Report error Found 143 with Last Name = 'frey' and Initial = 'km'
Affinity DataKd: 2.24E+4nMAssay Description:Binding affinity to wild type HIV1 reverse transcriptase by pre-steady state kinetics studyMore data for this Ligand-Target Pair
Affinity DataKd: 4.60E+3nMAssay Description:Binding affinity to wild type HIV1 reverse transcriptase by pre-steady state kinetics studyMore data for this Ligand-Target Pair
Affinity DataKd: 2.55E+4nMAssay Description:Binding affinity to wild type HIV1 reverse transcriptase by pre-steady state kinetics studyMore data for this Ligand-Target Pair
TargetReverse transcriptase protein(Human immunodeficiency virus type 1)
Yale University
Curated by ChEMBL
Yale University
Curated by ChEMBL
Affinity DataKd: 4.70E+3nMAssay Description:Binding affinity to HIV1 reverse transcriptase K65R mutant by pre-steady state kinetics studyMore data for this Ligand-Target Pair
Affinity DataKd: 2.04E+4nMAssay Description:Binding affinity to wild type HIV1 reverse transcriptase by pre-steady state kinetics studyMore data for this Ligand-Target Pair
Affinity DataKd: 6.50E+3nMAssay Description:Binding affinity to wild type HIV1 reverse transcriptase by pre-steady state kinetics studyMore data for this Ligand-Target Pair
TargetReverse transcriptase protein(Human immunodeficiency virus type 1)
Yale University
Curated by ChEMBL
Yale University
Curated by ChEMBL
Affinity DataKd: 6.60E+3nMAssay Description:Binding affinity to HIV1 reverse transcriptase K65R mutant by pre-steady state kinetics studyMore data for this Ligand-Target Pair
Affinity DataKd: 1.65E+4nMAssay Description:Binding affinity to wild type HIV1 reverse transcriptase by pre-steady state kinetics studyMore data for this Ligand-Target Pair
TargetReverse transcriptase protein(Human immunodeficiency virus type 1)
Yale University
Curated by ChEMBL
Yale University
Curated by ChEMBL
Affinity DataKd: 2.91E+4nMAssay Description:Binding affinity to HIV1 reverse transcriptase K65R mutant by pre-steady state kinetics studyMore data for this Ligand-Target Pair
Affinity DataIC50: 0.680nMAssay Description:Inhibition of recombinant HIV1 reverse transcriptase p66/p51 Y181C mutant expressed in Escherichia coli BL21 (DE3) pLysS cells preincubated followed ...More data for this Ligand-Target Pair
3D Structure (crystal)
Affinity DataIC50: 1.10nMAssay Description:Inhibition of wild-type HIV-1 reverse transcriptase by fluorescence assayMore data for this Ligand-Target Pair
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Cryptosporidium parvum)
University of Connecticut At Storrs
University of Connecticut At Storrs
Affinity DataIC50: 1.10nMpH: 7.0 T: 2°CAssay Description:Enzyme activity assays were performed by monitoring the change in UV absorbance at 340 nm. Enzyme assays were performed at least four times. IC50 val...More data for this Ligand-Target Pair
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Cryptosporidium parvum)
University of Connecticut At Storrs
University of Connecticut At Storrs
Affinity DataIC50: 1.10nMAssay Description:Compounds were evaluated in spectrophotometric enzyme assays using ChDHFR-TS and hDHFR. Inhibition constants (IC50) were measured (see Table 4). The ...More data for this Ligand-Target Pair
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Cryptosporidium parvum)
University of Connecticut At Storrs
University of Connecticut At Storrs
Affinity DataIC50: 1.80nMpH: 7.0 T: 2°CAssay Description:Enzyme activity assays were performed by monitoring the change in UV absorbance at 340 nm. Enzyme assays were performed at least four times. IC50 val...More data for this Ligand-Target Pair
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Cryptosporidium parvum)
University of Connecticut At Storrs
University of Connecticut At Storrs
Affinity DataIC50: 1.80nMAssay Description:Compounds were evaluated in spectrophotometric enzyme assays using ChDHFR-TS and hDHFR. Inhibition constants (IC50) were measured (see Table 4). The ...More data for this Ligand-Target Pair
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Cryptosporidium parvum)
University of Connecticut At Storrs
University of Connecticut At Storrs
Affinity DataIC50: 2.10nMpH: 7.0 T: 2°CAssay Description:Enzyme activity assays were performed by monitoring the change in UV absorbance at 340 nm. Enzyme assays were performed at least four times. IC50 val...More data for this Ligand-Target Pair
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Cryptosporidium parvum)
University of Connecticut At Storrs
University of Connecticut At Storrs
Affinity DataIC50: 2.10nMAssay Description:Compounds were evaluated in spectrophotometric enzyme assays using ChDHFR-TS and hDHFR. Inhibition constants (IC50) were measured (see Table 4). The ...More data for this Ligand-Target Pair
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Cryptosporidium parvum)
University of Connecticut At Storrs
University of Connecticut At Storrs
