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TargetBiotin--[biotin carboxyl-carrier protein] ligase(Mycobacterium tuberculosis (strain CDC 1551 / Oshk...)
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50119406(CHEMBL3613833)
Affinity DataKd:  0.0270nMAssay Description:Binding affinity to Mycobacterium tuberculosis H37Rv Biotin protein ligase expressed in Escherichia coli by ITC analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/1/2016
Entry Details Article
PubMed
TargetBiotin--[biotin carboxyl-carrier protein] ligase(Mycobacterium tuberculosis (strain CDC 1551 / Oshk...)
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50119307(CHEMBL3613835)
Affinity DataKd:  0.153nMAssay Description:Binding affinity to Mycobacterium tuberculosis H37Rv Biotin protein ligase expressed in Escherichia coli by ITC analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/1/2016
Entry Details Article
PubMed
TargetBiotin--[biotin carboxyl-carrier protein] ligase(Mycobacterium tuberculosis (strain CDC 1551 / Oshk...)
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50119456(CHEMBL3613839)
Affinity DataKd:  0.315nMAssay Description:Binding affinity to Mycobacterium tuberculosis H37Rv Biotin protein ligase expressed in Escherichia coli by ITC analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/1/2016
Entry Details Article
PubMed
TargetBiotin--[biotin carboxyl-carrier protein] ligase(Mycobacterium tuberculosis (strain CDC 1551 / Oshk...)
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50119305(CHEMBL3613837)
Affinity DataKd:  0.324nMAssay Description:Binding affinity to Mycobacterium tuberculosis H37Rv Biotin protein ligase expressed in Escherichia coli by ITC analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/1/2016
Entry Details Article
PubMed
TargetBiotin--[biotin carboxyl-carrier protein] ligase(Mycobacterium tuberculosis (strain CDC 1551 / Oshk...)
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50119447(CHEMBL3613830)
Affinity DataKd:  0.540nMAssay Description:Binding affinity to Mycobacterium tuberculosis H37Rv Biotin protein ligase expressed in Escherichia coli by ITC analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/1/2016
Entry Details Article
PubMed
TargetBiotin--[biotin carboxyl-carrier protein] ligase(Mycobacterium tuberculosis (strain CDC 1551 / Oshk...)
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50119455(CHEMBL3613838)
Affinity DataKd:  0.592nMAssay Description:Binding affinity to Mycobacterium tuberculosis H37Rv Biotin protein ligase expressed in Escherichia coli by ITC analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/1/2016
Entry Details Article
PubMed
TargetBiotin--[biotin carboxyl-carrier protein] ligase(Mycobacterium tuberculosis (strain CDC 1551 / Oshk...)
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50119364(CHEMBL3613834)
Affinity DataKd:  0.614nMAssay Description:Binding affinity to Mycobacterium tuberculosis H37Rv Biotin protein ligase expressed in Escherichia coli by ITC analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/1/2016
Entry Details Article
PubMed
TargetBiotin--[biotin carboxyl-carrier protein] ligase(Mycobacterium tuberculosis (strain CDC 1551 / Oshk...)
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50119427(CHEMBL3613832)
Affinity DataKd:  0.627nMAssay Description:Binding affinity to Mycobacterium tuberculosis H37Rv Biotin protein ligase expressed in Escherichia coli by ITC analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/1/2016
Entry Details Article
PubMed
TargetBiotin--[biotin carboxyl-carrier protein] ligase(Mycobacterium tuberculosis (strain CDC 1551 / Oshk...)
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50119453(CHEMBL3613828)
Affinity DataKd:  0.753nMAssay Description:Binding affinity to Mycobacterium tuberculosis H37Rv Biotin protein ligase expressed in Escherichia coli by ITC analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/1/2016
Entry Details Article
PubMed
TargetBiotin--[biotin carboxyl-carrier protein] ligase(Mycobacterium tuberculosis (strain CDC 1551 / Oshk...)
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50119306(CHEMBL3613836)
Affinity DataKd:  0.769nMAssay Description:Binding affinity to Mycobacterium tuberculosis H37Rv Biotin protein ligase expressed in Escherichia coli by ITC analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/1/2016
Entry Details Article
PubMed
TargetBiotin--[biotin carboxyl-carrier protein] ligase(Mycobacterium tuberculosis (strain CDC 1551 / Oshk...)
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50119454(CHEMBL3140272)
Affinity DataKd:  0.865nMAssay Description:Binding affinity to Mycobacterium tuberculosis H37Rv Biotin protein ligase expressed in Escherichia coli by ITC analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/1/2016
Entry Details Article
PubMed
TargetBiotin--[biotin carboxyl-carrier protein] ligase(Mycobacterium tuberculosis (strain CDC 1551 / Oshk...)
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50119431(CHEMBL3613831)
Affinity DataKd:  0.933nMAssay Description:Binding affinity to Mycobacterium tuberculosis H37Rv Biotin protein ligase expressed in Escherichia coli by ITC analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/1/2016
Entry Details Article
PubMed
TargetTGF-beta receptor type-1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50382322(CHEMBL2024689)
Affinity DataIC50: 1nMAssay Description:Inhibition of ALK5More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetTGF-beta receptor type-1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50382321(CHEMBL2024688)
Affinity DataIC50: 1nMAssay Description:Inhibition of ALK5More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetTGF-beta receptor type-1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50382324(CHEMBL2024691)
Affinity DataIC50: 2nMAssay Description:Inhibition of ALK5More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetBiotin--[biotin carboxyl-carrier protein] ligase(Mycobacterium tuberculosis (strain CDC 1551 / Oshk...)
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50119452(CHEMBL3613829)
Affinity DataKd:  2.10nMAssay Description:Binding affinity to Mycobacterium tuberculosis H37Rv Biotin protein ligase expressed in Escherichia coli by ITC analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/1/2016
Entry Details Article
PubMed
TargetTGF-beta receptor type-1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50382320(CHEMBL2024687)
Affinity DataIC50: 3nMAssay Description:Inhibition of ALK5More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetTGF-beta receptor type-1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50382318(CHEMBL2024685)
Affinity DataIC50: 4nMAssay Description:Inhibition of ALK5More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetTGF-beta receptor type-1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50382319(CHEMBL2024686)
Affinity DataIC50: 4nMAssay Description:Inhibition of ALK5More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetTGF-beta receptor type-1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50382325(CHEMBL2024693)
Affinity DataIC50: 5nMAssay Description:Inhibition of ALK5More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetTGF-beta receptor type-1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50382323(CHEMBL2024690)
Affinity DataIC50: 6nMAssay Description:Inhibition of ALK5More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetTGF-beta receptor type-1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50382317(CHEMBL2024684)
Affinity DataIC50: 13nMAssay Description:Inhibition of ALK5More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Upjohn

