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TargetE3 ubiquitin-protein ligase XIAP(Human)
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50239422(CHEMBL234346)
Affinity DataIC50: 0.0170nMAssay Description:Inhibition of SMAC-derived peptide abuRPFK (5 and 6FAM)-amide interaction with XIAP BIR3 domain (unknown origin) by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/22/2019
Entry Details Article
PubMed
TargetGrowth hormone secretagogue receptor type 1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50412965(CHEMBL480821)
Affinity DataEC50:  0.0501nMAssay Description:Agonist activity at human ghrelin receptor by cell based BACMAM FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
TargetGrowth hormone secretagogue receptor type 1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50412966(CHEMBL481013)
Affinity DataEC50:  0.158nMAssay Description:Agonist activity at human ghrelin receptor by cell based BACMAM FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
TargetGrowth hormone secretagogue receptor type 1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50412954(SB-791016 | SB-791016A | CHEMBL251572)
Affinity DataEC50:  0.158nMAssay Description:Agonist activity at human ghrelin receptor by cell based BACMAM FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
TargetGrowth hormone secretagogue receptor type 1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50412954(SB-791016 | SB-791016A | CHEMBL251572)
Affinity DataEC50:  0.158nMAssay Description:Agonist activity at GSHR by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details Article
PubMed
TargetGrowth hormone secretagogue receptor type 1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50477764(CHEMBL401134)
Affinity DataEC50:  0.200nMAssay Description:Agonist activity at GSHR by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details Article
PubMed
TargetGrowth hormone secretagogue receptor type 1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50412978(CHEMBL518774)
Affinity DataEC50:  0.200nMAssay Description:Agonist activity at human ghrelin receptor by cell based BACMAM FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1B(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50410424(CHEMBL199088)
Affinity DataKi:  0.251nMAssay Description:Mean binding affinity towards 5-hydroxytryptamine 1B receptor using [3H]5-HT or [3H]-8-OH-DPAT as the radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2013
Entry Details Article
PubMed
TargetGrowth hormone secretagogue receptor type 1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50412963(CHEMBL481796)
Affinity DataEC50:  0.251nMAssay Description:Agonist activity at human ghrelin receptor by cell based BACMAM FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
TargetGrowth hormone secretagogue receptor type 1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50412972(CHEMBL482220)
Affinity DataEC50:  0.316nMAssay Description:Agonist activity at human ghrelin receptor by cell based BACMAM FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1B(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50410426(CHEMBL370852)
Affinity DataKi:  0.316nMAssay Description:Mean binding affinity towards 5-hydroxytryptamine 1B receptor using [3H]5-HT or [3H]-8-OH-DPAT as the radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2013
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50410428(CHEMBL380812)
Affinity DataKi:  0.316nMAssay Description:Mean binding affinity towards 5-hydroxytryptamine 1A receptor using [3H]-5-HT or [3H]8-OH-DPAT as the radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2013
Entry Details Article
PubMed
TargetBaculoviral IAP repeat-containing protein 2(Human)
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50239422(CHEMBL234346)
Affinity DataIC50: 0.320nMAssay Description:Inhibition of SMAC-derived peptide abuRPFK (5 and 6FAM)-amide interaction with cIAP1 BIR3 domain (unknown origin) by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/22/2019
Entry Details Article
PubMed
TargetBaculoviral IAP repeat-containing protein 2(Human)
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50239425(CHEMBL4064619)
Affinity DataEC50:  0.320nMAssay Description:Induction of cIAP1 degradation in human MDA-MB-231 cells after 2 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/22/2019
Entry Details Article
PubMed
TargetGrowth hormone secretagogue receptor type 1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50412973(CHEMBL519301)
Affinity DataEC50:  0.398nMAssay Description:Agonist activity at human ghrelin receptor by cell based BACMAM FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
TargetGrowth hormone secretagogue receptor type 1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50478232(CHEMBL260819)
Affinity DataEC50:  0.398nMAssay Description:Agonist activity at human GHSR1a by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/25/2020
Entry Details Article
PubMed
TargetBaculoviral IAP repeat-containing protein 2(Human)
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50441356(CHEMBL2431768)
Affinity DataEC50:  0.400nMAssay Description:Induction of cIAP1 degradation in human MDA-MB-231 cells after 2 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/22/2019
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetPoly [ADP-ribose] polymerase 2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM27566(4-({3-[(4-cyclopropanecarbonylpiperazin-1-yl)carbo...)
Affinity DataKd:  0.5nMAssay Description:Binding affinity to PARP2 (unknown origin) assessed as apparent dissociation constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
Target5-hydroxytryptamine receptor 1D(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50410424(CHEMBL199088)
Affinity DataKi:  0.501nMAssay Description:Mean binding affinity towards 5-hydroxytryptamine 1D receptor using [3H]5-HT or [3H]-8-OH-DPAT as the radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2013
Entry Details Article
PubMed
TargetGrowth hormone secretagogue receptor type 1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50412976(CHEMBL480037)
Affinity DataEC50:  0.501nMAssay Description:Agonist activity at human ghrelin receptor by cell based BACMAM FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1D(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50410426(CHEMBL370852)
Affinity DataKi:  0.501nMAssay Description:Mean binding affinity towards 5-hydroxytryptamine 1D receptor using [3H]5-HT or [3H]-8-OH-DPAT as the radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2013
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1B(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50410427(CHEMBL194647)
Affinity DataKi:  0.501nMAssay Description:Mean binding affinity towards 5-hydroxytryptamine 1B receptor using [3H]5-HT or [3H]-8-OH-DPAT as the radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2013
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50219087(CHEMBL97637)
Affinity DataKi:  0.501nMAssay Description:Binding affinity against human 5-hydroxytryptamine 6 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/28/2018
Entry Details Article
PubMed
TargetGrowth hormone secretagogue receptor type 1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50478231(CHEMBL272753)
Affinity DataEC50:  0.501nMAssay Description:Agonist activity at human GHSR1a by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/25/2020
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50219087(CHEMBL97637)
Affinity DataKi:  0.501nMAssay Description:Binding affinity to human cloned 5-HT6 receptor in HeLa cells using [3H]- LSD as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/28/2018
Entry Details Article
PubMed
TargetGrowth hormone secretagogue receptor type 1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50477754(CHEMBL251169)
Affinity DataEC50:  0.501nMAssay Description:Agonist activity at GSHR by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50219081(CHEMBL261917)
Affinity DataKi:  0.631nMAssay Description:Binding affinity to human cloned 5-hydroxytryptamine 6 receptor in HeLa cells using [3H]- LSD as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/28/2018
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50219081(CHEMBL261917)
Affinity DataKi:  0.631nMAssay Description:Binding affinity against human 5-hydroxytryptamine 6 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/28/2018
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1D(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50410430(CHEMBL372743)
Affinity DataKi:  0.631nMAssay Description:Mean binding affinity towards 5-hydroxytryptamine 1D receptor using [3H]5-HT or [3H]-8-OH-DPAT as the radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2013
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1D(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50410440(CHEMBL198975)
Affinity DataKi:  0.631nMAssay Description:Mean binding affinity towards 5-hydroxytryptamine 1D receptor using [3H]5-HT or [3H]-8-OH-DPAT as the radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2013
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1B(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50410440(CHEMBL198975)
Affinity DataKi:  0.631nMAssay Description:Mean binding affinity towards 5-hydroxytryptamine 1B receptor using [3H]5-HT or [3H]-8-OH-DPAT as the radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2013
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50410440(CHEMBL198975)
Affinity DataKi:  0.631nMAssay Description:Mean binding affinity towards 5-hydroxytryptamine 1A receptor using [3H]-5-HT or [3H]8-OH-DPAT as the radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2013
Entry Details Article
PubMed
TargetProtein mono-ADP-ribosyltransferase PARP4(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50084621(BMN 673 | Talazoparib | US12427157, Example R8H-15)
Affinity DataKd:  0.700nMAssay Description:Binding affinity to PARP4 (unknown origin) assessed as apparent dissociation constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50410426(CHEMBL370852)
Affinity DataKi:  0.794nMAssay Description:Mean binding affinity towards 5-hydroxytryptamine 1A receptor using [3H]-5-HT or [3H]8-OH-DPAT as the radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2013
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1D(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50410427(CHEMBL194647)
Affinity DataKi:  0.794nMAssay Description:Mean binding affinity towards 5-hydroxytryptamine 1D receptor using [3H]5-HT or [3H]-8-OH-DPAT as the radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2013
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1B(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50410437(CHEMBL370625)
Affinity DataKi:  0.794nMAssay Description:Mean binding affinity towards 5-hydroxytryptamine 1B receptor using [3H]5-HT or [3H]-8-OH-DPAT as the radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2013
Entry Details Article
PubMed
TargetGrowth hormone secretagogue receptor type 1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50412955(CHEMBL407706)
Affinity DataEC50:  0.794nMAssay Description:Agonist activity at human ghrelin receptor by cell based BACMAM FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
TargetGrowth hormone secretagogue receptor type 1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50478228(CHEMBL272993)
Affinity DataEC50:  0.794nMAssay Description:Agonist activity at human GHSR1a by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/25/2020
Entry Details Article
PubMed
TargetGrowth hormone secretagogue receptor type 1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50412955(CHEMBL407706)
Affinity DataEC50:  0.794nMAssay Description:Agonist activity at human GHSR1a by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/25/2020
Entry Details Article
PubMed
TargetGrowth hormone secretagogue receptor type 1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50477767(CHEMBL248544)
Affinity DataEC50:  0.794nMAssay Description:Agonist activity at GSHR by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM27566(4-({3-[(4-cyclopropanecarbonylpiperazin-1-yl)carbo...)
Affinity DataKd:  0.800nMAssay Description:Binding affinity to PARP1 (unknown origin) assessed as apparent dissociation constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetNAD(P)H dehydrogenase [quinone] 1(Human)
Glaxosmithkline

US Patent
LigandPNGBDBM381902(rac-(R)-3-(1,4-Dimethyl-1H-benzo[d][1,2,3]triazol-...)
Affinity DataEC50: <1nMAssay Description:NAD(P)H:quinone oxidoreductase 1 (NQO1), also called DT diaphorase, is a homodimeric FAD-containing enzyme that catalyzes obligatory NAD(P)H-dependen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2020
Entry Details
US Patent

Target5-hydroxytryptamine receptor 6(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50219083(CHEMBL316081)
Affinity DataKi:  1nMAssay Description:Binding affinity to human cloned 5-HT6 receptor in HeLa cells using [3H]- LSD as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/28/2018
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1B(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50410430(CHEMBL372743)
Affinity DataKi:  1nMAssay Description:Mean binding affinity towards 5-hydroxytryptamine 1B receptor using [3H]5-HT or [3H]-8-OH-DPAT as the radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2013
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1B(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50410428(CHEMBL380812)
Affinity DataKi:  1nMAssay Description:Mean binding affinity towards 5-hydroxytryptamine 1B receptor using [3H]5-HT or [3H]-8-OH-DPAT as the radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2013
Entry Details Article
PubMed
TargetNAD(P)H dehydrogenase [quinone] 1(Human)
Glaxosmithkline

US Patent
LigandPNGBDBM381924(3-(1,4-Dimethyl-1H-benzo[d][1,2,3]triazol-5-yl)-3-...)
Affinity DataEC50: <1nMAssay Description:NAD(P)H:quinone oxidoreductase 1 (NQO1), also called DT diaphorase, is a homodimeric FAD-containing enzyme that catalyzes obligatory NAD(P)H-dependen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2020
Entry Details
US Patent

TargetGrowth hormone secretagogue receptor type 1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50412971(CHEMBL517543)
Affinity DataEC50:  1nMAssay Description:Agonist activity at human ghrelin receptor by cell based BACMAM FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50219083(CHEMBL316081)
Affinity DataKi:  1nMAssay Description:Binding affinity against human 5-hydroxytryptamine 6 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/28/2018
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1D(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50410432(CHEMBL197947)
Affinity DataKi:  1nMAssay Description:Mean binding affinity towards 5-hydroxytryptamine 1D receptor using [3H]5-HT or [3H]-8-OH-DPAT as the radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2013
Entry Details Article
PubMed
TargetNAD(P)H dehydrogenase [quinone] 1(Human)
Glaxosmithkline

US Patent
LigandPNGBDBM381884(3-(3-(2,2-Dimethyl-2,3-dihydrobenzo[f][1,4]oxazepi...)
Affinity DataEC50: <1nMAssay Description:NAD(P)H:quinone oxidoreductase 1 (NQO1), also called DT diaphorase, is a homodimeric FAD-containing enzyme that catalyzes obligatory NAD(P)H-dependen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2020
Entry Details
US Patent

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