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TargetDihydrofolate reductase(Human)
Abbott Laboratories

LigandPNGBDBM19352(6-ethyl-5-{1-[(4-methanesulfonylphenyl)methyl]-1H-...)
Affinity DatapH: 7.3 T: 2°CAssay Description:DHFR activity was determined by measuring the rate of depletion of NADPH, monitored at 340 nm, with a Beckman DU-7400 spectrophotometer. More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2007
Entry Details Article
PubMed
TargetGrowth hormone secretagogue receptor type 1(Human)
Abbott Laboratories

LigandPNGBDBM19374(3-(4-{2,4-diamino-6-[(benzyloxy)methyl]pyrimidin-5...)
Affinity DataEC50:  7nMpH: 7.4 T: 2°CAssay Description:Specific binding was determined by incubation of membranes from GHS-R1a transfected CHO-K cells with 125I-His9-ghrelin in the presence of increasing ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2007
Entry Details Article
PubMed
TargetGrowth hormone secretagogue receptor type 1(Human)
Abbott Laboratories

LigandPNGBDBM19373(3-(4-{2,4-diamino-6-[(benzyloxy)methyl]pyrimidin-5...)
Affinity DataEC50:  10nMpH: 7.4 T: 2°CAssay Description:Specific binding was determined by incubation of membranes from GHS-R1a transfected CHO-K cells with 125I-His9-ghrelin in the presence of increasing ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2007
Entry Details Article
PubMed
TargetGrowth hormone secretagogue receptor type 1(Human)
Abbott Laboratories

LigandPNGBDBM19372(1-benzyl-3-(4-{2,4-diamino-6-[(benzyloxy)methyl]py...)
Affinity DataEC50:  34nMpH: 7.4 T: 2°CAssay Description:Specific binding was determined by incubation of membranes from GHS-R1a transfected CHO-K cells with 125I-His9-ghrelin in the presence of increasing ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2007
Entry Details Article
PubMed
TargetGrowth hormone secretagogue receptor type 1(Human)
Abbott Laboratories

LigandPNGBDBM19371(3-(4-{2,4-diamino-6-[(benzyloxy)methyl]pyrimidin-5...)
Affinity DataEC50:  88nMpH: 7.4 T: 2°CAssay Description:Specific binding was determined by incubation of membranes from GHS-R1a transfected CHO-K cells with 125I-His9-ghrelin in the presence of increasing ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2007
Entry Details Article
PubMed
TargetGrowth hormone secretagogue receptor type 1(Human)
Abbott Laboratories

LigandPNGBDBM19370(3-tert-butyl-1-(4-{2,4-diamino-6-[(benzyloxy)methy...)
Affinity DataEC50:  7nMpH: 7.4 T: 2°CAssay Description:Specific binding was determined by incubation of membranes from GHS-R1a transfected CHO-K cells with 125I-His9-ghrelin in the presence of increasing ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2007
Entry Details Article
PubMed
TargetGrowth hormone secretagogue receptor type 1(Human)
Abbott Laboratories

LigandPNGBDBM19369(1-(4-{2,4-diamino-6-[(benzyloxy)methyl]pyrimidin-5...)
Affinity DataEC50: >1.00E+4nMpH: 7.4 T: 2°CAssay Description:Specific binding was determined by incubation of membranes from GHS-R1a transfected CHO-K cells with 125I-His9-ghrelin in the presence of increasing ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2007
Entry Details Article
PubMed
TargetGrowth hormone secretagogue receptor type 1(Human)
Abbott Laboratories

LigandPNGBDBM19368(1-(4-{2,4-diamino-6-[(benzyloxy)methyl]pyrimidin-5...)
Affinity DataEC50:  56nMpH: 7.4 T: 2°CAssay Description:Specific binding was determined by incubation of membranes from GHS-R1a transfected CHO-K cells with 125I-His9-ghrelin in the presence of increasing ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2007
Entry Details Article
PubMed
TargetGrowth hormone secretagogue receptor type 1(Human)
Abbott Laboratories

