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TargetCannabinoid receptor 1(Human)
University of Siena

Curated by ChEMBL
LigandPNGBDBM50543738(CHEMBL4644215)
Affinity DataEC50:  6.20nMAssay Description:Agonist activity at human CB1 receptor expressed in CHO cell membrane assessed as stimulation of [35S]-GTPgammaS binding incubated for 1 hr by by liq...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetCannabinoid receptor 1(Human)
University of Siena

Curated by ChEMBL
LigandPNGBDBM50543739(CHEMBL4647981)
Affinity DataEC50:  15nMAssay Description:Agonist activity at human CB1 receptor expressed in CHO cell membrane assessed as stimulation of [35S]-GTPgammaS binding incubated for 1 hr by by liq...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetCannabinoid receptor 1(Human)
University of Siena

Curated by ChEMBL
LigandPNGBDBM50543756(CHEMBL4646867)
Affinity DataEC50:  31nMAssay Description:Agonist activity at human CB1 receptor expressed in CHO cell membrane assessed as stimulation of [35S]-GTPgammaS binding incubated for 1 hr by by liq...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetCannabinoid receptor 1(Human)
University of Siena

Curated by ChEMBL
LigandPNGBDBM50072775(ChEMBL_75020 | 5-(1,1-Dimethyl-heptyl)-2-[(1R,2R,5...)
Affinity DataEC50:  1.70nMAssay Description:Agonist activity at human CB1 receptor expressed in CHO cell membrane assessed as stimulation of [35S]-GTPgammaS binding incubated for 1 hr by by liq...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCannabinoid receptor 2(Human)
University of Siena

Curated by ChEMBL
LigandPNGBDBM50543738(CHEMBL4644215)
Affinity DataEC50:  398nMAssay Description:Agonist activity at human CB2 receptor expressed in CHO cell membrane assessed as inhibition of [35S]-GTPgammaS binding incubated for 1 hr by by liqu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetCannabinoid receptor 2(Human)
University of Siena

Curated by ChEMBL
LigandPNGBDBM50543739(CHEMBL4647981)
Affinity DataEC50:  1.20nMAssay Description:Agonist activity at human CB2 receptor expressed in CHO cell membrane assessed as inhibition of [35S]-GTPgammaS binding incubated for 1 hr by by liqu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetCannabinoid receptor 2(Human)
University of Siena

Curated by ChEMBL
LigandPNGBDBM50543744(CHEMBL4637806)
Affinity DataEC50:  174nMAssay Description:Agonist activity at human CB2 receptor expressed in CHO cell membrane assessed as inhibition of [35S]-GTPgammaS binding incubated for 1 hr by by liqu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetCannabinoid receptor 2(Human)
University of Siena

