Compile Data Set for Download or QSAR
Found 948 with Last Name = 'goldman' and Initial = 'me'
TargetProgesterone receptor(Homo sapiens (Human))
Ligand Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM18627((10S,11S,14S,15S,17R)-17-[4-(dimethylamino)phenyl]...)
Show SMILES CC#C[C@]1(O)CC[C@H]2[C@@H]3CCC4=CC(=O)CCC4=C3[C@H](C[C@]12C)c1ccc(cc1)N(C)C
Show InChI InChI=1S/C29H35NO2/c1-5-15-29(32)16-14-26-24-12-8-20-17-22(31)11-13-23(20)27(24)25(18-28(26,29)2)19-6-9-21(10-7-19)30(3)4/h6-7,9-10,17,24-26,32H,8,11-14,16,18H2,1-4H3/t24-,25+,26-,28-,29-/m0/s1
Affinity DataKi:  0.580nMAssay Description:Binding affinity determined for human Progesterone receptor A isoformMore data for this Ligand-Target Pair
TargetGlucocorticoid receptor(Homo sapiens (Human))
Ligand Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM18627((10S,11S,14S,15S,17R)-17-[4-(dimethylamino)phenyl]...)
Show SMILES CC#C[C@]1(O)CC[C@H]2[C@@H]3CCC4=CC(=O)CCC4=C3[C@H](C[C@]12C)c1ccc(cc1)N(C)C
Show InChI InChI=1S/C29H35NO2/c1-5-15-29(32)16-14-26-24-12-8-20-17-22(31)11-13-23(20)27(24)25(18-28(26,29)2)19-6-9-21(10-7-19)30(3)4/h6-7,9-10,17,24-26,32H,8,11-14,16,18H2,1-4H3/t24-,25+,26-,28-,29-/m0/s1
Affinity DataKi:  0.680nMAssay Description:Binding affinity was determined for human glucocorticoid receptor(hGR).More data for this Ligand-Target Pair
TargetAndrogen receptor(Homo sapiens (Human))
Ligand Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM50049515((S)-4-Methylene-3-[2-[7a-methyl-1-((E)-1,4,5-trime...)
Show SMILES CC(C)C(C)\C=C\C(C)C1CCC2\C(CCCC12C)=C\C=C1\C[C@@H](O)CCC1=C
Show InChI InChI=1S/C28H44O/c1-19(2)20(3)9-10-22(5)26-15-16-27-23(8-7-17-28(26,27)6)12-13-24-18-25(29)14-11-21(24)4/h9-10,12-13,19-20,22,25-27,29H,4,7-8,11,14-18H2,1-3,5-6H3/b10-9+,23-12+,24-13-/t20?,22?,25-,26?,27?,28?/m0/s1
Affinity DataKi:  1.10nMAssay Description:Binding affinity for human Androgen receptorMore data for this Ligand-Target Pair
TargetProgesterone receptor(Homo sapiens (Human))
Ligand Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM50072024((11R,13S,14S,17S)-11-(4-Dimethylamino-phenyl)-17-h...)
Show SMILES CC#C[C@]1(O)CC[C@H]2[C@@H]3CCC4=CC(=O)CCC4=C3[C@H](C[C@]12C)c1ccc(cc1)N(C)C
Show InChI InChI=1S/C29H35NO2/c1-5-15-29(32)16-14-26-24-12-8-20-17-22(31)11-13-23(20)27(24)25(18-28(26,29)2)19-6-9-21(10-7-19)30(3)4/h6-7,9-10,17,24-26,32H,8,11-14,16,18H2,1-4H3/t24?,25-,26+,28+,29+/m1/s1
Affinity DataKi:  1.10nMAssay Description:Binding affinity against human progesterone receptor-A (hPR-A)More data for this Ligand-Target Pair
TargetProgesterone receptor(Homo sapiens (Human))
Ligand Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM18627((10S,11S,14S,15S,17R)-17-[4-(dimethylamino)phenyl]...)
Show SMILES CC#C[C@]1(O)CC[C@H]2[C@@H]3CCC4=CC(=O)CCC4=C3[C@H](C[C@]12C)c1ccc(cc1)N(C)C
Show InChI InChI=1S/C29H35NO2/c1-5-15-29(32)16-14-26-24-12-8-20-17-22(31)11-13-23(20)27(24)25(18-28(26,29)2)19-6-9-21(10-7-19)30(3)4/h6-7,9-10,17,24-26,32H,8,11-14,16,18H2,1-4H3/t24-,25+,26-,28-,29-/m0/s1
Affinity DataKi:  1.10nMAssay Description:Binding affinity against Baculovirus-Expressed hPR-AMore data for this Ligand-Target Pair
TargetProgesterone receptor(Homo sapiens (Human))
Ligand Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM50072018(5,8-difluoro-2,2,4-trimethyl-2,10-dihydro-1H-inden...)