Affinity DataIC50: 2.10nMAssay Description:Compounds were evaluated in spectrophotometric enzyme assays using ChDHFR-TS and hDHFR. Inhibition constants (IC50) were measured (see Table 4). The ...More data for this Ligand-Target Pair
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Cryptosporidium parvum)
University of Connecticut At Storrs
University of Connecticut At Storrs
Affinity DataIC50: 2.10nMpH: 7.0 T: 2°CAssay Description:Enzyme activity assays were performed by monitoring the change in UV absorbance at 340 nm. Enzyme assays were performed at least four times. IC50 val...More data for this Ligand-Target Pair
Affinity DataIC50: 2.40nMAssay Description:Heterocyclic analogs of propargyl-linked inhibitors of the third generation analogs were evaluated in enzyme inhibition assays, assessed for S. aureu...More data for this Ligand-Target Pair
Affinity DataIC50: 2.70nMAssay Description:Inhibition of wild-type HIV-1 reverse transcriptase by fluorescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 3.30nMAssay Description:Inhibition of wild-type HIV-1 reverse transcriptase by fluorescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 4.30nMAssay Description:Inhibition of HIV-1 6His-tagged reverse transcriptase p66/p51-mediated TTP incorporation into D23/D36 primer/template preincubated for 15 mins follow...More data for this Ligand-Target Pair
Affinity DataIC50: 4.5nMAssay Description:Inhibition of recombinant HIV1 reverse transcriptase p66/p51 expressed in Escherichia coli BL21 (DE3) pLysS cells preincubated followed by primer/tem...More data for this Ligand-Target Pair
Affinity DataIC50: 5.5nMAssay Description:Inhibition of recombinant HIV1 reverse transcriptase p66/p51 Y181C mutant expressed in Escherichia coli BL21 (DE3) pLysS cells preincubated followed ...More data for this Ligand-Target Pair
TargetDihydrofolate reductase(Streptococcus pyogenes (Firmicutes))
University of Connecticut
US Patent
University of Connecticut
US Patent
Affinity DataIC50: 5.90nMAssay Description:Heterocyclic analogs of propargyl-linked inhibitors of the third generation analogs were evaluated in enzyme inhibition assays, assessed for S. aureu...More data for this Ligand-Target Pair
Affinity DataIC50: 6nMAssay Description:Inhibition of HIV-1 6His-tagged reverse transcriptase p66/p51-mediated TTP incorporation into D23/D36 primer/template preincubated for 15 mins follow...More data for this Ligand-Target Pair
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Cryptosporidium parvum)
University of Connecticut At Storrs
University of Connecticut At Storrs
Affinity DataIC50: 7.40nMpH: 7.0 T: 2°CAssay Description:Enzyme activity assays were performed by monitoring the change in UV absorbance at 340 nm. Enzyme assays were performed at least four times. IC50 val...More data for this Ligand-Target Pair
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Cryptosporidium parvum)
University of Connecticut At Storrs
University of Connecticut At Storrs
Affinity DataIC50: 7.40nMAssay Description:Compounds were evaluated in spectrophotometric enzyme assays using ChDHFR-TS and hDHFR. Inhibition constants (IC50) were measured (see Table 4). The ...More data for this Ligand-Target Pair
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Cryptosporidium parvum)
University of Connecticut At Storrs
University of Connecticut At Storrs
Affinity DataIC50: 10nMAssay Description:Compounds were evaluated in spectrophotometric enzyme assays using ChDHFR-TS and hDHFR. Inhibition constants (IC50) were measured (see Table 4). The ...More data for this Ligand-Target Pair
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Cryptosporidium parvum)
University of Connecticut At Storrs
University of Connecticut At Storrs
Affinity DataIC50: 10nMpH: 7.0 T: 2°CAssay Description:Enzyme activity assays were performed by monitoring the change in UV absorbance at 340 nm. Enzyme assays were performed at least four times. IC50 val...More data for this Ligand-Target Pair
Affinity DataIC50: 12nMAssay Description:Heterocyclic analogs of propargyl-linked inhibitors of the third generation analogs were evaluated in enzyme inhibition assays, assessed for S. aureu...More data for this Ligand-Target Pair
Affinity DataIC50: 15nMAssay Description:Inhibition of wild-type HIV-1 reverse transcriptase by fluorescence assayMore data for this Ligand-Target Pair
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Cryptosporidium parvum)
University of Connecticut At Storrs
University of Connecticut At Storrs
Affinity DataIC50: 16nMpH: 7.0 T: 2°CAssay Description:Enzyme activity assays were performed by monitoring the change in UV absorbance at 340 nm. Enzyme assays were performed at least four times. IC50 val...More data for this Ligand-Target Pair
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Cryptosporidium parvum)
University of Connecticut At Storrs
University of Connecticut At Storrs
