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TargetPeroxisome proliferator-activated receptor gamma(Human)
Suez Canal University

Curated by ChEMBL
LigandPNGBDBM50030474(US9562012, rosiglitazone | CHEBI:50122 | Avandamet...)
Affinity DataEC50:  240nMAssay Description:Transactivation of recombinant human N-terminal GAL4-DBD fused PPARgamma LBD expressed in reporter cells measured after 24 hrs by luciferase reporter...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/26/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetPeroxisome proliferator-activated receptor gamma(Human)
Suez Canal University

Curated by ChEMBL
LigandPNGBDBM50271610(CHEMBL418695)
Affinity DataEC50:  3.94E+3nMAssay Description:Transactivation of recombinant human N-terminal GAL4-DBD fused PPARgamma LBD expressed in reporter cells measured after 24 hrs by luciferase reporter...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/26/2020
Entry Details Article
PubMed
TargetPeroxisome proliferator-activated receptor gamma(Human)
Suez Canal University

Curated by ChEMBL
LigandPNGBDBM50271611(CHEMBL4125720)
Affinity DataEC50:  4.51E+3nMAssay Description:Transactivation of recombinant human N-terminal GAL4-DBD fused PPARgamma LBD expressed in reporter cells measured after 24 hrs by luciferase reporter...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/26/2020
Entry Details Article
PubMed
TargetPeroxisome proliferator-activated receptor gamma(Human)
Suez Canal University

Curated by ChEMBL
LigandPNGBDBM50271612(CHEMBL4127761)
Affinity DataEC50:  2.32E+3nMAssay Description:Transactivation of recombinant human N-terminal GAL4-DBD fused PPARgamma LBD expressed in reporter cells measured after 24 hrs by luciferase reporter...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/26/2020
Entry Details Article
PubMed
TargetFree fatty acid receptor 1(Human)
Suez Canal University

Curated by ChEMBL
LigandPNGBDBM50271613(CHEMBL4127972)
Affinity DataEC50:  2.13E+4nMAssay Description:Transactivation of recombinant human FFAR1 expressed in CHOK1 cells co-expressing Galpha15 assessed as increase in calcium flux measured after 20 sec...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/26/2020
Entry Details Article
PubMed
TargetFree fatty acid receptor 1(Human)
Suez Canal University

Curated by ChEMBL
LigandPNGBDBM50271614(CHEMBL4126802)
Affinity DataEC50:  1.78E+4nMAssay Description:Transactivation of recombinant human FFAR1 expressed in CHOK1 cells co-expressing Galpha15 assessed as increase in calcium flux measured after 20 sec...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/26/2020
Entry Details Article
PubMed
TargetFree fatty acid receptor 1(Human)
Suez Canal University

Curated by ChEMBL
LigandPNGBDBM50271615(CHEMBL4130213)
Affinity DataEC50:  1.13E+4nMAssay Description:Transactivation of recombinant human FFAR1 expressed in CHOK1 cells co-expressing Galpha15 assessed as increase in calcium flux measured after 20 sec...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/26/2020
Entry Details Article
PubMed
TargetFree fatty acid receptor 1(Human)
Suez Canal University

Curated by ChEMBL
LigandPNGBDBM50271610(CHEMBL418695)
Affinity DataEC50:  2.19E+3nMAssay Description:Transactivation of recombinant human FFAR1 expressed in CHOK1 cells co-expressing Galpha15 assessed as increase in calcium flux measured after 20 sec...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/26/2020
Entry Details Article
PubMed
TargetFree fatty acid receptor 1(Human)
Suez Canal University

Curated by ChEMBL
LigandPNGBDBM50271611(CHEMBL4125720)
Affinity DataEC50:  5.06E+3nMAssay Description:Transactivation of recombinant human FFAR1 expressed in CHOK1 cells co-expressing Galpha15 assessed as increase in calcium flux measured after 20 sec...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/26/2020
Entry Details Article
PubMed
TargetFree fatty acid receptor 1(Human)
Suez Canal University

