Compile Data Set for Download or QSAR
Report error Found 495 with Last Name = 'fletcher' and Initial = 't'
TargetIleal sodium/bile acid cotransporter(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50140282(CHEMBL363392 | CHEMBL17879 | 1-{4-[4-((4R,5R)-3,3-...)
Affinity DataIC50: 0.280nMAssay Description:In vitro inhibition of ASBT mediated uptake of [14C]taurocholate (5 uM) in baby hamster cells expressing human IBATMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2012
Entry Details Article
PubMed
TargetIleal sodium/bile acid cotransporter(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50172695({2-[3-((4R,5R)-3,3-Dibutyl-7-dimethylamino-4-hydro...)
Affinity DataIC50: 0.300nMAssay Description:In vitro inhibition of ASBT mediated uptake of [14C]taurocholate (5 uM) in baby hamster cells expressing human IBATMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2012
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM11885(N-hydroxy-4-{[4-(phenylsulfanyl)benzene]sulfonyl}-...)
Affinity DataIC50: 0.330nMAssay Description:Inhibition of MMP2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM11885(N-hydroxy-4-{[4-(phenylsulfanyl)benzene]sulfonyl}-...)
Affinity DataIC50: 0.400nMAssay Description:Inhibition of MMP13More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50320414(1-cyclopropyl-N-hydroxy-4-(4-(4-(4-methoxyphenyl)p...)
Affinity DataIC50: 0.420nMAssay Description:Inhibition of MMP13More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetIleal sodium/bile acid cotransporter(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50172649(1-{5-[4-((4R,5R)-3,3-Dibutyl-7-dimethylamino-4-hyd...)
Affinity DataIC50: 0.5nMAssay Description:In vitro inhibition of ASBT mediated uptake of [14C]taurocholate (5 uM) in baby hamster cells expressing human IBATMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2012
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50320412(N-hydroxy-4-(4-(4-(4-(trifluoromethyl)phenyl)piper...)
Affinity DataIC50: 0.600nMAssay Description:Inhibition of MMP13More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50320410(N-hydroxy-4-(4-(4-(4-methoxyphenyl)piperazin-1-yl)...)
Affinity DataIC50: 0.630nMAssay Description:Inhibition of MMP13More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM16596(N,N -bis(4-fluoro-3-methylbenzyl)pyrimidine-4,6-di...)
Affinity DataIC50: 0.670nMAssay Description:Inhibition of MMP13 (unknown origin) using acetyl-Pro-Leu-Gly-[2-mercapto-4-methylpentanoyl]-Leu-Gly-O-ethyl ester as substrate by microplate reader ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2017
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCollagenase 3(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50320393(4-(4-(4-(4-chlorophenyl)piperidin-1-yl)phenylsulfo...)
Affinity DataIC50: 0.700nMAssay Description:Inhibition of MMP13More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetIleal sodium/bile acid cotransporter(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50172702(4-[4-((4R,5R)-3,3-Dibutyl-7-dimethylamino-4-hydrox...)
Affinity DataIC50: 0.75nMAssay Description:In vitro inhibition of ASBT mediated uptake of [14C]taurocholate (5 uM) in baby hamster cells expressing human IBATMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2012
Entry Details Article
PubMed
TargetIleal sodium/bile acid cotransporter(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50370667(CHEMBL555246)
Affinity DataIC50: 0.760nMAssay Description:In vitro inhibition of ASBT mediated uptake of [14C]taurocholate (5 uM) in baby hamster cells expressing human IBATMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2012
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50320413(4-(4-(4-(4-chlorophenyl)piperazin-1-yl)phenylsulfo...)
Affinity DataIC50: 1nMAssay Description:Inhibition of MMP13More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetIleal sodium/bile acid cotransporter(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50172668(1-{4-[4-((4R,5R)-3,3-Dibutyl-7-dimethylamino-4-hyd...)
Affinity DataIC50: 1nMAssay Description:In vitro inhibition of ASBT mediated uptake of [14C]taurocholate (5 uM) in baby hamster cells expressing human IBATMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2012
Entry Details Article
PubMed
TargetIleal sodium/bile acid cotransporter(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50172709(1-{4-[4-((4R,5R)-3,3-Dibutyl-7-dimethylamino-4-hyd...)
Affinity DataIC50: 1nMAssay Description:In vitro inhibition of ASBT mediated uptake of [14C]taurocholate (5 uM) in baby hamster cells expressing human IBATMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2012
Entry Details Article
PubMed
TargetMatrix metalloproteinase-9(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM11885(N-hydroxy-4-{[4-(phenylsulfanyl)benzene]sulfonyl}-...)
Affinity DataIC50: 1.5nMAssay Description:Inhibition of MMP9More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetIleal sodium/bile acid cotransporter(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50134416(Trifluoro-acetate{4-[3-((8R,9R)-7,7-dibutyl-2-dime...)
Affinity DataIC50: 1.60nMAssay Description:In vitro inhibitory activity against uptake of [14C]taurocholate in baby hamster kidney cells transfected with cDNA from human Apical Sodium-Codepend...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50320405(N-hydroxy-4-(4-(4-phenylpiperazin-1-yl)phenylsulfo...)
