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TargetPotassium voltage-gated channel subfamily H member 2(Human)
University of Washington

Curated by ChEMBL
LigandPNGBDBM50365230(CHEMBL1956285 | US9238653, Table 5, Compound 10 | ...)
Affinity DataEC50:  1.60E+3nMAssay Description:Inhibition of human ERG by patch clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2021
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
University of Washington

Curated by ChEMBL
LigandPNGBDBM50365230(CHEMBL1956285 | US9238653, Table 5, Compound 10 | ...)
Affinity DataEC50:  7.00E+3nMAssay Description:Inhibition of human ERG by IonWorks patch clamp electrophysiology assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2021
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
University of Washington

Curated by ChEMBL
LigandPNGBDBM50538344(CHEMBL4633246)
Affinity DataEC50: >3.30E+4nMAssay Description:Inhibition of human ERG by IonWorks patch clamp electrophysiology assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2021
Entry Details Article
PubMed
TargetSodium channel protein type 5 subunit alpha(Human)
University of Washington

Curated by ChEMBL
LigandPNGBDBM50538344(CHEMBL4633246)
Affinity DataEC50: >3.30E+4nMAssay Description:Inhibition of human Nav1.5 expressed in HEK293 cells by IonWorks patch clamp electrophysiology assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2021
Entry Details Article
PubMed
TargetVoltage-dependent L-type calcium channel subunit alpha-1C(Human)
University of Washington

Curated by ChEMBL
LigandPNGBDBM50538344(CHEMBL4633246)
Affinity DataEC50: >3.30E+4nMAssay Description:Inhibition of human Cav1.2 by fluorescence based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2021
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily A member 5(Human)
University of Washington

Curated by ChEMBL
LigandPNGBDBM50538344(CHEMBL4633246)
Affinity DataEC50: >1.10E+4nMAssay Description:Inhibition of human Kv1.5 by IonWorks patch clamp electrophysiology assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2021
Entry Details Article
PubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Rat)
University of Washington

Curated by ChEMBL
LigandPNGBDBM50018011(CHEBI:68540 | HMR-1726 | Aubagio | TERIFLUNOMIDE)
Affinity DataIC50: 17nMAssay Description:Inhibition of C-terminal His6-tagged rat DHODH expressed in Escherichia coli BL21(DE3) cells using L-DHO as substrate by DCIP dye based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCytochrome P450 3A4(Human)
University of Dundee

Curated by ChEMBL
LigandPNGBDBM50536191(CHEMBL4584780)
Affinity DataIC50: 100nMAssay Description:Inhibition of human CYP3A4 expressed in Escherichia coli pre-incubated for 5 mins before regenerating cofactor solution addition using Diethoxyfluore...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
University of Dundee

Curated by ChEMBL
LigandPNGBDBM50536193(CHEMBL548646 | GNF-Pf-1447 | TCMDC-125419)
Affinity DataIC50: 100nMAssay Description:Inhibition of human CYP3A4 expressed in Escherichia coli pre-incubated for 5 mins before regenerating cofactor solution addition using Diethoxyfluore...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
University of Dundee

Curated by ChEMBL
LigandPNGBDBM50536194(CHEMBL4569641)
Affinity DataIC50: 100nMAssay Description:Inhibition of human CYP3A4 expressed in Escherichia coli pre-incubated for 5 mins before regenerating cofactor solution addition using Diethoxyfluore...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Mouse)
University of Washington

Curated by ChEMBL
LigandPNGBDBM50018011(CHEBI:68540 | HMR-1726 | Aubagio | TERIFLUNOMIDE)
Affinity DataIC50: 110nMAssay Description:Inhibition of C-terminal His6-tagged mouse DHODH expressed in Escherichia coli BL21(DE3) cells using L-DHO as substrate by DCIP dye based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCyclin-dependent kinase 2(Human)
University of Dundee

Curated by ChEMBL
LigandPNGBDBM50384600(CHEMBL2036792 | US9744172, Compound UNC00000563A)
Affinity DataIC50: 114nMAssay Description:Inhibition of CDK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetCyclin-dependent kinase 4(Human)
University of Dundee

Curated by ChEMBL
LigandPNGBDBM50384600(CHEMBL2036792 | US9744172, Compound UNC00000563A)
Affinity DataIC50: 199nMAssay Description:Inhibition of CDK4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
University of Washington