Curated by ChEMBL
LigandPNGBDBM50271612(CHEMBL4127761)
Affinity DataEC50:  4.31E+3nMAssay Description:Transactivation of recombinant human FFAR1 expressed in CHOK1 cells co-expressing Galpha15 assessed as increase in calcium flux measured after 20 sec...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/26/2020
Entry Details Article
PubMed
TargetFree fatty acid receptor 1(Human)
Suez Canal University

Curated by ChEMBL
LigandPNGBDBM50271616(CHEMBL4127920)
Affinity DataEC50:  240nMAssay Description:Transactivation of recombinant human FFAR1 expressed in CHOK1 cells co-expressing Galpha15 assessed as increase in calcium flux measured after 20 sec...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/26/2020
Entry Details Article
PubMed
TargetFree fatty acid receptor 1(Human)
Suez Canal University

Curated by ChEMBL
LigandPNGBDBM50145471(US8637558, 116 | CHEMBL316370 | 5-(4-Benzyloxy-ben...)
Affinity DataEC50:  6.56E+3nMAssay Description:Agonist activity at human FFAR1 expressed in CHO-K1 cells assessed as calcium flux measured for 100 secs by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/8/2017
Entry Details Article
PubMed
TargetFree fatty acid receptor 1(Human)
Suez Canal University

Curated by ChEMBL
LigandPNGBDBM50143015(CHEMBL3758549)
Affinity DataEC50:  3.57E+3nMAssay Description:Agonist activity at human FFAR1 expressed in CHO-K1 cells assessed as calcium flux measured for 100 secs by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/8/2017
Entry Details Article
PubMed
TargetFree fatty acid receptor 1(Human)
Suez Canal University

Curated by ChEMBL
LigandPNGBDBM50143016(CHEMBL3759133)
Affinity DataEC50:  2.31E+4nMAssay Description:Agonist activity at human FFAR1 expressed in CHO-K1 cells assessed as calcium flux measured for 100 secs by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/8/2017
Entry Details Article
PubMed
TargetFree fatty acid receptor 1(Human)
Suez Canal University

Curated by ChEMBL
LigandPNGBDBM50143017(CHEMBL3759467)
Affinity DataEC50:  9.91E+3nMAssay Description:Agonist activity at human FFAR1 expressed in CHO-K1 cells assessed as calcium flux measured for 100 secs by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/8/2017
Entry Details Article
PubMed
TargetFree fatty acid receptor 1(Human)
Suez Canal University

Curated by ChEMBL
LigandPNGBDBM50143020(CHEMBL3759922)
Affinity DataEC50:  7.73E+3nMAssay Description:Agonist activity at human FFAR1 expressed in CHO-K1 cells assessed as calcium flux measured for 100 secs by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/8/2017
Entry Details Article
PubMed
TargetFree fatty acid receptor 1(Human)
Suez Canal University

Curated by ChEMBL
LigandPNGBDBM50143022(CHEMBL3759212)
Affinity DataEC50:  1.15E+3nMAssay Description:Agonist activity at human FFAR1 expressed in CHO-K1 cells assessed as calcium flux measured for 100 secs by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/8/2017
Entry Details Article
PubMed
TargetFree fatty acid receptor 1(Human)
Suez Canal University

Curated by ChEMBL
LigandPNGBDBM50143023(CHEMBL3758553)
Affinity DataEC50:  6.11E+3nMAssay Description:Agonist activity at human FFAR1 expressed in CHO-K1 cells assessed as calcium flux measured for 100 secs by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/8/2017
Entry Details Article
PubMed
TargetFree fatty acid receptor 1(Human)
Suez Canal University

Curated by ChEMBL
LigandPNGBDBM50143024(CHEMBL3759866)
Affinity DataEC50:  1.96E+4nMAssay Description:Agonist activity at human FFAR1 expressed in CHO-K1 cells assessed as calcium flux measured for 100 secs by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/8/2017
Entry Details Article
PubMed
TargetFree fatty acid receptor 1(Human)
Suez Canal University