LigandPNGBDBM19352(6-ethyl-5-{1-[(4-methanesulfonylphenyl)methyl]-1H-...)
Affinity DataIC50: 4nM EC50:  11nMpH: 7.4 T: 2°CAssay Description:Specific binding was determined by incubation of membranes from GHS-R1a transfected CHO-K cells with 125I-His9-ghrelin in the presence of increasing ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2007
Entry Details Article
PubMed
TargetGrowth hormone secretagogue receptor type 1(Human)
Abbott Laboratories

LigandPNGBDBM19351(6-ethyl-5-(4-{[(4-methanesulfonylphenyl)methyl]ami...)
Affinity DataIC50: 7nM EC50:  19nMpH: 7.4 T: 2°CAssay Description:Specific binding was determined by incubation of membranes from GHS-R1a transfected CHO-K cells with 125I-His9-ghrelin in the presence of increasing ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2007
Entry Details Article
PubMed
TargetGrowth hormone secretagogue receptor type 1(Human)
Abbott Laboratories

LigandPNGBDBM19353(5-{2-cyclopentyl-1-[(4-methanesulfonylphenyl)methy...)
Affinity DataIC50: 8nM EC50:  109nMpH: 7.4 T: 2°CAssay Description:Specific binding was determined by incubation of membranes from GHS-R1a transfected CHO-K cells with 125I-His9-ghrelin in the presence of increasing ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2007
Entry Details Article
PubMed
TargetDihydrofolate reductase(Human)
Abbott Laboratories

LigandPNGBDBM19351(6-ethyl-5-(4-{[(4-methanesulfonylphenyl)methyl]ami...)
Affinity DataIC50: 10nMpH: 7.3 T: 2°CAssay Description:DHFR activity was determined by measuring the rate of depletion of NADPH, monitored at 340 nm, with a Beckman DU-7400 spectrophotometer. More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2007
Entry Details Article
PubMed
TargetGrowth hormone secretagogue receptor type 1(Human)
Abbott Laboratories

LigandPNGBDBM19354(6-ethyl-5-{1-[(4-methanesulfonylphenyl)methyl]-2-p...)
Affinity DataIC50: 16nM EC50:  249nMpH: 7.4 T: 2°CAssay Description:Specific binding was determined by incubation of membranes from GHS-R1a transfected CHO-K cells with 125I-His9-ghrelin in the presence of increasing ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2007
Entry Details Article
PubMed
TargetGrowth hormone secretagogue receptor type 1(Human)
Abbott Laboratories

LigandPNGBDBM19359(N-(4-{2,4-diamino-6-[(benzyloxy)methyl]pyrimidin-5...)
Affinity DataIC50: 18nM EC50:  40nMpH: 7.4 T: 2°CAssay Description:Specific binding was determined by incubation of membranes from GHS-R1a transfected CHO-K cells with 125I-His9-ghrelin in the presence of increasing ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2007
Entry Details Article
PubMed
TargetGrowth hormone secretagogue receptor type 1(Human)
Abbott Laboratories

LigandPNGBDBM19366(N-(4-{2,4-diamino-6-[(benzyloxy)methyl]pyrimidin-5...)
Affinity DataIC50: 37nM EC50:  408nMpH: 7.4 T: 2°CAssay Description:Specific binding was determined by incubation of membranes from GHS-R1a transfected CHO-K cells with 125I-His9-ghrelin in the presence of increasing ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2007
Entry Details Article
PubMed
TargetVitamin D-binding protein(Rat)
Ligand Pharmaceuticals

LigandPNGBDBM36717(1,25(OH)2D3)
Affinity DataIC50: 40nMpH: 7.4 T: 2°CAssay Description:DBP competition binding assay were done using human serum (Scantibodies) or rat serum (Gibco-BRL).More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2011
Entry Details Article
PubMed
TargetGrowth hormone secretagogue receptor type 1(Human)
Abbott Laboratories

