Compile Data Set for Download or QSAR
Report error Found 1869 with Last Name = 'graham' and Initial = 'sl'
LigandPNGBDBM50460861(CHEMBL4229237)
Affinity DataEC50: >3.00E+4nMAssay Description:Activation of PXR (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
LigandPNGBDBM50460866(CHEMBL4226706)
Affinity DataEC50:  2.00E+3nMAssay Description:Activation of PXR (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
LigandPNGBDBM50115923(4-[3-(4-Cyano-benzyl)-2-methyl-3H-imidazol-4-ylmet...)
Affinity DataEC50:  680nMAssay Description:Inhibition of geranylgeranylation of C-terminal CAAX sequence of Rap 1a in PSN-1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50115911(4-[3-(4-Cyano-benzyl)-3H-imidazol-4-ylmethyl]-pipe...)
Affinity DataEC50:  71nMAssay Description:Inhibition of geranylgeranylation of the C-terminal CAAX sequence of Rap 1a in PSN-1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50130378(4-[1-Amino-1-(3-methyl-3H-imidazol-4-yl)-ethyl]-2-...)
Affinity DataEC50:  220nMAssay Description:Inhibition of Rap1a protein geranylgeranylation in human PSN1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
LigandPNGBDBM50460865(CHEMBL2324351)
Affinity DataEC50:  6.00E+3nMAssay Description:Activation of PXR (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
LigandPNGBDBM50130372(4-[1-Amino-1-(3-methyl-3H-imidazol-4-yl)-ethyl]-2-...)
Affinity DataEC50:  1.5nMAssay Description:Inhibition of hDJ2 protein farnesylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
LigandPNGBDBM50098002(N-Isopropyl-2-(1-methyl-2-phenyl-1H-indol-3-yl)-N-...)
Affinity DataEC50: >3.00E+4nMAssay Description:Inhibition of K-Ras farnesylation in PSN-1 cells without GGT1More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/5/2012
Entry Details Article
PubMed
LigandPNGBDBM50098002(N-Isopropyl-2-(1-methyl-2-phenyl-1H-indol-3-yl)-N-...)
Affinity DataEC50:  1.80E+3nMAssay Description:Inhibition of K-Ras farnesylation in PSN-1 cells with 100 nM GGT1More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/5/2012
Entry Details Article
PubMed
LigandPNGBDBM50130374(4-[1-Amino-1-(3-methyl-3H-imidazol-4-yl)-ethyl]-2-...)
Affinity DataEC50: >1.00E+3nMAssay Description:Inhibition of Rap1a protein geranylgeranylation in human PSN1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
LigandPNGBDBM50115916(4-[3-(4-Cyano-benzyl)-3H-imidazol-4-ylmethyl]-pipe...)
Affinity DataEC50:  18nMAssay Description:Inhibition of geranylgeranylation of the C-terminal CAAX sequence of Rap 1a in PSN-1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50130365(4-[1-Amino-1-(3-methyl-3H-imidazol-4-yl)-ethyl]-2-...)
Affinity DataEC50:  3.10nMAssay Description:Inhibition of hDJ2 protein farnesylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
LigandPNGBDBM50098002(N-Isopropyl-2-(1-methyl-2-phenyl-1H-indol-3-yl)-N-...)
Affinity DataEC50:  1.98E+3nMAssay Description:Inhibition of HDJ-2 farnesylation in PSN-1 cells at without GGT1More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/5/2012
Entry Details Article
PubMed
LigandPNGBDBM50115928(4-[3-(4-Cyano-benzyl)-3H-imidazol-4-ylmethyl]-pipe...)
Affinity DataEC50:  50nMAssay Description:Inhibition of geranylgeranylation of the C-terminal CAAX sequence of Rap 1a in PSN-1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50409707(CHEMBL2111612)
Affinity DataEC50:  720nMAssay Description:Inhibition of Rap1a protein geranylgeranylation in human PSN1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
LigandPNGBDBM50130378(4-[1-Amino-1-(3-methyl-3H-imidazol-4-yl)-ethyl]-2-...)
Affinity DataEC50:  0.900nMAssay Description:Inhibition of hDJ2 protein farnesylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
LigandPNGBDBM50409708(CHEMBL400694)
Affinity DataEC50:  3.20E+3nMAssay Description:Inhibition of Rap1a protein geranylgeranylation in human PSN1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
LigandPNGBDBM50130374(4-[1-Amino-1-(3-methyl-3H-imidazol-4-yl)-ethyl]-2-...)
Affinity DataEC50:  11nMAssay Description:Inhibition of hDJ2 protein farnesylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
LigandPNGBDBM50130368(4-[1-Amino-1-(3-methyl-3H-imidazol-4-yl)-ethyl]-2-...)
Affinity DataEC50:  26nMAssay Description:Inhibition of hDJ2 protein farnesylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
LigandPNGBDBM50130372(4-[1-Amino-1-(3-methyl-3H-imidazol-4-yl)-ethyl]-2-...)
Affinity DataEC50:  87nMAssay Description:Inhibition of Rap1a protein geranylgeranylation in human PSN1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
LigandPNGBDBM50098002(N-Isopropyl-2-(1-methyl-2-phenyl-1H-indol-3-yl)-N-...)
Affinity DataEC50:  1.33E+3nMAssay Description:Inhibition of HDJ-2 farnesylation in PSN-1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/5/2012
Entry Details Article
PubMed
LigandPNGBDBM50409709(CHEMBL439047)
Affinity DataEC50:  140nMAssay Description:Inhibition of Rap1a protein geranylgeranylation in human PSN1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
LigandPNGBDBM50098005(N-Isopropyl-2-(1-methyl-2-o-tolyl-1H-indol-3-yl)-N...)
Affinity DataEC50:  1.06E+3nMAssay Description:Inhibition of HDJ-2 farnesylation in PSN-1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/5/2012
Entry Details Article
PubMed
LigandPNGBDBM50098002(N-Isopropyl-2-(1-methyl-2-phenyl-1H-indol-3-yl)-N-...)
Affinity DataEC50:  1.00E+3nMAssay Description:Inhibition of HDJ-2 farnesylation in PSN-1 cells with 100 nM GGT1More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/5/2012
Entry Details Article
PubMed
LigandPNGBDBM50130373(4-[1-Amino-1-(3-methyl-3H-imidazol-4-yl)-ethyl]-2-...)
Affinity DataEC50:  250nMAssay Description:Inhibition of Rap1a protein geranylgeranylation in human PSN1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
LigandPNGBDBM50460862(CHEMBL4227222)
Affinity DataEC50:  1.80E+4nMAssay Description:Activation of PXR (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
LigandPNGBDBM50460864(CHEMBL4225135)
Affinity DataEC50: >3.00E+4nMAssay Description:Activation of PXR (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
LigandPNGBDBM50130368(4-[1-Amino-1-(3-methyl-3H-imidazol-4-yl)-ethyl]-2-...)
Affinity DataEC50:  3.99E+3nMAssay Description:Inhibition of Rap1a protein geranylgeranylation in human PSN1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
LigandPNGBDBM50130365(4-[1-Amino-1-(3-methyl-3H-imidazol-4-yl)-ethyl]-2-...)
Affinity DataEC50:  47nMAssay Description:Inhibition of Rap1a protein geranylgeranylation in human PSN1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
LigandPNGBDBM50143599(4-[(S)-1-Amino-1-(3-methyl-3H-imidazol-4-yl)-ethyl...)
Affinity DataEC50:  470nMAssay Description:Inhibition of Rap1a protein geranylgeranylation in human PSN1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
LigandPNGBDBM50130373(4-[1-Amino-1-(3-methyl-3H-imidazol-4-yl)-ethyl]-2-...)
Affinity DataEC50:  4nMAssay Description:Inhibition of hDJ2 protein farnesylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
LigandPNGBDBM50460860(CHEMBL4227903)
Affinity DataEC50: >3.00E+4nMAssay Description:Activation of PXR (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Merck Sharp and Dohme Research Laboratories