LigandPNGBDBM771(CHEMBL16584 | 3-[cyclopropyl(phenyl)methyl]-4-hydr...)
Affinity DataKi:  15nM ΔG°:  -44.2kJ/molepH: 5.0 T: 2°CAssay Description:HIV-1 protease was purified and refolded from E. coli inclusion bodies. The substrate used spans the p17-p24 processing site (R-V-S-Q-N-Y-P-I-V-Q-N-K...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/16/2004
Entry Details Article
PubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Pharmacia & Upjohn

Curated by ChEMBL
LigandPNGBDBM50054629(3-(Cyclopropyl-phenyl-methyl)-4-hydroxy-6,6-diprop...)
Affinity DataKi:  15nMAssay Description:HIV Protease inhibitory activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Pharmacia & Upjohn

Curated by ChEMBL
LigandPNGBDBM50054610(4-Hydroxy-6-phenethyl-3-(1-phenyl-allyl)-6-propyl-...)
Affinity DataKi:  16nMAssay Description:HIV Protease inhibitory activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Upjohn

LigandPNGBDBM784(5,6,7,8,9,1O-Hexahydro-4-hydroxy-3-(2-methyl-nylpr...)
Affinity DataKi:  22nM ΔG°:  -43.3kJ/molepH: 5.0 T: 2°CAssay Description:HIV-1 protease was purified and refolded from E. coli inclusion bodies. The substrate used spans the p17-p24 processing site (R-V-S-Q-N-Y-P-I-V-Q-N-K...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/16/2004
Entry Details Article
PubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Pharmacia & Upjohn

Curated by ChEMBL
LigandPNGBDBM50054615(4-Hydroxy-3-(1-phenyl-propyl)-6,6-dipropyl-5,6-dih...)
Affinity DataKi:  22nMAssay Description:HIV Protease inhibitory activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Upjohn

LigandPNGBDBM783(4-hydroxy-3-(1-phenylbutyl)-2H,5H,6H,7H,8H,9H,10H-...)
Affinity DataKi:  29nM ΔG°:  -42.6kJ/molepH: 5.0 T: 2°CAssay Description:HIV-1 protease was purified and refolded from E. coli inclusion bodies. The substrate used spans the p17-p24 processing site (R-V-S-Q-N-Y-P-I-V-Q-N-K...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/16/2004
Entry Details Article
PubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50166407((Z)-2-Benzoylamino-3-[4-(2-bromo-6-fluoro-phenoxy)...)
Affinity DataIC50: 30nMAssay Description:Inhibitory concentration against Hepatitis C virus NS5B polymeraseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50166407((Z)-2-Benzoylamino-3-[4-(2-bromo-6-fluoro-phenoxy)...)
Affinity DataIC50: 30nMAssay Description:Inhibitory concentration against RNA dependent RNA polymerase Nonstructural protein 5B (HCV NS5B polymerase) in Hepatitis C virusMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Pharmacia & Upjohn

Curated by ChEMBL
LigandPNGBDBM50054616(3-(1,3-Diphenyl-propyl)-4-hydroxy-6-phenethyl-6-pr...)
Affinity DataKi:  33nMAssay Description:HIV Protease inhibitory activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Pharmacia & Upjohn

