminescence based microplate reader assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
TargetBromodomain-containing protein 4 [75-147](Human)
Jacobio Pharmaceuticals

US Patent
LigandPNGBDBM575867(US11466005, Compound 13 | (S)-2-(6-(1,4-Dimethyl-1...)
Affinity DataIC50: 0.400nMAssay Description:Briefly, 20 nL of compounds were transferred to the 384-well plate by Echo 550 liquid handler (Labcyte, USA), then 5 μL of BRD4(BD1) (Reaction B...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2022
Entry Details
US Patent

TargetBromodomain-containing protein 4(Human)
Bristol Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM445527(US10683290, Example 19 | 2-[7-(Dimethyl-1H-1,2,3-t...)
Affinity DataIC50: 0.400nMAssay Description:Inhibition of BRD4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2023
Entry Details Article
PubMed
TargetHistone deacetylase 3(Human)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50578549(CHEMBL4876454)
Affinity DataIC50: 0.420nMAssay Description:Inhibition of HDAC3 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetBromodomain-containing protein 4 [75-147](Human)
Jacobio Pharmaceuticals

US Patent
LigandPNGBDBM575781(US11466005, Compound 1 | (S)-2-(6-(3,5-dimethyliso...)
Affinity DataIC50: 0.480nMAssay Description:Briefly, 20 nL of compounds were transferred to the 384-well plate by Echo 550 liquid handler (Labcyte, USA), then 5 μL of BRD4(BD1) (Reaction B...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2022
Entry Details
US Patent

TargetBromodomain-containing protein 4 [75-147](Human)
Jacobio Pharmaceuticals

US Patent
LigandPNGBDBM575853(US11466005, Compound 6 | (S)-2-(6-(1,4-dimethyl-1H...)
Affinity DataIC50: 0.490nMAssay Description:Briefly, 20 nL of compounds were transferred to the 384-well plate by Echo 550 liquid handler (Labcyte, USA), then 5 μL of BRD4(BD1) (Reaction B...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2022
Entry Details
US Patent

TargetNeuronal acetylcholine receptor subunit alpha-7(Rat)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50232594(CHEMBL4102566)
Affinity DataEC50:  0.490nMAssay Description:Agonist activity at rat alpha7 nAChR expressed in HEK293 cells co-expressing human RIC3 assessed as area under current curve at holding potential of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/1/2019
Entry Details Article
PubMed
TargetBromodomain-containing protein 4(Human)
Bristol Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50579853(CHEMBL5075294)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of BRD4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2023
Entry Details Article
PubMed
TargetHistone deacetylase 6(Human)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50504583(CHEMBL4444554)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of human HDAC6 using Arg-His-Lys-Lys (Ac) as substrate incubated for 2 hrs by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetBromodomain-containing protein 4 [75-147](Human)
Jacobio Pharmaceuticals

US Patent
LigandPNGBDBM575852(US11466005, Compound 23 | 2-(4-((3-Fluoropyridin-2...)
Affinity DataIC50: 0.540nMAssay Description:Briefly, 20 nL of compounds were transferred to the 384-well plate by Echo 550 liquid handler (Labcyte, USA), then 5 μL of BRD4(BD1) (Reaction B...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2022
Entry Details
US Patent

TargetBromodomain-containing protein 4 [75-147](Human)
Jacobio Pharmaceuticals

US Patent
LigandPNGBDBM575846(US11466005, Compound 17 | 6-(1,4-dimethyl-1H-1,2,3...)
Affinity DataIC50: 0.550nMAssay Description:Briefly, 20 nL of compounds were transferred to the 384-well plate by Echo 550 liquid handler (Labcyte, USA), then 5 μL of BRD4(BD1) (Reaction B...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2022
Entry Details
US Patent

LigandPNGBDBM700586(US20240336629, Compound 89A)
Affinity DataIC50: 0.560nMAssay Description:Inhibition of PARP7 (unknown origin) using histone as substrate incubated for 1 hr by chemiluminescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
TargetBromodomain-containing protein 4 [75-147](Human)
Jacobio Pharmaceuticals