Curated by ChEMBL
LigandPNGBDBM50543756(CHEMBL4646867)
Affinity DataEC50:  1.30nMAssay Description:Agonist activity at human CB2 receptor expressed in CHO cell membrane assessed as inhibition of [35S]-GTPgammaS binding incubated for 1 hr by by liqu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
LigandPNGBDBM50543739(CHEMBL4647981)
Affinity DataEC50:  120nMAssay Description:Activation of human TRPV1 expressed in HEK293 cells assessed as calcium influx preincubated for 5 mins by Fluo-4AM dye based fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
LigandPNGBDBM50543739(CHEMBL4647981)
Affinity DataEC50:  1.11E+4nMAssay Description:Activation of rat recombinant TRPA1 expressed in HEK293 cells assessed as calcium influx preincubated for 5 mins by Fluo-4AM dye based fluorescence a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
LigandPNGBDBM50525957(CHEMBL4461515)
Affinity DataEC50:  3.5nMAssay Description:Agonist activity at rat recombinant TRPV4 expressed in HEK293 cells assessed as increase in intracellular calcium accumulation by Fluo4-AM based assa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50622240(CHEMBL5416647)
Affinity DataEC50:  1.88E+3nMAssay Description:Agonist activity at human recombinant TRPV1 expressed in HEK293 cells assessed as increase in intracellular calcium level by Fluo4-AM based assayMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
LigandPNGBDBM50622241(CHEMBL5416035)
Affinity DataEC50:  234nMAssay Description:Agonist activity at human recombinant TRPV1 expressed in HEK293 cells assessed as increase in intracellular calcium level by Fluo4-AM based assayMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
LigandPNGBDBM50622242(CHEMBL5417721)
Affinity DataEC50:  1.15E+3nMAssay Description:Agonist activity at human recombinant TRPV1 expressed in HEK293 cells assessed as increase in intracellular calcium level by Fluo4-AM based assayMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
LigandPNGBDBM50622243(CHEMBL5417996)
Affinity DataEC50:  676nMAssay Description:Agonist activity at human recombinant TRPV1 expressed in HEK293 cells assessed as increase in intracellular calcium level by Fluo4-AM based assayMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
LigandPNGBDBM50622244(CHEMBL5418018)
Affinity DataEC50:  741nMAssay Description:Agonist activity at human recombinant TRPV1 expressed in HEK293 cells assessed as increase in intracellular calcium level by Fluo4-AM based assayMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
LigandPNGBDBM50622245(CHEMBL5403768)
Affinity DataEC50:  841nMAssay Description:Agonist activity at human recombinant TRPV1 expressed in HEK293 cells assessed as increase in intracellular calcium level by Fluo4-AM based assayMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
LigandPNGBDBM50622246(CHEMBL5396387)
Affinity DataEC50:  61nMAssay Description:Agonist activity at human recombinant TRPV1 expressed in HEK293 cells assessed as increase in intracellular calcium level by Fluo4-AM based assayMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
LigandPNGBDBM50622247(CHEMBL5426686)
Affinity DataEC50:  108nMAssay Description:Agonist activity at human recombinant TRPV1 expressed in HEK293 cells assessed as increase in intracellular calcium level by Fluo4-AM based assayMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
LigandPNGBDBM50622248(CHEMBL89848)
Affinity DataEC50:  109nMAssay Description:Agonist activity at human recombinant TRPV1 expressed in HEK293 cells assessed as increase in intracellular calcium level by Fluo4-AM based assayMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
LigandPNGBDBM50622249(CHEMBL5428602)
Affinity DataEC50:  2nMAssay Description:Agonist activity at human recombinant TRPV1 expressed in HEK293 cells assessed as increase in intracellular calcium level by Fluo4-AM based assayMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
LigandPNGBDBM50622250(CHEMBL5429923)
Affinity DataEC50:  76nMAssay Description:Agonist activity at human recombinant TRPV1 expressed in HEK293 cells assessed as increase in intracellular calcium level by Fluo4-AM based assayMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
LigandPNGBDBM50622251(CHEMBL5422020)
Affinity DataEC50:  7nMAssay Description:Agonist activity at human recombinant TRPV1 expressed in HEK293 cells assessed as increase in intracellular calcium level by Fluo4-AM based assayMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