Show SMILES CC1=CC(C)(C)Nc2cc3Cc4cc(F)ccc4-c3c(F)c12
Show InChI InChI=1S/C19H17F2N/c1-10-9-19(2,3)22-15-8-12-6-11-7-13(20)4-5-14(11)17(12)18(21)16(10)15/h4-5,7-9,22H,6H2,1-3H3
Affinity DataKi:  1.5nMAssay Description:Antagonist activity against human progesterone receptor B (hPR-B) in cotransfected CV-1 cellsMore data for this Ligand-Target Pair
TargetProgesterone receptor(Homo sapiens (Human))
Ligand Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM50071997(7-Fluoro-2,2,4-trimethyl-8-nitro-2,10-dihydro-1H-i...)
Show SMILES CC1=CC(C)(C)Nc2cc3Cc4cc(c(F)cc4-c3cc12)[N+]([O-])=O
Show InChI InChI=1S/C19H17FN2O2/c1-10-9-19(2,3)21-17-5-11-4-12-6-18(22(23)24)16(20)8-15(12)14(11)7-13(10)17/h5-9,21H,4H2,1-3H3
Affinity DataKi:  1.90nMAssay Description:Binding affinity against human progesterone receptor-A (hPR-A)More data for this Ligand-Target Pair
TargetProgesterone receptor(Homo sapiens (Human))
Ligand Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM50072007(9-Fluoro-2,2,4-trimethyl-2,10-dihydro-1H-indeno[1,...)
Show SMILES CC1=CC(C)(C)Nc2cc3Cc4c(cccc4F)-c3cc12
Show InChI InChI=1S/C19H18FN/c1-11-10-19(2,3)21-18-8-12-7-16-13(5-4-6-17(16)20)15(12)9-14(11)18/h4-6,8-10,21H,7H2,1-3H3
Affinity DataKi:  2.30nMAssay Description:Binding affinity against human progesterone receptor-A (hPR-A)More data for this Ligand-Target Pair
TargetProgesterone receptor(Homo sapiens (Human))
Ligand Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM50072014(6,9-difluoro-2,2,4-trimethyl-2,10-dihydro-1H-inden...)
Show SMILES CC1=CC(C)(C)Nc2cc3Cc4c(-c3cc12)c(F)ccc4F
Show InChI InChI=1S/C19H17F2N/c1-10-9-19(2,3)22-17-7-11-6-14-15(20)4-5-16(21)18(14)13(11)8-12(10)17/h4-5,7-9,22H,6H2,1-3H3
Affinity DataKi:  3.10nMAssay Description:Binding affinity against human progesterone receptor-A (hPR-A)More data for this Ligand-Target Pair
TargetProgesterone receptor(Homo sapiens (Human))
Ligand Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM8903((1S,2R,10S,11S,14S,15S)-14-acetyl-2,15-dimethyltet...)
Show SMILES CC(=O)[C@H]1CC[C@H]2[C@@H]3CCC4=CC(=O)CC[C@]4(C)[C@H]3CC[C@]12C
Show InChI InChI=1S/C21H30O2/c1-13(22)17-6-7-18-16-5-4-14-12-15(23)8-10-20(14,2)19(16)9-11-21(17,18)3/h12,16-19H,4-11H2,1-3H3/t16-,17+,18-,19-,20-,21+/m0/s1
Affinity DataKi:  3.5nMAssay Description:Binding affinity determined for human Progesterone receptor A isoformMore data for this Ligand-Target Pair
TargetProgesterone receptor(Homo sapiens (Human))
Ligand Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM50071990(8-Fluoro-2,2,4-trimethyl-2,10-dihydro-1H-indeno[1,...)
Show SMILES CC1=CC(C)(C)Nc2cc3Cc4cc(F)ccc4-c3cc12
Show InChI InChI=1S/C19H18FN/c1-11-10-19(2,3)21-18-8-13-6-12-7-14(20)4-5-15(12)17(13)9-16(11)18/h4-5,7-10,21H,6H2,1-3H3
Affinity DataKi:  3.5nMAssay Description:Binding affinity against human progesterone receptor-A (hPR-A)More data for this Ligand-Target Pair
TargetProgesterone receptor(Homo sapiens (Human))
Ligand Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM50072010(2,2,4-trimethyl-8-nitro-2,10-dihydro-1H-indeno[1,2...)