Curated by ChEMBL
LigandPNGBDBM50143030(CHEMBL3759746)
Affinity DataEC50:  7.42E+3nMAssay Description:Agonist activity at human FFAR1 expressed in CHO-K1 cells assessed as calcium flux measured for 100 secs by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/8/2017
Entry Details Article
PubMed
TargetFree fatty acid receptor 1(Human)
Suez Canal University

Curated by ChEMBL
LigandPNGBDBM50143041(CHEMBL3759913)
Affinity DataEC50:  8.51E+3nMAssay Description:Agonist activity at human FFAR1 expressed in CHO-K1 cells assessed as calcium flux measured for 100 secs by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/8/2017
Entry Details Article
PubMed
TargetFree fatty acid receptor 1(Human)
Suez Canal University

Curated by ChEMBL
LigandPNGBDBM50143042(CHEMBL3758719)
Affinity DataEC50:  1.66E+3nMAssay Description:Agonist activity at human FFAR1 expressed in CHO-K1 cells assessed as calcium flux measured for 100 secs by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/8/2017
Entry Details Article
PubMed
TargetFree fatty acid receptor 1(Human)
Suez Canal University

Curated by ChEMBL
LigandPNGBDBM50143043(CHEMBL3758919)
Affinity DataEC50:  4.11E+3nMAssay Description:Agonist activity at human FFAR1 expressed in CHO-K1 cells assessed as calcium flux measured for 100 secs by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/8/2017
Entry Details Article
PubMed
TargetFree fatty acid receptor 1(Human)
Suez Canal University

Curated by ChEMBL
LigandPNGBDBM50143044(CHEMBL3758197)
Affinity DataEC50:  1.89E+3nMAssay Description:Agonist activity at human FFAR1 expressed in CHO-K1 cells assessed as calcium flux measured for 100 secs by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/8/2017
Entry Details Article
PubMed
TargetFree fatty acid receptor 1(Human)
Suez Canal University

Curated by ChEMBL
LigandPNGBDBM50143045(CHEMBL3758885)
Affinity DataEC50:  2.10E+4nMAssay Description:Agonist activity at human FFAR1 expressed in CHO-K1 cells assessed as calcium flux measured for 100 secs by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/8/2017
Entry Details Article
PubMed
TargetFree fatty acid receptor 1(Human)
Suez Canal University

Curated by ChEMBL
LigandPNGBDBM50143046(CHEMBL3759448)
Affinity DataEC50:  1.66E+4nMAssay Description:Agonist activity at human FFAR1 expressed in CHO-K1 cells assessed as calcium flux measured for 100 secs by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/8/2017
Entry Details Article
PubMed
TargetFree fatty acid receptor 1(Human)
Suez Canal University

Curated by ChEMBL
LigandPNGBDBM50269532((6Z,9Z,12Z)-octadeca-6,9,12-trienoic acid | gamma-...)
Affinity DataEC50:  4.62E+3nMAssay Description:Agonist activity at human FFAR1 expressed in CHO-K1 cells assessed as calcium flux measured for 100 secs by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/8/2017
Entry Details Article
PubMed
TargetPeroxisome proliferator-activated receptor alpha(Human)
Suez Canal University

Curated by ChEMBL
LigandPNGBDBM50030474(US9562012, rosiglitazone | CHEBI:50122 | Avandamet...)
Affinity DataEC50:  240nMAssay Description:Transactivation of N-terminal Gal4 DNA binding domain-linked human PPARalpha ligand binding domain after 24 hrs by luciferase reporter gene assay rel...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/8/2017
Entry Details Article
PubMed
TargetPeroxisome proliferator-activated receptor alpha(Human)
Suez Canal University

Curated by ChEMBL
LigandPNGBDBM50143015(CHEMBL3758549)
Affinity DataEC50:  2.52E+4nMAssay Description:Transactivation of N-terminal Gal4 DNA binding domain-linked human PPARalpha ligand binding domain after 24 hrs by luciferase reporter gene assay rel...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/8/2017
Entry Details Article
PubMed
TargetPeroxisome proliferator-activated receptor alpha(Human)
Suez Canal University