Affinity DataIC50: 16nMAssay Description:Compounds were evaluated in spectrophotometric enzyme assays using ChDHFR-TS and hDHFR. Inhibition constants (IC50) were measured (see Table 4). The ...More data for this Ligand-Target Pair
TargetDihydrofolate reductase(Streptococcus pyogenes (Firmicutes))
University of Connecticut
US Patent
University of Connecticut
US Patent
Affinity DataIC50: 19nMAssay Description:Heterocyclic analogs of propargyl-linked inhibitors of the third generation analogs were evaluated in enzyme inhibition assays, assessed for S. aureu...More data for this Ligand-Target Pair
Affinity DataIC50: 19nMAssay Description:Heterocyclic analogs of propargyl-linked inhibitors of the third generation analogs were evaluated in enzyme inhibition assays, assessed for S. aureu...More data for this Ligand-Target Pair
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Cryptosporidium parvum)
University of Connecticut At Storrs
University of Connecticut At Storrs
Affinity DataIC50: 19nMpH: 7.0 T: 2°CAssay Description:Enzyme activity assays were performed by monitoring the change in UV absorbance at 340 nm. Enzyme assays were performed at least four times. IC50 val...More data for this Ligand-Target Pair
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Cryptosporidium parvum)
University of Connecticut At Storrs
University of Connecticut At Storrs
Affinity DataIC50: 19nMAssay Description:Compounds were evaluated in spectrophotometric enzyme assays using ChDHFR-TS and hDHFR. Inhibition constants (IC50) were measured (see Table 4). The ...More data for this Ligand-Target Pair
Affinity DataIC50: 20nMAssay Description:Heterocyclic analogs of propargyl-linked inhibitors of the third generation analogs were evaluated in enzyme inhibition assays, assessed for S. aureu...More data for this Ligand-Target Pair
Affinity DataIC50: 21nMAssay Description:Heterocyclic analogs of propargyl-linked inhibitors of the third generation analogs were evaluated in enzyme inhibition assays, assessed for S. aureu...More data for this Ligand-Target Pair
TargetDihydrofolate reductase(Streptococcus pyogenes (Firmicutes))
University of Connecticut
US Patent
University of Connecticut
US Patent
Affinity DataIC50: 23nMAssay Description:Heterocyclic analogs of propargyl-linked inhibitors of the third generation analogs were evaluated in enzyme inhibition assays, assessed for S. aureu...More data for this Ligand-Target Pair
TargetDihydrofolate reductase(Streptococcus pyogenes (Firmicutes))
University of Connecticut
US Patent
University of Connecticut
US Patent
Affinity DataIC50: 23nMAssay Description:Heterocyclic analogs of propargyl-linked inhibitors of the third generation analogs were evaluated in enzyme inhibition assays, assessed for S. aureu...More data for this Ligand-Target Pair
Affinity DataIC50: 26nMAssay Description:Heterocyclic analogs of propargyl-linked inhibitors of the third generation analogs were evaluated in enzyme inhibition assays, assessed for S. aureu...More data for this Ligand-Target Pair
TargetDihydrofolate reductase(Streptococcus pyogenes (Firmicutes))
University of Connecticut
US Patent
University of Connecticut
US Patent
Affinity DataIC50: 26nMAssay Description:Heterocyclic analogs of propargyl-linked inhibitors of the third generation analogs were evaluated in enzyme inhibition assays, assessed for S. aureu...More data for this Ligand-Target Pair
TargetDihydrofolate reductase(Streptococcus pyogenes (Firmicutes))
University of Connecticut
US Patent
University of Connecticut
US Patent
Affinity DataIC50: 26nMAssay Description:Heterocyclic analogs of propargyl-linked inhibitors of the third generation analogs were evaluated in enzyme inhibition assays, assessed for S. aureu...More data for this Ligand-Target Pair
TargetDihydrofolate reductase(Streptococcus pyogenes (Firmicutes))
University of Connecticut
US Patent
University of Connecticut
US Patent
Affinity DataIC50: 26nMAssay Description:Heterocyclic analogs of propargyl-linked inhibitors of the third generation analogs were evaluated in enzyme inhibition assays, assessed for S. aureu...More data for this Ligand-Target Pair
TargetDihydrofolate reductase(Streptococcus pyogenes (Firmicutes))
University of Connecticut
US Patent
University of Connecticut
US Patent
Affinity DataIC50: 28nMAssay Description:Heterocyclic analogs of propargyl-linked inhibitors of the third generation analogs were evaluated in enzyme inhibition assays, assessed for S. aureu...More data for this Ligand-Target Pair
Affinity DataIC50: 28nMAssay Description:Heterocyclic analogs of propargyl-linked inhibitors of the third generation analogs were evaluated in enzyme inhibition assays, assessed for S. aureu...More data for this Ligand-Target Pair
Affinity DataIC50: 29nMAssay Description:Heterocyclic analogs of propargyl-linked inhibitors of the third generation analogs were evaluated in enzyme inhibition assays, assessed for S. aureu...More data for this Ligand-Target Pair
