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TargetPolycomb protein EED(Human)
Novartis Institutes for Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50035558(5-(2-Fluoro-phenyl)-2,3-dihydro-imidazo[2,1-a]isoq...)
Affinity DataKd:  1.35E+4nMAssay Description:Binding affinity to his-tagged EED (76 to 441 residues) (unknown origin) expressed in Escherichia coli BL21 (DE3) assessed as dissociation constant b...More data for this Ligand-Target Pair
In DepthDetails
PubMedPDB3D3D Structure (crystal)
TargetDDB1- and CUL4-associated factor 15(Human)
Novartis Institutes for Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50035558(5-(2-Fluoro-phenyl)-2,3-dihydro-imidazo[2,1-a]isoq...)
Affinity DataKd: >1.00E+5nMAssay Description:Binding affinity to Avi-tagged DCAF1 (1073 to 1399 residues) (unknown origin) expressed in baculovirus infected in Sf9 insect cells by SPR analysisMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetDDB1- and CUL4-associated factor 15(Human)
Novartis Institutes for Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50627130(CHEMBL5417380)
Affinity DataKd: >1.00E+5nMAssay Description:Binding affinity to Avi-tagged DCAF1 (1073 to 1399 residues) (unknown origin) expressed in baculovirus infected in Sf9 insect cells by SPR analysisMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetDDB1- and CUL4-associated factor 15(Human)
Novartis Institutes for Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50627131(CHEMBL5413392)
Affinity DataKd:  4.10E+4nMAssay Description:Binding affinity to Avi-tagged DCAF1 (1073 to 1399 residues) (unknown origin) expressed in baculovirus infected in Sf9 insect cells by SPR analysisMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetDDB1- and CUL4-associated factor 15(Human)
Novartis Institutes for Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50627132(CHEMBL5397755)
Affinity DataKd: >5.00E+4nMAssay Description:Binding affinity to Avi-tagged DCAF1 (1073 to 1399 residues) (unknown origin) expressed in baculovirus infected in Sf9 insect cells by SPR analysisMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetDDB1- and CUL4-associated factor 15(Human)
Novartis Institutes for Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50627133(CHEMBL5430500)
Affinity DataKd:  1.14E+4nMAssay Description:Binding affinity to Avi-tagged DCAF1 (1073 to 1399 residues) (unknown origin) expressed in baculovirus infected in Sf9 insect cells by SPR analysisMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetDDB1- and CUL4-associated factor 15(Human)
Novartis Institutes for Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50627134(CHEMBL5424418)
Affinity DataKd:  2.67E+4nMAssay Description:Binding affinity to Avi-tagged DCAF1 (1073 to 1399 residues) (unknown origin) expressed in baculovirus infected in Sf9 insect cells by SPR analysisMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetDDB1- and CUL4-associated factor 15(Human)
Novartis Institutes for Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50627135(CHEMBL5409735)
Affinity DataKd:  5.60E+3nMAssay Description:Binding affinity to Avi-tagged DCAF1 (1073 to 1399 residues) (unknown origin) expressed in baculovirus infected in Sf9 insect cells by SPR analysisMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetDDB1- and CUL4-associated factor 15(Human)
Novartis Institutes for Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50627136(CHEMBL5424590)
Affinity DataKd:  1.50E+3nMAssay Description:Binding affinity to Avi-tagged DCAF1 (1073 to 1399 residues) (unknown origin) expressed in baculovirus infected in Sf9 insect cells by SPR analysisMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetDDB1- and CUL4-associated factor 15(Human)
Novartis Institutes for Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50627137(CHEMBL5439774)