Curated by ChEMBL
LigandPNGBDBM50143016(CHEMBL3759133)
Affinity DataEC50:  1.70E+4nMAssay Description:Transactivation of N-terminal Gal4 DNA binding domain-linked human PPARalpha ligand binding domain after 24 hrs by luciferase reporter gene assay rel...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/8/2017
Entry Details Article
PubMed
TargetPeroxisome proliferator-activated receptor alpha(Human)
Suez Canal University

Curated by ChEMBL
LigandPNGBDBM50143043(CHEMBL3758919)
Affinity DataEC50:  3.02E+4nMAssay Description:Transactivation of N-terminal Gal4 DNA binding domain-linked human PPARalpha ligand binding domain after 24 hrs by luciferase reporter gene assay rel...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/8/2017
Entry Details Article
PubMed
TargetPeroxisome proliferator-activated receptor alpha(Human)
Suez Canal University

Curated by ChEMBL
LigandPNGBDBM50143044(CHEMBL3758197)
Affinity DataEC50:  1.32E+4nMAssay Description:Transactivation of N-terminal Gal4 DNA binding domain-linked human PPARalpha ligand binding domain after 24 hrs by luciferase reporter gene assay rel...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/8/2017
Entry Details Article
PubMed
TargetPeroxisome proliferator-activated receptor alpha(Human)
Suez Canal University

Curated by ChEMBL
LigandPNGBDBM50143045(CHEMBL3758885)
Affinity DataEC50:  4.93E+3nMAssay Description:Transactivation of N-terminal Gal4 DNA binding domain-linked human PPARalpha ligand binding domain after 24 hrs by luciferase reporter gene assay rel...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/8/2017
Entry Details Article
PubMed
TargetPeroxisome proliferator-activated receptor alpha(Human)
Suez Canal University

Curated by ChEMBL
LigandPNGBDBM50143046(CHEMBL3759448)
Affinity DataEC50:  2.54E+4nMAssay Description:Transactivation of N-terminal Gal4 DNA binding domain-linked human PPARalpha ligand binding domain after 24 hrs by luciferase reporter gene assay rel...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/8/2017
Entry Details Article
PubMed
TargetFree fatty acid receptor 1(Human)
Suez Canal University

Curated by ChEMBL
LigandPNGBDBM50306393(5-(4-(4-fluorophenoxy)benzyl)thiazolidine-2,4-dion...)
Affinity DataEC50:  500nMAssay Description:Partial agonist activity at human GPR40 expressed in CHO cells assessed as fatty acid-induced calcium mobilization by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/8/2017
Entry Details Article
PubMed
TargetCytochrome P450 26A1(Human)
Cardiff University

Curated by ChEMBL
LigandPNGBDBM50353578(CHEMBL1831092)
Affinity DataIC50: 0.300nMAssay Description:Inhibition of CYP26 in human liver microsomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
TargetCytochrome P450 26A1(Human)
Cardiff University

Curated by ChEMBL
LigandPNGBDBM50353578(CHEMBL1831092)
Affinity DataIC50: 0.350nMAssay Description:Inhibition of human CYP26A1 assessed using [11,12-3H]ATRA as substrate by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
TargetCytochrome P450 26A1(Human)
Cardiff University

Curated by ChEMBL
LigandPNGBDBM50353582(CHEMBL1831083)
Affinity DataIC50: 0.350nMAssay Description:Inhibition of human CYP26A1 assessed using [11,12-3H]ATRA as substrate by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
TargetCytochrome P450 26A1(Human)
Cardiff University

Curated by ChEMBL
LigandPNGBDBM50342128(3-Imidazol-1-yl-2-methyl-3-[4-(naphthalen-2-ylamin...)
Affinity DataIC50: 3nMAssay Description:Inhibition of CYP26A1 in human MCF7 cell microsomes using [3H]ATRA after 1 hr by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetCytochrome P450 26A1(Human)
Cardiff University