Curated by ChEMBL
LigandPNGBDBM50018011(CHEBI:68540 | HMR-1726 | Aubagio | TERIFLUNOMIDE)
Affinity DataIC50: 300nMAssay Description:Inhibition of C-terminal His6-tagged human DHODH expressed in Escherichia coli BL21(DE3) cells using L-DHO as substrate by DCIP dye based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetPotassium voltage-gated channel subfamily H member 2(Human)
University of Washington

Curated by ChEMBL
LigandPNGBDBM50030836(CHEMBL3355639)
Affinity DataIC50: 400nMAssay Description:Inhibition of human ERG potassium channel by ionworks patch-clamp electrophysiology assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2016
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
University of Washington

Curated by ChEMBL
LigandPNGBDBM50129589(CHEMBL3628223)
Affinity DataIC50: 500nMAssay Description:Inhibition of human ERG potassium channel by ionworks patch-clamp electrophysiology assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2016
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
University of Dundee

Curated by ChEMBL
LigandPNGBDBM50536191(CHEMBL4584780)
Affinity DataIC50: 700nMAssay Description:Inhibition of human CYP2D6 expressed in Escherichia coli pre-incubated for 5 mins before regenerating cofactor solution addition using 7-methoxy-4-(a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
University of Dundee

Curated by ChEMBL
LigandPNGBDBM50536194(CHEMBL4569641)
Affinity DataIC50: 700nMAssay Description:Inhibition of human CYP2D6 expressed in Escherichia coli pre-incubated for 5 mins before regenerating cofactor solution addition using 7-methoxy-4-(a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50020412(CHEMBL3289811)
Affinity DataIC50: 780nMAssay Description:Inhibition of CYP2C19 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/11/2015
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
University of Washington

Curated by ChEMBL
LigandPNGBDBM50129559(CHEMBL3234071)
Affinity DataIC50: 900nMAssay Description:Inhibition of human ERG potassium channel by ionworks patch-clamp electrophysiology assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2016
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
University of Washington

Curated by ChEMBL
LigandPNGBDBM50129562(CHEMBL3628220)
Affinity DataIC50: 1.40E+3nMAssay Description:Inhibition of human ERG potassium channel by ionworks patch-clamp electrophysiology assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2016
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
University of Dundee

Curated by ChEMBL
LigandPNGBDBM50536191(CHEMBL4584780)
Affinity DataIC50: 1.90E+3nMAssay Description:Inhibition of human CYP2C9 expressed in Escherichia coli pre-incubated for 5 mins before regenerating cofactor solution addition using 7-methoxy-4-(t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
University of Washington

Curated by ChEMBL
LigandPNGBDBM50558661(CHEMBL4763231)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of human ERG by IonWorks patch clamp electrophysiology methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Mouse)
University of Washington

Curated by ChEMBL
LigandPNGBDBM50365230(CHEMBL1956285 | US9238653, Table 5, Compound 10 | ...)
Affinity DataIC50: 2.10E+3nMAssay Description:Inhibition of C-terminal His6-tagged mouse DHODH expressed in Escherichia coli BL21(DE3) cells using L-DHO as substrate by DCIP dye based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2021
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
University of Dundee

Curated by ChEMBL
LigandPNGBDBM50020412(CHEMBL3289811)
Affinity DataIC50: 2.40E+3nMAssay Description:Inhibition of CYP3A4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/11/2015
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50020404(CHEMBL3289803)
Affinity DataIC50: 2.70E+3nMAssay Description:Inhibition of CYP2C19 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/11/2015
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
University of Dundee

Curated by ChEMBL
LigandPNGBDBM50536194(CHEMBL4569641)
Affinity DataIC50: 3.50E+3nMAssay Description:Inhibition of human CYP2C9 expressed in Escherichia coli pre-incubated for 5 mins before regenerating cofactor solution addition using 7-methoxy-4-(t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
University of Washington

Curated by ChEMBL
LigandPNGBDBM50020413(CHEMBL3289807)
Affinity DataIC50: 3.50E+3nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/11/2015
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
University of Washington

Curated by ChEMBL
LigandPNGBDBM50099957(CHEMBL3321871)
Affinity DataIC50: 3.50E+3nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/28/2016
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
University of Washington

Curated by ChEMBL
LigandPNGBDBM50100083(CHEMBL3321972)
Affinity DataIC50: 4.30E+3nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/28/2016
Entry Details Article
PubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Rat)
University of Washington