LigandPNGBDBM1277(tert-butyl N-[(2S,3S,5R)-5-benzyl-5-{[(1S)-1-[(2,3...)
Affinity DataIC50: 0.0500nMpH: 5.5 T: 2°CAssay Description:Sensitivity of HIV-1 protease activity to protease inhibitors was determined by a peptide substrate cleavage assay. Protease products were analyzed o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2004
Entry Details Article
PubMed
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Merck Research Laboratories

LigandPNGBDBM1051(tert-butyl N-[(2S,3S,5R)-3-hydroxy-5-{[(1S,2R)-2-h...)
Affinity DataIC50: 0.0700nMpH: 5.5 T: 2°CAssay Description:Assay of HIV protease inhibition was performed by peptide cleavage using the substrate Val-Ser-Gln-Asn-beta-naphthylalanine*Pro-Ile-Val. Products of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/13/2004
Entry Details Article
PubMed
LigandPNGBDBM50315401((R)-1-((2'-oxo-1',2',6,8-tetrahydrospiro[cyclopent...)
Affinity DataIC50: 0.0770nMAssay Description:Antagonist activity at human CLR expressed in human HEK293 cells coexpressing human RAMP1 assessed as Inhibition of CGRP-induced cAMP productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2010
Entry Details Article
PubMed
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Merck Research Laboratories