Affinity DataKd:  98nMAssay Description:Binding affinity to Avi-tagged DCAF1 (1073 to 1399 residues) (unknown origin) expressed in baculovirus infected in Sf9 insect cells by SPR analysisMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetDDB1- and CUL4-associated factor 15(Human)
Novartis Institutes for Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50627138(CHEMBL5397181)
Affinity DataKd:  47nMAssay Description:Binding affinity to Avi-tagged DCAF1 (1073 to 1399 residues) (unknown origin) expressed in baculovirus infected in Sf9 insect cells by SPR analysisMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetDDB1- and CUL4-associated factor 15(Human)
Novartis Institutes for Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50627139(CHEMBL5431028)
Affinity DataKd:  83nMAssay Description:Binding affinity to Avi-tagged DCAF1 (1073 to 1399 residues) (unknown origin) expressed in baculovirus infected in Sf9 insect cells by SPR analysisMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetDDB1- and CUL4-associated factor 15(Human)
Novartis Institutes for Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50627140(CHEMBL5429394)
Affinity DataKd:  31nMAssay Description:Binding affinity to Avi-tagged DCAF1 (1073 to 1399 residues) (unknown origin) expressed in baculovirus infected in Sf9 insect cells by SPR analysisMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetDDB1- and CUL4-associated factor 15(Human)
Novartis Institutes for Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50035558(5-(2-Fluoro-phenyl)-2,3-dihydro-imidazo[2,1-a]isoq...)
Affinity DataKd: >5.00E+5nMAssay Description:Binding affinity to Avi-tagged DCAF1 (1039 to 1401 residues) (unknown origin) expressed in baculovirus infected in Sf9 insect cells by NMR analysisMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetDDB1- and CUL4-associated factor 15(Human)
Novartis Institutes for Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50627130(CHEMBL5417380)
Affinity DataKd: >5.00E+5nMAssay Description:Binding affinity to Avi-tagged DCAF1 (1039 to 1401 residues) (unknown origin) expressed in baculovirus infected in Sf9 insect cells by NMR analysisMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetDDB1- and CUL4-associated factor 15(Human)
Novartis Institutes for Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50627141(CHEMBL5403546)
Affinity DataKd:  4.00E+4nMAssay Description:Binding affinity to Avi-tagged DCAF1 (1039 to 1401 residues) (unknown origin) expressed in baculovirus infected in Sf9 insect cells by NMR analysisMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetDDB1- and CUL4-associated factor 15(Human)
Novartis Institutes for Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50627131(CHEMBL5413392)
Affinity DataKd:  1.30E+4nMAssay Description:Binding affinity to Avi-tagged DCAF1 (1039 to 1401 residues) (unknown origin) expressed in baculovirus infected in Sf9 insect cells by NMR analysisMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetPolycomb protein EED(Human)
Novartis Institutes for Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50627141(CHEMBL5403546)
Affinity DataKd:  2.10E+4nMAssay Description:Binding affinity to his-tagged EED (76 to 441 residues) (unknown origin) expressed in Escherichia coli BL21 (DE3) using H3K27me3 as substrate assesse...More data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetPolycomb protein EED(Human)
Novartis Institutes for Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50627131(CHEMBL5413392)
Affinity DataKd:  2.50E+4nMAssay Description:Binding affinity to his-tagged EED (76 to 441 residues) (unknown origin) expressed in Escherichia coli BL21 (DE3) using H3K27me3 as substrate assesse...More data for this Ligand-Target Pair
In DepthDetails
PubMed
LigandPNGBDBM695278(US12083101, Example 27a)
Affinity DataIC50: 1nMAssay Description:Avi-humanTEAD4217-434 (1 nM, produced as described in Hau et al. ChemBioChem 14, 1218, 2013) and LANCE Eu-W1024 Streptavidin (0.5 nM, PerkinElmer) we...More data for this Ligand-Target Pair
Ligand InfoSimilars
In DepthDetails
US Patent

LigandPNGBDBM695279(US12083101, Example 27b)
Affinity DataIC50: 1nMAssay Description:Avi-humanTEAD4217-434 (1 nM, produced as described in Hau et al. ChemBioChem 14, 1218, 2013) and LANCE Eu-W1024 Streptavidin (0.5 nM, PerkinElmer) we...More data for this Ligand-Target Pair
Ligand InfoSimilars
In DepthDetails
US Patent

LigandPNGBDBM695310(US12083101, Example 55b | US12083101, Example 55a)
Affinity DataIC50: 1nMAssay Description:Avi-humanTEAD4217-434 (1 nM, produced as described in Hau et al. ChemBioChem 14, 1218, 2013) and LANCE Eu-W1024 Streptavidin (0.5 nM, PerkinElmer) we...More data for this Ligand-Target Pair
Ligand InfoSimilars
In DepthDetails
US Patent

LigandPNGBDBM695340(US12083101, Example 71b)
Affinity DataIC50: 1nMAssay Description:Avi-humanTEAD4217-434 (1 nM, produced as described in Hau et al. ChemBioChem 14, 1218, 2013) and LANCE Eu-W1024 Streptavidin (0.5 nM, PerkinElmer) we...More data for this Ligand-Target Pair
Ligand InfoSimilars
In DepthDetails
US Patent

LigandPNGBDBM50626283(US12083101, Example 106 | CHEMBL5400107)
Affinity DataIC50: 1nMAssay Description:Avi-humanTEAD4217-434 (1 nM, produced as described in Hau et al. ChemBioChem 14, 1218, 2013) and LANCE Eu-W1024 Streptavidin (0.5 nM, PerkinElmer) we...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM695385(US12083101, Example 110)
Affinity DataIC50: 1nMAssay Description:Avi-humanTEAD4217-434 (1 nM, produced as described in Hau et al. ChemBioChem 14, 1218, 2013) and LANCE Eu-W1024 Streptavidin (0.5 nM, PerkinElmer) we...More data for this Ligand-Target Pair
Ligand InfoSimilars
In DepthDetails
US Patent

LigandPNGBDBM695387(US12083101, Example 112)
Affinity DataIC50: 1nMAssay Description:Avi-humanTEAD4217-434 (1 nM, produced as described in Hau et al. ChemBioChem 14, 1218, 2013) and LANCE Eu-W1024 Streptavidin (0.5 nM, PerkinElmer) we...More data for this Ligand-Target Pair
Ligand InfoSimilars
In DepthDetails
US Patent

LigandPNGBDBM695393(US12083101, Example 116a)
Affinity DataIC50: 1nMAssay Description:Avi-humanTEAD4217-434 (1 nM, produced as described in Hau et al. ChemBioChem 14, 1218, 2013) and LANCE Eu-W1024 Streptavidin (0.5 nM, PerkinElmer) we...More data for this Ligand-Target Pair
Ligand InfoSimilars
In DepthDetails
US Patent

LigandPNGBDBM695394(US12083101, Example 116b)
Affinity DataIC50: 1nMAssay Description:Avi-humanTEAD4217-434 (1 nM, produced as described in Hau et al. ChemBioChem 14, 1218, 2013) and LANCE Eu-W1024 Streptavidin (0.5 nM, PerkinElmer) we...More data for this Ligand-Target Pair
Ligand InfoSimilars
In DepthDetails
US Patent

LigandPNGBDBM695395(US12083101, Example 117a)
Affinity DataIC50: 1nMAssay Description:Avi-humanTEAD4217-434 (1 nM, produced as described in Hau et al. ChemBioChem 14, 1218, 2013) and LANCE Eu-W1024 Streptavidin (0.5 nM, PerkinElmer) we...More data for this Ligand-Target Pair
Ligand InfoSimilars
In DepthDetails
US Patent

LigandPNGBDBM695396(US12083101, Example 117b)
Affinity DataIC50: 1nMAssay Description:Avi-humanTEAD4217-434 (1 nM, produced as described in Hau et al. ChemBioChem 14, 1218, 2013) and LANCE Eu-W1024 Streptavidin (0.5 nM, PerkinElmer) we...More data for this Ligand-Target Pair
Ligand InfoSimilars
In DepthDetails
US Patent

LigandPNGBDBM695397(US12083101, Example 118)
Affinity DataIC50: 1nMAssay Description:Avi-humanTEAD4217-434 (1 nM, produced as described in Hau et al. ChemBioChem 14, 1218, 2013) and LANCE Eu-W1024 Streptavidin (0.5 nM, PerkinElmer) we...More data for this Ligand-Target Pair
Ligand InfoSimilars
In DepthDetails
US Patent