LigandPNGBDBM50622252(CHEMBL5423911)
Affinity DataEC50:  870nMAssay Description:Agonist activity at human recombinant TRPV1 expressed in HEK293 cells assessed as increase in intracellular calcium level by Fluo4-AM based assayMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
LigandPNGBDBM50622253(CHEMBL5410131)
Affinity DataEC50: >5.00E+4nMAssay Description:Agonist activity at human recombinant TRPV1 expressed in HEK293 cells assessed as increase in intracellular calcium level by Fluo4-AM based assayMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
LigandPNGBDBM50622254(CHEMBL5410838)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at human recombinant TRPV1 expressed in HEK293 cells assessed as increase in intracellular calcium level by Fluo4-AM based assayMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
LigandPNGBDBM50622255(CHEMBL5423032)
Affinity DataEC50:  4.90E+3nMAssay Description:Agonist activity at human recombinant TRPV1 expressed in HEK293 cells assessed as increase in intracellular calcium level by Fluo4-AM based assayMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
LigandPNGBDBM50622256(CHEMBL5430219)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at human recombinant TRPV1 expressed in HEK293 cells assessed as increase in intracellular calcium level by Fluo4-AM based assayMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
LigandPNGBDBM50622257(CHEMBL5412004)
Affinity DataEC50:  150nMAssay Description:Agonist activity at human recombinant TRPV1 expressed in HEK293 cells assessed as increase in intracellular calcium level by Fluo4-AM based assayMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
LigandPNGBDBM50622258(CHEMBL5417111)
Affinity DataEC50:  37nMAssay Description:Agonist activity at human recombinant TRPV1 expressed in HEK293 cells assessed as increase in intracellular calcium level by Fluo4-AM based assayMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
LigandPNGBDBM50622259(CHEMBL5398876)
Affinity DataEC50:  340nMAssay Description:Agonist activity at human recombinant TRPV1 expressed in HEK293 cells assessed as increase in intracellular calcium level by Fluo4-AM based assayMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
LigandPNGBDBM50622260(CHEMBL5399027)
Affinity DataEC50:  417nMAssay Description:Agonist activity at human recombinant TRPV1 expressed in HEK293 cells assessed as increase in intracellular calcium level by Fluo4-AM based assayMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
LigandPNGBDBM50622261(CHEMBL5432262)
Affinity DataEC50:  586nMAssay Description:Agonist activity at human recombinant TRPV1 expressed in HEK293 cells assessed as increase in intracellular calcium level by Fluo4-AM based assayMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
LigandPNGBDBM50622262(CHEMBL5424278)
Affinity DataEC50:  2.44E+3nMAssay Description:Agonist activity at human recombinant TRPV1 expressed in HEK293 cells assessed as increase in intracellular calcium level by Fluo4-AM based assayMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
LigandPNGBDBM96974(SMR000229037 | cid_836344 | N-benzyl-4-phenylbutan...)
Affinity DataEC50: >5.00E+4nMAssay Description:Agonist activity at human recombinant TRPV1 expressed in HEK293 cells assessed as increase in intracellular calcium level by Fluo4-AM based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
LigandPNGBDBM50622263(CHEMBL1802306)
Affinity DataEC50:  4.80E+3nMAssay Description:Agonist activity at human recombinant TRPV1 expressed in HEK293 cells assessed as increase in intracellular calcium level by Fluo4-AM based assayMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
LigandPNGBDBM50622264(CHEMBL5397480)
Affinity DataEC50:  2.63E+3nMAssay Description:Agonist activity at human recombinant TRPV1 expressed in HEK293 cells assessed as increase in intracellular calcium level by Fluo4-AM based assayMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
LigandPNGBDBM20461(Zostrix | (E)-N-[(4-hydroxy-3-methoxyphenyl)methyl...)
Affinity DataEC50:  5nMAssay Description:Agonist activity at human recombinant TRPV1 expressed in HEK293 cells assessed as increase in intracellular calcium level by Fluo4-AM based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetTransient receptor potential cation channel subfamily A member 1(Rattus norvegicus)
Magna Gracia University