LigandPNGBDBM19365(2-(2-bromothiophen-3-yl)-N-(4-{2,4-diamino-6-[(ben...)
Affinity DataIC50: 41nM EC50:  137nMpH: 7.4 T: 2°CAssay Description:Specific binding was determined by incubation of membranes from GHS-R1a transfected CHO-K cells with 125I-His9-ghrelin in the presence of increasing ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2007
Entry Details Article
PubMed
TargetGrowth hormone secretagogue receptor type 1(Human)
Abbott Laboratories

LigandPNGBDBM19367(N-(4-{2,4-diamino-6-[(benzyloxy)methyl]pyrimidin-5...)
Affinity DataIC50: 47nM EC50:  343nMpH: 7.4 T: 2°CAssay Description:Specific binding was determined by incubation of membranes from GHS-R1a transfected CHO-K cells with 125I-His9-ghrelin in the presence of increasing ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2007
Entry Details Article
PubMed
TargetGrowth hormone secretagogue receptor type 1(Human)
Abbott Laboratories

LigandPNGBDBM19358(N-(4-{2,4-diamino-6-[(benzyloxy)methyl]pyrimidin-5...)
Affinity DataIC50: 66nM EC50:  188nMpH: 7.4 T: 2°CAssay Description:Specific binding was determined by incubation of membranes from GHS-R1a transfected CHO-K cells with 125I-His9-ghrelin in the presence of increasing ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2007
Entry Details Article
PubMed
TargetGrowth hormone secretagogue receptor type 1(Human)
Abbott Laboratories

LigandPNGBDBM19364(N-(4-{2,4-diamino-6-[(benzyloxy)methyl]pyrimidin-5...)
Affinity DataIC50: 70nM EC50:  382nMpH: 7.4 T: 2°CAssay Description:Specific binding was determined by incubation of membranes from GHS-R1a transfected CHO-K cells with 125I-His9-ghrelin in the presence of increasing ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2007
Entry Details Article
PubMed
TargetGrowth hormone secretagogue receptor type 1(Human)
Abbott Laboratories

LigandPNGBDBM19357(N-(4-{2,4-diamino-6-[(benzyloxy)methyl]pyrimidin-5...)
Affinity DataIC50: 72nM EC50:  108nMpH: 7.4 T: 2°CAssay Description:Specific binding was determined by incubation of membranes from GHS-R1a transfected CHO-K cells with 125I-His9-ghrelin in the presence of increasing ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2007
Entry Details Article
PubMed
TargetGrowth hormone secretagogue receptor type 1(Human)
Abbott Laboratories

LigandPNGBDBM19363(N-(4-{2,4-diamino-6-[(benzyloxy)methyl]pyrimidin-5...)
Affinity DataIC50: 126nM EC50: >1.00E+4nMpH: 7.4 T: 2°CAssay Description:Specific binding was determined by incubation of membranes from GHS-R1a transfected CHO-K cells with 125I-His9-ghrelin in the presence of increasing ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2007
Entry Details Article
PubMed
TargetVitamin D-binding protein(Human)
Ligand Pharmaceuticals

LigandPNGBDBM36717(1,25(OH)2D3)
Affinity DataIC50: 200nMpH: 7.4 T: 2°CAssay Description:DBP competition binding assay were done using human serum (Scantibodies) or rat serum (Gibco-BRL).More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2011
Entry Details Article
PubMed
TargetGrowth hormone secretagogue receptor type 1(Human)
Abbott Laboratories

LigandPNGBDBM19356(N-(4-{2,4-diamino-6-[(benzyloxy)methyl]pyrimidin-5...)
Affinity DataIC50: 221nM EC50: >1.00E+4nMpH: 7.4 T: 2°CAssay Description:Specific binding was determined by incubation of membranes from GHS-R1a transfected CHO-K cells with 125I-His9-ghrelin in the presence of increasing ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2007
Entry Details Article
PubMed
TargetGrowth hormone secretagogue receptor type 1(Human)
Abbott Laboratories