Show SMILES CC1=CC(C)(C)Nc2cc3Cc4cc(ccc4-c3cc12)[N+]([O-])=O
Show InChI InChI=1S/C19H18N2O2/c1-11-10-19(2,3)20-18-8-13-6-12-7-14(21(22)23)4-5-15(12)17(13)9-16(11)18/h4-5,7-10,20H,6H2,1-3H3
Affinity DataKi:  3.60nMAssay Description:Binding affinity against human progesterone receptor-A (hPR-A)More data for this Ligand-Target Pair
TargetProgesterone receptor(Homo sapiens (Human))
Ligand Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM50066524(6-(3-Fluoro-5-nitro-phenyl)-2,2,4-trimethyl-1,2-di...)
Show SMILES CC1=CC(C)(C)Nc2ccc(cc12)-c1cc(F)cc(c1)[N+]([O-])=O
Show InChI InChI=1S/C18H17FN2O2/c1-11-10-18(2,3)20-17-5-4-12(8-16(11)17)13-6-14(19)9-15(7-13)21(22)23/h4-10,20H,1-3H3
Affinity DataKi:  5nMAssay Description:Binding affinity against Baculovirus-Expressed hPR-AMore data for this Ligand-Target Pair
TargetGlucocorticoid receptor(Homo sapiens (Human))
Ligand Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM18207((1R,2S,10S,11S,13R,14R,15S,17S)-1-fluoro-14,17-dih...)
Show SMILES C[C@@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@]2(C)[C@@]1(O)C(=O)CO
Show InChI InChI=1S/C22H29FO5/c1-12-8-16-15-5-4-13-9-14(25)6-7-19(13,2)21(15,23)17(26)10-20(16,3)22(12,28)18(27)11-24/h6-7,9,12,15-17,24,26,28H,4-5,8,10-11H2,1-3H3/t12-,15+,16+,17+,19+,20+,21+,22+/m1/s1
Affinity DataKi:  5.5nMAssay Description:Binding affinity was determined for human glucocorticoid receptor(hGR).More data for this Ligand-Target Pair
TargetAndrogen receptor(Homo sapiens (Human))
Ligand Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM8903((1S,2R,10S,11S,14S,15S)-14-acetyl-2,15-dimethyltet...)
Show SMILES CC(=O)[C@H]1CC[C@H]2[C@@H]3CCC4=CC(=O)CC[C@]4(C)[C@H]3CC[C@]12C
Show InChI InChI=1S/C21H30O2/c1-13(22)17-6-7-18-16-5-4-14-12-15(23)8-10-20(14,2)19(16)9-11-21(17,18)3/h12,16-19H,4-11H2,1-3H3/t16-,17+,18-,19-,20-,21+/m0/s1
Affinity DataKi:  8.5nMAssay Description:Binding affinity for human Androgen receptorMore data for this Ligand-Target Pair
TargetProgesterone receptor(Homo sapiens (Human))
Ligand Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM50066522(6-(3,5-Difluoro-phenyl)-2,2,4-trimethyl-1,2-dihydr...)
Show SMILES CC1=CC(C)(C)Nc2ccc(cc12)-c1cc(F)cc(F)c1
Show InChI InChI=1S/C18H17F2N/c1-11-10-18(2,3)21-17-5-4-12(8-16(11)17)13-6-14(19)9-15(20)7-13/h4-10,21H,1-3H3
Affinity DataKi:  10nMAssay Description:Binding affinity against Baculovirus-Expressed hPR-AMore data for this Ligand-Target Pair
TargetProgesterone receptor(Homo sapiens (Human))
Ligand Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM50066526(3-Fluoro-5-(2,2,4-trimethyl-1,2-dihydro-quinolin-6...)
Show SMILES CC1=CC(C)(C)Nc2ccc(cc12)-c1cc(F)cc(c1)C#N
Show InChI InChI=1S/C19H17FN2/c1-12-10-19(2,3)22-18-5-4-14(9-17(12)18)15-6-13(11-21)7-16(20)8-15/h4-10,22H,1-3H3
Affinity DataKi:  10nMAssay Description:Binding affinity against Baculovirus-Expressed hPR-AMore data for this Ligand-Target Pair
TargetAndrogen receptor(Homo sapiens (Human))
Ligand Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM18627((10S,11S,14S,15S,17R)-17-[4-(dimethylamino)phenyl]...)
Show SMILES CC#C[C@]1(O)CC[C@H]2[C@@H]3CCC4=CC(=O)CCC4=C3[C@H](C[C@]12C)c1ccc(cc1)N(C)C
Show InChI InChI=1S/C29H35NO2/c1-5-15-29(32)16-14-26-24-12-8-20-17-22(31)11-13-23(20)27(24)25(18-28(26,29)2)19-6-9-21(10-7-19)30(3)4/h6-7,9-10,17,24-26,32H,8,11-14,16,18H2,1-4H3/t24-,25+,26-,28-,29-/m0/s1
Affinity DataKi:  11nMAssay Description:Binding affinity determined against human Androgen receptorMore data for this Ligand-Target Pair
TargetProgesterone receptor(Homo sapiens (Human))
Ligand Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM50071995(6-fluoro-2,2,4-trimethyl-2,10-dihydro-1H-indeno[1,...)