Curated by ChEMBL
LigandPNGBDBM50342130(3-[4-(6-Hydroxy-naphthalen-2-ylamino)-phenyl]-3-im...)
Affinity DataIC50: 3nMAssay Description:Inhibition of CYP26A1 in human MCF7 cell microsomes using [3H]ATRA after 1 hr by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetCytochrome P450 26A1(Human)
Cardiff University

Curated by ChEMBL
LigandPNGBDBM50342128(3-Imidazol-1-yl-2-methyl-3-[4-(naphthalen-2-ylamin...)
Affinity DataIC50: 3nMAssay Description:Inhibition of CYP26 in human liver microsomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
TargetCytochrome P450 26A1(Human)
Cardiff University

Curated by ChEMBL
LigandPNGBDBM50342128(3-Imidazol-1-yl-2-methyl-3-[4-(naphthalen-2-ylamin...)
Affinity DataIC50: 3nMAssay Description:Inhibition of human CYP26A1 assessed using [11,12-3H]ATRA as substrate by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
TargetCytochrome P450 26A1(Human)
Cardiff University

Curated by ChEMBL
LigandPNGBDBM50377963(R-115866 | CHEMBL224305)
Affinity DataIC50: 5nMAssay Description:Inhibition of CYP26A1 in human MCF7 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2012
Entry Details Article
PubMed
TargetCytochrome P450 26A1(Human)
Cardiff University

Curated by ChEMBL
LigandPNGBDBM50391726(CHEMBL2146987)
Affinity DataIC50: 5.70nMAssay Description:Inhibition of CYP26A1-mediated retinoic acid metabolism in human MCF7 cell microsomes using [3H]ATRA as substrate after 1 hr by scintillation countin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetCytochrome P450 26A1(Human)
Cardiff University

Curated by ChEMBL
LigandPNGBDBM50342143(3-Imidazol-1-yl-2,2-dimethyl-3-[4-(naphthalen-1-yl...)
Affinity DataIC50: 6nMAssay Description:Inhibition of CYP26A1 in human MCF7 cell microsomes using [3H]ATRA after 1 hr by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetCytochrome P450 26A1(Human)
Cardiff University

Curated by ChEMBL
LigandPNGBDBM50391728(CHEMBL2147090)
Affinity DataIC50: 6.70nMAssay Description:Inhibition of CYP26A1-mediated retinoic acid metabolism in human MCF7 cell microsomes using [3H]ATRA as substrate after 1 hr by scintillation countin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
Target1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial(Human)
Cardiff University

Curated by ChEMBL
LigandPNGBDBM50370925(CHEMBL1627233)
Affinity DataIC50: 7.40nMAssay Description:Inhibition of human CYP24A1 expressed in chinese hamster V79 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/31/2012
Entry Details Article
PubMed
TargetCytochrome P450 26A1(Human)
Cardiff University

Curated by ChEMBL
LigandPNGBDBM50342129(3-Imidazol-1-yl-3-[4-(6-methoxy-naphthalen-2-ylami...)
Affinity DataIC50: 8nMAssay Description:Inhibition of CYP26A1 in human MCF7 cell microsomes using [3H]ATRA after 1 hr by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetCytochrome P450 26A1(Human)
Cardiff University

Curated by ChEMBL
LigandPNGBDBM50342141(3-[4-(Benzo[1,3]dioxol-5-ylamino)-phenyl]-3-imidaz...)
Affinity DataIC50: 8nMAssay Description:Inhibition of CYP26A1 in human MCF7 cell microsomes using [3H]ATRA after 1 hr by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetCytochrome P450 26A1(Human)
Cardiff University

Curated by ChEMBL
LigandPNGBDBM50342141(3-[4-(Benzo[1,3]dioxol-5-ylamino)-phenyl]-3-imidaz...)
Affinity DataIC50: 8nMAssay Description:Inhibition of CYP26A1-mediated retinoic acid metabolism in human MCF7 cell microsomes using [3H]ATRA as substrate after 1 hr by scintillation countin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
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