Affinity DataIC50: 1.70nMAssay Description:Inhibition of MMP13More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetNeutrophil collagenase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM11885(N-hydroxy-4-{[4-(phenylsulfanyl)benzene]sulfonyl}-...)
Affinity DataIC50: 1.80nMAssay Description:Inhibition of MMP8More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50320411(N-hydroxy-4-(4-(4-p-tolylpiperazin-1-yl)phenylsulf...)
Affinity DataIC50: 1.90nMAssay Description:Inhibition of MMP13More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50320393(4-(4-(4-(4-chlorophenyl)piperidin-1-yl)phenylsulfo...)
Affinity DataIC50: 2nMAssay Description:Inhibition of MMP2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetIleal sodium/bile acid cotransporter(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50172608((4R,5R)-3,3-Dibutyl-7-dimethylamino-9-methoxy-5-(4...)
Affinity DataIC50: 2nMAssay Description:In vitro inhibition of ASBT mediated uptake of [14C]taurocholate (5 uM) in Baby hamster cells expressing human IBATMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2012
Entry Details Article
PubMed
TargetIleal sodium/bile acid cotransporter(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50172652((4R,5R)-5-(3-Amino-phenyl)-3,3-dibutyl-7-dimethyla...)
Affinity DataIC50: 2nMAssay Description:In vitro inhibition of ASBT mediated uptake of [14C]taurocholate (5 uM) in baby hamster cells expressing human IBATMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2012
Entry Details Article
PubMed
TargetIleal sodium/bile acid cotransporter(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50172667(4-[3-((4R,5R)-3,3-Dibutyl-7-dimethylamino-4-hydrox...)
Affinity DataIC50: 2nMAssay Description:In vitro inhibition of ASBT mediated uptake of [14C]taurocholate (5 uM) in baby hamster cells expressing human IBATMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2012
Entry Details Article
PubMed
TargetIleal sodium/bile acid cotransporter(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50172681((Carboxymethyl-{4-[4-((4R,5R)-3,3-dibutyl-7-dimeth...)
Affinity DataIC50: 2nMAssay Description:In vitro inhibition of ASBT mediated uptake of [14C]taurocholate (5 uM) in baby hamster cells expressing human IBATMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2012
Entry Details Article
PubMed
TargetIleal sodium/bile acid cotransporter(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50370669(CHEMBL555022)
Affinity DataIC50: 2nMAssay Description:In vitro inhibition of ASBT mediated uptake of [14C]taurocholate (5 uM) in baby hamster cells expressing human IBATMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2012
Entry Details Article
PubMed
TargetIleal sodium/bile acid cotransporter(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50370670(CHEMBL540126)
Affinity DataIC50: 2nMAssay Description:In vitro inhibition of ASBT mediated uptake of [14C]taurocholate (5 uM) in baby hamster cells expressing human IBATMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2012
Entry Details Article
PubMed
TargetIleal sodium/bile acid cotransporter(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50172661((4R,5R)-3,3-Dibutyl-7-dimethylamino-5-(4-hydroxy-p...)
Affinity DataIC50: 2.20nMAssay Description:In vitro inhibition of ASBT mediated uptake of [14C]taurocholate (5 uM) in baby hamster cells expressing human IBATMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2012
Entry Details Article
PubMed
TargetIleal sodium/bile acid cotransporter(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50172690((Carboxymethyl-{5-[4-((4R,5R)-3,3-dibutyl-7-dimeth...)
Affinity DataIC50: 2.30nMAssay Description:In vitro inhibition of ASBT mediated uptake of [14C]taurocholate (5 uM) in baby hamster cells expressing human IBATMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2012
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50320390(1-cyclopropyl-N-hydroxy-4-(4-(4-(4-(trifluoromethy...)
Affinity DataIC50: 2.40nMAssay Description:Inhibition of MMP13More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50320406(4-(4-(4-(2-fluorophenyl)piperazin-1-yl)phenylsulfo...)
Affinity DataIC50: 2.70nMAssay Description:Inhibition of MMP13More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetIleal sodium/bile acid cotransporter(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50134424([2-(2-{2-[4-((8R,9R)-7,7-Dibutyl-2-dimethylamino-8...)
Affinity DataIC50: 3nMAssay Description:In vitro inhibitory activity against uptake of [14C]taurocholate in baby hamster kidney cells transfected with cDNA from human Apical Sodium-Codepend...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetIleal sodium/bile acid cotransporter(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50370665(CHEMBL555024)
Affinity DataIC50: 3nMAssay Description:In vitro inhibition of ASBT mediated uptake of [14C]taurocholate (5 uM) in Baby hamster cells expressing human IBATMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2012
Entry Details Article
PubMed
TargetIleal sodium/bile acid cotransporter(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50370665(CHEMBL555024)
Affinity DataIC50: 3nMAssay Description:In vitro inhibition of ASBT mediated uptake of [14C]taurocholate (5 uM) in baby hamster cells expressing human IBATMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2012
Entry Details Article
PubMed
TargetIleal sodium/bile acid cotransporter(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50172675(ASBT inhibitor 62 | 1-[2-(2-{2-[4-((4R,5R)-3,3-Dib...)