Show SMILES CC1=CC(C)(C)Nc2cc3Cc4cccc(F)c4-c3cc12
Show InChI InChI=1S/C19H18FN/c1-11-10-19(2,3)21-17-8-13-7-12-5-4-6-16(20)18(12)15(13)9-14(11)17/h4-6,8-10,21H,7H2,1-3H3
Affinity DataKi:  11nMAssay Description:Binding affinity against human progesterone receptor-A (hPR-A)More data for this Ligand-Target Pair
TargetProgesterone receptor(Homo sapiens (Human))
Ligand Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM50071988((2,2,4-Trimethyl-2,10-dihydro-1H-indeno[1,2-g]quin...)
Show SMILES CC1=CC(C)(C)Nc2cc3Cc4c(cccc4CO)-c3cc12
Show InChI InChI=1S/C20H21NO/c1-12-10-20(2,3)21-19-8-14-7-17-13(11-22)5-4-6-15(17)18(14)9-16(12)19/h4-6,8-10,21-22H,7,11H2,1-3H3
Affinity DataKi:  12nMAssay Description:Binding affinity against human progesterone receptor-A (hPR-A)More data for this Ligand-Target Pair
TargetProgesterone receptor(Homo sapiens (Human))
Ligand Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM50071989(1,3,3-trimethyl-4,11-dihydro-3H-indeno[2,1-f]quino...)
Show SMILES CC1=CC(C)(C)Nc2ccc-3c(Cc4ccccc-34)c12
Show InChI InChI=1S/C19H19N/c1-12-11-19(2,3)20-17-9-8-15-14-7-5-4-6-13(14)10-16(15)18(12)17/h4-9,11,20H,10H2,1-3H3
Affinity DataKi:  13nMAssay Description:Binding affinity against human progesterone receptor-A (hPR-A)More data for this Ligand-Target Pair
TargetProgesterone receptor(Homo sapiens (Human))
Ligand Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM50072005(2,2,4-Trimethyl-2,10-dihydro-1H-indeno[1,2-g]quino...)
Show SMILES CC1=CC(C)(C)Nc2cc3Cc4ccccc4-c3cc12
Show InChI InChI=1S/C19H19N/c1-12-11-19(2,3)20-18-9-14-8-13-6-4-5-7-15(13)17(14)10-16(12)18/h4-7,9-11,20H,8H2,1-3H3
Affinity DataKi:  14nMAssay Description:Binding affinity against human progesterone receptor-A (hPR-A)More data for this Ligand-Target Pair
TargetProgesterone receptor(Homo sapiens (Human))
Ligand Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM50071986(10-Fluoro-1,3,3-trimethyl-4,11-dihydro-3H-indeno[2...)
Show SMILES CC1=CC(C)(C)Nc2ccc-3c(Cc4c-3cccc4F)c12
Show InChI InChI=1S/C19H18FN/c1-11-10-19(2,3)21-17-8-7-13-12-5-4-6-16(20)14(12)9-15(13)18(11)17/h4-8,10,21H,9H2,1-3H3
Affinity DataKi:  16nMAssay Description:Binding affinity against human progesterone receptor-A (hPR-A)More data for this Ligand-Target Pair
TargetProgesterone receptor(Homo sapiens (Human))
Ligand Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM50366558(ONAPRISTONE | ZK-98299)
Show SMILES CN(C)c1ccc(cc1)[C@H]1C[C@]2(C)[C@@H](CC[C@]2(O)CCCO)[C@@H]2CCC3=CC(=O)CCC3=C12
Show InChI InChI=1S/C29H39NO3/c1-28-18-25(19-5-8-21(9-6-19)30(2)3)27-23-12-10-22(32)17-20(23)7-11-24(27)26(28)13-15-29(28,33)14-4-16-31/h5-6,8-9,17,24-26,31,33H,4,7,10-16,18H2,1-3H3/t24-,25+,26-,28+,29+/m0/s1
Affinity DataKi:  18nMAssay Description:Binding affinity determined for human Progesterone receptor A isoformMore data for this Ligand-Target Pair
TargetProgesterone receptor(Homo sapiens (Human))
Ligand Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM50366558(ONAPRISTONE | ZK-98299)
Show SMILES CN(C)c1ccc(cc1)[C@H]1C[C@]2(C)[C@@H](CC[C@]2(O)CCCO)[C@@H]2CCC3=CC(=O)CCC3=C12
Show InChI InChI=1S/C29H39NO3/c1-28-18-25(19-5-8-21(9-6-19)30(2)3)27-23-12-10-22(32)17-20(23)7-11-24(27)26(28)13-15-29(28,33)14-4-16-31/h5-6,8-9,17,24-26,31,33H,4,7,10-16,18H2,1-3H3/t24-,25+,26-,28+,29+/m0/s1
Affinity DataKi:  18nMAssay Description:Binding affinity against Baculovirus-Expressed hPR-AMore data for this Ligand-Target Pair
TargetProgesterone receptor(Homo sapiens (Human))
Ligand Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM50066529(3-(2,2,4-Trimethyl-1,2-dihydro-quinolin-6-yl)-benz...)