Curated by ChEMBL
LigandPNGBDBM50365230(CHEMBL1956285 | US9238653, Table 5, Compound 10 | ...)
Affinity DataIC50: 4.40E+3nMAssay Description:Inhibition of C-terminal His6-tagged rat DHODH expressed in Escherichia coli BL21(DE3) cells using L-DHO as substrate by DCIP dye based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2021
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
University of Washington

Curated by ChEMBL
LigandPNGBDBM50020414(CHEMBL3289797)
Affinity DataIC50: 4.50E+3nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/11/2015
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50020411(CHEMBL3289813)
Affinity DataIC50: 4.70E+3nMAssay Description:Inhibition of CYP2C19 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/11/2015
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
University of Washington

Curated by ChEMBL
LigandPNGBDBM50129560(CHEMBL3628216)
Affinity DataIC50: 4.80E+3nMAssay Description:Inhibition of human ERG potassium channel by ionworks patch-clamp electrophysiology assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2016
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
University of Washington

Curated by ChEMBL
LigandPNGBDBM50558662(CHEMBL4763365)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of human ERG by IonWorks patch clamp electrophysiology methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50020415(CHEMBL3289806)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of CYP2C19 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/11/2015
Entry Details Article
PubMed
TargetCytochrome P450 1A2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50020408(CHEMBL3289805)
Affinity DataIC50: 5.20E+3nMAssay Description:Inhibition of CYP1A2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/11/2015
Entry Details Article
PubMed
TargetCytochrome P450 3A4/3A5(Human)
University of Washington

Curated by ChEMBL
LigandPNGBDBM50538344(CHEMBL4633246)
Affinity DataIC50: 5.50E+3nMAssay Description:Inhibition of CYP3A4/5 in human liver microsomes using testosterone as substrate preincubated for 30 mins followed by substrate addition and measured...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2021
Entry Details Article
PubMed
TargetCytochrome P450 3A4/3A5(Human)
University of Washington

Curated by ChEMBL
LigandPNGBDBM50538344(CHEMBL4633246)
Affinity DataIC50: 5.50E+3nMAssay Description:Inhibition of CYP3A4/5 in human liver microsomes using midazolam as substrate preincubated for 30 mins followed by substrate addition and measured af...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2021
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50536191(CHEMBL4584780)
Affinity DataIC50: 6.30E+3nMAssay Description:Inhibition of human CYP2C19 expressed in Escherichia coli pre-incubated for 5 mins before regenerating cofactor solution addition using 3-Cyano-7-Eth...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
University of Dundee

Curated by ChEMBL
LigandPNGBDBM50517286(CHEMBL4516798)
Affinity DataIC50: 6.31E+3nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using midazolam as substrate preincubated for 20 mins followed by substrate addition and measured afte...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
University of Washington

Curated by ChEMBL
LigandPNGBDBM50100015(CHEMBL3321968)
Affinity DataIC50: 7.30E+3nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/28/2016
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
University of Washington

Curated by ChEMBL
LigandPNGBDBM50100085(CHEMBL3321980)
Affinity DataIC50: 8.80E+3nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/28/2016
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
University of Washington

Curated by ChEMBL
LigandPNGBDBM50558659(CHEMBL4530341)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human ERG by IonWorks patch clamp electrophysiology methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
University of Washington

Curated by ChEMBL
LigandPNGBDBM50558663(CHEMBL4798032)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human ERG by IonWorks patch clamp electrophysiology methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50020408(CHEMBL3289805)
Affinity DataIC50: 1.02E+4nMAssay Description:Inhibition of CYP2C19 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/11/2015
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
University of Washington

Curated by ChEMBL
LigandPNGBDBM50020416(CHEMBL3289799)
Affinity DataIC50: 1.03E+4nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/11/2015
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
University of Washington

Curated by ChEMBL
LigandPNGBDBM50020404(CHEMBL3289803)
Affinity DataIC50: 1.05E+4nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/11/2015
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
University of Washington

Curated by ChEMBL
LigandPNGBDBM50020415(CHEMBL3289806)
Affinity DataIC50: 1.22E+4nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/11/2015
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
University of Dundee

Curated by ChEMBL
LigandPNGBDBM50020412(CHEMBL3289811)
Affinity DataIC50: 1.25E+4nMAssay Description:Inhibition of CYP2D6 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/11/2015
Entry Details Article
PubMed
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