Affinity DataIC50: 3nMAssay Description:In vitro inhibition of ASBT mediated uptake of [14C]taurocholate (5 uM) in baby hamster cells expressing human IBATMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2012
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50320389(1-cyclopropyl-N-hydroxy-4-(4-(4-phenylpiperazin-1-...)
Affinity DataIC50: 3.30nMAssay Description:Inhibition of MMP13More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetIleal sodium/bile acid cotransporter(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50172700((4R,5R)-3,3-Dibutyl-7-dimethylamino-5-(3-fluoro-4-...)
Affinity DataIC50: 3.60nMAssay Description:In vitro inhibition of ASBT mediated uptake of [14C]taurocholate (5 uM) in baby hamster cells expressing human IBATMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2012
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50320413(4-(4-(4-(4-chlorophenyl)piperazin-1-yl)phenylsulfo...)
Affinity DataIC50: 3.70nMAssay Description:Inhibition of MMP2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetIleal sodium/bile acid cotransporter(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50172680([3-((2R,3R)-3,3-Dibutyl-7-dimethylamino-4-hydroxy-...)
Affinity DataIC50: 3.70nMAssay Description:In vitro inhibition of ASBT mediated uptake of [14C]taurocholate (5 uM) in baby hamster cells expressing human IBATMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2012
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50320443(4-(4-(4-(4-(2,3-dimethylphenyl)piperazine-1-carbon...)
Affinity DataIC50: 4nMAssay Description:Inhibition of MMP13More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetIleal sodium/bile acid cotransporter(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50172650((Carboxymethyl-{6-[4-((4R,5R)-3,3-dibutyl-7-dimeth...)
Affinity DataIC50: 4nMAssay Description:In vitro inhibition of ASBT mediated uptake of [14C]taurocholate (5 uM) in baby hamster cells expressing human IBATMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2012
Entry Details Article
PubMed
TargetIleal sodium/bile acid cotransporter(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50172653(1-{3-[4-((4R,5R)-3,3-Dibutyl-7-dimethylamino-4-hyd...)
Affinity DataIC50: 4nMAssay Description:In vitro inhibition of ASBT mediated uptake of [14C]taurocholate (5 uM) in baby hamster cells expressing human IBATMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2012
Entry Details Article
PubMed
TargetIleal sodium/bile acid cotransporter(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50172688([2-(2-{2-[4-((4R,5R)-3,3-Dibutyl-7-dimethylamino-4...)
Affinity DataIC50: 4nMAssay Description:In vitro inhibition of ASBT mediated uptake of [14C]taurocholate (5 uM) in baby hamster cells expressing human IBATMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2012
Entry Details Article
PubMed
TargetIleal sodium/bile acid cotransporter(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50172706(1-[2-(2-{2-[4-((4R,5R)-3,3-Dibutyl-7-dimethylamino...)
Affinity DataIC50: 4nMAssay Description:In vitro inhibition of ASBT mediated uptake of [14C]taurocholate (5 uM) in baby hamster cells expressing human IBATMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2012
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50320391(N-hydroxy-4-(4-(4-phenylpiperidin-1-yl)phenylsulfo...)
Affinity DataIC50: 4.40nMAssay Description:Inhibition of MMP2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50320424(4-(4-(4-(3,5-dimethylpiperazine-1-carbonyl)piperid...)
Affinity DataIC50: 4.40nMAssay Description:Inhibition of MMP13More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetIleal sodium/bile acid cotransporter(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50172671((4R,5R)-3,3-Dibutyl-7-dimethylamino-5-(3-hydroxyme...)
Affinity DataIC50: 4.5nMAssay Description:In vitro inhibition of ASBT mediated uptake of [14C]taurocholate (5 uM) in baby hamster cells expressing human IBATMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2012
Entry Details Article
PubMed
TargetIleal sodium/bile acid cotransporter(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50172631((3S,4R,5R)-3-Butyl-7-dimethylamino-3-ethyl-1,1-dio...)
Affinity DataIC50: 5nMAssay Description:In vitro inhibition of ASBT mediated uptake of [14C]taurocholate (5 uM) in Baby hamster cells expressing human IBATMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2012
Entry Details Article
PubMed
TargetIleal sodium/bile acid cotransporter(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50172655((4R,5S)-3,3-Dibutyl-7-dimethylamino-1,1-dioxo-5-py...)
Affinity DataIC50: 5nMAssay Description:In vitro inhibition of ASBT mediated uptake of [14C]taurocholate (5 uM) in baby hamster cells expressing human IBATMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2012
Entry Details Article
PubMed
TargetIleal sodium/bile acid cotransporter(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50172701((4R,5R)-3,3-Dibutyl-7-dimethylamino-1,1-dioxo-5-th...)
Affinity DataIC50: 5nMAssay Description:In vitro inhibition of ASBT mediated uptake of [14C]taurocholate (5 uM) in baby hamster cells expressing human IBATMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2012
Entry Details Article
PubMed
Displayed 1 to 50 (of 495 total ) | Next | Last >>
Jump to: