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TargetSphingosine 1-phosphate receptor 1(Human)
Oppilan Pharma

US Patent
LigandPNGBDBM445593(US10683291, Example 1)
Affinity DataEC50: <1.00E+3nMAssay Description:S1P1 membrane is prepared from CHO-K1 Gαqi5 cells expression full-length human S1P1. Scintillation proximity assay (SPA) is performed by incubat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetSphingosine 1-phosphate receptor 1(Human)
Oppilan Pharma

US Patent
LigandPNGBDBM445594(US10683291, Example 5)
Affinity DataEC50: <1.00E+3nMAssay Description:S1P1 membrane is prepared from CHO-K1 Gαqi5 cells expression full-length human S1P1. Scintillation proximity assay (SPA) is performed by incubat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetSphingosine 1-phosphate receptor 1(Human)
Oppilan Pharma

US Patent
LigandPNGBDBM445595(US10683291, Example 6)
Affinity DataEC50: <1.00E+3nMAssay Description:S1P1 membrane is prepared from CHO-K1 Gαqi5 cells expression full-length human S1P1. Scintillation proximity assay (SPA) is performed by incubat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
US Patent

TargetDiacylglycerol O-acyltransferase 1(Mouse)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50502585(CHEMBL4446248)
Affinity DataEC50:  12nMAssay Description:Inhibition of DGAT1 in mouse C2C12 cells assessed as reduction in intracellular triglyceride production incubated for 2 hrs in presence of BSA-comple...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetDiacylglycerol O-acyltransferase 1(Mouse)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50502588(CHEMBL4439533)
Affinity DataEC50:  206nMAssay Description:Inhibition of DGAT1 in mouse C2C12 cells assessed as reduction in intracellular triglyceride production incubated for 2 hrs in presence of BSA-comple...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetDiacylglycerol O-acyltransferase 1(Mouse)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50502589(CHEMBL4540189)
Affinity DataEC50:  27nMAssay Description:Inhibition of DGAT1 in mouse C2C12 cells assessed as reduction in intracellular triglyceride production incubated for 2 hrs in presence of BSA-comple...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetDiacylglycerol O-acyltransferase 1(Mouse)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50502593(CHEMBL4578901)
Affinity DataEC50:  8nMAssay Description:Inhibition of DGAT1 in mouse C2C12 cells assessed as reduction in intracellular triglyceride production incubated for 2 hrs in presence of BSA-comple...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetDiacylglycerol O-acyltransferase 1(Mouse)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50502594(CHEMBL4475779)
Affinity DataEC50:  2.30E+3nMAssay Description:Inhibition of DGAT1 in mouse C2C12 cells assessed as reduction in intracellular triglyceride production incubated for 2 hrs in presence of BSA-comple...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetDiacylglycerol O-acyltransferase 1(Mouse)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50502587(CHEMBL4463125)
Affinity DataEC50:  56nMAssay Description:Inhibition of DGAT1 in mouse C2C12 cells assessed as reduction in intracellular triglyceride production incubated for 2 hrs in presence of BSA-comple...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetDiacylglycerol O-acyltransferase 1(Mouse)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50502586(LCQ-908-NXA | LCQ-908NXA | LCQ908-NXA | Pradigasta...)
Affinity DataEC50:  71nMAssay Description:Inhibition of DGAT1 in mouse C2C12 cells assessed as reduction in intracellular triglyceride production incubated for 2 hrs in presence of BSA-comple...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetDiacylglycerol O-acyltransferase 1(Mouse)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50502590(CHEMBL4434994)
Affinity DataEC50:  12nMAssay Description:Inhibition of DGAT1 in mouse C2C12 cells assessed as reduction in intracellular triglyceride production incubated for 2 hrs in presence of BSA-comple...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetDiacylglycerol O-acyltransferase 1(Mouse)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50502592(CHEMBL4555623)
Affinity DataEC50:  98nMAssay Description:Inhibition of DGAT1 in mouse C2C12 cells assessed as reduction in intracellular triglyceride production incubated for 2 hrs in presence of BSA-comple...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetDiacylglycerol O-acyltransferase 1(Mouse)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50502595(CHEMBL4554065)
Affinity DataEC50:  8nMAssay Description:Inhibition of DGAT1 in mouse C2C12 cells assessed as reduction in intracellular triglyceride production incubated for 2 hrs in presence of BSA-comple...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetDiacylglycerol O-acyltransferase 1(Mouse)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50502591(CHEMBL4563171)
Affinity DataEC50:  413nMAssay Description:Inhibition of DGAT1 in mouse C2C12 cells assessed as reduction in intracellular triglyceride production incubated for 2 hrs in presence of BSA-comple...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
PubMed
TargetTelomerase reverse transcriptase(Human)
University of London