LigandPNGBDBM695431(US12083101, Example 147)
Affinity DataIC50: 1nMAssay Description:Avi-humanTEAD4217-434 (1 nM, produced as described in Hau et al. ChemBioChem 14, 1218, 2013) and LANCE Eu-W1024 Streptavidin (0.5 nM, PerkinElmer) we...More data for this Ligand-Target Pair
Ligand InfoSimilars
In DepthDetails
US Patent

LigandPNGBDBM695437(US12083101, Example 153 | 2-((2S,4S)-5-Chloro-6-fl...)
Affinity DataIC50: 1nMAssay Description:Avi-humanTEAD4217-434 (1 nM, produced as described in Hau et al. ChemBioChem 14, 1218, 2013) and LANCE Eu-W1024 Streptavidin (0.5 nM, PerkinElmer) we...More data for this Ligand-Target Pair
Ligand InfoSimilars
In DepthDetails
US Patent

LigandPNGBDBM695454(US12083101, Example 170)
Affinity DataIC50: 1nMAssay Description:Avi-humanTEAD4217-434 (1 nM, produced as described in Hau et al. ChemBioChem 14, 1218, 2013) and LANCE Eu-W1024 Streptavidin (0.5 nM, PerkinElmer) we...More data for this Ligand-Target Pair
Ligand InfoSimilars
In DepthDetails
US Patent

LigandPNGBDBM695263(US12083101, Example 12)
Affinity DataIC50: 1.5nMAssay Description:Avi-humanTEAD4217-434 (1 nM, produced as described in Hau et al. ChemBioChem 14, 1218, 2013) and LANCE Eu-W1024 Streptavidin (0.5 nM, PerkinElmer) we...More data for this Ligand-Target Pair
Ligand InfoSimilars
In DepthDetails
US Patent

TargetSerine/threonine-protein kinase mTOR(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM92862(mTOR Inhibitor, BEZ235 | US9284315, BEZ-235)
Affinity DataIC50: 1.90nMAssay Description:Displacement of Alexa Fluor labelled Tracer-314 from human N-terminal GST-tagged mTOR incubated for 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
LigandPNGBDBM695291(US12083101, Example 37)
Affinity DataIC50: 2nMAssay Description:Avi-humanTEAD4217-434 (1 nM, produced as described in Hau et al. ChemBioChem 14, 1218, 2013) and LANCE Eu-W1024 Streptavidin (0.5 nM, PerkinElmer) we...More data for this Ligand-Target Pair
Ligand InfoSimilars
In DepthDetails
US Patent

LigandPNGBDBM695292(US12083101, Example 38)
Affinity DataIC50: 2nMAssay Description:Avi-humanTEAD4217-434 (1 nM, produced as described in Hau et al. ChemBioChem 14, 1218, 2013) and LANCE Eu-W1024 Streptavidin (0.5 nM, PerkinElmer) we...More data for this Ligand-Target Pair
Ligand InfoSimilars
In DepthDetails
US Patent

LigandPNGBDBM695302(US12083101, Example 48)
Affinity DataIC50: 2nMAssay Description:Avi-humanTEAD4217-434 (1 nM, produced as described in Hau et al. ChemBioChem 14, 1218, 2013) and LANCE Eu-W1024 Streptavidin (0.5 nM, PerkinElmer) we...More data for this Ligand-Target Pair
Ligand InfoSimilars
In DepthDetails
US Patent

LigandPNGBDBM695310(US12083101, Example 55b | US12083101, Example 55a)
Affinity DataIC50: 2nMAssay Description:Avi-humanTEAD4217-434 (1 nM, produced as described in Hau et al. ChemBioChem 14, 1218, 2013) and LANCE Eu-W1024 Streptavidin (0.5 nM, PerkinElmer) we...More data for this Ligand-Target Pair
Ligand InfoSimilars
In DepthDetails
US Patent

LigandPNGBDBM695312(US12083101, Example 56b | US12083101, Example 56a)
Affinity DataIC50: 2nMAssay Description:Avi-humanTEAD4217-434 (1 nM, produced as described in Hau et al. ChemBioChem 14, 1218, 2013) and LANCE Eu-W1024 Streptavidin (0.5 nM, PerkinElmer) we...More data for this Ligand-Target Pair
Ligand InfoSimilars
In DepthDetails
US Patent

