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TargetB2 bradykinin receptor(Human)
Roche Bioscience

Curated by ChEMBL
LigandPNGBDBM50093761(1-[(R)-5-Amino-1-(4-aminomethyl-benzylcarbamoyl)-p...)
Affinity DataKd:  2.80E+4nMAssay Description:Compound was assayed for binding against the human Bradykinin receptor B2 expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetB2 bradykinin receptor(Human)
Roche Bioscience

Curated by ChEMBL
LigandPNGBDBM50093760(4-Aminomethyl-N-(3-amino-propyl)-N-(2,2-dibutyl-be...)
Affinity DataKd:  1.40E+4nMAssay Description:Compound was assayed for binding against the human Bradykinin receptor B2 expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetB2 bradykinin receptor(Human)
Roche Bioscience

Curated by ChEMBL
LigandPNGBDBM50093759((R)-3-Amino-N-(4-aminomethyl-benzyl)-2-{2-[(2-cycl...)
Affinity DataKd:  1.70E+4nMAssay Description:Compound was assayed for binding against the human Bradykinin receptor B2 expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetB2 bradykinin receptor(Human)
Roche Bioscience

Curated by ChEMBL
LigandPNGBDBM50093762(3-Aminomethyl-1-(3-amino-propyl)-7-dibenzylamino-5...)
Affinity DataKd:  4.30E+3nMAssay Description:Compound was assayed for binding against the human Bradykinin receptor B2 expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetB2 bradykinin receptor(Human)
Roche Bioscience

Curated by ChEMBL
LigandPNGBDBM50093763(N-{3-[7-Dibenzylamino-3-(2-guanidino-ethyl)-2-oxo-...)
Affinity DataKd:  4.50E+3nMAssay Description:Compound was assayed for binding against the human Bradykinin receptor B2 expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetB2 bradykinin receptor(Human)
Roche Bioscience

Curated by ChEMBL
LigandPNGBDBM50093764(cyclic nonapeptide analogue | CHEMBL2369879)
Affinity DataKd:  200nMAssay Description:Compound was assayed for binding against the human Bradykinin receptor B2 expressed in CHO cells; 0.2-16More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetB2 bradykinin receptor(Human)
Roche Bioscience

Curated by ChEMBL
LigandPNGBDBM50093765((R)-3-Amino-N-(4-aminomethyl-benzyl)-2-{2-[(2-cycl...)
Affinity DataKd:  1.01E+5nMAssay Description:Compound was assayed for binding against the human Bradykinin receptor B2 expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetB2 bradykinin receptor(Human)
Roche Bioscience

Curated by ChEMBL
LigandPNGBDBM50093767(1-(3-Aminomethyl-benzyl)-6,6-dibenzyl-1,4,5,6-tetr...)
Affinity DataKd:  7.60E+3nMAssay Description:Compound was assayed for binding against the human Bradykinin receptor B2 expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetB2 bradykinin receptor(Human)
Roche Bioscience

Curated by ChEMBL
LigandPNGBDBM50093766(((2R,4R)-2-Aminomethyl-4-benzyloxy-pyrrolidin-1-yl...)
Affinity DataKd:  6.60E+4nMAssay Description:Compound was assayed for binding against the human Bradykinin receptor B2 expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetB2 bradykinin receptor(Human)
Roche Bioscience

Curated by ChEMBL
LigandPNGBDBM50093768(5-Dibutylamino-pentanoic acid [(S)-1-(4-butyl-pyri...)
Affinity DataKd:  2.30E+4nMAssay Description:Compound was assayed for binding against the human Bradykinin receptor B2 expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetB2 bradykinin receptor(Human)
Roche Bioscience

Curated by ChEMBL
LigandPNGBDBM50218386(CHEMBL3142416)
Affinity DataKd:  200nMAssay Description:Compound was assayed for binding against the human Bradykinin receptor B2 expressed in CHO cells; 0.2-16More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetB2 bradykinin receptor(Human)
Roche Bioscience

Curated by ChEMBL
LigandPNGBDBM50093770(4-Aminomethyl-N-[(S)-1-(4-butyl-pyridin-2-yl)-2-cy...)
Affinity DataKd:  7.40E+3nMAssay Description:Compound was assayed for binding against the human Bradykinin receptor B2 expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetB2 bradykinin receptor(Human)
Roche Bioscience