Curated by ChEMBL
LigandPNGBDBM50133999(N-[9-(2-Amino-phenylamino)-7-(3-pyrrolidin-1-yl-pr...)
Affinity DataEC50:  170nMAssay Description:Inhibitory activity against human telomeraseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTelomerase reverse transcriptase(Human)
University of London

Curated by ChEMBL
LigandPNGBDBM50134000(N,N'-(9-(cyclohexylamino)acridine-3,6-diyl)bis(3-(...)
Affinity DataEC50:  90nMAssay Description:Inhibitory activity against human telomeraseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTelomerase reverse transcriptase(Human)
University of London

Curated by ChEMBL
LigandPNGBDBM50134004(N,N'-(9-(phenylamino)acridine-2,6-diyl)bis(3-(pyrr...)
Affinity DataEC50:  1.33E+3nMAssay Description:Inhibitory activity against human telomeraseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTelomerase reverse transcriptase(Human)
University of London

Curated by ChEMBL
LigandPNGBDBM50134010(N-[9-(2-Amino-phenylamino)-6-(3-pyrrolidin-1-yl-pr...)
Affinity DataEC50:  20nMAssay Description:Inhibitory activity against human telomeraseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTelomerase reverse transcriptase(Human)
University of London

Curated by ChEMBL
LigandPNGBDBM50134007(N-[9-Heptylamino-6-(3-pyrrolidin-1-yl-propionylami...)
Affinity DataEC50:  210nMAssay Description:Inhibitory activity against human telomeraseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTelomerase reverse transcriptase(Human)
University of London

Curated by ChEMBL
LigandPNGBDBM50134009(N,N'-(9-(3-(dimethylamino)propylamino)acridine-3,6...)
Affinity DataEC50:  60nMAssay Description:Inhibitory activity against human telomeraseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTelomerase reverse transcriptase(Human)
University of London

Curated by ChEMBL
LigandPNGBDBM50134011(N-[9-(2-Amino-phenylamino)-6-(3-pyrrolidin-1-yl-pr...)
Affinity DataEC50:  21nMAssay Description:Inhibitory activity against human telomeraseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTelomerase reverse transcriptase(Human)
University of London

Curated by ChEMBL
LigandPNGBDBM50134012(N-[9-(3-Amino-phenylamino)-6-(3-pyrrolidin-1-yl-pr...)
Affinity DataEC50:  210nMAssay Description:Inhibitory activity against human telomeraseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTelomerase reverse transcriptase(Human)
University of London

Curated by ChEMBL
LigandPNGBDBM50134014(N,N'-(9-(2-hydroxyphenylamino)acridine-2,7-diyl)bi...)
Affinity DataEC50:  1.03E+3nMAssay Description:Inhibitory activity against human telomeraseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTelomerase reverse transcriptase(Human)
University of London

Curated by ChEMBL
LigandPNGBDBM50134018(N-[9-(4-Amino-phenylamino)-6-(3-pyrrolidin-1-yl-pr...)
Affinity DataEC50:  74nMAssay Description:Inhibitory activity against human telomeraseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTelomerase reverse transcriptase(Human)
University of London