LigandPNGBDBM695326(US12083101, Example 64a)
Affinity DataIC50: 2nMAssay Description:Avi-humanTEAD4217-434 (1 nM, produced as described in Hau et al. ChemBioChem 14, 1218, 2013) and LANCE Eu-W1024 Streptavidin (0.5 nM, PerkinElmer) we...More data for this Ligand-Target Pair
Ligand InfoSimilars
In DepthDetails
US Patent

LigandPNGBDBM695330(US12083101, Example 66a)
Affinity DataIC50: 2nMAssay Description:Avi-humanTEAD4217-434 (1 nM, produced as described in Hau et al. ChemBioChem 14, 1218, 2013) and LANCE Eu-W1024 Streptavidin (0.5 nM, PerkinElmer) we...More data for this Ligand-Target Pair
Ligand InfoSimilars
In DepthDetails
US Patent

LigandPNGBDBM695331(US12083101, Example 66b)
Affinity DataIC50: 2nMAssay Description:Avi-humanTEAD4217-434 (1 nM, produced as described in Hau et al. ChemBioChem 14, 1218, 2013) and LANCE Eu-W1024 Streptavidin (0.5 nM, PerkinElmer) we...More data for this Ligand-Target Pair
Ligand InfoSimilars
In DepthDetails
US Patent

LigandPNGBDBM695332(US12083101, Example 67a)
Affinity DataIC50: 2nMAssay Description:Avi-humanTEAD4217-434 (1 nM, produced as described in Hau et al. ChemBioChem 14, 1218, 2013) and LANCE Eu-W1024 Streptavidin (0.5 nM, PerkinElmer) we...More data for this Ligand-Target Pair
Ligand InfoSimilars
In DepthDetails
US Patent

LigandPNGBDBM695339(US12083101, Example 71a)
Affinity DataIC50: 2nMAssay Description:Avi-humanTEAD4217-434 (1 nM, produced as described in Hau et al. ChemBioChem 14, 1218, 2013) and LANCE Eu-W1024 Streptavidin (0.5 nM, PerkinElmer) we...More data for this Ligand-Target Pair
Ligand InfoSimilars
In DepthDetails
US Patent

LigandPNGBDBM695341(US12083101, Example 72)
Affinity DataIC50: 2nMAssay Description:Avi-humanTEAD4217-434 (1 nM, produced as described in Hau et al. ChemBioChem 14, 1218, 2013) and LANCE Eu-W1024 Streptavidin (0.5 nM, PerkinElmer) we...More data for this Ligand-Target Pair
Ligand InfoSimilars
In DepthDetails
US Patent

LigandPNGBDBM695365(US12083101, Example 94a)
Affinity DataIC50: 2nMAssay Description:Avi-humanTEAD4217-434 (1 nM, produced as described in Hau et al. ChemBioChem 14, 1218, 2013) and LANCE Eu-W1024 Streptavidin (0.5 nM, PerkinElmer) we...More data for this Ligand-Target Pair
Ligand InfoSimilars
In DepthDetails
US Patent

LigandPNGBDBM695372(US12083101, Example 99)
Affinity DataIC50: 2nMAssay Description:Avi-humanTEAD4217-434 (1 nM, produced as described in Hau et al. ChemBioChem 14, 1218, 2013) and LANCE Eu-W1024 Streptavidin (0.5 nM, PerkinElmer) we...More data for this Ligand-Target Pair
Ligand InfoSimilars
In DepthDetails
US Patent

LigandPNGBDBM695373(US12083101, Example 100a)
Affinity DataIC50: 2nMAssay Description:Avi-humanTEAD4217-434 (1 nM, produced as described in Hau et al. ChemBioChem 14, 1218, 2013) and LANCE Eu-W1024 Streptavidin (0.5 nM, PerkinElmer) we...More data for this Ligand-Target Pair
Ligand InfoSimilars
In DepthDetails
US Patent

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