US Patent
LigandPNGBDBM575849(US11466005, Compound 4 | 2-(6-(1,4-Dimethyl-1H-1,2...)
Affinity DataIC50: 0.570nMAssay Description:Briefly, 20 nL of compounds were transferred to the 384-well plate by Echo 550 liquid handler (Labcyte, USA), then 5 μL of BRD4(BD1) (Reaction B...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2022
Entry Details
US Patent

TargetBromodomain-containing protein 4 [75-147](Human)
Jacobio Pharmaceuticals

US Patent
LigandPNGBDBM575851(US11466005, Compound 5 | 2-(6-(1,4-Dimethyl-1H-1,2...)
Affinity DataIC50: 0.590nMAssay Description:Briefly, 20 nL of compounds were transferred to the 384-well plate by Echo 550 liquid handler (Labcyte, USA), then 5 μL of BRD4(BD1) (Reaction B...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2022
Entry Details
US Patent

TargetBromodomain-containing protein 4(Human)
Bristol Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50566615(CHEMBL4846895)
Affinity DataIC50: 0.600nMAssay Description:Inhibition of BRD4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetBromodomain-containing protein 4(Human)
Bristol Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM445524(US10683290, Example 16 | 2-{7-[4-(2H3)Methyl-1-met...)
Affinity DataIC50: 0.600nMAssay Description:Inhibition of BRD4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2023
Entry Details Article
PubMed
TargetBromodomain-containing protein 4(Human)
Bristol Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50579851(CHEMBL5084198)
Affinity DataIC50: 0.600nMAssay Description:Inhibition of BRD4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2023
Entry Details Article
PubMed
TargetBromodomain-containing protein 4(Human)
Bristol Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50579852(CHEMBL5090513)
Affinity DataIC50: 0.600nMAssay Description:Inhibition of BRD4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2023
Entry Details Article
PubMed
TargetMyc proto-oncogene protein(Human)
Bristol Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM445528(US10683290, Example 20 | 2-[7-(Dimethyl-1H-1,2,3-t...)
Affinity DataIC50: 0.600nMAssay Description:Inhibition of c-MYC (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2023
Entry Details Article
PubMed
TargetBromodomain-containing protein 4 [75-147](Human)
Jacobio Pharmaceuticals

US Patent
LigandPNGBDBM575869(US11466005, Compound 15 | 6-(1,4-Dimethyl-1H-1,2,3...)
Affinity DataIC50: 0.610nMAssay Description:Briefly, 20 nL of compounds were transferred to the 384-well plate by Echo 550 liquid handler (Labcyte, USA), then 5 μL of BRD4(BD1) (Reaction B...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2022
Entry Details
US Patent

TargetBromodomain-containing protein 4 [75-147](Human)
Jacobio Pharmaceuticals

US Patent
LigandPNGBDBM575847(US11466005, Compound 3 | 2-(6-(1,4-Dimethyl-1H-1,2...)
Affinity DataIC50: 0.660nMAssay Description:Briefly, 20 nL of compounds were transferred to the 384-well plate by Echo 550 liquid handler (Labcyte, USA), then 5 μL of BRD4(BD1) (Reaction B...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2022
Entry Details
US Patent

LigandPNGBDBM50652258(CHEMBL5647433)
Affinity DataIC50: 0.660nMAssay Description:Inhibition of PARP7 (unknown origin) using histone as substrate incubated for 1 hr by chemiluminescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
TargetBromodomain-containing protein 4 [75-147](Human)
Jacobio Pharmaceuticals

US Patent
LigandPNGBDBM575856(US11466005, Compound 26 | 2-(6-(1,4-Dimethyl-1H-1,...)
Affinity DataIC50: 0.680nMAssay Description:Briefly, 20 nL of compounds were transferred to the 384-well plate by Echo 550 liquid handler (Labcyte, USA), then 5 μL of BRD4(BD1) (Reaction B...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2022
Entry Details
US Patent

