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TargetCarbon monoxide dehydrogenase small chain(Oligotropha carboxidovorans)
University of California Riverside

LigandPNGBDBM22774(1,4-Benzoquinone | benzoquinone | cid_4650 | CHEMB...)
Affinity DataKd:  4.76E+4nMAssay Description:Inhibition of CODH by Diphenyliodomium chloride. Inactivation of the FAD cofactor of CODH was accomplished by covalent modification of the flavin wi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/12/2013
Entry Details Article
PubMed
TargetCarbon monoxide dehydrogenase small chain(Oligotropha carboxidovorans)
University of California Riverside

LigandPNGBDBM24776(1,4-dihydronaphthalene-1,4-dione | 1,4-Naphthoquin...)
Affinity DataKd:  1.40E+5nMAssay Description:Inhibition of CODH by Diphenyliodomium chloride. Inactivation of the FAD cofactor of CODH was accomplished by covalent modification of the flavin wi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/12/2013
Entry Details Article
PubMed
TargetFatty acid synthase(Human)
Forma Therapeutics

Curated by ChEMBL
LigandPNGBDBM50526389(CHEMBL4450081)
Affinity DataIC50: 10nMAssay Description:Inhibition of full length recombinant human FASN using acetyl-CoA/malonyl-CoA as substrate preincubated for 60 mins followed by substrate addition an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetFatty acid synthase(Human)
Forma Therapeutics

Curated by ChEMBL
LigandPNGBDBM50526400(CHEMBL4553437)
Affinity DataIC50: 11nMAssay Description:Inhibition of FASN in human BT474 cells preincubated for 1 hr followed by [14C]-acetate addition and measured after 4 hrs by scintillation counting a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetFatty acid synthase(Human)
Forma Therapeutics

Curated by ChEMBL
LigandPNGBDBM50526390(CHEMBL4462401)
Affinity DataIC50: 11nMAssay Description:Inhibition of FASN in human BT474 cells preincubated for 1 hr followed by [14C]-acetate addition and measured after 4 hrs by scintillation counting a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetFatty acid synthase(Human)
Forma Therapeutics

Curated by ChEMBL
LigandPNGBDBM50526397(CHEMBL4440024)
Affinity DataIC50: 12nMAssay Description:Inhibition of full length recombinant human FASN using acetyl-CoA/malonyl-CoA as substrate preincubated for 60 mins followed by substrate addition an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetFatty acid synthase(Human)
Forma Therapeutics

Curated by ChEMBL
LigandPNGBDBM50526389(CHEMBL4450081)
Affinity DataIC50: 12nMAssay Description:Inhibition of FASN in human BT474 cells preincubated for 1 hr followed by [14C]-acetate addition and measured after 4 hrs by scintillation counting a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetFatty acid synthase(Human)
Forma Therapeutics

Curated by ChEMBL
LigandPNGBDBM50526400(CHEMBL4553437)
Affinity DataIC50: 13nMAssay Description:Inhibition of full length recombinant human FASN using acetyl-CoA/malonyl-CoA as substrate preincubated for 60 mins followed by substrate addition an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetFatty acid synthase(Human)
Forma Therapeutics

Curated by ChEMBL
LigandPNGBDBM50526391(CHEMBL4529391)
Affinity DataIC50: 16nMAssay Description:Inhibition of full length recombinant human FASN using acetyl-CoA/malonyl-CoA as substrate preincubated for 60 mins followed by substrate addition an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetFatty acid synthase(Human)
Forma Therapeutics

Curated by ChEMBL
LigandPNGBDBM50526391(CHEMBL4529391)
Affinity DataIC50: 18nMAssay Description:Inhibition of FASN in human BT474 cells preincubated for 1 hr followed by [14C]-acetate addition and measured after 4 hrs by scintillation counting a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetFatty acid synthase(Human)
Forma Therapeutics

Curated by ChEMBL
LigandPNGBDBM50526397(CHEMBL4440024)
Affinity DataIC50: 19nMAssay Description:Inhibition of FASN in human BT474 cells preincubated for 1 hr followed by [14C]-acetate addition and measured after 4 hrs by scintillation counting a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetFatty acid synthase(Human)
Forma Therapeutics

Curated by ChEMBL
LigandPNGBDBM50526383(CHEMBL4575847)
Affinity DataIC50: 26nMAssay Description:Inhibition of full length recombinant human FASN using acetyl-CoA/malonyl-CoA as substrate preincubated for 60 mins followed by substrate addition an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetFatty acid synthase(Human)
Forma Therapeutics

Curated by ChEMBL
LigandPNGBDBM50526390(CHEMBL4462401)
Affinity DataIC50: 32nMAssay Description:Inhibition of full length recombinant human FASN using acetyl-CoA/malonyl-CoA as substrate preincubated for 60 mins followed by substrate addition an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetFatty acid synthase(Human)
Forma Therapeutics

Curated by ChEMBL
LigandPNGBDBM50526388(CHEMBL4518496)
Affinity DataIC50: 32nMAssay Description:Inhibition of full length recombinant human FASN using acetyl-CoA/malonyl-CoA as substrate preincubated for 60 mins followed by substrate addition an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetFatty acid synthase(Human)
Forma Therapeutics

Curated by ChEMBL
LigandPNGBDBM50526382(CHEMBL4466578)
Affinity DataIC50: 33nMAssay Description:Inhibition of full length recombinant human FASN using acetyl-CoA/malonyl-CoA as substrate preincubated for 60 mins followed by substrate addition an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetFatty acid synthase(Human)
Forma Therapeutics

Curated by ChEMBL
LigandPNGBDBM50526387(CHEMBL4449818)
Affinity DataIC50: 54nMAssay Description:Inhibition of full length recombinant human FASN using acetyl-CoA/malonyl-CoA as substrate preincubated for 60 mins followed by substrate addition an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetFatty acid synthase(Human)
Forma Therapeutics

Curated by ChEMBL
LigandPNGBDBM50526399(CHEMBL4570684)
Affinity DataIC50: 57nMAssay Description:Inhibition of full length recombinant human FASN using acetyl-CoA/malonyl-CoA as substrate preincubated for 60 mins followed by substrate addition an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetBromodomain-containing protein 4(Human)
Forma Therapeutics

Curated by ChEMBL
LigandPNGBDBM50457130(CHEMBL4203456)
Affinity DataIC50: 60nMAssay Description:Inhibition of His-epitope tagged BRD4 bromodomain 1 (44 to 168 residues) (unknown origin) using biotinylated K5,8,12,16 tetra-acetylated histone H4 (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetFatty acid synthase(Human)
Forma Therapeutics

Curated by ChEMBL
LigandPNGBDBM50526401(CHEMBL4445590)
Affinity DataIC50: 61nMAssay Description:Inhibition of FASN in human BT474 cells preincubated for 1 hr followed by [14C]-acetate addition and measured after 4 hrs by scintillation counting a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetFatty acid synthase(Human)
Forma Therapeutics

Curated by ChEMBL
LigandPNGBDBM50526399(CHEMBL4570684)
Affinity DataIC50: 67nMAssay Description:Inhibition of FASN in human BT474 cells preincubated for 1 hr followed by [14C]-acetate addition and measured after 4 hrs by scintillation counting a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetFatty acid synthase(Human)
Forma Therapeutics

Curated by ChEMBL
LigandPNGBDBM50526386(CHEMBL4575998)
Affinity DataIC50: 69nMAssay Description:Inhibition of full length recombinant human FASN using acetyl-CoA/malonyl-CoA as substrate preincubated for 60 mins followed by substrate addition an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetFatty acid synthase(Human)
Forma Therapeutics

Curated by ChEMBL
LigandPNGBDBM50526382(CHEMBL4466578)
Affinity DataIC50: 70nMAssay Description:Inhibition of FASN in human BT474 cells preincubated for 1 hr followed by [14C]-acetate addition and measured after 4 hrs by scintillation counting a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetFatty acid synthase(Human)
Forma Therapeutics

Curated by ChEMBL
LigandPNGBDBM50526381(CHEMBL4565279)
Affinity DataIC50: 90nMAssay Description:Inhibition of FASN in human BT474 cells preincubated for 1 hr followed by [14C]-acetate addition and measured after 4 hrs by scintillation counting a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetFatty acid synthase(Human)
Forma Therapeutics

Curated by ChEMBL
LigandPNGBDBM50526385(CHEMBL4440104)
Affinity DataIC50: 97nMAssay Description:Inhibition of full length recombinant human FASN using acetyl-CoA/malonyl-CoA as substrate preincubated for 60 mins followed by substrate addition an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetBromodomain-containing protein 4(Human)
Forma Therapeutics

Curated by ChEMBL
LigandPNGBDBM50457141(CHEMBL4215658)
Affinity DataIC50: 100nMAssay Description:Inhibition of His-epitope tagged BRD4 bromodomain 1 (44 to 168 residues) (unknown origin) using biotinylated K5,8,12,16 tetra-acetylated histone H4 (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetFatty acid synthase(Human)
Forma Therapeutics

Curated by ChEMBL
LigandPNGBDBM50526387(CHEMBL4449818)
Affinity DataIC50: 101nMAssay Description:Inhibition of FASN in human BT474 cells preincubated for 1 hr followed by [14C]-acetate addition and measured after 4 hrs by scintillation counting a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetFatty acid synthase(Human)
Forma Therapeutics

Curated by ChEMBL
LigandPNGBDBM50526388(CHEMBL4518496)
Affinity DataIC50: 101nMAssay Description:Inhibition of FASN in human BT474 cells preincubated for 1 hr followed by [14C]-acetate addition and measured after 4 hrs by scintillation counting a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetFatty acid synthase(Human)
Forma Therapeutics

Curated by ChEMBL
LigandPNGBDBM50526385(CHEMBL4440104)
Affinity DataIC50: 104nMAssay Description:Inhibition of FASN in human BT474 cells preincubated for 1 hr followed by [14C]-acetate addition and measured after 4 hrs by scintillation counting a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetFatty acid synthase(Human)
Forma Therapeutics

Curated by ChEMBL
LigandPNGBDBM50526398(CHEMBL4454062)
Affinity DataIC50: 110nMAssay Description:Inhibition of full length recombinant human FASN using acetyl-CoA/malonyl-CoA as substrate preincubated for 60 mins followed by substrate addition an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetFatty acid synthase(Human)
Forma Therapeutics

Curated by ChEMBL
LigandPNGBDBM50526403(CHEMBL4457855)
Affinity DataIC50: 110nMAssay Description:Inhibition of full length recombinant human FASN using acetyl-CoA/malonyl-CoA as substrate preincubated for 60 mins followed by substrate addition an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetFatty acid synthase(Human)
Forma Therapeutics

Curated by ChEMBL
LigandPNGBDBM50526386(CHEMBL4575998)
Affinity DataIC50: 136nMAssay Description:Inhibition of FASN in human BT474 cells preincubated for 1 hr followed by [14C]-acetate addition and measured after 4 hrs by scintillation counting a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetFatty acid synthase(Human)
Forma Therapeutics

Curated by ChEMBL
LigandPNGBDBM50526404(CHEMBL4548362)
Affinity DataIC50: 142nMAssay Description:Inhibition of full length recombinant human FASN using acetyl-CoA/malonyl-CoA as substrate preincubated for 60 mins followed by substrate addition an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetFatty acid synthase(Human)
Forma Therapeutics

Curated by ChEMBL
LigandPNGBDBM50526398(CHEMBL4454062)
Affinity DataIC50: 158nMAssay Description:Inhibition of FASN in human BT474 cells preincubated for 1 hr followed by [14C]-acetate addition and measured after 4 hrs by scintillation counting a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetFatty acid synthase(Human)
Forma Therapeutics

Curated by ChEMBL
LigandPNGBDBM50526401(CHEMBL4445590)
Affinity DataIC50: 192nMAssay Description:Inhibition of full length recombinant human FASN using acetyl-CoA/malonyl-CoA as substrate preincubated for 60 mins followed by substrate addition an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetFatty acid synthase(Human)
Forma Therapeutics

Curated by ChEMBL
LigandPNGBDBM50526381(CHEMBL4565279)
Affinity DataIC50: 213nMAssay Description:Inhibition of full length recombinant human FASN using acetyl-CoA/malonyl-CoA as substrate preincubated for 60 mins followed by substrate addition an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetFatty acid synthase(Human)
Forma Therapeutics

Curated by ChEMBL
LigandPNGBDBM50526404(CHEMBL4548362)
Affinity DataIC50: 257nMAssay Description:Inhibition of FASN in human BT474 cells preincubated for 1 hr followed by [14C]-acetate addition and measured after 4 hrs by scintillation counting a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetBromodomain-containing protein 4(Human)
Forma Therapeutics

Curated by ChEMBL
LigandPNGBDBM50457145(CHEMBL4211224)
Affinity DataIC50: 260nMAssay Description:Inhibition of His-epitope tagged BRD4 bromodomain 1 (44 to 168 residues) (unknown origin) using biotinylated K5,8,12,16 tetra-acetylated histone H4 (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetFatty acid synthase(Human)
Forma Therapeutics

Curated by ChEMBL
LigandPNGBDBM50526393(CHEMBL4439223)
Affinity DataIC50: 310nMAssay Description:Inhibition of full length recombinant human FASN using acetyl-CoA/malonyl-CoA as substrate preincubated for 60 mins followed by substrate addition an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetFatty acid synthase(Human)
Forma Therapeutics

Curated by ChEMBL
LigandPNGBDBM50526403(CHEMBL4457855)
Affinity DataIC50: 336nMAssay Description:Inhibition of FASN in human BT474 cells preincubated for 1 hr followed by [14C]-acetate addition and measured after 4 hrs by scintillation counting a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetFatty acid synthase(Human)
Forma Therapeutics

Curated by ChEMBL
LigandPNGBDBM50526379(CHEMBL4442092)
Affinity DataIC50: 350nMAssay Description:Inhibition of full length recombinant human FASN using acetyl-CoA/malonyl-CoA as substrate preincubated for 60 mins followed by substrate addition an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetBromodomain-containing protein 4(Human)
Forma Therapeutics

Curated by ChEMBL
LigandPNGBDBM50457140(CHEMBL4211739)
Affinity DataIC50: 370nMAssay Description:Inhibition of His-epitope tagged BRD4 bromodomain 1 (44 to 168 residues) (unknown origin) using biotinylated K5,8,12,16 tetra-acetylated histone H4 (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetBromodomain-containing protein 4(Human)
Forma Therapeutics

Curated by ChEMBL
LigandPNGBDBM50457132(CHEMBL4217059)
Affinity DataIC50: 380nMAssay Description:Inhibition of His-epitope tagged BRD4 bromodomain 1 (44 to 168 residues) (unknown origin) using biotinylated K5,8,12,16 tetra-acetylated histone H4 (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetBromodomain-containing protein 4(Human)
Forma Therapeutics

Curated by ChEMBL
LigandPNGBDBM50457129(CHEMBL4208315)
Affinity DataIC50: 380nMAssay Description:Inhibition of His-epitope tagged BRD4 bromodomain 1 (44 to 168 residues) (unknown origin) using biotinylated K5,8,12,16 tetra-acetylated histone H4 (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetBromodomain-containing protein 4(Human)
Forma Therapeutics

Curated by ChEMBL
LigandPNGBDBM50457133(CHEMBL4206854)
Affinity DataIC50: 420nMAssay Description:Inhibition of His-epitope tagged BRD4 bromodomain 1 (44 to 168 residues) (unknown origin) using biotinylated K5,8,12,16 tetra-acetylated histone H4 (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetBromodomain-containing protein 4(Human)
Forma Therapeutics

Curated by ChEMBL
LigandPNGBDBM50457141(CHEMBL4215658)
Affinity DataIC50: 460nMAssay Description:Inhibition of BRD4 in human MV411 cells assessed as reduction in MYC mRNA expressionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetBromodomain-containing protein 4(Human)
Forma Therapeutics

Curated by ChEMBL
LigandPNGBDBM50457139(CHEMBL4209209)
Affinity DataIC50: 650nMAssay Description:Inhibition of His-epitope tagged BRD4 bromodomain 1 (44 to 168 residues) (unknown origin) using biotinylated K5,8,12,16 tetra-acetylated histone H4 (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetBromodomain-containing protein 4(Human)
Forma Therapeutics

Curated by ChEMBL
LigandPNGBDBM50457138(CHEMBL4214127)
Affinity DataIC50: 760nMAssay Description:Inhibition of His-epitope tagged BRD4 bromodomain 1 (44 to 168 residues) (unknown origin) using biotinylated K5,8,12,16 tetra-acetylated histone H4 (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetBromodomain-containing protein 4(Human)
Forma Therapeutics

Curated by ChEMBL
LigandPNGBDBM50457135(CHEMBL4203897)
Affinity DataIC50: 790nMAssay Description:Inhibition of His-epitope tagged BRD4 bromodomain 1 (44 to 168 residues) (unknown origin) using biotinylated K5,8,12,16 tetra-acetylated histone H4 (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetFatty acid synthase(Human)
Forma Therapeutics

Curated by ChEMBL
LigandPNGBDBM50526405(CHEMBL4439986)
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of full length recombinant human FASN using acetyl-CoA/malonyl-CoA as substrate preincubated for 60 mins followed by substrate addition an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetFatty acid synthase(Human)
Forma Therapeutics

Curated by ChEMBL
LigandPNGBDBM50526384(CHEMBL4581195)
Affinity DataIC50: 1.14E+3nMAssay Description:Inhibition of full length recombinant human FASN using acetyl-CoA/malonyl-CoA as substrate preincubated for 60 mins followed by substrate addition an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
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