Curated by ChEMBL
LigandPNGBDBM50093771(N-[(S)-1-(4-Butyl-pyridin-2-yl)-2-cyclohexyl-ethyl...)
Affinity DataKd:  5.00E+3nMAssay Description:Compound was assayed for binding against the human Bradykinin receptor B2 expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetB2 bradykinin receptor(Human)
Roche Bioscience

Curated by ChEMBL
LigandPNGBDBM50093772(N-[3-(7-Dibenzylamino-3-guanidinomethyl-2-oxo-5-ph...)
Affinity DataKd:  1.20E+4nMAssay Description:Compound was assayed for binding against the human Bradykinin receptor B2 expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetB2 bradykinin receptor(Human)
Roche Bioscience

Curated by ChEMBL
LigandPNGBDBM50093773(3-(2-Amino-ethyl)-1-(3-amino-propyl)-7-dibenzylami...)
Affinity DataKd:  1.50E+4nMAssay Description:Compound was assayed for binding against the human Bradykinin receptor B2 expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetB2 bradykinin receptor(Human)
Roche Bioscience

Curated by ChEMBL
LigandPNGBDBM50093774(N-[(2R,4R)-4-Benzyloxy-1-(naphthalene-2-carbonyl)-...)
Affinity DataKd:  1.50E+4nMAssay Description:Compound was assayed for binding against the human Bradykinin receptor B2 expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetB2 bradykinin receptor(Human)
Roche Bioscience

Curated by ChEMBL
LigandPNGBDBM50093775(5-Amino-pentanoic acid [(S)-1-(4-butyl-pyridin-2-y...)
Affinity DataKd:  6.20E+4nMAssay Description:Compound was assayed for binding against the human Bradykinin receptor B2 expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetB2 bradykinin receptor(Human)
Roche Bioscience

Curated by ChEMBL
LigandPNGBDBM50093776(4-Aminomethyl-N-(2,2-dibutyl-benzo[1,3]dioxol-4-yl...)
Affinity DataKd:  1.30E+4nMAssay Description:Compound was assayed for binding against the human Bradykinin receptor B2 expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSubstance-P receptor(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50289763(1N-{4-[1-cyclohexylamino(cyclohexylimino)methylami...)
Affinity DataKd:  1.50E+3nMAssay Description:Binding affinity towards Tachykinin receptor 1, activity expressed as KdMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2010
Entry Details Article

TargetSubstance-P receptor(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50289768(Tributyl-{4-[(S)-2-(N',N''-dicyclohexyl-guanidino)...)
Affinity DataKd:  540nMAssay Description:Binding affinity towards Tachykinin receptor 1, activity expressed as KdMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2010
Entry Details Article

TargetSubstance-P receptor(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50289765(Tributyl-{4-[(R)-2-(N',N''-dicyclohexyl-guanidino)...)
Affinity DataKd:  290nMAssay Description:Binding affinity towards Tachykinin receptor 1, activity expressed as KdMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2010
Entry Details Article

TargetSubstance-P receptor(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50289770((S)-N-(4-Aminomethyl-phenyl)-2-(N',N''-dicyclohexy...)
Affinity DataKd:  1.30E+3nMAssay Description:Binding affinity towards Tachykinin receptor 1, activity expressed as KdMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2010
Entry Details Article

TargetSubstance-P receptor(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50289772(5-Aminomethyl-2-[(S)-2-(N',N''-dicyclohexyl-guanid...)
Affinity DataKd:  3.80E+3nMAssay Description:Binding affinity towards Tachykinin receptor 1, activity expressed as KdMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2010
Entry Details Article

TargetSubstance-P receptor(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50289766(Tributyl-{4-[(S)-2-(3-cyclohexyl-ureido)-3-naphtha...)
Affinity DataKd:  1.30E+3nMAssay Description:Binding affinity towards Tachykinin receptor 1, activity expressed as KdMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2010
Entry Details Article