TargetEpidermal growth factor receptor(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM50185140(AP-26113 | Brigatinib | US11248003, Example Brigat...)
Affinity DataIC50: 0.700nMAssay Description:Inhibition of EGFR del19/T790M mutant (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetMyc proto-oncogene protein(Human)
Bristol Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50579853(CHEMBL5075294)
Affinity DataIC50: 0.700nMAssay Description:Inhibition of c-MYC (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2023
Entry Details Article
PubMed
TargetBromodomain-containing protein 4(Human)
Bristol Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM445515(US10683290, Example 11 | 2-[7-(Dimethyl-1H-1,2,3-t...)
Affinity DataIC50: 0.700nMAssay Description:Inhibition of BRD4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2023
Entry Details Article
PubMed
TargetMyc proto-oncogene protein(Human)
Bristol Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM296947(US10112941, Example 54 | 2-[3-(Dimethyl-1H-1,2,3-t...)
Affinity DataIC50: 0.700nMAssay Description:Inhibition of c-MYC (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2023
Entry Details Article
PubMed
LigandPNGBDBM50652255(CHEMBL5646537)
Affinity DataIC50: 0.710nMAssay Description:Inhibition of PARP7 (unknown origin) using histone as substrate incubated for 1 hr by chemiluminescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
TargetBromodomain-containing protein 4 [75-147](Human)
Jacobio Pharmaceuticals

US Patent
LigandPNGBDBM575850(US11466005, Compound 19 | 3-(6-(1,4-Dimethyl-1H-1,...)
Affinity DataIC50: 0.790nMAssay Description:Briefly, 20 nL of compounds were transferred to the 384-well plate by Echo 550 liquid handler (Labcyte, USA), then 5 μL of BRD4(BD1) (Reaction B...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2022
Entry Details
US Patent

TargetBromodomain-containing protein 4(Human)
Bristol Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM296947(US10112941, Example 54 | 2-[3-(Dimethyl-1H-1,2,3-t...)
Affinity DataIC50: 0.800nMAssay Description:Inhibition of BRD4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2023
Entry Details Article
PubMed
TargetBromodomain-containing protein 4(Human)
Bristol Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM297236(US10112941, Example 354 | 2-[3-(Dimethyl-1H-1,2,3-...)
Affinity DataIC50: 0.800nMAssay Description:Inhibition of N-terminal His6-tagged recombinant human BRD4 (44 to 168 residues) expressed in Escherichia coli BL21 (DE3) incubated for 60 mins by TR...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetMyc proto-oncogene protein(Human)
Bristol Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM445527(US10683290, Example 19 | 2-[7-(Dimethyl-1H-1,2,3-t...)
Affinity DataIC50: 0.800nMAssay Description:Inhibition of c-MYC (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2023
Entry Details Article
PubMed
TargetBromodomain-containing protein 4 [75-147](Human)
Jacobio Pharmaceuticals

US Patent
LigandPNGBDBM575854(US11466005, Compound 24 | 2-(6-(1,4-Dimethyl-1H-1,...)
Affinity DataIC50: 0.880nMAssay Description:Briefly, 20 nL of compounds were transferred to the 384-well plate by Echo 550 liquid handler (Labcyte, USA), then 5 μL of BRD4(BD1) (Reaction B...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2022
Entry Details
US Patent

TargetEpidermal growth factor receptor(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM50591813(CHEMBL5206715)
Affinity DataIC50: 0.900nMAssay Description:Inhibition of EGFR del19 mutant (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetBromodomain-containing protein 4(Human)
Bristol Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50566614(CHEMBL4848871)
Affinity DataIC50: 0.900nMAssay Description:Inhibition of BRD4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2022
Entry Details Article
PubMed
TargetBromodomain-containing protein 4(Human)
Bristol Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM297163(US10112941, Example 279 | 2-{8-Fluoro-3-[4-(2H3)me...)
Affinity DataIC50: 0.900nMAssay Description:Inhibition of N-terminal His6-tagged recombinant human BRD4 (44 to 168 residues) expressed in Escherichia coli BL21 (DE3) incubated for 60 mins by TR...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
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