LigandPNGBDBM1053(tert-butyl N-[(2S,3S,5R)-5-{[4-(3,3-dimethoxypropy...)
Affinity DataIC50: 0.0800nMpH: 5.5 T: 2°CAssay Description:Assay of HIV protease inhibition was performed by peptide cleavage using the substrate Val-Ser-Gln-Asn-beta-naphthylalanine*Pro-Ile-Val. Products of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/13/2004
Entry Details Article
PubMed
LigandPNGBDBM50440789(CHEMBL2431248)
Affinity DataIC50: 0.0970nMAssay Description:Antagonist activity at CGRP receptor (unknown origin) by cell based cAMP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
LigandPNGBDBM50101929(3-oxo-18-oxa-2,5,9,11-tetraazahexacyclo[17.6.2.22,...)
Affinity DataIC50: 0.100nMAssay Description:Inhibition of human Farnesyltransferase -catalyzed incorporation of [3H]FPP into recombinant Ras-CVIM.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Merck Research Laboratories

LigandPNGBDBM1050(N-[2(R)-Hydroxy-1(S)-indanyl]-5(S)-[[(1,1-dimethyl...)
Affinity DataIC50: 0.100nMpH: 5.5 T: 2°CAssay Description:Assay of HIV protease inhibition was performed by peptide cleavage using the substrate Val-Ser-Gln-Asn-beta-naphthylalanine*Pro-Ile-Val. Products of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/13/2004
Entry Details Article
PubMed
TargetCalcitonin gene-related peptide type 1 receptor/Receptor activity-modifying protein 1(Human)
Department of Medicinal Chemistry Merck

Curated by ChEMBL
LigandPNGBDBM50184069(CHEMBL207197 | N-((R)-1-((S)-6-amino-1-oxo-1-(4-(p...)
Affinity DataIC50: 0.100nMAssay Description:Antagonist activity at human cloned CLR/RAMP1 receptor expressed in E10 cells measured as inhibition of CGRP-mediated cAMP productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50101929(3-oxo-18-oxa-2,5,9,11-tetraazahexacyclo[17.6.2.22,...)
Affinity DataIC50: 0.100nMAssay Description:In vitro inhibitory activity to reduce the human farnesyltransferase catalyzed incorporation of [3H]FPP into recombinant Ras-CVIMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50139186(4-allyl-23-oxo-8-oxa-1,15,17,21-tetraazapentacyclo...)
Affinity DataIC50: 0.100nMAssay Description:Inhibition of human Farnesyltransferase -catalyzed incorporation of [3H]FPP into recombinant Ras-CVIM.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50130373(4-[1-Amino-1-(3-methyl-3H-imidazol-4-yl)-ethyl]-2-...)
Affinity DataIC50: 0.120nMAssay Description:Concentration required to inhibit recombinant human farnesyltransferase (FTase) catalyzed incorporation of [3H]FPP into recombinant Ras-CVIM.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
LigandPNGBDBM50079974((S)-2-[2-({(S)-3-Methyl-2-[2-(3-naphthalen-1-ylmet...)
Affinity DataIC50: 0.120nMAssay Description:Inhibition of [3H]FPP incorporation into recombinant [Leu68]-RAS1CVIM by FarnesyltransferaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/12/2012
Entry Details Article
PubMed
LigandPNGBDBM50079961((S)-2-[2-({(S)-3-Methyl-2-[2-(3-naphthalen-2-ylmet...)
Affinity DataIC50: 0.120nMAssay Description:Inhibition of [3H]FPP incorporation into recombinant [Leu68]-RAS1CVIM by FarnesyltransferaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/12/2012
Entry Details Article
PubMed
TargetCalcitonin gene-related peptide 1(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50356282(CHEMBL1910936)
Affinity DataIC50: 0.120nMAssay Description:Inhibition of human CGRP receptor expressed in huamn HEK293 cells coexpressing CLR/RAMP1 assessed as inhibition of CGRP-stimulated cAMP production af...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/20/2012
Entry Details Article
PubMed
LigandPNGBDBM50369371(CHEMBL1790750)
Affinity DataIC50: 0.123nMAssay Description:Inhibition of [3H]FPP incorporation into recombinant human Ha-Ras by FarnesyltransferaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2012
Entry Details Article
PubMed
LigandPNGBDBM50072639((S)-2-(2-{[(S)-2-((R)-2-Amino-3-mercapto-propylami...)
Affinity DataIC50: 0.123nMAssay Description:Inhibition of [3H]- FPP incorporation into recombinant Ha-Ras by farnesyl transferase at 10 pMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/29/2012
Entry Details Article
PubMed
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Merck Research Laboratories

LigandPNGBDBM1049(tert-butyl N-[(2S,3S,5R)-3-hydroxy-5-{[(1S,2R)-2-h...)
Affinity DataIC50: 0.130nMpH: 5.5 T: 2°CAssay Description:Assay of HIV protease inhibition was performed by peptide cleavage using the substrate Val-Ser-Gln-Asn-beta-naphthylalanine*Pro-Ile-Val. Products of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/13/2004
Entry Details Article
PubMed
LigandPNGBDBM50369443(CHEMBL252953)
Affinity DataIC50: 0.150nMAssay Description:Inhibition of [3H]FPP incorporation into recombinant [Leu68]-RAS1CVIM by FarnesyltransferaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/12/2012
Entry Details Article
PubMed
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