LigandPNGBDBM19375(N-(4-{2,4-diamino-6-[(benzyloxy)methyl]pyrimidin-5...)
Affinity DataIC50: 391nM EC50: >1.00E+4nMpH: 7.4 T: 2°CAssay Description:Specific binding was determined by incubation of membranes from GHS-R1a transfected CHO-K cells with 125I-His9-ghrelin in the presence of increasing ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2007
Entry Details Article
PubMed
TargetGrowth hormone secretagogue receptor type 1(Human)
Abbott Laboratories

LigandPNGBDBM19362(N-(4-{2,4-diamino-6-[(benzyloxy)methyl]pyrimidin-5...)
Affinity DataIC50: 1.00E+3nM EC50: >1.00E+4nMpH: 7.4 T: 2°CAssay Description:Specific binding was determined by incubation of membranes from GHS-R1a transfected CHO-K cells with 125I-His9-ghrelin in the presence of increasing ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2007
Entry Details Article
PubMed
TargetVitamin D-binding protein(Human)
Ligand Pharmaceuticals

LigandPNGBDBM36722(LG190178)
Affinity DataIC50: 1.00E+3nMpH: 7.4 T: 2°CAssay Description:DBP competition binding assay were done using human serum (Scantibodies) or rat serum (Gibco-BRL).More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2011
Entry Details Article
PubMed
TargetVitamin D-binding protein(Human)
Ligand Pharmaceuticals

LigandPNGBDBM36721(LG190176)
Affinity DataIC50: 1.00E+3nMpH: 7.4 T: 2°CAssay Description:DBP competition binding assay were done using human serum (Scantibodies) or rat serum (Gibco-BRL).More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2011
Entry Details Article
PubMed
TargetVitamin D-binding protein(Human)
Ligand Pharmaceuticals

LigandPNGBDBM36720(LG190155)
Affinity DataIC50: 1.00E+3nMpH: 7.4 T: 2°CAssay Description:DBP competition binding assay were done using human serum (Scantibodies) or rat serum (Gibco-BRL).More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2011
Entry Details Article
PubMed
TargetVitamin D-binding protein(Human)
Ligand Pharmaceuticals

LigandPNGBDBM36719(LG190119)
Affinity DataIC50: 1.00E+3nMpH: 7.4 T: 2°CAssay Description:DBP competition binding assay were done using human serum (Scantibodies) or rat serum (Gibco-BRL).More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2011
Entry Details Article
PubMed
TargetVitamin D-binding protein(Human)
Ligand Pharmaceuticals

LigandPNGBDBM36718(LG190090)
Affinity DataIC50: 1.00E+3nMpH: 7.4 T: 2°CAssay Description:DBP competition binding assay were done using human serum (Scantibodies) or rat serum (Gibco-BRL).More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2011
Entry Details Article
PubMed
TargetGrowth hormone secretagogue receptor type 1(Human)
Abbott Laboratories

LigandPNGBDBM19360(N-(4-{2,4-diamino-6-[(benzyloxy)methyl]pyrimidin-5...)
Affinity DataIC50: 1.67E+3nM EC50: >1.00E+4nMpH: 7.4 T: 2°CAssay Description:Specific binding was determined by incubation of membranes from GHS-R1a transfected CHO-K cells with 125I-His9-ghrelin in the presence of increasing ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2007
Entry Details Article
PubMed
TargetDihydrofolate reductase(Human)
Abbott Laboratories

LigandPNGBDBM19353(5-{2-cyclopentyl-1-[(4-methanesulfonylphenyl)methy...)
Affinity DataIC50: 1.83E+3nMpH: 7.3 T: 2°CAssay Description:DHFR activity was determined by measuring the rate of depletion of NADPH, monitored at 340 nm, with a Beckman DU-7400 spectrophotometer. More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2007
Entry Details Article
PubMed
TargetGrowth hormone secretagogue receptor type 1(Human)
Abbott Laboratories

LigandPNGBDBM19355(N-(4-{2,4-diamino-6-[(benzyloxy)methyl]pyrimidin-5...)
Affinity DataIC50: 2.27E+3nM EC50: >1.00E+4nMpH: 7.4 T: 2°CAssay Description:Specific binding was determined by incubation of membranes from GHS-R1a transfected CHO-K cells with 125I-His9-ghrelin in the presence of increasing ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2007
Entry Details Article
PubMed
TargetDihydrofolate reductase(Human)
Abbott Laboratories