Show SMILES CC1=CC(C)(C)Nc2ccc(cc12)-c1cccc(c1)C#N
Show InChI InChI=1S/C19H18N2/c1-13-11-19(2,3)21-18-8-7-16(10-17(13)18)15-6-4-5-14(9-15)12-20/h4-11,21H,1-3H3
Affinity DataKi:  19nMAssay Description:Binding affinity against Baculovirus-Expressed hPR-AMore data for this Ligand-Target Pair
TargetProgesterone receptor(Homo sapiens (Human))
Ligand Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM50066523(2,2,4-Trimethyl-6-(3-nitro-phenyl)-1,2-dihydro-qui...)
Show SMILES CC1=CC(C)(C)Nc2ccc(cc12)-c1cccc(c1)[N+]([O-])=O
Show InChI InChI=1S/C18H18N2O2/c1-12-11-18(2,3)19-17-8-7-14(10-16(12)17)13-5-4-6-15(9-13)20(21)22/h4-11,19H,1-3H3
Affinity DataKi:  20nMAssay Description:Binding affinity against Baculovirus-Expressed hPR-AMore data for this Ligand-Target Pair
TargetProgesterone receptor(Homo sapiens (Human))
Ligand Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM50049510(Acetic acid 5-bromo-2-((1S,6R)-4,6-dimethyl-2-meth...)
Show SMILES COc1cc(C[C@H]2[C@H](C)CC(C)=CC2=C)c(OC(C)=O)cc1Br
Show InChI InChI=1S/C19H23BrO3/c1-11-6-12(2)16(13(3)7-11)8-15-9-19(22-5)17(20)10-18(15)23-14(4)21/h6,9-10,13,16H,2,7-8H2,1,3-5H3/t13-,16-/m1/s1
Affinity DataKi:  21nMAssay Description:Binding affinity determined for human Progesterone receptor A isoformMore data for this Ligand-Target Pair
TargetProgesterone receptor(Homo sapiens (Human))
Ligand Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM50071993(6,9-Difluoro-1,3,3-trimethyl-4,11-dihydro-3H-inden...)
Show SMILES CC1=CC(C)(C)Nc2cc(F)c-3c(Cc4cc(F)ccc-34)c12
Show InChI InChI=1S/C19H17F2N/c1-10-9-19(2,3)22-16-8-15(21)18-13-5-4-12(20)6-11(13)7-14(18)17(10)16/h4-6,8-9,22H,7H2,1-3H3
Affinity DataKi:  21nMAssay Description:Binding affinity against human progesterone receptor-A (hPR-A)More data for this Ligand-Target Pair
TargetProgesterone receptor(Homo sapiens (Human))
Ligand Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM50049508(5-Bromo-4-methoxy-2-((1S,4R)-2,2,4-trimethyl-6-met...)
Show SMILES COc1cc(C[C@@H]2C(=C)C[C@H](C)CC2(C)C)c(O)cc1Br
Show InChI InChI=1S/C18H25BrO2/c1-11-6-12(2)14(18(3,4)10-11)7-13-8-17(21-5)15(19)9-16(13)20/h8-9,11,14,20H,2,6-7,10H2,1,3-5H3/t11-,14+/m0/s1
Affinity DataKi:  22nMAssay Description:Binding affinity determined for human Progesterone receptor A isoformMore data for this Ligand-Target Pair
TargetProgesterone receptor(Homo sapiens (Human))
Ligand Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM50072004(8-bromo-2,2,4-trimethyl-2,10-dihydro-1H-indeno[1,2...)
Show SMILES CC1=CC(C)(C)Nc2cc3Cc4cc(Br)ccc4-c3cc12
Show InChI InChI=1S/C19H18BrN/c1-11-10-19(2,3)21-18-8-13-6-12-7-14(20)4-5-15(12)17(13)9-16(11)18/h4-5,7-10,21H,6H2,1-3H3
Affinity DataKi:  24nMAssay Description:Antagonist activity against human progesterone receptor B (hPR-B) in cotransfected CV-1 cellsMore data for this Ligand-Target Pair
TargetProgesterone receptor(Homo sapiens (Human))
Ligand Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM50072013(6,8-Difluoro-2,2,4-trimethyl-2,10-dihydro-1H-inden...)