Curated by ChEMBL
LigandPNGBDBM50622249(CHEMBL5428602)
Affinity DataEC50:  1.87E+4nMAssay Description:Agonist activity at rat recombinant TRPA1 expressed in HEK293 cells assessed as increase in intracellular calcium accumulation by Fluo4-AM based assa...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetTransient receptor potential cation channel subfamily A member 1(Rattus norvegicus)
Magna Gracia University

Curated by ChEMBL
LigandPNGBDBM50622248(CHEMBL89848)
Affinity DataEC50:  2.72E+4nMAssay Description:Agonist activity at rat recombinant TRPA1 expressed in HEK293 cells assessed as increase in intracellular calcium accumulation by Fluo4-AM based assa...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetTransient receptor potential cation channel subfamily A member 1(Rattus norvegicus)
Magna Gracia University

Curated by ChEMBL
LigandPNGBDBM50622247(CHEMBL5426686)
Affinity DataEC50: >5.00E+4nMAssay Description:Agonist activity at rat recombinant TRPA1 expressed in HEK293 cells assessed as increase in intracellular calcium accumulation by Fluo4-AM based assa...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetTransient receptor potential cation channel subfamily A member 1(Rattus norvegicus)
Magna Gracia University

Curated by ChEMBL
LigandPNGBDBM50622243(CHEMBL5417996)
Affinity DataEC50:  3.03E+4nMAssay Description:Agonist activity at rat recombinant TRPA1 expressed in HEK293 cells assessed as increase in intracellular calcium accumulation by Fluo4-AM based assa...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetTransient receptor potential cation channel subfamily A member 1(Rattus norvegicus)
Magna Gracia University

Curated by ChEMBL
LigandPNGBDBM50622241(CHEMBL5416035)
Affinity DataEC50:  1.04E+4nMAssay Description:Agonist activity at rat recombinant TRPA1 expressed in HEK293 cells assessed as increase in intracellular calcium accumulation by Fluo4-AM based assa...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetTransient receptor potential cation channel subfamily A member 1(Rattus norvegicus)
Magna Gracia University

Curated by ChEMBL
LigandPNGBDBM50622240(CHEMBL5416647)
Affinity DataEC50:  2.71E+4nMAssay Description:Agonist activity at rat recombinant TRPA1 expressed in HEK293 cells assessed as increase in intracellular calcium accumulation by Fluo4-AM based assa...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetTransient receptor potential cation channel subfamily A member 1(Rattus norvegicus)
Magna Gracia University

Curated by ChEMBL
LigandPNGBDBM50622253(CHEMBL5410131)
Affinity DataEC50: >5.00E+4nMAssay Description:Agonist activity at rat recombinant TRPA1 expressed in HEK293 cells assessed as increase in intracellular calcium accumulation by Fluo4-AM based assa...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetTransient receptor potential cation channel subfamily A member 1(Rattus norvegicus)
Magna Gracia University

Curated by ChEMBL
LigandPNGBDBM50622257(CHEMBL5412004)
Affinity DataEC50:  1.20E+4nMAssay Description:Agonist activity at rat recombinant TRPA1 expressed in HEK293 cells assessed as increase in intracellular calcium accumulation by Fluo4-AM based assa...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetTransient receptor potential cation channel subfamily A member 1(Rattus norvegicus)
Magna Gracia University

Curated by ChEMBL
LigandPNGBDBM50622261(CHEMBL5432262)
Affinity DataEC50:  1.07E+4nMAssay Description:Agonist activity at rat recombinant TRPA1 expressed in HEK293 cells assessed as increase in intracellular calcium accumulation by Fluo4-AM based assa...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetTransient receptor potential cation channel subfamily A member 1(Rattus norvegicus)
Magna Gracia University

Curated by ChEMBL
LigandPNGBDBM50203072(Allylisothiocyanate | 3-isothiocyanatoprop-1-ene |...)
Affinity DataEC50:  1.41E+3nMAssay Description:Agonist activity at rat recombinant TRPA1 expressed in HEK293 cells assessed as increase in intracellular calcium accumulation by Fluo4-AM based assa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetCannabinoid receptor 1(Mouse)
University of Siena

Curated by ChEMBL
LigandPNGBDBM50358949(CHEMBL1923763)
Affinity DataEC50:  6.30nMAssay Description:Agonist activity at MF1 mouse brain CB1 receptor assessed as induction of [35S]GTPgammaS binding after 60 mins by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
TargetCannabinoid receptor 1(Mouse)
University of Siena

Curated by ChEMBL
LigandPNGBDBM50358947(CHEMBL1923761)
Affinity DataEC50:  78.4nMAssay Description:Agonist activity at MF1 mouse brain CB1 receptor assessed as induction of [35S]GTPgammaS binding after 60 mins by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
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