TargetSubstance-P receptor(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50289775((R)-2-(N',N''-Dicyclohexyl-guanidino)-N-(4-guanidi...)
Affinity DataKd:  860nMAssay Description:Binding affinity towards Tachykinin receptor 1, activity expressed as KdMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2010
Entry Details Article

TargetSubstance-P receptor(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50289776(Tributyl-{4-[(S)-2-(N',N''-dicyclohexyl-guanidino)...)
Affinity DataKd:  670nMAssay Description:Binding affinity towards Tachykinin receptor 1, activity expressed as KdMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2010
Entry Details Article

TargetSubstance-P receptor(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50289778((S)-2-(N',N''-Dicyclohexyl-guanidino)-N-(4-guanidi...)
Affinity DataKd:  1.10E+3nMAssay Description:Binding affinity towards Tachykinin receptor 1, activity expressed as KdMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2010
Entry Details Article

TargetSubstance-P receptor(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50289769(Tributyl-{4-[(R)-2-(N',N''-dicyclohexyl-guanidino)...)
Affinity DataKd:  370nMAssay Description:Binding affinity towards Tachykinin receptor 1, activity expressed as KdMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2010
Entry Details Article

TargetSubstance-P receptor(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50289777((S)-2-(N',N''-Dicyclohexyl-guanidino)-N-[4-(N',N''...)
Affinity DataKd:  1.80E+3nMAssay Description:Binding affinity towards Tachykinin receptor 1, activity expressed as KdMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2010
Entry Details Article

TargetEpidermal growth factor receptor(Human)
University of Ferrara

Curated by ChEMBL
LigandPNGBDBM5446(Erlotinib | OSI-774 | N-(3-ethynylphenyl)-6,7-bis(...)
Affinity DataIC50: 1.5nMAssay Description:Inhibition of wild type EGFR (unknown origin) by bioluminescent ADP-glo kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
Target1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial(Human)
Cardiff University

Curated by ChEMBL
LigandPNGBDBM50176808(6-((3-chlorophenyl)(1H-imidazol-1-yl)methyl)-1H-be...)
Affinity DataIC50: 2.30nMAssay Description:Inhibition of human MBP-tagged CYP24A1 expressed in Escherichia coli using 1,25(OH)2D3 substrate in presence of bovine adrenodoxin, adrenodoxin reduc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2016
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
University of Ferrara

Curated by ChEMBL
LigandPNGBDBM50517548(CHEMBL4460381)
Affinity DataIC50: 2.5nMAssay Description:Inhibition of wild type EGFR (unknown origin) by bioluminescent ADP-glo kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
University of Ferrara

Curated by ChEMBL
LigandPNGBDBM50137185((1H-Indol-5-yl)-(6-phenyl-thieno[3,2-d]pyrimidin-4...)
Affinity DataIC50: 3nMAssay Description:Inhibition of EGFR (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
Target1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial(Human)
Cardiff University

Curated by ChEMBL
LigandPNGBDBM50370925(CHEMBL1627233)
Affinity DataIC50: 6.5nMAssay Description:Inhibition of human MBP-tagged CYP24A1 expressed in Escherichia coli using 1,25(OH)2D3 substrate in presence of bovine adrenodoxin, adrenodoxin reduc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2016
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
University of Ferrara

Curated by ChEMBL
LigandPNGBDBM50517546(CHEMBL4473768)
Affinity DataIC50: 10nMAssay Description:Inhibition of wild type EGFR (unknown origin) by bioluminescent ADP-glo kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
Target1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial(Human)
Cardiff University

Curated by ChEMBL
LigandPNGBDBM50322358(4'-Chloro-biphenyl-4-carboxylic acid((R)-2-imidazo...)
Affinity DataIC50: 15nMAssay Description:Inhibition of human MBP-tagged CYP24A1 expressed in Escherichia coli using 1,25(OH)2D3 substrate in presence of bovine adrenodoxin, adrenodoxin reduc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2016
Entry Details Article
PubMed
TargetN6-adenosine-methyltransferase catalytic subunit(Human)
Swansea University

Curated by ChEMBL
LigandPNGBDBM50611061(CHEMBL5291234)
Affinity DataIC50: 17nMAssay Description:Inhibition of full length His-tagged METTL3 in baculovirus expression system (unknown origin) measured by mass spectrometric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
University of Ferrara