Show SMILES CC1=CC(C)(C)Nc2cc3C(O)c4cc(F)cc(F)c4-c3cc12
Show InChI InChI=1S/C19H17F2NO/c1-9-8-19(2,3)22-16-7-13-12(6-11(9)16)17-14(18(13)23)4-10(20)5-15(17)21/h4-8,18,22-23H,1-3H3
Affinity DataKi:  26nMAssay Description:Antagonist activity against human progesterone receptor B (hPR-B) in cotransfected CV-1 cellsMore data for this Ligand-Target Pair
TargetProgesterone receptor(Homo sapiens (Human))
Ligand Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM50071992(6-Fluoro-2,2,4-trimethyl-1,2-dihydro-indeno[1,2-g]...)
Show SMILES CC1=CC(C)(C)Nc2cc3C(=O)c4cccc(F)c4-c3cc12
Show InChI InChI=1S/C19H16FNO/c1-10-9-19(2,3)21-16-8-14-13(7-12(10)16)17-11(18(14)22)5-4-6-15(17)20/h4-9,21H,1-3H3
Affinity DataKi:  29nMAssay Description:Binding affinity against human progesterone receptor-A (hPR-A)More data for this Ligand-Target Pair
TargetProgesterone receptor(Homo sapiens (Human))
Ligand Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM50072008(8-chloro-2,2,4-trimethyl-2,10-dihydro-1H-indeno[1,...)
Show SMILES CC1=CC(C)(C)Nc2cc3Cc4cc(Cl)ccc4-c3cc12
Show InChI InChI=1S/C19H18ClN/c1-11-10-19(2,3)21-18-8-13-6-12-7-14(20)4-5-15(12)17(13)9-16(11)18/h4-5,7-10,21H,6H2,1-3H3
Affinity DataKi:  29nMAssay Description:Binding affinity against human progesterone receptor-A (hPR-A)More data for this Ligand-Target Pair
TargetProgesterone receptor(Homo sapiens (Human))
Ligand Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM50049505(2-Methyl-1-nitro-4-(4,6,6-trimethyl-2-methylene-cy...)
Show SMILES CC1=CC(=C)C(Cc2ccc(c(C)c2)[N+]([O-])=O)C(C)(C)C1
Show InChI InChI=1S/C18H23NO2/c1-12-8-13(2)16(18(4,5)11-12)10-15-6-7-17(19(20)21)14(3)9-15/h6-9,16H,2,10-11H2,1,3-5H3
Affinity DataKi:  29nMAssay Description:Binding affinity determined for human Progesterone receptor A isoformMore data for this Ligand-Target Pair
TargetGlucocorticoid receptor(Homo sapiens (Human))
Ligand Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM8903((1S,2R,10S,11S,14S,15S)-14-acetyl-2,15-dimethyltet...)
Show SMILES CC(=O)[C@H]1CC[C@H]2[C@@H]3CCC4=CC(=O)CC[C@]4(C)[C@H]3CC[C@]12C
Show InChI InChI=1S/C21H30O2/c1-13(22)17-6-7-18-16-5-4-14-12-15(23)8-10-20(14,2)19(16)9-11-21(17,18)3/h12,16-19H,4-11H2,1-3H3/t16-,17+,18-,19-,20-,21+/m0/s1
Affinity DataKi:  31nMAssay Description:Binding affinity was determined for human glucocorticoid receptor(hGR).More data for this Ligand-Target Pair
TargetProgesterone receptor(Homo sapiens (Human))
Ligand Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM50049503(5-Bromo-4-methoxy-2-(4,6,6-trimethyl-2-methylene-c...)
Show SMILES COc1cc(CC2C(=C)C=C(C)CC2(C)C)c(O)cc1Br
Show InChI InChI=1S/C18H23BrO2/c1-11-6-12(2)14(18(3,4)10-11)7-13-8-17(21-5)15(19)9-16(13)20/h6,8-9,14,20H,2,7,10H2,1,3-5H3
Affinity DataKi:  31nMAssay Description:Binding affinity determined for human Progesterone receptor A isoformMore data for this Ligand-Target Pair
TargetProgesterone receptor(Homo sapiens (Human))
Ligand Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM50049512(5-Bromo-2-((S)-2,2-dimethyl-6-methylene-cyclohexyl...)