Curated by ChEMBL
LigandPNGBDBM50054619(4-Hydroxy-6-phenethyl-3-(1-phenyl-propyl)-6-propyl...)
Affinity DataKi:  35nMAssay Description:HIV Protease inhibitory activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Pharmacia & Upjohn

Curated by ChEMBL
LigandPNGBDBM50054630(3-(Cyclopentyl-phenyl-methyl)-4-hydroxy-6,6-diprop...)
Affinity DataKi:  39nMAssay Description:HIV Protease inhibitory activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50166360((Z)-2-Benzoylamino-3-[4-(2-iodo-phenoxy)-phenyl]-a...)
Affinity DataIC50: 40nMAssay Description:Inhibitory concentration against Hepatitis C virus NS5B polymeraseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTGF-beta receptor type-1(Mouse)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50382318(CHEMBL2024685)
Affinity DataIC50: 44nMAssay Description:Inhibition of ALK5 in mouse NIH/3T3 cells by smad binding element reporter based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetTGF-beta receptor type-1(Mouse)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50382325(CHEMBL2024693)
Affinity DataIC50: 46nMAssay Description:Inhibition of ALK5 in mouse NIH/3T3 cells by smad binding element reporter based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetTGF-beta receptor type-1(Mouse)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50382324(CHEMBL2024691)
Affinity DataIC50: 47nMAssay Description:Inhibition of ALK5 in mouse NIH/3T3 cells by smad binding element reporter based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50167658((Z)-3-[4-(2-Bromo-phenoxy)-phenyl]-2-(2-ethyl-benz...)
Affinity DataIC50: 50nMAssay Description:Inhibitory concentration against RNA dependent RNA polymerase Nonstructural protein 5B (HCV NS5B polymerase) in Hepatitis C virusMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Pharmacia & Upjohn

Curated by ChEMBL
LigandPNGBDBM50054614(3-((E)-1,3-Diphenyl-allyl)-4-hydroxy-6-phenethyl-6...)
Affinity DataKi:  50nMAssay Description:HIV Protease inhibitory activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Upjohn

LigandPNGBDBM789(3-(dicyclopropylmethyl)-4-hydroxy-2H,5H,6H,7H,8H,9...)
Affinity DataKi:  57nM ΔG°:  -40.9kJ/molepH: 5.0 T: 2°CAssay Description:HIV-1 protease was purified and refolded from E. coli inclusion bodies. The substrate used spans the p17-p24 processing site (R-V-S-Q-N-Y-P-I-V-Q-N-K...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/16/2004
Entry Details Article
PubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Pharmacia & Upjohn

Curated by ChEMBL
LigandPNGBDBM50054618(3-(Cyclopentyl-phenyl-methyl)-4-hydroxy-6-phenethy...)
Affinity DataKi:  59nMAssay Description:HIV Protease inhibitory activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetActivin receptor type-1B(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50382317(CHEMBL2024684)
Affinity DataIC50: 59nMAssay Description:Inhibition of ALK4More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50167655({(Z)-2-Benzoylamino-3-[4-(2-bromo-phenoxy)-phenyl]...)
Affinity DataIC50: 60nMAssay Description:Inhibitory concentration against RNA dependent RNA polymerase Nonstructural protein 5B (HCV NS5B polymerase) in Hepatitis C virusMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTGF-beta receptor type-1(Mouse)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50382321(CHEMBL2024688)
Affinity DataIC50: 61nMAssay Description:Inhibition of ALK5 in mouse NIH/3T3 cells by smad binding element reporter based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Upjohn

LigandPNGBDBM786(5,6,7,8,9,10-Hexahydroro-4-hydroxy- 1-phenylpentyl...)
Affinity DataKi:  62nM ΔG°:  -40.7kJ/molepH: 5.0 T: 2°CAssay Description:HIV-1 protease was purified and refolded from E. coli inclusion bodies. The substrate used spans the p17-p24 processing site (R-V-S-Q-N-Y-P-I-V-Q-N-K...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/16/2004
Entry Details Article
PubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Pharmacia & Upjohn

Curated by ChEMBL
LigandPNGBDBM50054628(3-(Cyclopropyl-phenyl-methyl)-4-hydroxy-6-phenethy...)
Affinity DataKi:  64nMAssay Description:HIV Protease inhibitory activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTGF-beta receptor type-1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50382326(CHEMBL2024692)
Affinity DataIC50: 69nMAssay Description:Inhibition of ALK5More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50166374((Z)-2-Benzoylamino-3-[4-(2-chloro-6-fluoro-phenoxy...)
Affinity DataIC50: 70nMAssay Description:Inhibitory concentration against Hepatitis C virus NS5B polymeraseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50167633((Z)-2-[(Adamantane-1-carbonyl)-amino]-3-[4-(2-brom...)
Affinity DataIC50: 70nMAssay Description:Inhibitory concentration against RNA dependent RNA polymerase Nonstructural protein 5B (HCV NS5B polymerase) in Hepatitis C virusMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTGF-beta receptor type-1(Mouse)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50382323(CHEMBL2024690)
Affinity DataIC50: 73nMAssay Description:Inhibition of ALK5 in mouse NIH/3T3 cells by smad binding element reporter based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
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