Curated by ChEMBL
LigandPNGBDBM50517547(CHEMBL4541014)
Affinity DataIC50: 23nMAssay Description:Inhibition of wild type EGFR (unknown origin) by bioluminescent ADP-glo kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
Target1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial(Human)
Cardiff University

Curated by ChEMBL
LigandPNGBDBM50023361(Cta018 | Lunacalcipol)
Affinity DataIC50: 27nMAssay Description:Inhibition of human MBP-tagged CYP24A1 expressed in Escherichia coli using 1,25(OH)2D3 substrate in presence of bovine adrenodoxin, adrenodoxin reduc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2016
Entry Details Article
PubMed
LigandPNGBDBM50171117({4-[[3-Bromo-4-(difluoro-phosphono-methyl)-benzyl]...)
Affinity DataIC50: 28nMAssay Description:Inhibitory activity against protein tyrosine phosphatase 1B using O-methyl fluorescein monophosphateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
University of Ferrara

Curated by ChEMBL
LigandPNGBDBM50517542(CHEMBL4569885)
Affinity DataIC50: 30nMAssay Description:Inhibition of wild type EGFR (unknown origin) by bioluminescent ADP-glo kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
LigandPNGBDBM50171106((4-{[(Benzyl-methyl-carbamoyl)-methyl]-[3-bromo-4-...)
Affinity DataIC50: 31nMAssay Description:Inhibitory activity against protein tyrosine phosphatase 1B using O-methyl fluorescein monophosphateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50171096({4-[[3-Bromo-4-(difluoro-phosphono-methyl)-benzyl]...)
Affinity DataIC50: 35nMAssay Description:Inhibitory activity against protein tyrosine phosphatase 1B using O-methyl fluorescein monophosphateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAndrogen receptor(Rat)
Cardiff University

Curated by ChEMBL
LigandPNGBDBM50516763(CHEMBL3185021)
Affinity DataIC50: 36nMAssay Description:Antagonist activity at GAL4-DBD fused rat androgen receptor expressed in UAS-bla 293 cells assessed as reduction in R1881-induced activation incubate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetAndrogen receptor(Rat)
Cardiff University

Curated by ChEMBL
LigandPNGBDBM50529668(Enobosarm | Gtx-024 | MK-2866 | Ostarine | US10806...)
Affinity DataIC50: 36nMAssay Description:Antagonist activity at rat androgen receptor fused with DNA-binding domain of GAL4 expressed in AR-UAS-bla GripTite 293 cells assessed as inhibition ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
Target25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial(Mouse)
Cardiff University

Curated by ChEMBL
LigandPNGBDBM50023359(CHEMBL3329778)
Affinity DataIC50: 36nMAssay Description:Inhibition of mouse CYP27B1 using 1,25(OH)2D3 substrate in presence of bovine adrenodoxin, adrenodoxin reductase and NADPH incubated at 37 degC for 2...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2016
Entry Details Article
PubMed
TargetAndrogen receptor(Rat)
Cardiff University

Curated by ChEMBL
LigandPNGBDBM50535824(CHEMBL4575144)
Affinity DataIC50: 49nMAssay Description:Antagonist activity at rat androgen receptor fused with DNA-binding domain of GAL4 expressed in AR-UAS-bla GripTite 293 cells assessed as inhibition ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
University of Ferrara

Curated by ChEMBL
LigandPNGBDBM50517545(CHEMBL4546122)
Affinity DataIC50: 52nMAssay Description:Inhibition of wild type EGFR (unknown origin) by bioluminescent ADP-glo kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetAndrogen receptor(Rat)
Cardiff University

Curated by ChEMBL
LigandPNGBDBM50535836(CHEMBL4558169)
Affinity DataIC50: 59nMAssay Description:Antagonist activity at rat androgen receptor fused with DNA-binding domain of GAL4 expressed in AR-UAS-bla GripTite 293 cells assessed as inhibition ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
LigandPNGBDBM50171091({4-[[4-(Difluoro-phosphono-methyl)-3-methoxy-benzy...)
Affinity DataIC50: 60nMAssay Description:Inhibitory activity against protein tyrosine phosphatase 1B using O-methyl fluorescein monophosphateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
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