Curated by ChEMBL
LigandPNGBDBM50133998(N-[9-(2-Methylsulfanyl-phenylamino)-6-(3-pyrrolidi...)
Affinity DataEC50:  30nMAssay Description:Inhibitory activity against human telomeraseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTelomerase reverse transcriptase(Human)
University of London

Curated by ChEMBL
LigandPNGBDBM50134024(N,N'-(9-(3-aminophenylamino)acridine-2,7-diyl)bis(...)
Affinity DataEC50:  1.09E+3nMAssay Description:Inhibitory activity against human telomeraseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTelomerase reverse transcriptase(Human)
University of London

Curated by ChEMBL
LigandPNGBDBM50080849(3-PYRROLIDIN-1-YL-N-[6-(3-PYRROLIDIN-1-YL-PROPIONY...)
Affinity DataEC50:  5.20E+3nMAssay Description:Inhibitory activity against human telomeraseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTelomerase reverse transcriptase(Human)
University of London

Curated by ChEMBL
LigandPNGBDBM50134025(N-[9-(4-Fluoro-phenylamino)-6-(3-pyrrolidin-1-yl-p...)
Affinity DataEC50:  70nMAssay Description:Inhibitory activity against human telomeraseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTelomerase reverse transcriptase(Human)
University of London

Curated by ChEMBL
LigandPNGBDBM50134021(N-[9-(3-Methylsulfanyl-phenylamino)-6-(3-pyrrolidi...)
Affinity DataEC50:  60nMAssay Description:Inhibitory activity against human telomeraseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTelomerase reverse transcriptase(Human)
University of London

Curated by ChEMBL
LigandPNGBDBM50134029(N,N'-(9-(phenylamino)acridine-2,7-diyl)bis(3-(pyrr...)
Affinity DataEC50:  1.29E+3nMAssay Description:Inhibitory activity against human telomeraseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTelomerase reverse transcriptase(Human)
University of London

Curated by ChEMBL
LigandPNGBDBM50134016(N,N'-(9-(3-methoxyphenylamino)acridine-2,7-diyl)bi...)
Affinity DataEC50:  2.73E+3nMAssay Description:Inhibitory activity against human telomeraseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTelomerase reverse transcriptase(Human)
University of London

Curated by ChEMBL
LigandPNGBDBM50134002(N-[9-(2-Piperidin-1-yl-ethylamino)-6-(3-pyrrolidin...)
Affinity DataEC50:  500nMAssay Description:Inhibitory activity against human telomeraseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTelomerase reverse transcriptase(Human)
University of London

Curated by ChEMBL
LigandPNGBDBM50134028(N-[9-(4-Amino-phenylamino)-7-(3-pyrrolidin-1-yl-pr...)
Affinity DataEC50:  200nMAssay Description:Inhibitory activity against human telomeraseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTelomerase reverse transcriptase(Human)
University of London

Curated by ChEMBL
LigandPNGBDBM50134019(N,N'-(9-(3-aminophenylamino)acridine-3,6-diyl)bis(...)
Affinity DataEC50:  60nMAssay Description:Inhibitory activity against human telomeraseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTelomerase reverse transcriptase(Human)
University of London

Curated by ChEMBL
LigandPNGBDBM50134032(N,N'-(9-(cyclopropylamino)acridine-3,6-diyl)bis(3-...)
Affinity DataEC50:  50nMAssay Description:Inhibitory activity against human telomeraseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTelomerase reverse transcriptase(Human)
University of London

Curated by ChEMBL
LigandPNGBDBM50134030(N,N'-(9-{[4-(dimethylamino)phenyl]amino}acridine-3...)
Affinity DataEC50:  115nMAssay Description:Inhibitory activity against human telomeraseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTelomerase reverse transcriptase(Human)
University of London

Curated by ChEMBL
LigandPNGBDBM50134031(N-[9-Cyclohexylamino-6-(3-pyrrolidin-1-yl-propiony...)
Affinity DataEC50:  210nMAssay Description:Inhibitory activity against human telomeraseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTelomerase reverse transcriptase(Human)
University of London