Show SMILES COc1cc(C[C@@H]2C(=C)CCCC2(C)C)c(O)cc1Br
Show InChI InChI=1S/C17H23BrO2/c1-11-6-5-7-17(2,3)13(11)8-12-9-16(20-4)14(18)10-15(12)19/h9-10,13,19H,1,5-8H2,2-4H3/t13-/m1/s1
Affinity DataKi:  34nMAssay Description:Binding affinity determined for human Progesterone receptor A isoformMore data for this Ligand-Target Pair
TargetGlucocorticoid receptor(Homo sapiens (Human))
Ligand Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM50366558(ONAPRISTONE | ZK-98299)
Show SMILES CN(C)c1ccc(cc1)[C@H]1C[C@]2(C)[C@@H](CC[C@]2(O)CCCO)[C@@H]2CCC3=CC(=O)CCC3=C12
Show InChI InChI=1S/C29H39NO3/c1-28-18-25(19-5-8-21(9-6-19)30(2)3)27-23-12-10-22(32)17-20(23)7-11-24(27)26(28)13-15-29(28,33)14-4-16-31/h5-6,8-9,17,24-26,31,33H,4,7,10-16,18H2,1-3H3/t24-,25+,26-,28+,29+/m0/s1
Affinity DataKi:  42nMAssay Description:Binding affinity was determined for human glucocorticoid receptor(hGR).More data for this Ligand-Target Pair
TargetProgesterone receptor(Homo sapiens (Human))
Ligand Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM50072015(5-Chloro-2,2,4-trimethyl-2,10-dihydro-1H-indeno[1,...)
Show SMILES CC1=CC(C)(C)Nc2cc3C(O)c4ccccc4-c3c(Cl)c12
Show InChI InChI=1S/C19H18ClNO/c1-10-9-19(2,3)21-14-8-13-16(17(20)15(10)14)11-6-4-5-7-12(11)18(13)22/h4-9,18,21-22H,1-3H3
Affinity DataKi:  53nMAssay Description:Binding affinity against human progesterone receptor-A (hPR-A)More data for this Ligand-Target Pair
TargetProgesterone receptor(Homo sapiens (Human))
Ligand Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM50049486(1-Nitro-4-(4,6,6-trimethyl-2-methylene-cyclohex-3-...)
Show SMILES CC1=CC(=C)C(Cc2ccc(cc2)[N+]([O-])=O)C(C)(C)C1
Show InChI InChI=1S/C17H21NO2/c1-12-9-13(2)16(17(3,4)11-12)10-14-5-7-15(8-6-14)18(19)20/h5-9,16H,2,10-11H2,1,3-4H3
Affinity DataKi:  54nMAssay Description:Binding affinity determined for human Progesterone receptor A isoformMore data for this Ligand-Target Pair
TargetProgesterone receptor(Homo sapiens (Human))
Ligand Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM50071996(1,3,3-Trimethyl-9-nitro-4,11-dihydro-3H-indeno[2,1...)
Show SMILES CC1=CC(C)(C)Nc2ccc-3c(Cc4cc(ccc-34)[N+]([O-])=O)c12
Show InChI InChI=1S/C19H18N2O2/c1-11-10-19(2,3)20-17-7-6-15-14-5-4-13(21(22)23)8-12(14)9-16(15)18(11)17/h4-8,10,20H,9H2,1-3H3
Affinity DataKi:  57nMAssay Description:Antagonist activity against human progesterone receptor B (hPR-B) in cotransfected CV-1 cellsMore data for this Ligand-Target Pair
TargetProgesterone receptor(Homo sapiens (Human))
Ligand Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM50049490(Acetic acid 5-bromo-4-methoxy-2-(4,6,6-trimethyl-2...)
Show SMILES COc1cc(CC2C(=C)C=C(C)CC2(C)C)c(OC(C)=O)cc1Br
Show InChI InChI=1S/C20H25BrO3/c1-12-7-13(2)16(20(4,5)11-12)8-15-9-19(23-6)17(21)10-18(15)24-14(3)22/h7,9-10,16H,2,8,11H2,1,3-6H3
Affinity DataKi:  60nMAssay Description:Binding affinity determined for human Progesterone receptor A isoformMore data for this Ligand-Target Pair
TargetProgesterone receptor(Homo sapiens (Human))
Ligand Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM50071999(CHEMBL327934 | Trifluoro-acetic acid 5,8-difluoro-...)
Show SMILES CC1=CC(C)(C)Nc2cc3C(OC(=O)C(F)(F)F)c4cc(F)ccc4-c3c(F)c12
Show InChI InChI=1S/C21H16F5NO2/c1-9-8-20(2,3)27-14-7-13-16(17(23)15(9)14)11-5-4-10(22)6-12(11)18(13)29-19(28)21(24,25)26/h4-8,18,27H,1-3H3
Affinity DataKi:  63nMAssay Description:Binding affinity against human progesterone receptor-A (hPR-A)More data for this Ligand-Target Pair
TargetLethal factor(Bacillus anthracis)
Hawaii Biotech Inc.