LigandPNGBDBM19354(6-ethyl-5-{1-[(4-methanesulfonylphenyl)methyl]-2-p...)
Affinity DataIC50: 2.30E+3nMpH: 7.3 T: 2°CAssay Description:DHFR activity was determined by measuring the rate of depletion of NADPH, monitored at 340 nm, with a Beckman DU-7400 spectrophotometer. More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2007
Entry Details Article
PubMed
TargetGrowth hormone secretagogue receptor type 1(Human)
Abbott Laboratories

LigandPNGBDBM19361(N-(4-{2,4-diamino-6-[(benzyloxy)methyl]pyrimidin-5...)
Affinity DataIC50: 3.08E+3nM EC50: >1.00E+4nMpH: 7.4 T: 2°CAssay Description:Specific binding was determined by incubation of membranes from GHS-R1a transfected CHO-K cells with 125I-His9-ghrelin in the presence of increasing ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2007
Entry Details Article
PubMed
TargetDihydrofolate reductase(Human)
Abbott Laboratories

LigandPNGBDBM19358(N-(4-{2,4-diamino-6-[(benzyloxy)methyl]pyrimidin-5...)
Affinity DataIC50: 2.80E+4nMpH: 7.3 T: 2°CAssay Description:DHFR activity was determined by measuring the rate of depletion of NADPH, monitored at 340 nm, with a Beckman DU-7400 spectrophotometer. More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2007
Entry Details Article
PubMed
TargetVitamin D3 receptor(Human)
Ligand Pharmaceuticals

LigandPNGBDBM36717(1,25(OH)2D3)
Affinity DataKi:  0.5nM ΔG°:  -49.3kJ/molepH: 7.5 T: 2°CAssay Description:VDR in vitro ligand-binding assay using human VDR constructed into a yeast expression plasmid.More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2011
Entry Details Article
PubMed
TargetVitamin D3 receptor(Human)
Ligand Pharmaceuticals

LigandPNGBDBM36722(LG190178)
Affinity DataKi:  150nM ΔG°:  -36.2kJ/molepH: 7.5 T: 2°CAssay Description:VDR in vitro ligand-binding assay using human VDR constructed into a yeast expression plasmid.More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2011
Entry Details Article
PubMed
TargetVitamin D3 receptor(Human)
Ligand Pharmaceuticals

LigandPNGBDBM36720(LG190155)
Affinity DataKi: >1.00E+3nM ΔG°: >-31.8kJ/molepH: 7.5 T: 2°CAssay Description:VDR in vitro ligand-binding assay using human VDR constructed into a yeast expression plasmid.More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2011
Entry Details Article
PubMed
TargetVitamin D3 receptor(Human)
Ligand Pharmaceuticals

LigandPNGBDBM36721(LG190176)
Affinity DataKi: >1.00E+3nM ΔG°: >-31.8kJ/molepH: 7.5 T: 2°CAssay Description:VDR in vitro ligand-binding assay using human VDR constructed into a yeast expression plasmid.More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2011
Entry Details Article
PubMed
TargetVitamin D3 receptor(Human)
Ligand Pharmaceuticals

LigandPNGBDBM36719(LG190119)
Affinity DataKi: >1.00E+3nM ΔG°: >-31.8kJ/molepH: 7.5 T: 2°CAssay Description:VDR in vitro ligand-binding assay using human VDR constructed into a yeast expression plasmid.More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2011
Entry Details Article
PubMed
TargetVitamin D3 receptor(Human)
Ligand Pharmaceuticals

LigandPNGBDBM36718(LG190090)
Affinity DataKi: >1.00E+3nM ΔG°: >-31.8kJ/molepH: 7.5 T: 2°CAssay Description:VDR in vitro ligand-binding assay using human VDR constructed into a yeast expression plasmid.More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2011
Entry Details Article
PubMed