Curated by ChEMBL
LigandPNGBDBM50134013(N-[9-(4-Dimethylamino-phenylamino)-7-(3-pyrrolidin...)
Affinity DataEC50:  500nMAssay Description:Inhibitory activity against human telomeraseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTelomerase reverse transcriptase(Human)
University of London

Curated by ChEMBL
LigandPNGBDBM50134022(N,N'-(9-(4-acetylphenylamino)acridine-3,6-diyl)bis...)
Affinity DataEC50:  40nMAssay Description:Inhibitory activity against human telomeraseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTelomerase reverse transcriptase(Human)
University of London

Curated by ChEMBL
LigandPNGBDBM50134017(N,N'-(9-(4-(dimethylamino)phenylamino)acridine-2,6...)
Affinity DataEC50:  170nMAssay Description:Inhibitory activity against human telomeraseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTelomerase reverse transcriptase(Human)
University of London

Curated by ChEMBL
LigandPNGBDBM50134026(N,N'-(9-(3-(dimethylamino)phenylamino)acridine-3,6...)
Affinity DataEC50:  100nMAssay Description:Inhibitory activity against human telomeraseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTelomerase reverse transcriptase(Human)
University of London

Curated by ChEMBL
LigandPNGBDBM50134033(N,N'-(9-(3-(dimethylamino)phenylamino)acridine-2,7...)
Affinity DataEC50:  600nMAssay Description:Inhibitory activity against human telomeraseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTelomerase reverse transcriptase(Human)
University of London

Curated by ChEMBL
LigandPNGBDBM50134015(N-[9-[2-(2-Amino-ethyl)-pyrrolidin-1-yl]-6-(3-pyrr...)
Affinity DataEC50:  18nMAssay Description:Inhibitory activity against human telomeraseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTelomerase reverse transcriptase(Human)
University of London

Curated by ChEMBL
LigandPNGBDBM50134008(N-[9-(3-Dimethylamino-propylamino)-6-(3-pyrrolidin...)
Affinity DataEC50:  80nMAssay Description:Inhibitory activity against human telomeraseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTelomerase reverse transcriptase(Human)
University of London

Curated by ChEMBL
LigandPNGBDBM50134023(N,N'-(9-(4-aminophenylamino)acridine-2,6-diyl)bis(...)
Affinity DataEC50:  2nMAssay Description:Inhibitory activity against human telomeraseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTelomerase reverse transcriptase(Human)
University of London

Curated by ChEMBL
LigandPNGBDBM50134006(N-[9-(2-Methoxy-ethylamino)-6-(3-pyrrolidin-1-yl-p...)
Affinity DataEC50:  140nMAssay Description:Inhibitory activity against human telomeraseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTelomerase reverse transcriptase(Human)
University of London

Curated by ChEMBL
LigandPNGBDBM50134027(N-[9-(2-Dimethylamino-ethylamino)-6-(3-pyrrolidin-...)
Affinity DataEC50:  18nMAssay Description:Inhibitory activity against human telomeraseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTelomerase reverse transcriptase(Human)
University of London

Curated by ChEMBL
LigandPNGBDBM50134020(N,N'-(9-(3-acetamidophenylamino)acridine-3,6-diyl)...)
Affinity DataEC50:  100nMAssay Description:Inhibitory activity against human telomeraseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTelomerase reverse transcriptase(Human)
University of London

Curated by ChEMBL
LigandPNGBDBM50134003(N,N'-(9-(4-methoxyphenylamino)acridine-2,7-diyl)bi...)
Affinity DataEC50:  460nMAssay Description:Inhibitory activity against human telomeraseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTelomerase reverse transcriptase(Human)
University of London

Curated by ChEMBL
LigandPNGBDBM50134005(N-[9-(2-Dimethylamino-ethylamino)-7-(3-pyrrolidin-...)
Affinity DataEC50:  570nMAssay Description:Inhibitory activity against human telomeraseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
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