LigandPNGBDBM8525(4-{[(1S,2R,4S,5R)-2,4-bis(carbamimidamidomethyl)-5...)
Show SMILES NC(N)=NC[C@H]1C[C@@H](CN=C(N)N)[C@@H](C[C@@H]1Oc1ccc(cc1N=C(N)N)N=C(N)N)Oc1ccc(cc1N=C(N)N)N=C(N)N
Show InChI InChI=1S/C26H42N18O2/c27-21(28)39-9-11-5-12(10-40-22(29)30)20(46-18-4-2-14(42-24(33)34)7-16(18)44-26(37)38)8-19(11)45-17-3-1-13(41-23(31)32)6-15(17)43-25(35)36/h1-4,6-7,11-12,19-20H,5,8-10H2,(H4,27,28,39)(H4,29,30,40)(H4,31,32,41)(H4,33,34,42)(H4,35,36,43)(H4,37,38,44)/t11-,12+,19+,20-
Affinity DataKi:  65nM ΔG°:  -40.6kJ/molepH: 7.4 T: 2°CAssay Description:The enzymatic reaction started by the addition fluorogenic peptide substrate, MAPKKide to the buffer containing LF and inhibitor compound. Cleavage o...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetProgesterone receptor(Homo sapiens (Human))
Ligand Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM50049511(5-Bromo-4-methoxy-2-((1S,2R)-2-methyl-6-methylene-...)
Show SMILES COc1cc(C[C@H]2[C@H](C)CCCC2=C)c(O)cc1Br
Show InChI InChI=1S/C16H21BrO2/c1-10-5-4-6-11(2)13(10)7-12-8-16(19-3)14(17)9-15(12)18/h8-9,11,13,18H,1,4-7H2,2-3H3/t11-,13-/m1/s1
Affinity DataKi:  69nMAssay Description:Binding affinity determined for human Progesterone receptor A isoformMore data for this Ligand-Target Pair
TargetProgesterone receptor(Homo sapiens (Human))
Ligand Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM50049513(5-Bromo-4-methoxy-2-((1R,2S)-2-methyl-6-methylene-...)
Show SMILES COc1cc(C[C@@H]2[C@@H](C)CCCC2=C)c(O)cc1Br
Show InChI InChI=1S/C16H21BrO2/c1-10-5-4-6-11(2)13(10)7-12-8-16(19-3)14(17)9-15(12)18/h8-9,11,13,18H,1,4-7H2,2-3H3/t11-,13-/m0/s1
Affinity DataKi:  71nMAssay Description:Binding affinity determined for human Progesterone receptor A isoformMore data for this Ligand-Target Pair
TargetProgesterone receptor(Homo sapiens (Human))
Ligand Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM50072011(11-butyl-1,3,3-trimethyl-4,11-dihydro-3H-pyrido[3,...)
Show SMILES CCCCn1c2ccccc2c2ccc3NC(C)(C)C=C(C)c3c12
Show InChI InChI=1S/C22H26N2/c1-5-6-13-24-19-10-8-7-9-16(19)17-11-12-18-20(21(17)24)15(2)14-22(3,4)23-18/h7-12,14,23H,5-6,13H2,1-4H3
Affinity DataKi:  77nMAssay Description:Antagonist activity against human progesterone receptor B (hPR-B) in cotransfected CV-1 cellsMore data for this Ligand-Target Pair
TargetProgesterone receptor(Homo sapiens (Human))
Ligand Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM50072016(1,3,3-Trimethyl-3,4-dihydro-benzo[4,5]furo[2,3-f]q...)
Show SMILES CC1=CC(C)(C)Nc2ccc3c4ccccc4oc3c12
Show InChI InChI=1S/C18H17NO/c1-11-10-18(2,3)19-14-9-8-13-12-6-4-5-7-15(12)20-17(13)16(11)14/h4-10,19H,1-3H3
Affinity DataKi:  77nMAssay Description:Binding affinity against human progesterone receptor-A (hPR-A)More data for this Ligand-Target Pair
TargetProgesterone receptor(Homo sapiens (Human))
Ligand Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM50049493(5-Bromo-2-(2,2-dimethyl-6-methylene-cyclohexylmeth...)
Show SMILES COc1cc(CC2C(=C)CCCC2(C)C)c(O)cc1Br
Show InChI InChI=1S/C17H23BrO2/c1-11-6-5-7-17(2,3)13(11)8-12-9-16(20-4)14(18)10-15(12)19/h9-10,13,19H,1,5-8H2,2-4H3
Affinity DataKi:  77nMAssay Description:Binding affinity determined for human Progesterone receptor A isoformMore data for this Ligand-Target Pair
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